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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29487

FusionGeneSummary for PTPRA_TADA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRA_TADA2A
Fusion gene ID: 29487
HgeneTgene
Gene symbol

PTPRA

TADA2A

Gene ID

5786

6871

Gene nameprotein tyrosine phosphatase, receptor type Atranscriptional adaptor 2A
SynonymsHEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPAADA2|ADA2A|KL04P|TADA2L|hADA2
Cytomap

20p13

17q12

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alphtranscriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alpha
Modification date2018052720180523
UniProtAcc

P18433

O75478

Ensembl transtripts involved in fusion geneENST00000380393, ENST00000216877, 
ENST00000358719, ENST00000399903, 
ENST00000425918, ENST00000318266, 
ENST00000356147, 
ENST00000394395, 
ENST00000586023, ENST00000225396, 
ENST00000417170, ENST00000591992, 
Fusion gene scores* DoF score13 X 10 X 8=10407 X 5 X 3=105
# samples 147
** MAII scorelog2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRA [Title/Abstract] AND TADA2A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTADA2A

GO:0043966

histone H3 acetylation

9674425


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-97-A4LX-01APTPRAchr20

2854406

+TADA2Achr17

35771356

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000380393ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000380393ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000380393ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000380393ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-intronENST00000380393ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000216877ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000216877ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000216877ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000216877ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-intronENST00000216877ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000358719ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000358719ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000358719ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000358719ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-intronENST00000358719ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000399903ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000399903ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000399903ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000399903ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-intronENST00000399903ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000425918ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000425918ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000425918ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000425918ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-intronENST00000425918ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000318266ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000318266ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000318266ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-5UTRENST00000318266ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
5UTR-intronENST00000318266ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000356147ENST00000394395PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000356147ENST00000586023PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000356147ENST00000225396PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-5UTRENST00000356147ENST00000417170PTPRAchr20

2854406

+TADA2Achr17

35771356

+
intron-intronENST00000356147ENST00000591992PTPRAchr20

2854406

+TADA2Achr17

35771356

+

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FusionProtFeatures for PTPRA_TADA2A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRA

P18433

TADA2A

O75478

Component of the ATAC complex, a complex with histoneacetyltransferase activity on histones H3 and H4. Required for thefunction of some acidic activation domains, which activatetranscription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker regionbetween neighboring nucleosomes. Plays a role in chromatinremodeling. May promote TP53/p53 'Lys-321' acetylation, leading toreduced TP53 stability and transcriptional activity(PubMed:22644376). May also promote XRCC6 acetylation thusfacilitating cell apoptosis in response to DNA damage(PubMed:22644376). {ECO:0000250|UniProtKB:Q8CHV6,ECO:0000269|PubMed:19103755, ECO:0000269|PubMed:22644376}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRA_TADA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRA_TADA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRAGRB2, KCNA2, SRC, FYN, UVRAG, GABARAPL2, CALM1, LGALS8, FCN1, HSPB1, YWHAZ, SMEK1, EGFR, ERBB2, ARL2, ATXN2, KCNMA1, NCBP1, PSAT1, PTPRE, VPS25, TMEM51, CCDC88A, EPB41L1, PSD3, BASP1, GPRIN3, EXOC3, BAIAP2, RAPH1, NF2, GAB1, ASNSD1, DENND4A, TPCN2, SP4, CYB561, GALNT12, LGALS1, PTPRA, TXNDC5, XPO5, TNPO3, SAAL1, XPO4, B4GAT1, XPO6, PDIA6, NCDN, CSE1L, TNPO1, XPOT, CANX, MBP, PTPRGTADA2AEXOC8, FAM107A, HGS, TADA3, MYC, NR3C1, KAT2A, ATXN7, TP53, CTNNB1, KAT2B, MED1, MED26, CCDC101, ERCC4, CDK8, SRSF1, DDX3X, LUC7L, RNF41, DHX16, DDB1, MED29, TRIM28, SNRPA, SSB, NCBP1, PRPF6, CDC40, SRSF3, WDTC1, RBM39, MED30, MED28, PSPC1, TRA2B, TRA2A, RALY, NONO, PRRC2B, PLRG1, HELT, SRSF4, XAB2, MED8, PUF60, MED25, DHX15, RNPS1, SRSF5, EIF3H, SRRM1, LRCH4, MYEF2, RBM14, EIF3I, MED20, EIF3C, EIF3M, SIN3A, EIF3B, EIF3L, PRPF19, HNRNPC, ILF3, CDC5L, AKAP8, MED18, SNW1, HDAC1, MARK3, PABPC1P1, C11orf30, KRT8, POLR2A, SRRM2, MED16, ILF2, HSPA5, MED14, MED31, LUC7L3, DDX5, MED4, SFPQ, MED15, MED17, DDX17, POLR2B, WDR5, HNRNPF, ACTC1, DOCK6, LUZP1, MED27, POLR2C, HNRNPM, MARK2, MED22, MED23, ZZZ3, MED6, MED12, MED13, YEATS2, DR1, MBIP, SUPT3H, TCF3, PAXIP1, HSP90AA1, HNF4A, LYN, MCPH1, USP22, ARNT2, PRKAB2, KPNA2, MAGOH, MFAP1, EIF4E2, MTX2, FARS2, SF3A3, ZFYVE26, PPP1R16B, PRPF31, CCHCR1, C1orf109, CDCA7L, GPSM3, TTC23, FBF1, KLC4, LOC149950, TEKT4, ZNF564, TTC9C, KLHL38, FAM127C, PSME3, CARD8, PSMC3, IKZF5, CDH19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRA_TADA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRA_TADA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRAC0036341Schizophrenia2PSYGENET
HgenePTPRAC0151744Myocardial Ischemia1CTD_human