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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 29350

FusionGeneSummary for PTK2_PPP2R5E

check button Fusion gene summary
Fusion gene informationFusion gene name: PTK2_PPP2R5E
Fusion gene ID: 29350
HgeneTgene
Gene symbol

PTK2

PPP2R5E

Gene ID

5747

5529

Gene nameprotein tyrosine kinase 2protein phosphatase 2 regulatory subunit B'epsilon
SynonymsFADK|FAK|FAK1|FRNK|PPP1R71|p125FAK|pp125FAKB56E|B56epsilon
Cytomap

8q24.3

14q23.2

Type of geneprotein-codingprotein-coding
Descriptionfocal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoformPP2A, B subunit, B' epsilonPP2A, B subunit, B56 epsilonPP2A, B subunit, PR61 epsilonPP2A, B subunit, R5 epsilonepsilon isoform of regulatory subunit B56, protein phospha
Modification date2018052720180523
UniProtAcc

Q05397

Q16537

Ensembl transtripts involved in fusion geneENST00000522684, ENST00000535192, 
ENST00000519465, ENST00000517887, 
ENST00000521059, ENST00000395218, 
ENST00000538769, ENST00000340930, 
ENST00000519419, ENST00000430260, 
ENST00000519881, ENST00000520892, 
ENST00000519635, ENST00000517712, 
ENST00000522950, ENST00000520151, 
ENST00000337537, ENST00000555899, 
ENST00000422769, ENST00000553266, 
Fusion gene scores* DoF score23 X 15 X 10=34504 X 4 X 4=64
# samples 254
** MAII scorelog2(25/3450*10)=-3.78659636189081
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTK2 [Title/Abstract] AND PPP2R5E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTK2

GO:0007179

transforming growth factor beta receptor signaling pathway

24036928

HgenePTK2

GO:0007229

integrin-mediated signaling pathway

24036928

HgenePTK2

GO:0018108

peptidyl-tyrosine phosphorylation

10655584|11331870

HgenePTK2

GO:0022408

negative regulation of cell-cell adhesion

21703394

HgenePTK2

GO:0030335

positive regulation of cell migration

11331870|21703394

HgenePTK2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgenePTK2

GO:0046777

protein autophosphorylation

10655584|11331870

HgenePTK2

GO:0048013

ephrin receptor signaling pathway

10655584

HgenePTK2

GO:0060396

growth hormone receptor signaling pathway

10925297


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-BH-A0B6-01APTK2chr8

141900642

-PPP2R5Echr14

63920603

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000522684ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000522684ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000522684ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000522684ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000535192ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000535192ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000535192ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000535192ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000519465ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000519465ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000519465ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000519465ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000517887ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000517887ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000517887ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000517887ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000521059ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000521059ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000521059ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000521059ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000395218ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000395218ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000395218ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000395218ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000538769ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000538769ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000538769ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000538769ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000340930ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000340930ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000340930ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000340930ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000519419ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000519419ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000519419ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000519419ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000430260ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000430260ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000430260ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000430260ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000519881ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
Frame-shiftENST00000519881ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000519881ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000519881ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
In-frameENST00000520892ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
In-frameENST00000520892ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-5UTRENST00000520892ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
5CDS-intronENST00000520892ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000519635ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000519635ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000519635ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000519635ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000517712ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000517712ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000517712ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000517712ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000522950ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000522950ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000522950ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000522950ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000520151ENST00000337537PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-3CDSENST00000520151ENST00000555899PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-5UTRENST00000520151ENST00000422769PTK2chr8

141900642

-PPP2R5Echr14

63920603

-
intron-intronENST00000520151ENST00000553266PTK2chr8

141900642

-PPP2R5Echr14

63920603

-

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FusionProtFeatures for PTK2_PPP2R5E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTK2

