FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29474

FusionGeneSummary for PTPN9_TOR1AIP2

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN9_TOR1AIP2
Fusion gene ID: 29474
HgeneTgene
Gene symbol

PTPN9

TOR1AIP2

Gene ID

5780

163590

Gene nameprotein tyrosine phosphatase, non-receptor type 9torsin 1A interacting protein 2
SynonymsMEG2|PTPMEG2IFRG15|LULL1|NET9
Cytomap

15q24.2

1q25.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2torsin-1A-interacting protein 2interferon alpha responsive protein15 kDa interferon-responsive proteininterferon responsive gene 15lumenal domain like LAP1torsin A interacting protein 2
Modification date2018052020180519
UniProtAcc

P43378

Q8NFQ8

Ensembl transtripts involved in fusion geneENST00000306726, ENST00000564970, 
ENST00000367612, ENST00000609928, 
ENST00000482587, 
Fusion gene scores* DoF score8 X 6 X 7=3363 X 3 X 1=9
# samples 133
** MAII scorelog2(13/336*10)=-1.36994960975031
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPN9 [Title/Abstract] AND TOR1AIP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN9

GO:0010977

negative regulation of neuron projection development

27655914

HgenePTPN9

GO:0035335

peptidyl-tyrosine dephosphorylation

27655914

HgenePTPN9

GO:1903078

positive regulation of protein localization to plasma membrane

27655914

TgeneTOR1AIP2

GO:0032781

positive regulation of ATPase activity

23569223|24275647

TgeneTOR1AIP2

GO:0090435

protein localization to nuclear envelope

19339278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK126088PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000306726ENST00000367612PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
intron-intronENST00000306726ENST00000609928PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
intron-5UTRENST00000306726ENST00000482587PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
intron-intronENST00000564970ENST00000367612PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
intron-intronENST00000564970ENST00000609928PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-
intron-5UTRENST00000564970ENST00000482587PTPN9chr15

75767662

+TOR1AIP2chr1

179831838

-

Top

FusionProtFeatures for PTPN9_TOR1AIP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN9

P43378

TOR1AIP2

Q8NFQ8

Protein-tyrosine phosphatase that could participate inthe transfer of hydrophobic ligands or in functions of the Golgiapparatus. {ECO:0000269|PubMed:19167335}. Required for endoplasmic reticulum integrity. Regulatesthe distribution of TOR1A between the endoplasmic reticulum andthe nuclear envelope as well as induces TOR1A, TOR1B and TOR3AATPase activity. {ECO:0000269|PubMed:19339278,ECO:0000269|PubMed:23569223, ECO:0000269|PubMed:24275647}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTPN9_TOR1AIP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PTPN9_TOR1AIP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PTPN9_TOR1AIP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PTPN9_TOR1AIP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource