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Fusion gene ID: 29472 |
FusionGeneSummary for PTPN9_SCAPER |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN9_SCAPER | Fusion gene ID: 29472 | Hgene | Tgene | Gene symbol | PTPN9 | SCAPER | Gene ID | 5780 | 49855 |
| Gene name | protein tyrosine phosphatase, non-receptor type 9 | S-phase cyclin A associated protein in the ER | |
| Synonyms | MEG2|PTPMEG2 | MSTP063|ZNF291|Zfp291 | |
| Cytomap | 15q24.2 | 15q24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2 | S phase cyclin A-associated protein in the endoplasmic reticulumzinc finger protein 291 | |
| Modification date | 20180520 | 20180519 | |
| UniProtAcc | P43378 | Q9BY12 | |
| Ensembl transtripts involved in fusion gene | ENST00000306726, ENST00000564970, | ENST00000538941, ENST00000563290, ENST00000324767, ENST00000562890, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 6 X 6 X 3=108 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/336*10)=-1.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/108*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN9 [Title/Abstract] AND SCAPER [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN9 | GO:0010977 | negative regulation of neuron projection development | 27655914 |
| Hgene | PTPN9 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27655914 |
| Hgene | PTPN9 | GO:1903078 | positive regulation of protein localization to plasma membrane | 27655914 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1511-01A | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306726 | ENST00000538941 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| In-frame | ENST00000306726 | ENST00000563290 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| In-frame | ENST00000306726 | ENST00000324767 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| 5CDS-intron | ENST00000306726 | ENST00000562890 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| intron-3CDS | ENST00000564970 | ENST00000538941 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| intron-3CDS | ENST00000564970 | ENST00000563290 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| intron-3CDS | ENST00000564970 | ENST00000324767 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
| intron-intron | ENST00000564970 | ENST00000562890 | PTPN9 | chr15 | 75871055 | - | SCAPER | chr15 | 76726651 | - |
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FusionProtFeatures for PTPN9_SCAPER |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN9 | SCAPER |
| Protein-tyrosine phosphatase that could participate inthe transfer of hydrophobic ligands or in functions of the Golgiapparatus. {ECO:0000269|PubMed:19167335}. | CCNA2/CDK2 regulatory protein that transiently maintainsCCNA2 in the cytoplasm. {ECO:0000269|PubMed:17698606}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >SCAPER | chr15:75871055 | chr15:76726651 | ENST00000538941 | - | 24 | 32 | 792_816 | 780 | 1155 | Zinc finger | Note=C2H2-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PTPN9 | chr15:75871055 | chr15:76726651 | ENST00000306726 | - | 1 | 13 | 303_574 | 21 | 594 | Domain | Tyrosine-protein phosphatase |
| Hgene | >PTPN9 | chr15:75871055 | chr15:76726651 | ENST00000306726 | - | 1 | 13 | 84_243 | 21 | 594 | Domain | CRAL-TRIO |
| Hgene | >PTPN9 | chr15:75871055 | chr15:76726651 | ENST00000306726 | - | 1 | 13 | 515_521 | 21 | 594 | Region | Substrate binding |
| Tgene | SCAPER | chr15:75871055 | chr15:76726651 | ENST00000324767 | - | 23 | 31 | 395_770 | 1026 | 1401 | Compositional bias | Note=Glu-rich |