Q05397

PPP2R5E

Q16537

Non-receptor protein-tyrosine kinase that plays anessential role in regulating cell migration, adhesion, spreading,reorganization of the actin cytoskeleton, formation anddisassembly of focal adhesions and cell protrusions, cell cycleprogression, cell proliferation and apoptosis. Required for earlyembryonic development and placenta development. Required forembryonic angiogenesis, normal cardiomyocyte migration andproliferation, and normal heart development. Regulates axon growthand neuronal cell migration, axon branching and synapse formation;required for normal development of the nervous system. Plays arole in osteogenesis and differentiation of osteoblasts. Functionsin integrin signal transduction, but also in signaling downstreamof numerous growth factor receptors, G-protein coupled receptors(GPCR), EPHA2, netrin receptors and LDL receptors. Formsmultisubunit signaling complexes with SRC and SRC family membersupon activation; this leads to the phosphorylation of additionaltyrosine residues, creating binding sites for scaffold proteins,effectors and substrates. Regulates numerous signaling pathways.Promotes activation of phosphatidylinositol 3-kinase and the AKT1signaling cascade. Promotes activation of MAPK1/ERK2, MAPK3/ERK1and the MAP kinase signaling cascade. Promotes localized andtransient activation of guanine nucleotide exchange factors (GEFs)and GTPase-activating proteins (GAPs), and thereby modulates theactivity of Rho family GTPases. Signaling via CAS family membersmediates activation of RAC1. Recruits the ubiquitin ligase MDM2 toP53/TP53 in the nucleus, and thereby regulates P53/TP53 activity,P53/TP53 ubiquitination and proteasomal degradation.Phosphorylates SRC; this increases SRC kinase activity.Phosphorylates ACTN1, ARHGEF7, GRB7, RET and WASL. Promotesphosphorylation of PXN and STAT1; most likely PXN and STAT1 arephosphorylated by a SRC family kinase that is recruited toautophosphorylated PTK2/FAK1, rather than by PTK2/FAK1 itself.Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requiresboth SRC and PTK2/FAK1. Promotes phosphorylation of BMX andPIK3R1. Isoform 6 (FRNK) does not contain a kinase domain andinhibits PTK2/FAK1 phosphorylation and signaling. Its enhancedexpression can attenuate the nuclear accumulation of LPXN andlimit its ability to enhance serum response factor (SRF)-dependentgene transcription. {ECO:0000269|PubMed:10655584,ECO:0000269|PubMed:11331870, ECO:0000269|PubMed:11980671,ECO:0000269|PubMed:15166238, ECO:0000269|PubMed:15561106,ECO:0000269|PubMed:15895076, ECO:0000269|PubMed:16919435,ECO:0000269|PubMed:16927379, ECO:0000269|PubMed:17395594,ECO:0000269|PubMed:17431114, ECO:0000269|PubMed:17968709,ECO:0000269|PubMed:18006843, ECO:0000269|PubMed:18206965,ECO:0000269|PubMed:18256281, ECO:0000269|PubMed:18292575,ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:18677107,ECO:0000269|PubMed:19138410, ECO:0000269|PubMed:19147981,ECO:0000269|PubMed:19224453, ECO:0000269|PubMed:20332118,ECO:0000269|PubMed:20495381, ECO:0000269|PubMed:21454698}. The B regulatory subunit might modulate substrateselectivity and catalytic activity, and also might direct thelocalization of the catalytic enzyme to a particular subcellularcompartment.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTK2_PPP2R5E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000337537_chr14_63920603_-_480aa
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRTFHPQSSLNCSXRNFSSAVSFLTSW
TRYLILKXKNTSAPLLMNWWTTLQXAEAVXQSRLTLKXLEWYLAIYSELSLLVTAMNLIQKKMNLPLRHRGHTYSLYMNFSYDFWKAKNS
NPALPKNIXIRNLYYSFWSYLTAKTLGNGTTXKQSYTEFMASFLVLEHLSENRLTIFFXGLFMKQNTSMVXLNCWKYXEVLSMALLYLLR
QNTNSFWXKYXSLYTLSGAYHSSMHSWHIVXYSFWRKILHSQNQLLGGXXNFGLKHVVKKRSCSLGNWKKYWMXLNLHNLLKSKNLCLNK
SPSVYLAPIFRWQKEHSIIGIMNTSXVXXKKTLTSSFPSCFPAFIGFQKNIGIRLLWRWCTMCXRHLWKXTAPCLTSXQPHTSQIVSVRK

>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000555899_chr14_63920603_-_475aa
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRTFHPQSSLNCSXRNFSSAVSFLTSW
TRYLILKXKNTSAPLLMNWWTTLQXAEAVXQSRLTLKXLEWYLAIYSELSLLVTAMNLIQKKMNLPLRHRGHTYSLYMNFSYDFWKAKNS
NPALPKNIXIRNLYYSFWSYLTAKTLGNGTTXKQSYTEFMASFLVLEHLSENRLTIFFXGLFMKQNTSMVXLNCWKYXEVLSMALLYLLR
QNTNSFWXKYXSLYTLSGAYHSSMHSWHIVXYSFWRKILHSQNQLLGGXXNFGLKHVVKKRSCSLGNWKKYWMXLNLHNLLKSKNLCLNK
SPSVYLAPIFRWQKEHSIIGIMNTSXVXXKKTLTSSFPSCFPAFIGFQKNIGIRLLWRWCTMCXRHLWKXTAPCLTSXQPHTMRKRKKRS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000337537_chr14_63920603_-_1442nt
ATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCT
GGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGAT
GCTACTGATGTCAGGACGTTCCATCCTCAGAGCAGCCTGAACTGTTCCTAAAGAAACTTCAGCAGTGCTGTGTCATTTTTGACTTCATGG
ACACGCTATCTGATCTTAAAATGAAAGAATACAAGCGCTCCACTCTTAATGAACTGGTGGACTACATTACAATAAGCAGAGGCTGTTTGA
CAGAGCAGACTTACCCTGAAGTAGTTAGAATGGTATCTTGCAATATATTCAGAACTCTCCCTCCTAGTGACAGCAATGAATTTGATCCAG
AAGAAGATGAACCTACCCTTGAGGCATCGTGGCCACACTTACAGCTTGTATATGAATTTTTCATACGATTTTTGGAAAGCCAAGAATTCC
AACCCAGCATTGCCAAAAAATATATAGATCAGAAATTTGTATTACAGCTTCTGGAGCTATTTGACAGCGAAGACCCTCGGGAACGGGACT
ACTTAAAAACAGTCTTACACAGAATTTATGGCAAGTTTCTTGGTCTTAGAGCATTTATCCGAAAACAGATTAACAATATTTTTCTAAGGT
TTGTTTATGAAACAGAACACTTCAATGGTGTAGCTGAACTGCTGGAAATATTAGGAAGTATTATCAATGGCTTTGCTTTACCTCTTAAGG
CAGAACACAAACAGTTTCTGGTGAAAGTATTGATCCCTTTACACACTGTCAGGAGCTTATCACTCTTCCATGCACAGCTGGCATATTGTA
TAGTACAGTTTCTGGAGAAAGATCCTTCACTCACAGAACCAGTTATTAGGGGGTTAATGAAATTTTGGCCTAAAACATGTAGTCAAAAAG
AGGTCATGTTCCTTGGGGAACTGGAAGAAATATTGGATGTGATTGAACCTTCACAATTTGTTAAAATCCAAGAACCTTTGTTTAAACAAA
TCGCCAAGTGTGTATCTAGCCCCCATTTTCAGGTGGCAGAAAGAGCACTCTATTATTGGAATAATGAATACATCATGAGTTTGATAGAAG
AAAACTCTAACGTCATCCTTCCCATCATGTTTTCCAGCCTTTATAGGATTTCAAAAGAACATTGGAATCCGGCTATTGTGGCGTTGGTGT
ACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGTCAGCGTGAGAAAA
AGAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTT

>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000555899_chr14_63920603_-_1427nt
ATGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCT
GGTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGAT
GCTACTGATGTCAGGACGTTCCATCCTCAGAGCAGCCTGAACTGTTCCTAAAGAAACTTCAGCAGTGCTGTGTCATTTTTGACTTCATGG
ACACGCTATCTGATCTTAAAATGAAAGAATACAAGCGCTCCACTCTTAATGAACTGGTGGACTACATTACAATAAGCAGAGGCTGTTTGA
CAGAGCAGACTTACCCTGAAGTAGTTAGAATGGTATCTTGCAATATATTCAGAACTCTCCCTCCTAGTGACAGCAATGAATTTGATCCAG
AAGAAGATGAACCTACCCTTGAGGCATCGTGGCCACACTTACAGCTTGTATATGAATTTTTCATACGATTTTTGGAAAGCCAAGAATTCC
AACCCAGCATTGCCAAAAAATATATAGATCAGAAATTTGTATTACAGCTTCTGGAGCTATTTGACAGCGAAGACCCTCGGGAACGGGACT
ACTTAAAAACAGTCTTACACAGAATTTATGGCAAGTTTCTTGGTCTTAGAGCATTTATCCGAAAACAGATTAACAATATTTTTCTAAGGT
TTGTTTATGAAACAGAACACTTCAATGGTGTAGCTGAACTGCTGGAAATATTAGGAAGTATTATCAATGGCTTTGCTTTACCTCTTAAGG
CAGAACACAAACAGTTTCTGGTGAAAGTATTGATCCCTTTACACACTGTCAGGAGCTTATCACTCTTCCATGCACAGCTGGCATATTGTA
TAGTACAGTTTCTGGAGAAAGATCCTTCACTCACAGAACCAGTTATTAGGGGGTTAATGAAATTTTGGCCTAAAACATGTAGTCAAAAAG
AGGTCATGTTCCTTGGGGAACTGGAAGAAATATTGGATGTGATTGAACCTTCACAATTTGTTAAAATCCAAGAACCTTTGTTTAAACAAA
TCGCCAAGTGTGTATCTAGCCCCCATTTTCAGGTGGCAGAAAGAGCACTCTATTATTGGAATAATGAATACATCATGAGTTTGATAGAAG
AAAACTCTAACGTCATCCTTCCCATCATGTTTTCCAGCCTTTATAGGATTTCAAAAGAACATTGGAATCCGGCTATTGTGGCGTTGGTGT
ACAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAATGAGAAAAAGAAAGAAAAGGAGC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000337537_chr14_63920603_-_6273nt
GAGGCCGGTGGCCGTGAGGAGGTTGGGGGCCCTCGCGGAGGCCGAGAGGCTTAAGGAGGCAGAACTGGGGCTCCCTTGCATCTTCCAGTT
ACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTCAAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAA
TGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTG
GTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATG
CTACTGATGTCAGGACGTTCCATCCTCAGAGCAGCCTGAACTGTTCCTAAAGAAACTTCAGCAGTGCTGTGTCATTTTTGACTTCATGGA
CACGCTATCTGATCTTAAAATGAAAGAATACAAGCGCTCCACTCTTAATGAACTGGTGGACTACATTACAATAAGCAGAGGCTGTTTGAC
AGAGCAGACTTACCCTGAAGTAGTTAGAATGGTATCTTGCAATATATTCAGAACTCTCCCTCCTAGTGACAGCAATGAATTTGATCCAGA
AGAAGATGAACCTACCCTTGAGGCATCGTGGCCACACTTACAGCTTGTATATGAATTTTTCATACGATTTTTGGAAAGCCAAGAATTCCA
ACCCAGCATTGCCAAAAAATATATAGATCAGAAATTTGTATTACAGCTTCTGGAGCTATTTGACAGCGAAGACCCTCGGGAACGGGACTA
CTTAAAAACAGTCTTACACAGAATTTATGGCAAGTTTCTTGGTCTTAGAGCATTTATCCGAAAACAGATTAACAATATTTTTCTAAGGTT
TGTTTATGAAACAGAACACTTCAATGGTGTAGCTGAACTGCTGGAAATATTAGGAAGTATTATCAATGGCTTTGCTTTACCTCTTAAGGC
AGAACACAAACAGTTTCTGGTGAAAGTATTGATCCCTTTACACACTGTCAGGAGCTTATCACTCTTCCATGCACAGCTGGCATATTGTAT
AGTACAGTTTCTGGAGAAAGATCCTTCACTCACAGAACCAGTTATTAGGGGGTTAATGAAATTTTGGCCTAAAACATGTAGTCAAAAAGA
GGTCATGTTCCTTGGGGAACTGGAAGAAATATTGGATGTGATTGAACCTTCACAATTTGTTAAAATCCAAGAACCTTTGTTTAAACAAAT
CGCCAAGTGTGTATCTAGCCCCCATTTTCAGGTGGCAGAAAGAGCACTCTATTATTGGAATAATGAATACATCATGAGTTTGATAGAAGA
AAACTCTAACGTCATCCTTCCCATCATGTTTTCCAGCCTTTATAGGATTTCAAAAGAACATTGGAATCCGGCTATTGTGGCGTTGGTGTA
CAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAAGTCAGATCGTCAGCGTGAGAAAAA
GAAAGAAAAGGAGCGTGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTTA
ACAAAAACAATGACAACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTATTGTGCAACT
TTACAGTAGATTTCACCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAAATAAGGACTTCAA
TCCAAAGTTTGGACAGTAGATGGACTTCTCAGAACTTTGCAAACATAATCATTGTTCTCACCCTCTTTTAAAAAAAAAAATCGGTCTTCA
AAGATCTGTTGATGAAATTGCTATGTTAAAATTCCATTATCGGGAGTTCCTTATTTATCACTAGCAGAGAGTATGATACAATTTTCAAAT
GTGAACAATCTTAAATTTAGCTTGTCTTTCTGCTAAGCTGTTAAATGTATTTATAGTAAAGGAAGAAAAAAAGACTGTCATTTCCTTATA
AGTTTGTGTAACATCCTCCTCTGGATAACTTGACTGTAATTTAACATCTTTTTCTTTTGCACATCTTCCTGAGTTGAATGTCCACGTGGA
ATGGGGTCATGAATTATAAAAGTCCCTGATAAAAGTTTTGTTTACTGGGGTGAACATCTTTCCAGTAACCAGGTAGTCCTGGTACTCCTT
TAGTTTTAAAATTAGGAGTTAAGAGAGAAGAGGTGATAAACATAGTAGGGAAGGGAATATCGGATTCATGCATCAGTTTATGGTGAATCC
AAATCAATGTCTTGAATCCTTTGAAAACAGGCACTGGGACATCACAGGCTTCAGTACCTGACCAGTATTAGTTGCATATATCATTGAACA
CACATACCAGAGATGTTTTAGAAATGTGAGAAAAACATCCTTTTGGACCATTTGAAATAAGAAAGACAAACACTAAACAATACAACCATG
AAATTGATCACCGGGATTGCAAATCTAATTGGGAAAAGAGTTGAGCAAACAGCTTGGACTGTTTGGAGTTGTTGCCTTACTTTTTAATAT
GTATTTATAAAGTATTCCAGCAAAAGAGGATGTAGCCTCTGGGAAAAAACAAACATGTTACAGTGTTTTTTGTAGATTCTCGTTCTATAT
CTCATCACAGCGCCAGCCCTGTTTTTAGCCGGAAAGGATTCAGGATAAACATTATTATGCATTCTGAATTGGATGCATATTCCTAACTAC
TGTATTTGTTACCAAAAGTGGTTCTACAAATGCTACTGAAAAAAATCTGGAAATTCCTAATGTCCTGAGTATTAATAATAAAGTTTAAAA
ATGCTTTTATATCAAAGGTGCATCGTGACCAAATTGTTTAAGAAAAAAAAACAAAAAAAACAAAATCTAGGGCTGTATTTTATATATATA
TATATATATATATATATATATATATCTTATTGGCTCTCTGCTTTGTATTTAAATGAAGAATCTTACATCTTGGGTAGGTAAACTGCTGAT
AAAATTTGTGTACAGTATGTACTTACCTAATGCAGTTGCATTATTACGTACTGAAAGATATGTGTTTGGAGGTTTATTTCCAGGATGCAT
TTGCTTGTTTTGGTCATGGCAGCAGTGAGTTGGTAATCCTAAACCATCACTTCCAGCAGTATTCATGGTATAGAGCTGATCTGTGTTCAT
ATGTTGAATTGTGATAGTAGCAAACATGAACATATGAACTATTGTTGCTCTTAATAGAAATACAATATAAATATGGGCTTGTATATTTTC
TTCCTTACATTTAAATATAAAGTAGAATACGCAGTTTTATTATTTTCAAGAAAAAGAAAGAGAAGCTGCTGACCTTTCTCCCCCATAAAG
TTTTTCAGGATGATCAGGTCACAGTGTGTACGTAAGAGTCAGCTAATTATGGATATTGTCATCTCGGTAACTTTGTAAAAAAACAAACAA
AACTGGCATTGTTAATTCCAAAAAGAAAAAAAAAAGCAGTAAAAAAAAAAAGTCATATGCAACACCAGACGCAACATGGTTTAATGGAAT
TAATAGTTTTTTTTTTTTTTTTTTTAAAGAACATTGATGGGGATTCACTGTAAAGTTGGCAGAGGCTGCCAAAGACGAAACAACTGACTT
TAAAAATGCTGGAACAATGTGATAAAAAATAAATTTGTAACAAATCTTCTCCTTTTTAGCCCTTGTCATTTTAGCCCTTTAGTTTCAACT
CTGCATTATATTTAGTTTATATAGTGTAAACTTTTGTTTGCCATTAATTCATCTTTTTAGGTAGAAGACATTAAAATCACAGGTTTATGA
AGAATCTCTGCTCATTGGAATGAAATGCAGTCATTTGAAATGAGAAAGGCCAGGATCCTTTTTTGTACCTTACCCTGTCTTCAAGAGTAA
AGGTGAACACTTACAGCTCTCCTCCTTGATGTCAATTTTGTATGTTGATCATTCCAAACTGAGAAGAATAAAGCCACATTTTAGACATAT
TTATAGAATCAATTAAAGCTATATGTCTAAAATTCGTAGGGCAACTTCTGAGAAGAAACACCGTCTTTTTCTTTTTTAATGGAAAGTGAC
AATGTGACATTAGTCATGTTGTGTGCGGTGACGCAGAGTAACTGAGGTAATCTGACTGTTGCACTATGTGACATATTTCAGGACGTACTT
GCTGCATTTGCAGCAGCCCTCTCTCTCTGTCCCTTCCCACAATTCTGCTGTTGCTGCAACTTGAGTTAATTGTGACAAATGCATCTTTGT
GTTATATTTTGTTTGCTTCATAATTTCCAGAACTATATATAAATATATTTTTTAAATAGCAAATATTGTAGTTAGTGAGTGATGATCACT
CCAACCTTATCCTTACCATATTGGTTTCAGGGATAGGATTAAGAGTGTCTTTGGAAGAGAAAAATACACACAACCCTGTGGTTTAGAATG
ACGCTGAGGCCTTAGGCTGTGGGCCTAGAACAACTATGTGAGTGAATTCACCCATCTCATACTTTGAATCAAGCATGCATTCCTGTTTCT
CATTGTGAAGTATCCCCAGTTGTTTTCCTTCAGTGTTGAGTTTTTGTCCTTTTAAATTTTATTATATTTTGCTCTCCCTAACATTTGACT
GTTTTTTATAAAAGAAAAGAAAAAAAAAGAAATAAATAATACCCTCGATGCCACTGGATACTCACAAGCAGGGTTATGCTCCTTCATCTT
GGGCTTGTTTGCCTAAATGAAAGGGTTTAATTTATTTTGTACCTCCTATGCGTGGGATAGTCCAGGGTGCAGAGCCAGGACTTGCTTGTA
ATTGCACCTGCTATACTTAAATGTATAGCCCTAGGCTCAATCACACTATGGAAAGAAACAAAAAAAGTATATTTAGAGCTTTAAAAGCTT
TTTTATTTTTTTGTGGGGATGAGGGTGGGATGGGAAAGGGATGTATGGATGTTATTGGCATTTTTAAGTGTTTAGAGTTTTTTGGGGTTT
GGGGTGGTTTTTTTTCCTTGTTTTCCTTTTTTCCTTTTAATTGGATGCACTGACCTGGCCCAGGAAATGAAGAGATTCTCTTTTGATGCT
ATTACCAATGTTATCATAAAGTGACAGTCACCTGTAACAAAAAGGTGGCACCAGACATGATCACTGATGTTTTATTTGCACATCAATATT
TTTATTTTTGTATTCTGGCTCAGCTGCTTCTCTGAGTGGAGTTAAGGAATGAGCCACAAAGATTTTTGTAGTAGGTATATTGGCATTGCA
TTTTATATTCCTCTATATTTAATTTTGAAAACCTAAAAGAAGGATTGTGCATCTTGAGAGAAAGTTGAGCAAATTGTGATCTAGCGGAAT
GTTAATTTGTGCTGCTTCTTGTGCACGATAGCAGCAGTAGTATCTCTCTTGGAAATAAACATCCCATATTATGATGTCTATGAATATAGG
TTTCCTTTTCTTCCTTCCCTCCCTCCTTCCCCCACCTTTCTCTTTTTTTTTTCTCTCTCAGCTTCTCTTTTCCTCCTTCCCTCTTCCCTT
CCTCTTTCTTTACTTTTTTTGAAATCACTTATTGTAAATAAGTTGTAATCCAAACCTCATGTATCAATGGGGAATTTTCAAATATAAATA
TTACCAATGCATTTTCTGGTTGTTGTCTGATTTTTGATTGAAGTATAATGAGAATGACATGTCTGTTGCTTTTGGTTTGAGGACTTCGCT
TTAGCTTCATAAATCTTTTGGTATTTTAGTATTTCATTGTTTTAGCAGGAGAGGGCAGCAAAAGTTCATTTTCCCTGTTAGTAATGCTGT
GGTTCATGATCGGTTTTAAATTTAGCTGTGTGTGTGTTTTTTTAAACAGCATCTCTTTGTGAGTAGAGGTAAAAATGAAACATTTTTGAT
ATGAAAAGTTGCATATGAAAATTATAGACTGGTTCAACCAGACAGTGAAGACTTCTGATCCACATCAAACTTAAAATGCCACAAAACAAT
CTTCCACCTCTGGCTAAAACATGCTACTTCCTTTTCAAACACCACAAAATACAAGCTGAGTCTTAAACACTTGGAATTTAAAATGTTTTT
CTTTGGAAATGATTTGCTTTCTTCAAAGTGGTAACAGAAACAAAAATGAAGGTGCTCCCCAAAAAGAAATGTAACCTTCCCCTTTCACAG

>In-frame_PTK2_ENST00000520892_chr8_141900642_-_PPP2R5E_ENST00000555899_chr14_63920603_-_1854nt
GAGGCCGGTGGCCGTGAGGAGGTTGGGGGCCCTCGCGGAGGCCGAGAGGCTTAAGGAGGCAGAACTGGGGCTCCCTTGCATCTTCCAGTT
ACAAATTCAGTGCCTTCTGCAGTTTCCCCAGAGCTCCTCAAGAATAACGGAAGGGAGAATATGACAGATACCTAGCATCTAGCAAAATAA
TGGCAGCTGCTTACCTTGACCCCAACTTGAATCACACACCAAATTCGAGTACTAAGACTCACCTGGGTACTGGTATGGAACGTTCTCCTG
GTGCAATGGAGCGAGTATTAAAGGTCTTTCATTATTTTGAAAGCAATAGTGAGCCAACCACCTGGGCCAGTATTATCAGGCATGGAGATG
CTACTGATGTCAGGACGTTCCATCCTCAGAGCAGCCTGAACTGTTCCTAAAGAAACTTCAGCAGTGCTGTGTCATTTTTGACTTCATGGA
CACGCTATCTGATCTTAAAATGAAAGAATACAAGCGCTCCACTCTTAATGAACTGGTGGACTACATTACAATAAGCAGAGGCTGTTTGAC
AGAGCAGACTTACCCTGAAGTAGTTAGAATGGTATCTTGCAATATATTCAGAACTCTCCCTCCTAGTGACAGCAATGAATTTGATCCAGA
AGAAGATGAACCTACCCTTGAGGCATCGTGGCCACACTTACAGCTTGTATATGAATTTTTCATACGATTTTTGGAAAGCCAAGAATTCCA
ACCCAGCATTGCCAAAAAATATATAGATCAGAAATTTGTATTACAGCTTCTGGAGCTATTTGACAGCGAAGACCCTCGGGAACGGGACTA
CTTAAAAACAGTCTTACACAGAATTTATGGCAAGTTTCTTGGTCTTAGAGCATTTATCCGAAAACAGATTAACAATATTTTTCTAAGGTT
TGTTTATGAAACAGAACACTTCAATGGTGTAGCTGAACTGCTGGAAATATTAGGAAGTATTATCAATGGCTTTGCTTTACCTCTTAAGGC
AGAACACAAACAGTTTCTGGTGAAAGTATTGATCCCTTTACACACTGTCAGGAGCTTATCACTCTTCCATGCACAGCTGGCATATTGTAT
AGTACAGTTTCTGGAGAAAGATCCTTCACTCACAGAACCAGTTATTAGGGGGTTAATGAAATTTTGGCCTAAAACATGTAGTCAAAAAGA
GGTCATGTTCCTTGGGGAACTGGAAGAAATATTGGATGTGATTGAACCTTCACAATTTGTTAAAATCCAAGAACCTTTGTTTAAACAAAT
CGCCAAGTGTGTATCTAGCCCCCATTTTCAGGTGGCAGAAAGAGCACTCTATTATTGGAATAATGAATACATCATGAGTTTGATAGAAGA
AAACTCTAACGTCATCCTTCCCATCATGTTTTCCAGCCTTTATAGGATTTCAAAAGAACATTGGAATCCGGCTATTGTGGCGTTGGTGTA
CAATGTGTTGAAGGCATTTATGGAAATGAACAGCACCATGTTTGACGAGCTGACAGCCACATACAATGAGAAAAAGAAAGAAAAGGAGCG
TGAAGAATTGTGGAAAAAATTGGAGGATCTGGAGTTAAAGAGAGGTCTTAGACGTGATGGAATAATTCCAACTTAACAAAAACAATGACA
ACAACATTACTAACCTGTGGAGTCACACGTTTATGTAGTAGAAGATGGAGCAACAGTTTTCTGTATTGTGCAACTTTACAGTAGATTTCA
CCTTTGTTTCATTATTACAGCAGCACTGTATATACCTGTCTCTAAGTAAAGGAAAAAACAAAATAAGGACTTCAATCCAAAGTTTGGACA


