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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29386

FusionGeneSummary for PTMS_FHOD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMS_FHOD3
Fusion gene ID: 29386
HgeneTgene
Gene symbol

PTMS

FHOD3

Gene ID

5763

91010

Gene nameparathymosinformin like 3
SynonymsParaTFHOD3|FRL2|WBP-3|WBP3
Cytomap

12p13.31

12q13.12

Type of geneprotein-codingprotein-coding
Descriptionparathymosinformin-like protein 3WW domain binding protein 3formin homology 2 domain-containing protein 3
Modification date2018051920180519
UniProtAcc

P20962

Q2V2M9

Ensembl transtripts involved in fusion geneENST00000389462, ENST00000309083, 
ENST00000538057, 
ENST00000257209, 
ENST00000445677, ENST00000590592, 
ENST00000359247, ENST00000591635, 
ENST00000592128, ENST00000587493, 
Fusion gene scores* DoF score8 X 8 X 3=1923 X 3 X 2=18
# samples 83
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTMS [Title/Abstract] AND FHOD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF091881PTMSchr12

6879138

-FHOD3chr18

34232499

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000389462ENST00000257209PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000445677PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000590592PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000359247PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000591635PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000592128PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000389462ENST00000587493PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000257209PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000445677PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000590592PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000359247PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000591635PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000592128PTMSchr12

6879138

-FHOD3chr18

34232499

+
5CDS-intronENST00000309083ENST00000587493PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000257209PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000445677PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000590592PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000359247PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000591635PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000592128PTMSchr12

6879138

-FHOD3chr18

34232499

+
3UTR-intronENST00000538057ENST00000587493PTMSchr12

6879138

-FHOD3chr18

34232499

+

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FusionProtFeatures for PTMS_FHOD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTMS

P20962

FHOD3

Q2V2M9

Parathymosin may mediate immune function by blocking theeffect of prothymosin alpha which confers resistance to certainopportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTMS_FHOD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTMS_FHOD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTMS_FHOD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTMS_FHOD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFHOD3C0236969Substance-Related Disorders1CTD_human