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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29481

FusionGeneSummary for PTPRA_PSMF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPRA_PSMF1
Fusion gene ID: 29481
HgeneTgene
Gene symbol

PTPRA

PSMF1

Gene ID

5786

9491

Gene nameprotein tyrosine phosphatase, receptor type Aproteasome inhibitor subunit 1
SynonymsHEPTP|HLPR|HPTPA|HPTPalpha|LRP|PTPA|PTPRL2|R-PTP-alpha|RPTPAPI31
Cytomap

20p13

20p13

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase alphaLeukocyte common antigen-related peptide (protein tyrosine phosphate)PTPLCA-related phosphatasePTPase-alphaprotein tyrosine phosphatase, receptor type, alpha polypeptideprotein-tyrosine phosphatase alphproteasome inhibitor PI31 subunitproteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Modification date2018052720180523
UniProtAcc

P18433

Q92530

Ensembl transtripts involved in fusion geneENST00000380393, ENST00000216877, 
ENST00000358719, ENST00000399903, 
ENST00000425918, ENST00000318266, 
ENST00000356147, 
ENST00000381898, 
ENST00000333082, ENST00000246015, 
ENST00000335877, ENST00000438768, 
ENST00000484891, 
Fusion gene scores* DoF score13 X 10 X 8=10405 X 5 X 3=75
# samples 145
** MAII scorelog2(14/1040*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTPRA [Title/Abstract] AND PSMF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePSMF1

GO:0006511

ubiquitin-dependent protein catabolic process

10764772

TgenePSMF1

GO:1901799

negative regulation of proteasomal protein catabolic process

10764772


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-HC-8265-01APTPRAchr20

2969120

+PSMF1chr20

1115764

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000380393ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000380393ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000380393ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000380393ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000380393ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000380393ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000216877ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000216877ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000216877ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000216877ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000216877ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000216877ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000358719ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000358719ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000358719ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000358719ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000358719ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000358719ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000399903ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000399903ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000399903ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000399903ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000399903ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000399903ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000425918ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000425918ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000425918ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000425918ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000425918ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000425918ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000318266ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000318266ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000318266ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000318266ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000318266ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000318266ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000356147ENST00000381898PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000356147ENST00000333082PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000356147ENST00000246015PTPRAchr20

2969120

+PSMF1chr20

1115764

+
Frame-shitENST00000356147ENST00000335877PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-intronENST00000356147ENST00000438768PTPRAchr20

2969120

+PSMF1chr20

1115764

+
5CDS-3UTRENST00000356147ENST00000484891PTPRAchr20

2969120

+PSMF1chr20

1115764

+

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FusionProtFeatures for PTPRA_PSMF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPRA

P18433

PSMF1

Q92530

Plays an important role in control of proteasomefunction. Inhibits the hydrolysis of protein and peptidesubstrates by the 20S proteasome. Also inhibits the activation ofthe proteasome by the proteasome regulatory proteins PA700 andPA28. {ECO:0000269|PubMed:10764772}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPRA_PSMF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPRA_PSMF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPRAGRB2, KCNA2, SRC, FYN, UVRAG, GABARAPL2, CALM1, LGALS8, FCN1, HSPB1, YWHAZ, SMEK1, EGFR, ERBB2, ARL2, ATXN2, KCNMA1, NCBP1, PSAT1, PTPRE, VPS25, TMEM51, CCDC88A, EPB41L1, PSD3, BASP1, GPRIN3, EXOC3, BAIAP2, RAPH1, NF2, GAB1, ASNSD1, DENND4A, TPCN2, SP4, CYB561, GALNT12, LGALS1, PTPRA, TXNDC5, XPO5, TNPO3, SAAL1, XPO4, B4GAT1, XPO6, PDIA6, NCDN, CSE1L, TNPO1, XPOT, CANX, MBP, PTPRGPSMF1MAGEA11, PDLIM7, KHDRBS3, TRAF2, MIEF2, HOOK2, RNF126, NUDT21, BEND7, CCDC85B, CTBP2, RBMX, RHOXF2, FBXO7, PSMA2, CUL1, CD2BP2, RBFOX1, QKI, RALYL, DVL3, PAK7, LDOC1, RBFOX2, PSMA7, SHFM1, HIST1H1A, PSMA1, C9orf24, PSMB4, PSMG2, PSMB7, PSMB9, CYP1A1, PSMF1, PSMB1, PSMB2, PSMB3, ALOX5, SNRNP27, MRPS11, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPRA_PSMF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPRA_PSMF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPRAC0036341Schizophrenia2PSYGENET
HgenePTPRAC0151744Myocardial Ischemia1CTD_human