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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29372

FusionGeneSummary for PTK7_VEGFA

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK7_VEGFA
Fusion gene ID: 29372
HgeneTgene
Gene symbol

PTK7

VEGFA

Gene ID

5754

7422

Gene nameprotein tyrosine kinase 7 (inactive)vascular endothelial growth factor A
SynonymsCCK-4|CCK4MVCD1|VEGF|VPF
Cytomap

6p21.1

6p21.1

Type of geneprotein-codingprotein-coding
Descriptioninactive tyrosine-protein kinase 7PTK7 protein tyrosine kinase 7colon carcinoma kinase 4pseudo tyrosine kinase receptor 7tyrosine-protein kinase-like 7vascular endothelial growth factor Avascular endothelial growth factor A121vascular endothelial growth factor A165vascular permeability factor
Modification date2018052320180527
UniProtAcc

Q13308

P15692

Ensembl transtripts involved in fusion geneENST00000230419, ENST00000349241, 
ENST00000345201, ENST00000352931, 
ENST00000481273, ENST00000476760, 
ENST00000471863, 
ENST00000372067, 
ENST00000417285, ENST00000324450, 
ENST00000413642, ENST00000372055, 
ENST00000482630, ENST00000425836, 
ENST00000372064, ENST00000372077, 
ENST00000520948, ENST00000523873, 
ENST00000523950, ENST00000518689, 
ENST00000523125, ENST00000457104, 
ENST00000518824, ENST00000230480, 
Fusion gene scores* DoF score10 X 3 X 10=3004 X 3 X 4=48
# samples 104
** MAII scorelog2(10/300*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK7 [Title/Abstract] AND VEGFA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneVEGFA

GO:0000122

negative regulation of transcription by RNA polymerase II

18093989

TgeneVEGFA

GO:0001525

angiogenesis

11427521|21771332

TgeneVEGFA

GO:0001666

response to hypoxia

16490744

TgeneVEGFA

GO:0001934

positive regulation of protein phosphorylation

18386220|19033661

TgeneVEGFA

GO:0001938

positive regulation of endothelial cell proliferation

9202027|10022831|12714610|16489009|18386220|18577655|20497126

TgeneVEGFA

GO:0002042

cell migration involved in sprouting angiogenesis

18059339|20660291

TgeneVEGFA

GO:0002092

positive regulation of receptor internalization

20660291

TgeneVEGFA

GO:0008284

positive regulation of cell proliferation

7929439

TgeneVEGFA

GO:0008360

regulation of cell shape

7929439|10527820

TgeneVEGFA

GO:0010595

positive regulation of endothelial cell migration

10022831|19033661

TgeneVEGFA

GO:0010628

positive regulation of gene expression

18386220

TgeneVEGFA

GO:0010629

negative regulation of gene expression

28977001

TgeneVEGFA

GO:0030224

monocyte differentiation

21149635

TgeneVEGFA

GO:0030225

macrophage differentiation

21149635

TgeneVEGFA

GO:0030335

positive regulation of cell migration

7929439|17470632

TgeneVEGFA

GO:0030823

regulation of cGMP metabolic process

16150726

TgeneVEGFA

GO:0030949

positive regulation of vascular endothelial growth factor receptor signaling pathway

