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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 29438

FusionGeneSummary for PTPN21_EML5

check button Fusion gene summary
Fusion gene informationFusion gene name: PTPN21_EML5
Fusion gene ID: 29438
HgeneTgene
Gene symbol

PTPN21

EML5

Gene ID

11099

161436

Gene nameprotein tyrosine phosphatase, non-receptor type 21echinoderm microtubule associated protein like 5
SynonymsPTPD1|PTPRL10EMAP-2
Cytomap

14q31.3

14q31.3

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein phosphatase non-receptor type 21dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21)protein-tyrosine phosphatase D1echinoderm microtubule-associated protein-like 5EMAP-5
Modification date2018051920180523
UniProtAcc

Q16825

Q05BV3

Ensembl transtripts involved in fusion geneENST00000328736, ENST00000556564, 
ENST00000554628, 		ENST00000554922, 
ENST00000352093, ENST00000380664, 
ENST00000553320, 
Fusion gene scores* DoF score2 X 2 X 2=82 X 2 X 2=8
# samples 22
** MAII scorelog2(2/8*10)=1.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PTPN21 [Title/Abstract] AND EML5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPCPGTCGA-WB-A81W-01APTPN21chr14

88962757

-EML5chr14

89110855

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000328736ENST00000554922PTPN21chr14

88962757

-EML5chr14

89110855

-
In-frameENST00000328736ENST00000352093PTPN21chr14

88962757

-EML5chr14

89110855

-
In-frameENST00000328736ENST00000380664PTPN21chr14

88962757

-EML5chr14

89110855

-
5CDS-intronENST00000328736ENST00000553320PTPN21chr14

88962757

-EML5chr14

89110855

-
Frame-shiftENST00000556564ENST00000554922PTPN21chr14

88962757

-EML5chr14

89110855

-
Frame-shiftENST00000556564ENST00000352093PTPN21chr14

88962757

-EML5chr14

89110855

-
Frame-shiftENST00000556564ENST00000380664PTPN21chr14

88962757

-EML5chr14

89110855

-
5CDS-intronENST00000556564ENST00000553320PTPN21chr14

88962757

-EML5chr14

89110855

-
5UTR-3CDSENST00000554628ENST00000554922PTPN21chr14

88962757

-EML5chr14

89110855

-
5UTR-3CDSENST00000554628ENST00000352093PTPN21chr14

88962757

-EML5chr14

89110855

-
5UTR-3CDSENST00000554628ENST00000380664PTPN21chr14

88962757

-EML5chr14

89110855

-
5UTR-intronENST00000554628ENST00000553320PTPN21chr14

88962757

-EML5chr14

89110855

-

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FusionProtFeatures for PTPN21_EML5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTPN21

Q16825

EML5

Q05BV3

May modify the assembly dynamics of microtubules, suchthat microtubules are slightly longer, but more dynamic.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-91823_3083101175DomainFERM
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-101923_3083101175DomainFERM
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421412_146313341970RepeatNote=WD 20
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421467_150813341970RepeatNote=WD 21
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421511_155013341970RepeatNote=WD 22
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421560_159813341970RepeatNote=WD 23
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421600_164613341970RepeatNote=WD 24
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421691_173113341970RepeatNote=WD 25
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421733_177413341970RepeatNote=WD 26
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421775_181413341970RepeatNote=WD 27
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421887_192613341970RepeatNote=WD 28
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421932_196913341970RepeatNote=WD 29
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441412_146313421978RepeatNote=WD 20
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441467_150813421978RepeatNote=WD 21
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441511_155013421978RepeatNote=WD 22
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441560_159813421978RepeatNote=WD 23
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441600_164613421978RepeatNote=WD 24
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441691_173113421978RepeatNote=WD 25
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441733_177413421978RepeatNote=WD 26
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441775_181413421978RepeatNote=WD 27
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441887_192613421978RepeatNote=WD 28
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441932_196913421978RepeatNote=WD 29

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-918340_3433101175Compositional biasNote=Poly-Pro
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-918565_5743101175Compositional biasNote=Poly-Pro
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-918712_7173101175Compositional biasNote=Poly-Glu
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-1019340_3433101175Compositional biasNote=Poly-Pro
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-1019565_5743101175Compositional biasNote=Poly-Pro
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-1019712_7173101175Compositional biasNote=Poly-Glu
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-918896_11673101175DomainTyrosine-protein phosphatase
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-1019896_11673101175DomainTyrosine-protein phosphatase
HgenePTPN21chr14:88962757chr14:89110855ENST00000328736-9181108_11143101175RegionSubstrate binding
HgenePTPN21chr14:88962757chr14:89110855ENST00000556564-10191108_11143101175RegionSubstrate binding
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421038_107713341970RepeatNote=WD 17
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642104_14513341970RepeatNote=WD 2
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421080_112013341970RepeatNote=WD 18
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-26421236_127613341970RepeatNote=WD 19
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642148_18713341970RepeatNote=WD 3
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642195_23313341970RepeatNote=WD 4
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642235_27313341970RepeatNote=WD 5
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642280_32113341970RepeatNote=WD 6
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642323_36213341970RepeatNote=WD 7
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642406_44513341970RepeatNote=WD 8
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642449_48813341970RepeatNote=WD 9
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642561_60113341970RepeatNote=WD 10
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-264259_10013341970RepeatNote=WD 1
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642725_76613341970RepeatNote=WD 11
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642770_81113341970RepeatNote=WD 12
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642814_85313341970RepeatNote=WD 13
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642861_90013341970RepeatNote=WD 14
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642901_94013341970RepeatNote=WD 15
TgeneEML5chr14:88962757chr14:89110855ENST00000380664-2642996_103513341970RepeatNote=WD 16
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441038_107713421978RepeatNote=WD 17
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844104_14513421978RepeatNote=WD 2
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441080_112013421978RepeatNote=WD 18
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-28441236_127613421978RepeatNote=WD 19
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844148_18713421978RepeatNote=WD 3
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844195_23313421978RepeatNote=WD 4
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844235_27313421978RepeatNote=WD 5
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844280_32113421978RepeatNote=WD 6
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844323_36213421978RepeatNote=WD 7
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844406_44513421978RepeatNote=WD 8
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844449_48813421978RepeatNote=WD 9
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844561_60113421978RepeatNote=WD 10
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-284459_10013421978RepeatNote=WD 1
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844725_76613421978RepeatNote=WD 11
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844770_81113421978RepeatNote=WD 12
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844814_85313421978RepeatNote=WD 13
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844861_90013421978RepeatNote=WD 14
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844901_94013421978RepeatNote=WD 15
TgeneEML5chr14:88962757chr14:89110855ENST00000554922-2844996_103513421978RepeatNote=WD 16


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FusionGeneSequence for PTPN21_EML5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000554922_chr14_89110855_-_946aa
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDK
YALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFA
LELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLN
DGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCS
VSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQT
MLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATD
CVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYS
PEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADS
SYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKF

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000352093_chr14_89110855_-_946aa
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDK
YALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFA
LELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLN
DGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVVLSCSLLTTAPSIHIWDAMNKQTLSILRCYHSKGVCS
VSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQT
MLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATD
CVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYS
PEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADS
SYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKF

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000380664_chr14_89110855_-_946aa
MPLPFGLKLKRTRRYTVSSKSCLVARIQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWYYNKQNQRRWVDLEKPLKKQLDK
YALEPTVYFGVVFYVPSVSQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYESQDFLQKFALFPVGWLQDEKV
LEEATQKVALLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGIFVKHKNGRHPVVFRWHDIANMSHNKSFFA
LELANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQCNLPPVSRAPPQPEKLQTNNVGKKKRPIEDLVLELIFGYRGRDCRNNVHYLN
DGDDIIYHTASVGILHNVATGSQSFYQEHNDDILCLTVNQHPKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGVCS
VSFSATGKLLLSVGLDPEHTITIWRWQEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVGVKHVKFWTLAGRALLSKKGLLSTLEDARMQT
MLAIAFGANNLTFTGTISGDVCVWKDHILCRIVARAHNGPVFAMYTTLRDGLIVTGGKERPSKEGGAVKLWDQELRRCRAFRLETGQATD
CVRSVCRGKGKILVGTRNAEIIEVGEKNAACNILVNGHVDGPIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYS
PEGDMVAIGMKNGEFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNRISYCKDIPSFVIQMDFSADS
SYLQVSSGCYKRHVYEVPSGKHLMDHAAIDRITWATWTSILGDEVLGIWSRHAEKADVNCACVSHSGISLVTGDDFGMVKLFDFPCPEKF


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000554922_chr14_89110855_-_2838nt
ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTGCCTGGTTGCCCGGATCCAACTGCTT
AATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG
GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAAACCTTTGAAGAAGCAGCTGGATAAA
TATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT
TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCAGCTAGCAGGCTTAGCTGTTCAAGCG
GATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA
TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGATGCTGAAATGCTGTACATGCAGGAG
GTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT
ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACATGTCCCACAACAAGTCCTTTTTTGCA
TTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA
CACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGAGAAACTCCAGACAAACAATGTAGGC
AAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTGTAGGAATAATGTTCACTATTTAAAT
GATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTCTCAGAGTTTTTATCAGGAACATAAT
GATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCAAGTAGGTGATTCAGCAGACATGTCA
GCTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATGCTACCATTCAAAGGGAGTATGTTCA
GTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTACCATTTGGAGATGGCAGGAAGGTGCC
AAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGATACCCAGTTTGTCTCAGTGGGAGTA
AAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCACACTGGAAGATGCCCGGATGCAGACC
ATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTGTGTGTGGAAAGATCACATATTGTGT
AGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACTTATCGTGACTGGGGGAAAGGAAAGG
CCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAGGCTTGAGACAGGACAAGCCACAGAT
TGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAATCGAAGTTGGAGAGAAAAATGCAGCT
TGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAGGGATTTTTTCCTTTCTGCTGCAGAA
GATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACATGCTGCTCGTACTGTGTGTTACAGC
CCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTCTCTAAAAATATGGGGAAAGAAGAGA
GACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTCTAGTGAGAACTCAGTGGATTTTTAT
GACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCATTCAAATGGACTTCTCTGCAGATAGC
AGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACATCTTATGGATCATGCCGCTATTGAC
AGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACATGCTGAGAAAGCTGATGTCAACTGT
GCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATTTGACTTCCCATGTCCAGAAAAATTT
GCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGATCGACATGTTGTTAGTGCTGGAGGT

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000352093_chr14_89110855_-_2838nt
ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTGCCTGGTTGCCCGGATCCAACTGCTT
AATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG
GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAAACCTTTGAAGAAGCAGCTGGATAAA
TATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT
TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCAGCTAGCAGGCTTAGCTGTTCAAGCG
GATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA
TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGATGCTGAAATGCTGTACATGCAGGAG
GTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT
ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACATGTCCCACAACAAGTCCTTTTTTGCA
TTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA
CACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGAGAAACTCCAGACAAACAATGTAGGC
AAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTGTAGGAATAATGTTCACTATTTAAAT
GATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTCTCAGAGTTTTTATCAGGAACATAAT
GATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCAAGTAGTTTTGAGCTGTTCTTTGTTA
ACTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATGCTACCATTCAAAGGGAGTATGTTCA
GTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTACCATTTGGAGATGGCAGGAAGGTGCC
AAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGATACCCAGTTTGTCTCAGTGGGAGTA
AAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCACACTGGAAGATGCCCGGATGCAGACC
ATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTGTGTGTGGAAAGATCACATATTGTGT
AGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACTTATCGTGACTGGGGGAAAGGAAAGG
CCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAGGCTTGAGACAGGACAAGCCACAGAT
TGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAATCGAAGTTGGAGAGAAAAATGCAGCT
TGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAGGGATTTTTTCCTTTCTGCTGCAGAA
GATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACATGCTGCTCGTACTGTGTGTTACAGC
CCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTCTCTAAAAATATGGGGAAAGAAGAGA
GACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTCTAGTGAGAACTCAGTGGATTTTTAT
GACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCATTCAAATGGACTTCTCTGCAGATAGC
AGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACATCTTATGGATCATGCCGCTATTGAC
AGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACATGCTGAGAAAGCTGATGTCAACTGT
GCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATTTGACTTCCCATGTCCAGAAAAATTT
GCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGATCGACATGTTGTTAGTGCTGGAGGT

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000380664_chr14_89110855_-_2838nt
ATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTGCCTGGTTGCCCGGATCCAACTGCTT
AATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGTGGCCCAGAGGCTGGAGCTGCGGGAG
GTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAAACCTTTGAAGAAGCAGCTGGATAAA
TATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCAGCAGGAGATTACCAGGTATCAGTAT
TATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCAGCTAGCAGGCTTAGCTGTTCAAGCG
GATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGTGGGATGGTTACAAGATGAAAAAGTA
TTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGATGCTGAAATGCTGTACATGCAGGAG
GTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACATATCCATTGGAGCGTGTCTTGAAGGT
ATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACATGTCCCACAACAAGTCCTTTTTTGCA
TTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATACATTTGGAGACTCTGTGTTGCGCGA
CACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGAGAAACTCCAGACAAACAATGTAGGC
AAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTGTAGGAATAATGTTCACTATTTAAAT
GATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTCTCAGAGTTTTTATCAGGAACATAAT
GATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCAAGTAGGTGATTCAGCAGACATGTCA
GCTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATGCTACCATTCAAAGGGAGTATGTTCA
GTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTACCATTTGGAGATGGCAGGAAGGTGCC
AAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGATACCCAGTTTGTCTCAGTGGGAGTA
AAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCACACTGGAAGATGCCCGGATGCAGACC
ATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTGTGTGTGGAAAGATCACATATTGTGT
AGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACTTATCGTGACTGGGGGAAAGGAAAGG
CCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAGGCTTGAGACAGGACAAGCCACAGAT
TGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAATCGAAGTTGGAGAGAAAAATGCAGCT
TGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAGGGATTTTTTCCTTTCTGCTGCAGAA
GATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACATGCTGCTCGTACTGTGTGTTACAGC
CCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTCTCTAAAAATATGGGGAAAGAAGAGA
GACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTCTAGTGAGAACTCAGTGGATTTTTAT
GACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCATTCAAATGGACTTCTCTGCAGATAGC
AGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACATCTTATGGATCATGCCGCTATTGAC
AGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACATGCTGAGAAAGCTGATGTCAACTGT
GCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATTTGACTTCCCATGTCCAGAAAAATTT
GCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGATCGACATGTTGTTAGTGCTGGAGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000554922_chr14_89110855_-_6430nt
CAGCGCTGGCGTCAATGCTCCCTTCCTCGGGCCATTGGAGACTCCGTTGCTTTTTAATGGCGGCAGCGGCTGCTGGGTGAGCAGCTGGAG
GCCGGACAGTGTTCGTCCCATCCGGAGAGGATCGCTTTCTCCTGGCGTCACCAGCGCTGGGTTGGTGGGGGTAGCTTTTCCCTCTTTGCT
CCTCCATTCTTGAAGAAAGAAGAAGATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTG
CCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGT
GGCCCAGAGGCTGGAGCTGCGGGAGGTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAA
ACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCA
GCAGGAGATTACCAGGTATCAGTATTATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCA
GCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGT
GGGATGGTTACAAGATGAAAAAGTATTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGA
TGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACAT
ATCCATTGGAGCGTGTCTTGAAGGTATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACAT
GTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATA
CATTTGGAGACTCTGTGTTGCGCGACACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGA
GAAACTCCAGACAAACAATGTAGGCAAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTG
TAGGAATAATGTTCACTATTTAAATGATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTC
TCAGAGTTTTTATCAGGAACATAATGATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCA
AGTAGGTGATTCAGCAGACATGTCAGCTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATG
CTACCATTCAAAGGGAGTATGTTCAGTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTAC
CATTTGGAGATGGCAGGAAGGTGCCAAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGA
TACCCAGTTTGTCTCAGTGGGAGTAAAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCAC
ACTGGAAGATGCCCGGATGCAGACCATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTG
TGTGTGGAAAGATCACATATTGTGTAGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACT
TATCGTGACTGGGGGAAAGGAAAGGCCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAG
GCTTGAGACAGGACAAGCCACAGATTGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAAT
CGAAGTTGGAGAGAAAAATGCAGCTTGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAG
GGATTTTTTCCTTTCTGCTGCAGAAGATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACA
TGCTGCTCGTACTGTGTGTTACAGCCCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTC
TCTAAAAATATGGGGAAAGAAGAGAGACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTC
TAGTGAGAACTCAGTGGATTTTTATGACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCAT
TCAAATGGACTTCTCTGCAGATAGCAGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACA
TCTTATGGATCATGCCGCTATTGACAGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACA
TGCTGAGAAAGCTGATGTCAACTGTGCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATT
TGACTTCCCATGTCCAGAAAAATTTGCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGA
TCGACATGTTGTTAGTGCTGGAGGTGATGACTGCAGCTTATTTGTCTGGAAATGTGTACATACACCTCACTGAGAGATGCTGAGATGACT
ACAGAAATTAACTTTGAGACCAGAATTACAGAGAAGAAAAACCAAAACCCAACCCTGCATGGTCAAGTGGTGCTAACCCAAGACTGTAAC
AGGGAGAAATGCCCAGAATCATCAAAATAGTGAAAGACTGATCTGTTCAAAATATTTGCTATATGCACTGGGTATAATCCGTAATCCATA
CACTGCCAGATAATGCCATTTCAAGGAAGGATCGAATACTTGATGGTAAAGGCCAAGTCCCCCTGTATTGGGAAGTGTGTGATTTCGGCA
GACCTGCTGGGAAAATTTAGGGTAGAGCACTCTTTACAGAAGAACTCAAAAACCCAATTTGGATAATTTTCATTATCTTTTTAGCAAAAT
GGTTTCTTAATGTTTATATTTTATTTTCAAGGTTCATTGTTTAATGAAATATTTTATTCTTGCATTTCCATAAGGAAAGGGAAAGTCATG
ATCATCCTAAAGGATCACAGTTTTTAAAAGGCAAACATTTTCCCTAAGGAAACAGACACAAGCTTTCCTAGAGAATATGATGTTTTTTAG
GCATTAATAAGGTCCTTTTTTATAAAGGACACTTTTCTCCTAGTAGTTTTGAATTCAGGAACAGATCCAAAGTTAGCAGTATATGGCTGC
TACATTTCCATTTTCATTTTCGAGCCATCAGTTTATGTTCAGATGCCATCTCTGTAATCGCACATTTAAAACATAACTGTAGCCTCACTA
ATGGAAAAGTAGTATGATGAACAATCATTCCCAATGGTGTACAATGTAAGGGTTTTAGGGAGCAACAGTATTTAACTGGAAGAAAGAATT
GCATATTTAATGTAGTCTAATATATACACATTTGTTTAACATGTAAACAAAAGTGTTAAATTCACATATACAACATTATACAATTTAATC
ACTCTTGGAATAAAATTTTTATAGCCTTTTTTCTATTGGGAAAATTTGTTTAGATGTGTGCCACTCCATAGGTTTATTTCCAAAATGAAT
GAGCCCAACTCCATTTGTAAAAACTTGTCAGTTAGAATTCCTTTTTTTAGTGGATTAGGGCTGAATTCTTAGATCCTTATTTCTTTTCAC
TTTAAATGCTGCCAAAGATCACTACTCATCATTCAGGAATTCGCTGTCTAGCCTATCTGTAGTTTCCTGAAGATTGAAAATTATGTAGAC
TGCTATTTAAAAATATATTTTTCTAAGTGTGAGGTTTAAGATGCTGTATTGACCCTATGAGTTTTTAATGTGTTAATTATCTTTATAGCA
TAATAGATCGCTTTAGGTTCCTGGAATCCCATTTGGTCTGACAGGATATATGAAGATTCTTAATACCTATTTTCTGTGTCTAATACTTGG
TTAATACTAAAAATAGAAATGACTAAATTACATCACAGAAAGCATAACCAGTGATTGAACCTGGTAGTTTTAAAGCTCTAAATAGCTGTG
GCTGAAGGACTGATTATGGGGCTAAGAAGCTTGAAACGTAAGTTGGTACTTGTTCATCAGTGGATTCTCCTAAATTAAGCCAAATTTTGA
AATACATGACTATTAAGTTTCTACTCATGTATTTACAGTCAGTCAATAAATTAAAGGAGGAAAAAAATCCCTGAACAACCTGCCCATAAA
AAGAAAAATACTCTACATTTGAGCCTGCTGCAGTTTTAAATTTTCCCTCTGGGTCAAGTTTGCCAGCTTTTGGCTACAGAGAAATTATAT
TTCCATTACAGTGCAGGTAGAAACTCTGTAACCTTAAGCATGTAAACTACATAGAATAAAACTGTTTCCACTGCATTTCTGTCCTTCAAA
GTGGCCAACCTGATTAAGTCAGCCTTAATCACTGCTGCTGTCAGTTTCACGACTAAAGGTCATATTGACTAAGTAGTCATCAGCTGACCA
CCTCGCTGTATCAGCCAGCAACGAGGGGAAGGTGAAGAAACATGATAGGCCATATAGAATCTGCCCTATGTTTACTTTTTTAACCCAGAT
AATTATTTTTGTGTGCAGTATCTAAGCTCCTGATTGTGTAACCTGGGACTTCTGGCACCTTTTGTTCCATTCATTTTATGTATAAAATGC
ATGCCAAAGCACACTGTGCCCTCTGGTACCCTTGCTTCCAATCGCCAACCATGCTCATTTCCTTCCTTTTTTTGTGGTCCCTTTTTGTGG
TGATCATTTTAAACCACGTCATCCAACAAATGTTTTATGGTCAACCTTAGCTTGTTCATAAGCCATAGCAACTGAAAGATTAAACTCTTA
AATATGTGTCTGGGCAGTGGCTATTAAATAGCAAAAAACAATCAGATTTTAGTATTTTATTATTTCCTTGTAAAATGGCTGAACTAAATT
AAACCCTTGTTTCCCATTTGTTCTATAATTTATAGTGAAACTGAGAACAAAACTATCTTTATAAATGATAGCTAAAAGTATTTCCAGATA
TTTAAACAATTTAAAATAAATTTCTTCTGCAGAGATGCAAAGCATCTCAACACTGGAATGAACAAATGCCTTAAATTCAATGGAGTAAAC
CTTTAGAATGAAGAGGAACTGTCATTTCACCCAAGCCGAAGACAACAGCCTTATGCACTTGTGTGCTCTGTCTTTGCTGCTTCTCGTGTT
TCAAGCCTTTCCTGTGGGATCAGCACAGCAAAGTGCAACTTACCAAATGGTTTAATGACTGGTTAATTCTTTCTTCTCCCAATGGAAAAG
CAATGGCAACACAACAGTAGACTGCTGGCTTGACAATCTTAAACGTGAGCCTTTGCACATGTAGGTTTATCATCATTTGAGTATACGACT
AAGCAAGTCAATGAACTTTTTTTTTTTTTTTAGCAGTTTAATTTGGTCCTGAGAATGTTGCAGTCTTTATTACCCCTTTTGCATTAATCC
ACTTTTCTAACCACCTTTTAAGCTTTAATTTTTAACACTATACACCAAGTCTTTGAAATCAGTGATCTGTTATTTAACTCTAAAGCATTT
GACACTTCTTGCCTTAACAGTTTTAAAAACCACACACAAAAAAACTCTGTAAGTAATACAGTAGGCCAAAAGTTTCATCCTATCTATCTT
GCAGTTTACCTATCTGATCTGATCTCTGTAATTATAGTTCTGTCATTTAAAATATACTATTTAAATCTAATTTTTACATTTCAAAAATTA
TCTTCAGTAGTAACTAAGTATATTTTCTGTGGATTCTGAGAATGTTATTTTTCAGAATGTGAGAATATATATGTACATTTATAATCTTGT
GACTTTAAAGTCTGTTTTCAGATACAGTATGTAAATACTTGTAAAAAAATTTGTATAATTTTGTGATAATGTAGTTTCCCAAAAAAATTA

