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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29457

FusionGeneSummary for PTPN3_ZBTB38

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN3_ZBTB38
Fusion gene ID: 29457
HgeneTgene
Gene symbol

PTPN3

ZBTB38

Gene ID

5774

253461

Gene nameprotein tyrosine phosphatase, non-receptor type 3zinc finger and BTB domain containing 38
SynonymsPTP-H1|PTPH1CIBZ|PPP1R171|ZNF921
Cytomap

9q31.3

3q23

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 3cytoskeletal-associated protein tyrosine phosphataseprotein-tyrosine phosphatase H1zinc finger and BTB domain-containing protein 38protein phosphatase 1, regulatory subunit 171
Modification date2018052720180523
UniProtAcc

P26045

Q8NAP3

Ensembl transtripts involved in fusion geneENST00000412145, ENST00000446349, 
ENST00000374541, ENST00000262539, 
ENST00000394827, ENST00000497739, 
ENST00000514251, ENST00000321464, 
ENST00000441582, ENST00000512327, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 5 X 3=60
# samples 47
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/60*10)=0.222392421336448
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTPN3 [Title/Abstract] AND ZBTB38 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPN3

GO:0006470

protein dephosphorylation

10364224

HgenePTPN3

GO:0045930

negative regulation of mitotic cell cycle

10364224

HgenePTPN3

GO:0098902

regulation of membrane depolarization during action potential

16930557

HgenePTPN3

GO:2000649

regulation of sodium ion transmembrane transporter activity

16930557

TgeneZBTB38

GO:0045892

negative regulation of transcription, DNA-templated

16354688|24726359


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF368991PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000412145ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000412145ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000412145ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000412145ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000446349ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000446349ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000446349ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000446349ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000374541ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000374541ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000374541ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000374541ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000262539ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000262539ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000262539ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000262539ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000394827ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000394827ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000394827ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000394827ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000497739ENST00000514251PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000497739ENST00000321464PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000497739ENST00000441582PTPN3chr9

112201174

-ZBTB38chr3

141156199

+
intron-intronENST00000497739ENST00000512327PTPN3chr9

112201174

-ZBTB38chr3

141156199

+

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FusionProtFeatures for PTPN3_ZBTB38


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN3

P26045

ZBTB38

Q8NAP3

May act at junctions between the membrane and thecytoskeleton. Possesses tyrosine phosphatase activity. Transcriptional regulator with bimodal DNA-bindingspecificity. Binds with a higher affinity to methylated CpGdinucleotides in the consensus sequence 5'-CGCG-3' but can alsobind to E-box elements (5'-CACGTG-3'). Can also bind specificallyto a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed:16354688). Plays an important role inregulating DNA replication and common fragile sites (CFS)stability in a RBBP6- and MCM10-dependent manner; repressesexpression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). Acts as a transcriptionalactivator. May be involved in the differentiation and/or survivalof late postmitotic neurons (By similarity).{ECO:0000250|UniProtKB:Q5EXX3, ECO:0000269|PubMed:16354688,ECO:0000269|PubMed:24726359}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTPN3_ZBTB38


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTPN3_ZBTB38


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPN3_ZBTB38


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPN3_ZBTB38


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource