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Fusion gene ID: 29467 |
FusionGeneSummary for PTPN9_AGBL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTPN9_AGBL1 | Fusion gene ID: 29467 | Hgene | Tgene | Gene symbol | PTPN9 | AGBL1 | Gene ID | 5780 | 123624 |
| Gene name | protein tyrosine phosphatase, non-receptor type 9 | ATP/GTP binding protein like 1 | |
| Synonyms | MEG2|PTPMEG2 | CCP4|FECD8 | |
| Cytomap | 15q24.2 | 15q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein phosphatase non-receptor type 9PTPase-MEG2protein-tyrosine phosphatase MEG2 | cytosolic carboxypeptidase 4 | |
| Modification date | 20180520 | 20180519 | |
| UniProtAcc | P43378 | Q96MI9 | |
| Ensembl transtripts involved in fusion gene | ENST00000306726, ENST00000564970, | ENST00000441037, ENST00000421325, ENST00000389298, | |
| Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 6 X 4 X 4=96 |
| # samples | 13 | 6 | |
| ** MAII score | log2(13/336*10)=-1.36994960975031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/96*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTPN9 [Title/Abstract] AND AGBL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTPN9 | GO:0010977 | negative regulation of neuron projection development | 27655914 |
| Hgene | PTPN9 | GO:0035335 | peptidyl-tyrosine dephosphorylation | 27655914 |
| Hgene | PTPN9 | GO:1903078 | positive regulation of protein localization to plasma membrane | 27655914 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-EW-A1P0-01A | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000306726 | ENST00000441037 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| In-frame | ENST00000306726 | ENST00000421325 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| In-frame | ENST00000306726 | ENST00000389298 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| intron-3CDS | ENST00000564970 | ENST00000441037 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| intron-3CDS | ENST00000564970 | ENST00000421325 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
| intron-3CDS | ENST00000564970 | ENST00000389298 | PTPN9 | chr15 | 75801258 | - | AGBL1 | chr15 | 87217504 | + |
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FusionProtFeatures for PTPN9_AGBL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTPN9 | AGBL1 |
| Protein-tyrosine phosphatase that could participate inthe transfer of hydrophobic ligands or in functions of the Golgiapparatus. {ECO:0000269|PubMed:19167335}. | Metallocarboxypeptidase that mediates deglutamylation oftarget proteins. Catalyzes the deglutamylation of polyglutamateside chains generated by post-translational polyglutamylation inproteins such as tubulins. Also removes gene-encodedpolyglutamates from the carboxy-terminus of target proteins suchas MYLK. Acts as a long-chain deglutamylase and specificallyshortens long polyglutamate chains, while it is not able to removethe branching point glutamate, a process catalyzed by AGBL5/CCP5.{ECO:0000250|UniProtKB:Q09M05}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PTPN9 | chr15:75801258 | chr15:87217504 | ENST00000306726 | - | 6 | 13 | 303_574 | 213 | 594 | Domain | Tyrosine-protein phosphatase |
| Hgene | >PTPN9 | chr15:75801258 | chr15:87217504 | ENST00000306726 | - | 6 | 13 | 84_243 | 213 | 594 | Domain | CRAL-TRIO |
| Hgene | >PTPN9 | chr15:75801258 | chr15:87217504 | ENST00000306726 | - | 6 | 13 | 515_521 | 213 | 594 | Region | Substrate binding |
| Tgene | AGBL1 | chr15:75801258 | chr15:87217504 | ENST00000441037 | + | 20 | 24 | 251_284 | 973 | 1067 | Compositional bias | Note=Asp-rich |
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FusionGeneSequence for PTPN9_AGBL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000441037_chr15_87217504_+_307aa MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSE ILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERGLQFGTRELEEMGAMFCLGLLILELKSASCSHQLLAQAATLLSAEEDALDQHLQRLK >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000421325_chr15_87217504_+_303aa MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSE ILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERGLQFGTRELEEMGAMFCLGLLILELKSASCSHQLLAQAATLLSAEEDALDQHLQRLK >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000389298_chr15_87217504_+_303aa MEPATAPRPDMAPELTPEEEQATKQFLEEINKWTVQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSE ILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDLGKKVLNLLKGAFP ARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERGLQFGTRELEEMGAMFCLGLLILELKSASCSHQLLAQAATLLSAEEDALDQHLQRLK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000441037_chr15_87217504_+_921nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATT AACAAGTGGACAGTTCAGTACAATGTTTCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGT GCCATAGAATTGTTCCACTCCTACAGAGAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAG ATCCTCAGTGGAAAATTCACCATCTTAAATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCAC AAGTCAGTCCAACATGTGGTACTTCAGGCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTG TTTATCTATGACATGTGTGGTTCTAATTATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCA GCTCGTTTGAAGAAGGTGCTGATTGTGGGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTC CGGGAGAGGGGTCTACAGTTTGGTACCAGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCT GCCAGCTGCAGCCATCAGCTCCTGGCTCAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAA TCATCCAATTTCCTGCCAAAGCATATTTGGTTTGCTTACCACTTTTTTGCCATTACAAACTTTTTCAAGATGAACCTTCTTCTGCATGTC >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000421325_chr15_87217504_+_909nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATT AACAAGTGGACAGTTCAGTACAATGTTTCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGT GCCATAGAATTGTTCCACTCCTACAGAGAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAG ATCCTCAGTGGAAAATTCACCATCTTAAATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCAC AAGTCAGTCCAACATGTGGTACTTCAGGCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTG TTTATCTATGACATGTGTGGTTCTAATTATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCA GCTCGTTTGAAGAAGGTGCTGATTGTGGGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTC CGGGAGAGGGGTCTACAGTTTGGTACCAGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCT GCCAGCTGCAGCCATCAGCTCCTGGCTCAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAA TCATCCAATTTCCTGCCAAAGCATATTTGGTTTGCTTACCACTTTTTTGCCATTACAAACTTTTTCAAGATGAACCTTCTTCTGCATGTC >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000389298_chr15_87217504_+_909nt ATGGAGCCCGCGACCGCGCCCCGGCCCGACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATT AACAAGTGGACAGTTCAGTACAATGTTTCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGT GCCATAGAATTGTTCCACTCCTACAGAGAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAG ATCCTCAGTGGAAAATTCACCATCTTAAATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCAC AAGTCAGTCCAACATGTGGTACTTCAGGCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTG TTTATCTATGACATGTGTGGTTCTAATTATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCA GCTCGTTTGAAGAAGGTGCTGATTGTGGGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTC CGGGAGAGGGGTCTACAGTTTGGTACCAGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCT GCCAGCTGCAGCCATCAGCTCCTGGCTCAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAA TCATCCAATTTCCTGCCAAAGCATATTTGGTTTGCTTACCACTTTTTTGCCATTACAAACTTTTTCAAGATGAACCTTCTTCTGCATGTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000441037_chr15_87217504_+_1646nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATTAACAAGTGGACAGTTCAGTACAATGTT TCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGTGCCATAGAATTGTTCCACTCCTACAGA GAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAGATCCTCAGTGGAAAATTCACCATCTTA AATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCACAAGTCAGTCCAACATGTGGTACTTCAG GCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTGTTTATCTATGACATGTGTGGTTCTAAT TATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCAGCTCGTTTGAAGAAGGTGCTGATTGTG GGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTCCGGGAGAGGGGTCTACAGTTTGGTACC AGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCTGCCAGCTGCAGCCATCAGCTCCTGGCT CAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAATCATCCAATTTCCTGCCAAAGCATATT TGGTTTGCTTACCACTTTTTTGCCATTACAAACTTTTTCAAGATGAACCTTCTTCTGCATGTCTCCCCAGTTTGTGACACTTGATGAGGC TCCCTTCAAATGAGCAAGTATTGAAGTTCATGCCATGTGCCCAGCTCCTCCTGGATCTGTGAGGAAATATCTGAAACCTTCAAGATGTTG TACATGTCTTATGGAAAATGTTGCTCCATCATCCCTGCACTCCCTTATCTAGTATATCTACCTCCATAAGAAAACATAAGGACAGGCAAT >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000421325_chr15_87217504_+_1422nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATTAACAAGTGGACAGTTCAGTACAATGTT TCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGTGCCATAGAATTGTTCCACTCCTACAGA GAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAGATCCTCAGTGGAAAATTCACCATCTTA AATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCACAAGTCAGTCCAACATGTGGTACTTCAG GCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTGTTTATCTATGACATGTGTGGTTCTAAT TATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCAGCTCGTTTGAAGAAGGTGCTGATTGTG GGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTCCGGGAGAGGGGTCTACAGTTTGGTACC AGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCTGCCAGCTGCAGCCATCAGCTCCTGGCT CAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAATCATCCAATTTCCTGCCAAAGCATATT >In-frame_PTPN9_ENST00000306726_chr15_75801258_-_AGBL1_ENST00000389298_chr15_87217504_+_1422nt AGCCTGGCTGAGGCAGCCGCGCAGGTCGCAGGGCCAGCGTCCGCGAGGACGGCCCGGCTGGGCGGCCCCGAGCTCTGTGGCGCTGTGGAG GAGCGGGAGCGCGGCCGAGGAAGCGGGGCGCCGAGGGGGTCGGCGGCCTTCGGGAAATTTCCGCCGACCCTTCGCTCCCGGCTCTAAAAG TTCCTGATTTCCTATTTCCTTTTAAATCCCGAGTGGCTGTTAGCTCTTCGCCTGCACTTTTTCTTCCCCAGGAGATAAGGGGGAGTGTGA GGAACGGAGCGAATAATATAAAAAAGGATTTCCTCCCGGAAGAGAGCGGCAGTTCGGAGAGATTTTTCTTAAGGAAGCAGAAGCGGCGTT TGCGGCCGCTGCAGGCGCCGGGCCCTGCCGGCCACACTATGCGCGAGCCGGCCCCGGGCTGCTGAGGCGCGGGGACGCGGAAGCGGAGGC CGAGCGCGCCGGGCTCCCGCGCTCGCGAGCGAGTTTTGTCCGCCCGGCGGCGGTGGCGGGGGGATGGAGCCCGCGACCGCGCCCCGGCCC GACATGGCGCCGGAGCTGACCCCGGAGGAGGAGCAGGCTACCAAGCAGTTTCTCGAAGAGATTAACAAGTGGACAGTTCAGTACAATGTT TCCCCGCTGTCTTGGAATGTGGCTGTCAAGTTCCTCATGGCAAGGAAGTTTGATGTGCTCCGTGCCATAGAATTGTTCCACTCCTACAGA GAAACTCGAAGGAAGGAAGGCATTGTAAAGCTGAAACCTCATGAGGAACCTCTTCGTTCTGAGATCCTCAGTGGAAAATTCACCATCTTA AATGTTCGGGACCCAACAGGAGCCTCCATTGCCCTCTTTACTGCCAGGTTGCATCATCCCCACAAGTCAGTCCAACATGTGGTACTTCAG GCTCTGTTTTACTTGCTAGACAGAGCTGTGGATAGCTTTGAAACTCAGAGGAATGGACTGGTGTTTATCTATGACATGTGTGGTTCTAAT TATGCCAACTTTGAGCTGGATCTTGGCAAGAAAGTCCTAAACCTGCTGAAGGGAGCATTTCCAGCTCGTTTGAAGAAGGTGCTGATTGTG GGGGCACCCATATGGTTCCGAGTGCCCTATTCCATCATCAGTCTCCTCCTGAAGGACAAAGTCCGGGAGAGGGGTCTACAGTTTGGTACC AGAGAACTGGAGGAGATGGGAGCCATGTTCTGTTTGGGCCTCCTCATCCTGGAGCTCAAATCTGCCAGCTGCAGCCATCAGCTCCTGGCT CAAGCTGCAACTCTGCTGAGTGCTGAGGAGGACGCTCTGGACCAGCACCTCCAACGATTAAAATCATCCAATTTCCTGCCAAAGCATATT |
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FusionGenePPI for PTPN9_AGBL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTPN9 | RTN3, GHR, MYC, TP53BP1, VCP, AGTRAP, REEP6, MAL2, CMTM5, ENO1, MOV10, NXF1, NTRK1, CREB3, LZTR1, PC, EYA1, RAD51C, FAM26D, VSIG8, C5AR2, MDK, PDCD1, PTPN9, GEMIN8, FSIP1, SMN1, DDX20, GEMIN4, PMPCA, SLC39A7, STRAP, TUBA3C, AAR2, SMN2, TUBA3D, LMNA | AGBL1 | FOXA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTPN9_AGBL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PTPN9_AGBL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AGBL1 | C3809798 | CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 8 | 1 | UNIPROT |
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