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000352093_chr14_89110855_-_4031nt
CAGCGCTGGCGTCAATGCTCCCTTCCTCGGGCCATTGGAGACTCCGTTGCTTTTTAATGGCGGCAGCGGCTGCTGGGTGAGCAGCTGGAG
GCCGGACAGTGTTCGTCCCATCCGGAGAGGATCGCTTTCTCCTGGCGTCACCAGCGCTGGGTTGGTGGGGGTAGCTTTTCCCTCTTTGCT
CCTCCATTCTTGAAGAAAGAAGAAGATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTG
CCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGT
GGCCCAGAGGCTGGAGCTGCGGGAGGTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAA
ACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCA
GCAGGAGATTACCAGGTATCAGTATTATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCA
GCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGT
GGGATGGTTACAAGATGAAAAAGTATTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGA
TGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACAT
ATCCATTGGAGCGTGTCTTGAAGGTATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACAT
GTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATA
CATTTGGAGACTCTGTGTTGCGCGACACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGA
GAAACTCCAGACAAACAATGTAGGCAAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTG
TAGGAATAATGTTCACTATTTAAATGATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTC
TCAGAGTTTTTATCAGGAACATAATGATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCA
AGTAGTTTTGAGCTGTTCTTTGTTAACTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATG
CTACCATTCAAAGGGAGTATGTTCAGTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTAC
CATTTGGAGATGGCAGGAAGGTGCCAAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGA
TACCCAGTTTGTCTCAGTGGGAGTAAAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCAC
ACTGGAAGATGCCCGGATGCAGACCATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTG
TGTGTGGAAAGATCACATATTGTGTAGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACT
TATCGTGACTGGGGGAAAGGAAAGGCCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAG
GCTTGAGACAGGACAAGCCACAGATTGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAAT
CGAAGTTGGAGAGAAAAATGCAGCTTGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAG
GGATTTTTTCCTTTCTGCTGCAGAAGATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACA
TGCTGCTCGTACTGTGTGTTACAGCCCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTC
TCTAAAAATATGGGGAAAGAAGAGAGACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTC
TAGTGAGAACTCAGTGGATTTTTATGACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCAT
TCAAATGGACTTCTCTGCAGATAGCAGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACA
TCTTATGGATCATGCCGCTATTGACAGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACA
TGCTGAGAAAGCTGATGTCAACTGTGCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATT
TGACTTCCCATGTCCAGAAAAATTTGCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGA
TCGACATGTTGTTAGTGCTGGAGGTGATGACTGCAGCTTATTTGTCTGGAAATGTGTACATACACCTCACTGAGAGATGCTGAGATGACT
ACAGAAATTAACTTTGAGACCAGAATTACAGAGAAGAAAAACCAAAACCCAACCCTGCATGGTCAAGTGGTGCTAACCCAAGACTGTAAC
AGGGAGAAATGCCCAGAATCATCAAAATAGTGAAAGACTGATCTGTTCAAAATATTTGCTATATGCACTGGGTATAATCCGTAATCCATA
CACTGCCAGATAATGCCATTTCAAGGAAGGATCGAATACTTGATGGTAAAGGCCAAGTCCCCCTGTATTGGGAAGTGTGTGATTTCGGCA
GACCTGCTGGGAAAATTTAGGGTAGAGCACTCTTTACAGAAGAACTCAAAAACCCAATTTGGATAATTTTCATTATCTTTTTAGCAAAAT
GGTTTCTTAATGTTTATATTTTATTTTCAAGGTTCATTGTTTAATGAAATATTTTATTCTTGCATTTCCATAAGGAAAGGGAAAGTCATG
ATCATCCTAAAGGATCACAGTTTTTAAAAGGCAAACATTTTCCCTAAGGAAACAGACACAAGCTTTCCTAGAGAATATGATGTTTTTTAG
GCATTAATAAGGTCCTTTTTTATAAAGGACACTTTTCTCCTAGTAGTTTTGAATTCAGGAACAGATCCAAAGTTAGCAGTATATGGCTGC
TACATTTCCATTTTCATTTTCGAGCCATCAGTTTATGTTCAGATGCCATCTCTGTAATCGCACATTTAAAACATAACTGTAGCCTCACTA
ATGGAAAAGTAGTATGATGAACAATCATTCCCAATGGTGTACAATGTAAGGGTTTTAGGGAGCAACAGTATTTAACTGGAAGAAAGAATT
GCATATTTAATGTAGTCTAATATATACACATTTGTTTAACATGTAAACAAAAGTGTTAAATTCACATATACAACATTATACAATTTAATC

