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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29374

FusionGeneSummary for PTMA_ANKRD28

check button Fusion gene summary
Fusion gene informationFusion gene name: PTMA_ANKRD28
Fusion gene ID: 29374
HgeneTgene
Gene symbol

PTMA

ANKRD28

Gene ID

5757

23243

Gene nameprothymosin alphaankyrin repeat domain 28
SynonymsTMSAPITK|PPP1R65
Cytomap

2q37.1

3p25.1

Type of geneprotein-codingprotein-coding
Descriptionprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory
Modification date2018052220180519
UniProtAcc

P06454

O15084

Ensembl transtripts involved in fusion geneENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
ENST00000383777, ENST00000399451, 
ENST00000497037, 
Fusion gene scores* DoF score10 X 11 X 4=4403 X 3 X 1=9
# samples 113
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTMA [Title/Abstract] AND ANKRD28 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ900403PTMAchr2

232576668

-ANKRD28chr3

15719859

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000466801ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
3UTR-3CDSENST00000466801ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
3UTR-5UTRENST00000466801ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409321ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409321ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
5CDS-5UTRENST00000409321ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409115ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409115ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
5CDS-5UTRENST00000409115ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000341369ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000341369ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
5CDS-5UTRENST00000341369ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409683ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000409683ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
5CDS-5UTRENST00000409683ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000410064ENST00000383777PTMAchr2

232576668

-ANKRD28chr3

15719859

-
Frame-shitENST00000410064ENST00000399451PTMAchr2

232576668

-ANKRD28chr3

15719859

-
5CDS-5UTRENST00000410064ENST00000497037PTMAchr2

232576668

-ANKRD28chr3

15719859

-

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FusionProtFeatures for PTMA_ANKRD28


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTMA

P06454

ANKRD28

O15084

Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections. Putative regulatory subunit of protein phosphatase 6(PP6) that may be involved in the recognition of phosphoproteinsubstrates. Involved in the PP6-mediated dephosphorylation ofNFKBIE opposing its degradation in response to TNF-alpha.Selectively inhibits the phosphatase activity of PPP1C. TargetsPPP1C to modulate HNRPK phosphorylation.{ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTMA_ANKRD28


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTMA_ANKRD28


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTMA_ANKRD28


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTMA_ANKRD28


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTMAC0001430Adenoma1CTD_human
HgenePTMAC0015695Fatty Liver1CTD_human
HgenePTMAC0024121Lung Neoplasms1CTD_human
HgenePTMAC0035412Rhabdomyosarcoma1CTD_human