| Tgene | SCAPER | chr15:75871055 | chr15:76726651 | ENST00000538941 | - | 24 | 32 | 395_770 | 780 | 1155 | Compositional bias | Note=Glu-rich |
| Tgene | SCAPER | chr15:75871055 | chr15:76726651 | ENST00000563290 | - | 24 | 32 | 395_770 | 1026 | 1401 | Compositional bias | Note=Glu-rich |
| Tgene | SCAPER | chr15:75871055 | chr15:76726651 | ENST00000324767 | - | 23 | 31 | 792_816 | 1026 | 1401 | Zinc finger | Note=C2H2-type |
| Tgene | SCAPER | chr15:75871055 | chr15:76726651 | ENST00000563290 | - | 24 | 32 | 792_816 | 1026 | 1401 | Zinc finger | Note=C2H2-type |
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FusionGeneSequence for PTPN9_SCAPER |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000538941_chr15_76726651_-_396aa MEPATAPRPDMAPELTPEEEQVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPF NNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLH MLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVG YFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQP >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000563290_chr15_76726651_-_396aa MEPATAPRPDMAPELTPEEEQVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPF NNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLH MLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVG YFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQP >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000324767_chr15_76726651_-_396aa MEPATAPRPDMAPELTPEEEQVYVPDENNTILGRNTNKQVFEGLTTGLLKVSAVVLGCLIANRPDGNCQPATPKIPTQEMKNKPSQGDPF NNRVQDLISYVVNMGLIDKLCACFLSVQGPVDENPKMAIFLQHAAGLLHAMCTLCFAVTGRSYSIFDNNRQDPTGLTAALQATDLAGVLH MLYCVLFHGTILDPSTASPKENYTQNTIQVAIQSLRFFNSFAALHLPAFQSIVGAEGLSLAFRHMASSLLGHCSQVSCESLLHEVIVCVG YFTVNHPDNQVIVQSGRHPTVLQKLCQLPFQYFSDPRLIKVLFPSLIAACYNNHQNKIILEQEMSCVLLATFIQDLAQTPGQAENQPYQP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000538941_chr15_76726651_-_1188nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACT ATTTTGGGGAGAAATACAAATAAACAAGTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATT GCCAATCGACCAGATGGAAACTGCCAGCCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTT AACAATCGAGTTCAGGACCTTATCAGCTACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCA GTGGATGAGAATCCCAAGATGGCCATATTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGA AGGTCATACAGCATATTTGACAATAATCGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCAT ATGCTCTACTGTGTCCTCTTCCATGGCACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTG GCCATTCAGAGTTTACGTTTCTTCAACAGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTT GCATTCCGGCACATGGCCAGCTCCCTGCTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGC TACTTCACTGTCAACCACCCAGATAACCAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTC CAGTATTTCAGTGACCCACGGCTGATCAAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTG GAGCAAGAGATGAGCTGTGTTTTACTGGCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCC AAAGGGAAATGCCTTGGTTCCCAAGACTATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTG >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000563290_chr15_76726651_-_1188nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACT ATTTTGGGGAGAAATACAAATAAACAAGTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATT GCCAATCGACCAGATGGAAACTGCCAGCCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTT AACAATCGAGTTCAGGACCTTATCAGCTACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCA GTGGATGAGAATCCCAAGATGGCCATATTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGA AGGTCATACAGCATATTTGACAATAATCGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCAT ATGCTCTACTGTGTCCTCTTCCATGGCACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTG GCCATTCAGAGTTTACGTTTCTTCAACAGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTT GCATTCCGGCACATGGCCAGCTCCCTGCTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGC TACTTCACTGTCAACCACCCAGATAACCAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTC CAGTATTTCAGTGACCCACGGCTGATCAAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTG GAGCAAGAGATGAGCTGTGTTTTACTGGCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCC AAAGGGAAATGCCTTGGTTCCCAAGACTATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTG >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000324767_chr15_76726651_-_1188nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACT ATTTTGGGGAGAAATACAAATAAACAAGTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATT GCCAATCGACCAGATGGAAACTGCCAGCCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTT AACAATCGAGTTCAGGACCTTATCAGCTACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCA GTGGATGAGAATCCCAAGATGGCCATATTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGA AGGTCATACAGCATATTTGACAATAATCGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCAT ATGCTCTACTGTGTCCTCTTCCATGGCACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTG GCCATTCAGAGTTTACGTTTCTTCAACAGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTT GCATTCCGGCACATGGCCAGCTCCCTGCTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGC TACTTCACTGTCAACCACCCAGATAACCAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTC CAGTATTTCAGTGACCCACGGCTGATCAAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTG GAGCAAGAGATGAGCTGTGTTTTACTGGCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCC AAAGGGAAATGCCTTGGTTCCCAAGACTATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000538941_chr15_76726651_-_2149nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACTATTTTGGGGAGAAATACAAATAAACAA GTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATTGCCAATCGACCAGATGGAAACTGCCAG CCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTTAACAATCGAGTTCAGGACCTTATCAGC TACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCAGTGGATGAGAATCCCAAGATGGCCATA TTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGAAGGTCATACAGCATATTTGACAATAAT CGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCATATGCTCTACTGTGTCCTCTTCCATGGC ACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTGGCCATTCAGAGTTTACGTTTCTTCAAC AGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTTGCATTCCGGCACATGGCCAGCTCCCTG CTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGCTACTTCACTGTCAACCACCCAGATAAC CAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTCCAGTATTTCAGTGACCCACGGCTGATC AAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTGGAGCAAGAGATGAGCTGTGTTTTACTG GCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCCAAAGGGAAATGCCTTGGTTCCCAAGAC TATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTGAAAAAAGAGAAAAAATAAATGTTTTGG TTGATTCTGTATTTGAGTACCCTTGTTAATATTTTAAATTGTCCAAACAAACATTCTAATTGTTCCTTAAGAACTCATTTTCCCATGTTT ATACTCTTCCCACACTGTAGATATGGCATGTACTTTACACTATTTATAATGACTGTAGATACTTGAATGTTCTACTTGCTAATTTTGCAA GTTGAGTTTATTTCATTTATGCAGAGTATCTTGGAGTTTGGTAATTTCCATCTTATGATAATATATACTTTGCATTTGTGATATGGGTGA AAGGAGACATAAAATTAGCAAGTCTGTTTTGTTCTTGTAATAAAGTAACTTATTCTGTTTTCATTGTTGACTTTTCATGTTAAGGAAATA >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000563290_chr15_76726651_-_2149nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACTATTTTGGGGAGAAATACAAATAAACAA GTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATTGCCAATCGACCAGATGGAAACTGCCAG CCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTTAACAATCGAGTTCAGGACCTTATCAGC TACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCAGTGGATGAGAATCCCAAGATGGCCATA TTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGAAGGTCATACAGCATATTTGACAATAAT CGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCATATGCTCTACTGTGTCCTCTTCCATGGC ACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTGGCCATTCAGAGTTTACGTTTCTTCAAC AGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTTGCATTCCGGCACATGGCCAGCTCCCTG CTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGCTACTTCACTGTCAACCACCCAGATAAC CAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTCCAGTATTTCAGTGACCCACGGCTGATC AAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTGGAGCAAGAGATGAGCTGTGTTTTACTG GCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCCAAAGGGAAATGCCTTGGTTCCCAAGAC TATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTGAAAAAAGAGAAAAAATAAATGTTTTGG TTGATTCTGTATTTGAGTACCCTTGTTAATATTTTAAATTGTCCAAACAAACATTCTAATTGTTCCTTAAGAACTCATTTTCCCATGTTT ATACTCTTCCCACACTGTAGATATGGCATGTACTTTACACTATTTATAATGACTGTAGATACTTGAATGTTCTACTTGCTAATTTTGCAA GTTGAGTTTATTTCATTTATGCAGAGTATCTTGGAGTTTGGTAATTTCCATCTTATGATAATATATACTTTGCATTTGTGATATGGGTGA AAGGAGACATAAAATTAGCAAGTCTGTTTTGTTCTTGTAATAAAGTAACTTATTCTGTTTTCATTGTTGACTTTTCATGTTAAGGAAATA >In-frame_PTPN9_ENST00000306726_chr15_75871055_-_SCAPER_ENST00000324767_chr15_76726651_-_2146nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGTTTATGTTCCAGATGAAAATAATACTATTTTGGGGAGAAATACAAATAAACAA GTTTTTGAAGGCTTGACAACTGGACTTCTCAAAGTCAGTGCTGTGGTTTTGGGCTGCCTGATTGCCAATCGACCAGATGGAAACTGCCAG CCAGCTACCCCAAAAATACCAACACAGGAAATGAAAAACAAACCCTCACAAGGTGATCCTTTTAACAATCGAGTTCAGGACCTTATCAGC TACGTGGTGAACATGGGTCTGATTGACAAACTGTGTGCCTGCTTCCTCTCGGTGCAAGGCCCAGTGGATGAGAATCCCAAGATGGCCATA TTTCTGCAGCATGCCGCAGGACTCTTACATGCAATGTGTACACTGTGCTTTGCTGTCACTGGAAGGTCATACAGCATATTTGACAATAAT CGCCAGGATCCCACAGGGCTGACAGCTGCTCTTCAGGCAACCGACCTGGCTGGAGTTCTTCATATGCTCTACTGTGTCCTCTTCCATGGC ACCATCTTGGACCCCAGCACTGCCAGTCCCAAGGAGAATTACACTCAAAATACCATCCAAGTGGCCATTCAGAGTTTACGTTTCTTCAAC AGCTTTGCAGCTCTTCATCTGCCTGCTTTTCAGTCTATTGTAGGGGCAGAGGGCTTGTCCCTTGCATTCCGGCACATGGCCAGCTCCCTG CTGGGCCACTGCAGCCAAGTCTCCTGTGAAAGCCTCCTTCATGAGGTCATCGTCTGTGTGGGCTACTTCACTGTCAACCACCCAGATAAC CAGGTGATCGTGCAGTCCGGCCGCCACCCCACAGTGCTGCAGAAGCTCTGCCAGTTGCCCTTCCAGTATTTCAGTGACCCACGGCTGATC AAAGTACTGTTCCCTTCACTTATCGCTGCTTGTTACAACAACCATCAGAACAAGATCATTCTGGAGCAAGAGATGAGCTGTGTTTTACTG GCCACTTTCATTCAGGATTTGGCACAGACTCCAGGTCAAGCGGAAAACCAGCCTTACCAACCCAAAGGGAAATGCCTTGGTTCCCAAGAC TATCTTGAGCTGGCTAACAGATTTCCTCAGCAGGCCTGGGAAGAAGCTCGACAGTTTTTCTTGAAAAAAGAGAAAAAATAAATGTTTTGG TTGATTCTGTATTTGAGTACCCTTGTTAATATTTTAAATTGTCCAAACAAACATTCTAATTGTTCCTTAAGAACTCATTTTCCCATGTTT ATACTCTTCCCACACTGTAGATATGGCATGTACTTTACACTATTTATAATGACTGTAGATACTTGAATGTTCTACTTGCTAATTTTGCAA GTTGAGTTTATTTCATTTATGCAGAGTATCTTGGAGTTTGGTAATTTCCATCTTATGATAATATATACTTTGCATTTGTGATATGGGTGA AAGGAGACATAAAATTAGCAAGTCTGTTTTGTTCTTGTAATAAAGTAACTTATTCTGTTTTCATTGTTGACTTTTCATGTTAAGGAAATA |
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FusionGenePPI for PTPN9_SCAPER |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTPN9 | RTN3, GHR, MYC, TP53BP1, VCP, AGTRAP, REEP6, MAL2, CMTM5, ENO1, MOV10, NXF1, NTRK1, CREB3, LZTR1, PC, EYA1, RAD51C, FAM26D, VSIG8, C5AR2, MDK, PDCD1, PTPN9, GEMIN8, FSIP1, SMN1, DDX20, GEMIN4, PMPCA, SLC39A7, STRAP, TUBA3C, AAR2, SMN2, TUBA3D, LMNA | SCAPER | CALM1, HECW2, CCNA2, APPL1, MZT1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN9_SCAPER |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN9_SCAPER |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | SCAPER | C3714756 | Intellectual Disability | 1 | CTD_human |
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