>In-frame_PTPN21_ENST00000328736_chr14_88962757_-_EML5_ENST00000380664_chr14_89110855_-_3043nt
CAGCGCTGGCGTCAATGCTCCCTTCCTCGGGCCATTGGAGACTCCGTTGCTTTTTAATGGCGGCAGCGGCTGCTGGGTGAGCAGCTGGAG
GCCGGACAGTGTTCGTCCCATCCGGAGAGGATCGCTTTCTCCTGGCGTCACCAGCGCTGGGTTGGTGGGGGTAGCTTTTCCCTCTTTGCT
CCTCCATTCTTGAAGAAAGAAGAAGATGCCACTGCCATTTGGGTTGAAACTGAAACGCACCCGGCGCTACACGGTGTCCAGCAAGAGTTG
CCTGGTTGCCCGGATCCAACTGCTTAATAACGAGTTTGTGGAGTTCACCCTGTCCGTGGAGAGCACTGGCCAGGAAAGCCTCGAGGCCGT
GGCCCAGAGGCTGGAGCTGCGGGAGGTCACTTACTTCAGCCTCTGGTACTACAACAAGCAAAATCAGCGCCGGTGGGTAGATTTGGAAAA
ACCTTTGAAGAAGCAGCTGGATAAATATGCATTGGAACCTACCGTCTATTTTGGAGTGGTGTTTTATGTGCCTTCAGTTTCTCAGCTGCA
GCAGGAGATTACCAGGTATCAGTATTATCTGCAACTGAAGAAAGATATCTTGGAAGGAAGTATTCCTTGTACCTTAGAACAAGCAATTCA
GCTAGCAGGCTTAGCTGTTCAAGCGGATTTTGGTGACTTTGATCAGTATGAATCCCAGGACTTTCTTCAGAAATTTGCCTTGTTTCCTGT
GGGATGGTTACAAGATGAAAAAGTATTGGAAGAAGCAACCCAAAAAGTGGCCTTACTACATCAGAAATACAGAGGGCTCACAGCTCCTGA
TGCTGAAATGCTGTACATGCAGGAGGTAGAGAGAATGGATGGCTATGGAGAAGAGAGCTACCCTGCTAAGGATAGCCAAGGAAGTGACAT
ATCCATTGGAGCGTGTCTTGAAGGTATCTTTGTGAAACACAAGAATGGAAGGCATCCTGTGGTATTTAGGTGGCATGACATTGCCAACAT
GTCCCACAACAAGTCCTTTTTTGCATTAGAGCTGGCAAATAAAGAGGAGACCATTCAATTTCAAACTGAAGACATGGAAACAGCAAAATA
CATTTGGAGACTCTGTGTTGCGCGACACAAGTTTTACAGACTAAACCAGTGTAACCTGCCTCCAGTGAGCAGGGCCCCACCACAGCCAGA
GAAACTCCAGACAAACAATGTAGGCAAGAAAAAGAGACCTATAGAGGACCTTGTGTTGGAGCTCATTTTTGGTTATCGAGGCAGAGACTG
TAGGAATAATGTTCACTATTTAAATGATGGTGATGATATAATTTATCACACTGCATCTGTTGGAATTCTGCACAATGTTGCTACAGGTTC
TCAGAGTTTTTATCAGGAACATAATGATGATATTCTGTGCCTCACAGTAAACCAGCACCCCAAATTTATCAACATAGTGGCAACTGGCCA
AGTAGGTGATTCAGCAGACATGTCAGCTACAGCTCCTTCTATTCACATCTGGGATGCAATGAACAAGCAGACTTTATCTATCCTAAGATG
CTACCATTCAAAGGGAGTATGTTCAGTCAGCTTCAGTGCTACTGGCAAACTATTGCTGTCTGTGGGACTAGACCCAGAACATACTATTAC
CATTTGGAGATGGCAGGAAGGTGCCAAAATTGCCAGCAGAGCTGGTCACAATCAACGTATTTTTGTGGCAGAATTCCGACCAGATTCAGA
TACCCAGTTTGTCTCAGTGGGAGTAAAACATGTGAAGTTCTGGACCCTGGCAGGAAGAGCTCTTCTTAGCAAAAAAGGGCTACTGAGCAC
