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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29380

FusionGeneSummary for PTMA_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMA_PTMA
Fusion gene ID: 29380
HgeneTgene
Gene symbol

PTMA

PTMA

Gene ID

5757

5757

Gene nameprothymosin alphaprothymosin alpha
SynonymsTMSATMSA
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
Descriptionprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-prothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date2018052220180522
UniProtAcc

P06454

P06454

Ensembl transtripts involved in fusion geneENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
ENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
Fusion gene scores* DoF score10 X 11 X 4=44017 X 17 X 2=578
# samples 1118
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTMA [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA356995PTMAchr2

232577540

+PTMAchr2

232576117

-
ChiTaRS3.1BQ322331PTMAchr2

232576064

-PTMAchr2

232577619

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000466801ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409321ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409115ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000341369ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000409683ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000466801PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000409321PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000409115PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000341369PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000409683PTMAchr2

232577540

+PTMAchr2

232576117

-
5CDS-3UTRENST00000410064ENST00000410064PTMAchr2

232577540

+PTMAchr2

232576117

-
3UTR-3UTRENST00000466801ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
3UTR-3UTRENST00000466801ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
3UTR-3UTRENST00000466801ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
3UTR-3UTRENST00000466801ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
3UTR-3UTRENST00000466801ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
3UTR-intronENST00000466801ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409321ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409321ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409321ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409321ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409321ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-intronENST00000409321ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409115ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409115ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409115ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409115ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409115ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-intronENST00000409115ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000341369ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000341369ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000341369ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000341369ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000341369ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-intronENST00000341369ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409683ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409683ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409683ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409683ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000409683ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-intronENST00000409683ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000410064ENST00000466801PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000410064ENST00000409321PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000410064ENST00000409115PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000410064ENST00000341369PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-3UTRENST00000410064ENST00000409683PTMAchr2

232576064

-PTMAchr2

232577619

-
5CDS-intronENST00000410064ENST00000410064PTMAchr2

232576064

-PTMAchr2

232577619

-

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FusionProtFeatures for PTMA_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTMA

P06454

PTMA

P06454

Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections. Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTMA_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTMA_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTMA_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTMA_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTMAC0001430Adenoma1CTD_human
HgenePTMAC0015695Fatty Liver1CTD_human
HgenePTMAC0024121Lung Neoplasms1CTD_human
HgenePTMAC0035412Rhabdomyosarcoma1CTD_human
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human