1312256|7929439

TgeneVEGFA

GO:0031334

positive regulation of protein complex assembly

16489009|19033661

TgeneVEGFA

GO:0031954

positive regulation of protein autophosphorylation

20497126

TgeneVEGFA

GO:0032147

activation of protein kinase activity

18059339|20497126

TgeneVEGFA

GO:0032793

positive regulation of CREB transcription factor activity

20497126

TgeneVEGFA

GO:0033138

positive regulation of peptidyl-serine phosphorylation

18440775|20497126

TgeneVEGFA

GO:0035148

tube formation

19033661

TgeneVEGFA

GO:0035767

endothelial cell chemotaxis

18440775

TgeneVEGFA

GO:0035924

cellular response to vascular endothelial growth factor stimulus

18440775|20497126

TgeneVEGFA

GO:0038033

positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

18440775|20497126|21245381

TgeneVEGFA

GO:0038091

positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

17470632

TgeneVEGFA

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

19390056

TgeneVEGFA

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18386220

TgeneVEGFA

GO:0043406

positive regulation of MAP kinase activity

18440775

TgeneVEGFA

GO:0043536

positive regulation of blood vessel endothelial cell migration

9202027|18440775|20497126

TgeneVEGFA

GO:0045766

positive regulation of angiogenesis

18440775|18577655|19033661|20497126

TgeneVEGFA

GO:0045785

positive regulation of cell adhesion

19674970

TgeneVEGFA

GO:0045944

positive regulation of transcription by RNA polymerase II

18059339

TgeneVEGFA

GO:0048010

vascular endothelial growth factor receptor signaling pathway

21245381

TgeneVEGFA

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

10022831|16489009|21245381

TgeneVEGFA

GO:0050918

positive chemotaxis

20497126

TgeneVEGFA

GO:0050927

positive regulation of positive chemotaxis

7929439|12744932

TgeneVEGFA

GO:0051272

positive regulation of cellular component movement

10527820|12744932

TgeneVEGFA

GO:0051894

positive regulation of focal adhesion assembly

16489009

TgeneVEGFA

GO:0071456

cellular response to hypoxia

10575000

TgeneVEGFA

GO:0090037

positive regulation of protein kinase C signaling

18059339

TgeneVEGFA

GO:0090050

positive regulation of cell migration involved in sprouting angiogenesis

20551324

TgeneVEGFA

GO:0097533

cellular stress response to acid chemical

26299712

TgeneVEGFA

GO:1900086

positive regulation of peptidyl-tyrosine autophosphorylation

20660291

TgeneVEGFA

GO:1900745

positive regulation of p38MAPK cascade

18386220

TgeneVEGFA

GO:1901727

positive regulation of histone deacetylase activity

20497126

TgeneVEGFA

GO:1903572

positive regulation of protein kinase D signaling

20497126

TgeneVEGFA

GO:1903672

positive regulation of sprouting angiogenesis

26299712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-KK-A8ID-01APTK7chr6

43044305

+VEGFAchr6

43742078

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000230419ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000230419ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000230419ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000349241ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000349241ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000345201ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000345201ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000352931ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000352931ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-3CDSENST00000481273ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
intron-5UTRENST00000481273ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000476760ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000476760ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000372067PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000417285PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000324450PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000413642PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000372055PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000482630PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000425836PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000372064PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000372077PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000520948PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000523873PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000523950PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000518689PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000523125PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000457104PTK7chr6

43044305

+VEGFAchr6

43742078

+
Frame-shitENST00000471863ENST00000518824PTK7chr6

43044305

+VEGFAchr6

43742078

+
5CDS-5UTRENST00000471863ENST00000230480PTK7chr6

43044305

+VEGFAchr6

43742078

+

Top

FusionProtFeatures for PTK7_VEGFA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTK7

Q13308

VEGFA

P15692


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTK7_VEGFA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PTK7_VEGFA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTK7RYK, TSHR, CEACAM21, ATP1B4, BTNL8, NTRK1, PPM1G, CLNK, TMEM17, PPP3CA, PPP3CB, PPM1A, PPM1B, PPM1F, PPM1K, ILKAP, CTDSP2, PTPRR, PTPN6, PTPN7, PTPN11, PTPN12, DUSP10, DUSP14, DUSP15, DUSP18, DUSP19, DUSP21, DUSP26, DUPD1, STYX, CDC14A, PTEN, TPTE, TPTE2, MTMR1, MTMR6, MTMR9, MTMR10VEGFAADAMTS1, KDR, PGF, VEGFA, CTGF, NRP1, IGFBP7, SPARC, VTN, GPC1, HSP90AA1, HSPA4, HGS, ELAVL1, CRYAB, HNRNPD, LYVE1, FLT1, VPS35, U2AF1, PRRG4, HNRNPL, ILF3, VEGFB, UBIAD1, PTPRB, PTPRZ1, CLU, CHEK1, BRCA1, VHL, ACTBL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTK7_VEGFA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneVEGFAP15692DB01120GliclazideVascular endothelial growth factor Asmall moleculeapproved
TgeneVEGFAP15692DB01270RanibizumabVascular endothelial growth factor Abiotechapproved
TgeneVEGFAP15692DB03754TromethamineVascular endothelial growth factor Asmall moleculeapproved
TgeneVEGFAP15692DB05294VandetanibVascular endothelial growth factor Asmall moleculeapproved
TgeneVEGFAP15692DB06779DalteparinVascular endothelial growth factor Asmall moleculeapproved
TgeneVEGFAP15692DB08885AfliberceptVascular endothelial growth factor Abiotechapproved
TgeneVEGFAP15692DB00112BevacizumabVascular endothelial growth factor Abiotechapproved|investigational
TgeneVEGFAP15692DB01017MinocyclineVascular endothelial growth factor Asmall moleculeapproved|investigational
TgeneVEGFAP15692DB01136CarvedilolVascular endothelial growth factor Asmall moleculeapproved|investigational
TgeneVEGFAP15692DB09301Chondroitin sulfateVascular endothelial growth factor Asmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for PTK7_VEGFA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneVEGFAC0011570Mental Depression5PSYGENET
TgeneVEGFAC0011581Depressive disorder5PSYGENET
TgeneVEGFAC0151744Myocardial Ischemia5CTD_human
TgeneVEGFAC1269683Major Depressive Disorder5PSYGENET
TgeneVEGFAC0033578Prostatic Neoplasms4CTD_human
TgeneVEGFAC0004096Asthma3CTD_human
TgeneVEGFAC0011884Diabetic Retinopathy3CTD_human
TgeneVEGFAC0027627Neoplasm Metastasis3CTD_human
TgeneVEGFAC0005586Bipolar Disorder2PSYGENET
TgeneVEGFAC0007137Squamous cell carcinoma2CTD_human
TgeneVEGFAC0018801Heart failure2CTD_human
TgeneVEGFAC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneVEGFAC0027659Neoplasms, Experimental2CTD_human
TgeneVEGFAC0027686Pathologic Neovascularization2CTD_human
TgeneVEGFAC0525045Mood Disorders2PSYGENET
TgeneVEGFAC0993582Arthritis, Experimental2CTD_human
TgeneVEGFAC1956346Coronary Artery Disease2CTD_human
TgeneVEGFAC2609414Acute kidney injury2CTD_human
TgeneVEGFAC0001418Adenocarcinoma1CTD_human
TgeneVEGFAC0002395Alzheimer's Disease1CTD_human
TgeneVEGFAC0003873Rheumatoid Arthritis1CTD_human
TgeneVEGFAC0004153Atherosclerosis1CTD_human
TgeneVEGFAC0006118Brain Neoplasms1CTD_human
TgeneVEGFAC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneVEGFAC0007873Uterine Cervical Neoplasm1CTD_human
TgeneVEGFAC0008677Bronchitis, Chronic1CTD_human
TgeneVEGFAC0009375Colonic Neoplasms1CTD_human
TgeneVEGFAC0011616Contact Dermatitis1CTD_human
TgeneVEGFAC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneVEGFAC0011881Diabetic Nephropathy1CTD_human
TgeneVEGFAC0014170Endometrial Neoplasms1CTD_human
TgeneVEGFAC0014556Epilepsy, Temporal Lobe1CTD_human
TgeneVEGFAC0017636Glioblastoma1CTD_human
TgeneVEGFAC0018671Head and Neck Neoplasms1CTD_human
TgeneVEGFAC0018798Congenital Heart Defects1CTD_human
TgeneVEGFAC0018799Heart Diseases1CTD_human
TgeneVEGFAC0018923Hemangiosarcoma1CTD_human
TgeneVEGFAC0020541Hypertension, Portal1CTD_human
TgeneVEGFAC0021368Inflammation1CTD_human
TgeneVEGFAC0023186Learning Disorders1CTD_human
TgeneVEGFAC0023470Myeloid Leukemia1CTD_human
TgeneVEGFAC0023890Liver Cirrhosis1CTD_human
TgeneVEGFAC0024115Lung diseases1CTD_human
TgeneVEGFAC0025261Memory Disorders1CTD_human
TgeneVEGFAC0027055Myocardial Reperfusion Injury1CTD_human
TgeneVEGFAC0027643Neoplasm Recurrence, Local1CTD_human
TgeneVEGFAC0029422Osteochondrodysplasias1CTD_human
TgeneVEGFAC0029463Osteosarcoma1CTD_human
TgeneVEGFAC0032927Precancerous Conditions1CTD_human
TgeneVEGFAC0033687Proteinuria1CTD_human
TgeneVEGFAC0033860Psoriasis1CTD_human
TgeneVEGFAC0035309Retinal Diseases1CTD_human
TgeneVEGFAC0035328Retinal Vein Occlusion1CTD_human
TgeneVEGFAC0035412Rhabdomyosarcoma1CTD_human
TgeneVEGFAC0036341Schizophrenia1PSYGENET
TgeneVEGFAC0038220Status Epilepticus1CTD_human
TgeneVEGFAC0038358Gastric ulcer1CTD_human
TgeneVEGFAC0042076Urologic Neoplasms1CTD_human
TgeneVEGFAC0085109Corneal Neovascularization1CTD_human
TgeneVEGFAC0085605Liver Failure1CTD_human
TgeneVEGFAC0206726gliosarcoma1CTD_human
TgeneVEGFAC0242350Erectile dysfunction1CTD_human
TgeneVEGFAC0242383Age related macular degeneration1CTD_human
TgeneVEGFAC0271051Macular retinal edema1CTD_human
TgeneVEGFAC0342257Complications of Diabetes Mellitus1CTD_human
TgeneVEGFAC0600518Choroidal Neovascularization1CTD_human
TgeneVEGFAC0678807prenatal alcohol exposure1PSYGENET
TgeneVEGFAC0752308Hypoxia-Ischemia, Brain1CTD_human
TgeneVEGFAC0887833Carcinoma, Pancreatic Ductal1CTD_human
TgeneVEGFAC2063866Depressive Disorder, Treatment-Resistant1PSYGENET
TgeneVEGFAC2717961Thrombotic Microangiopathies1CTD_human
TgeneVEGFAC2931852Clear-cell metastatic renal cell carcinoma1CTD_human
TgeneVEGFAC2937358Cerebral Hemorrhage1CTD_human