ACTGGAAGATGCCCGGATGCAGACCATGCTCGCTATTGCATTTGGTGCAAATAACTTGACGTTTACAGGTACCATCAGTGGTGATGTCTG
TGTGTGGAAAGATCACATATTGTGTAGAATCGTGGCGAGAGCTCACAACGGGCCTGTGTTTGCCATGTACACCACCCTGCGAGATGGACT
TATCGTGACTGGGGGAAAGGAAAGGCCGTCAAAAGAAGGAGGAGCGGTTAAACTGTGGGATCAGGAACTGAGGCGGTGCCGTGCCTTCAG
GCTTGAGACAGGACAAGCCACAGATTGTGTTCGTTCTGTGTGCAGAGGCAAAGGCAAGATCCTTGTTGGGACAAGGAATGCTGAAATAAT
CGAAGTTGGAGAGAAAAATGCAGCTTGTAATATTTTAGTTAACGGTCATGTGGATGGGCCAATCTGGGGACTAGCAACACATCCTTCCAG
GGATTTTTTCCTTTCTGCTGCAGAAGATGGGACAGTGAGACTTTGGGATATTGCTGATAAAAAGATGTTAAACAAAGTGAATTTGGGACA
TGCTGCTCGTACTGTGTGTTACAGCCCTGAAGGGGACATGGTGGCTATTGGAATGAAAAATGGAGAATTTATCATTTTACTAGTGAGTTC
TCTAAAAATATGGGGAAAGAAGAGAGACAGGAGATGTGCAATCCATGATATCAGATTTAGTCCGGATTCCCGGTATCTGGCAGTAGGTTC
TAGTGAGAACTCAGTGGATTTTTATGACCTAACGCTGGGCCCCACTCTTAACAGAATCAGCTACTGCAAAGACATTCCAAGCTTTGTCAT
TCAAATGGACTTCTCTGCAGATAGCAGTTATCTCCAGGTCTCTAGTGGCTGCTATAAACGGCATGTCTATGAAGTGCCTTCAGGAAAACA
TCTTATGGATCATGCCGCTATTGACAGAATTACTTGGGCTACATGGACTAGTATTCTAGGAGATGAGGTTTTGGGAATCTGGTCCAGACA
TGCTGAGAAAGCTGATGTCAACTGTGCCTGTGTATCTCATTCAGGAATCAGTCTTGTTACAGGAGATGACTTTGGCATGGTTAAGTTATT
TGACTTCCCATGTCCAGAAAAATTTGCAAAACACAAAAGGTTCTTGGGTCATTCGCCCCATGTGACAAATATTCGATTTACCAGTGGTGA


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FusionGenePPI for PTPN21_EML5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTPN21BMX, SRC, KIF1C, PARD6B, AJUBA, LPP, PFDN4, PFDN6, TRIP6, USP9X, VBP1, WWC2, WWC1, YAP1, RHPN1, PTPN21, NEK7, PM20D2, RMND5A, IFT52, AMOT, WDR5, TTC26, DCAF8, CSNK2A2, POLR1B, WDR26, AHCYL2, BPIFB1, NAF1, CSNK2A1, AKR7A2, ARMC8, DCAF5, ELP2, STXBP4, ACAD8, AHCYL1, POLR1C, TMX3, CDK4, DNAJB11, NDUFA9, DUSP7, WWP1EML5FBXW11, NTRK1, DNAJC7, CRYBA4, BTRC, C15orf26


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTPN21_EML5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTPN21_EML5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTPN21C0036341Schizophrenia1PSYGENET
TgeneEML5C0036341Schizophrenia1PSYGENET