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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29378

FusionGeneSummary for PTMA_PPIE

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMA_PPIE
Fusion gene ID: 29378
HgeneTgene
Gene symbol

PTMA

PPIE

Gene ID

5757

10450

Gene nameprothymosin alphapeptidylprolyl isomerase E
SynonymsTMSACYP-33|CYP33
Cytomap

2q37.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-peptidyl-prolyl cis-trans isomerase EPPIase Ecyclophilin-33peptidylprolyl isomerase E (cyclophilin E)rotamase E
Modification date2018052220180523
UniProtAcc

P06454

Q9UNP9

Ensembl transtripts involved in fusion geneENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
ENST00000324379, ENST00000356511, 
ENST00000470213, ENST00000372830, 
ENST00000480169, 
Fusion gene scores* DoF score10 X 11 X 4=4404 X 5 X 2=40
# samples 115
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTMA [Title/Abstract] AND PPIE [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePPIE

GO:0000398

mRNA splicing, via spliceosome

28076346

TgenePPIE

GO:0000413

protein peptidyl-prolyl isomerization

20676357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ923234PTMAchr2

232578241

+PPIEchr1

40204568

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000466801ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000466801ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000466801ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000466801ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-intronENST00000466801ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409321ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409321ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409321ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409321ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-intronENST00000409321ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+
3UTR-5UTRENST00000409115ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
3UTR-5UTRENST00000409115ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
3UTR-5UTRENST00000409115ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
3UTR-5UTRENST00000409115ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
3UTR-intronENST00000409115ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+
5CDS-5UTRENST00000341369ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
5CDS-5UTRENST00000341369ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
5CDS-5UTRENST00000341369ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
5CDS-5UTRENST00000341369ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
5CDS-intronENST00000341369ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409683ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409683ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409683ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000409683ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-intronENST00000409683ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000410064ENST00000324379PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000410064ENST00000356511PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000410064ENST00000470213PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-5UTRENST00000410064ENST00000372830PTMAchr2

232578241

+PPIEchr1

40204568

+
intron-intronENST00000410064ENST00000480169PTMAchr2

232578241

+PPIEchr1

40204568

+

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FusionProtFeatures for PTMA_PPIE


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTMA

P06454

PPIE

Q9UNP9

Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTMA_PPIE


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTMA_PPIE


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTMA_PPIE


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTMA_PPIE


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTMAC0001430Adenoma1CTD_human
HgenePTMAC0015695Fatty Liver1CTD_human
HgenePTMAC0024121Lung Neoplasms1CTD_human
HgenePTMAC0035412Rhabdomyosarcoma1CTD_human