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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29381

FusionGeneSummary for PTMA_SAP30BP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMA_SAP30BP
Fusion gene ID: 29381
HgeneTgene
Gene symbol

PTMA

SAP30BP

Gene ID

5757

29115

Gene nameprothymosin alphaSAP30 binding protein
SynonymsTMSAHCNGP|HTRG|HTRP
Cytomap

2q37.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-SAP30-binding proteinHSV-1 bindingtranscriptional regulator protein HCNGP
Modification date2018052220180523
UniProtAcc

P06454

Q9UHR5

Ensembl transtripts involved in fusion geneENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
ENST00000584667, ENST00000355423, 
ENST00000579864, 
Fusion gene scores* DoF score10 X 11 X 4=4409 X 9 X 5=405
# samples 1112
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/405*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTMA [Title/Abstract] AND SAP30BP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSAP30BP

GO:0010942

positive regulation of cell death

15496587


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUADTCGA-62-A471-01APTMAchr2

232576129

+SAP30BPchr17

73686751

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000466801ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
3UTR-intronENST00000466801ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
3UTR-intronENST00000466801ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409321ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409321ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409321ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409115ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409115ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409115ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000341369ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000341369ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000341369ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409683ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409683ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000409683ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000410064ENST00000584667PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000410064ENST00000355423PTMAchr2

232576129

+SAP30BPchr17

73686751

+
5CDS-intronENST00000410064ENST00000579864PTMAchr2

232576129

+SAP30BPchr17

73686751

+

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FusionProtFeatures for PTMA_SAP30BP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTMA

P06454

SAP30BP

Q9UHR5

Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections. Induces cell death. May act as a transcriptionalcorepressor of a gene related to cell survival. May be involved inthe regulation of beta-2-microglobulin genes.{ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:15496587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTMA_SAP30BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTMA_SAP30BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTMAPHB2, ESR1, HDAC1, HDAC2, NCOR1, SIN3A, CREBBP, EP300, SET, ELAVL1, TERF1, TERF2IP, TERF2, DSTN, PSME2, NUBP2, PSMA1, PTMS, PSRC1, SRSF2, PPIA, IL7R, PAN2, KPNA2, RAN, RCC1, KPNB1, PCNA, CDK2, CDK4, CDK1, CCNB1, CDK17, ASNS, ATIC, CAPNS1, CAPZA2, ISOC1, MCTS1, MSN, NSFL1C, PDIA4, PROSC, CAPN2, CTH, FH, GMDS, STK26, OGFOD1, PAPSS1, RAP1GDS1, TATDN1, TBCB, YWHAE, YWHAH, KEAP1, HIST1H1A, NUPR1, ZDHHC17, C11orf58, EIF5B, GTF2A1, NCL, RPGRIP1L, SYNCRIP, BAG6, DLD, TRIM25SAP30BPPUF60, MEPCE, TERF1, TERF2, GSK3B, RPS6KA6, SF3A2, SNCA, EWSR1, TAF15, DYNC1H1, DDX1, HSPD1, FLNC, DCTN1, FUS, DDB1, FHL2, MLX, ZNF212, ZNF408, RBM17, U2AF2, RBM39, DHX8, THOC1, WDR83, FRA10AC1, WDR77, CSNK2A1, LMNA, CSNK2A2, HUWE1, FHL3, GOLGA2, TFIP11, THAP1, SHMT2, MOV10, NXF1, CDK11A, NTRK1, TRIM25, TXNIP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTMA_SAP30BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTMA_SAP30BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTMAC0001430Adenoma1CTD_human
HgenePTMAC0015695Fatty Liver1CTD_human
HgenePTMAC0024121Lung Neoplasms1CTD_human
HgenePTMAC0035412Rhabdomyosarcoma1CTD_human
TgeneSAP30BPC0036341Schizophrenia1CTD_human