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FusionGenePPI for PTK2_PPP2R5E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTK2IRS1, SOCS2, ATG12, TRIP6, BCAR1, CIB1, GIT1, DOCK1, SRC, CRK, PXN, ITGB5, ITGB3, MAPK8IP3, EGFR, GRB2, JAK2, SHC1, EZR, PTEN, STAT1, TGFB1I1, CCR5, GSK3B, CXCR4, BMX, TSC2, TSC1, PLCG1, IGF1R, PTPN11, EPHA2, ARHGAP26, ITGA4, NCK1, FGR, TLN1, GSN, AMPH, BIN1, FYN, YES1, NEDD9, STAT3, PPP1CB, PTK2, SYK, LYN, PIK3R1, RB1CC1, NCK2, GRB7, CSK, DCC, NEO1, GAPDH, PARP1, TP53, MDM2, RAC1, SOCS3, HES1, NASP, FBP1, F13A1, BBS10, NACAD, EEF1G, DDX39A, ZNF331, EPS8L2, LPXN, CBL, DAG1, ELAVL1, SH3KBP1, PDCD6IP, CTTN, ASAP1, PPP1CA, STAP2, STUB1, PTAFR, RBSN, APP, HSP90AA1, PTRH2, SAE1, SRPK1, TRIM72, UBE2H, IQGAP1, DEF6, OTUD6B, TRMT6, NTRK1, SELE, SH2D1A, DOK4, PTPN6, SH2D2A, HCK, PIK3R3, SH2D1B, PKD1, GNB1, GNG2, VPS16, ERBB2, CCNA1, PIAS1, RET, APC, TRIM15, ITGB1, ITGAV, PRKG1, SERPINB2, TEK, AKT1, CDH5, TRIM25PPP2R5EPPP2CA, PPP2R1A, PPP2R1B, PPP2CB, CHEK2, ELAVL1, NOD2, APP, CBX5, SMAD9, EGFR, AARS, TRMT10A, TERF2IP, SAE1, TPD52L2, ZDHHC17, CLOCK, CRY1, CSNK1E, CSNK2B, DEC1, BHLHE41, FBXW11, RORC, CRY2, PPP2R5E, PPP1CA, VTI1B, MOS, DNASE2B, FAM43A, WNT3A, DCLRE1C, CDK17, CCNG1, API5, IK, PPP2R5C, MARK2, SAMHD1, CDC20, NANOG, ZNF785, PRR14, ZFPL1, DCAF11, CRIP1, KLF15, GJB7, ZNF517, LPAR4, VSIG1, TMEM206, C1QL4, CCNG2, RPS27, C19orf57, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTK2_PPP2R5E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTK2_PPP2R5E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTK2C0007137Squamous cell carcinoma2CTD_human
HgenePTK2C0027626Neoplasm Invasiveness2CTD_human
HgenePTK2C0003873Rheumatoid Arthritis1CTD_human
HgenePTK2C0007621Neoplastic Cell Transformation1CTD_human
HgenePTK2C0017636Glioblastoma1CTD_human
HgenePTK2C0024668Mammary Neoplasms, Experimental1CTD_human
HgenePTK2C0026640Mouth Neoplasms1CTD_human
HgenePTK2C2239176Liver carcinoma1CTD_human
TgenePPP2R5EC1257806Chromosomal Instability1CTD_human
TgenePPP2R5EC1449861Micronuclei, Chromosome-Defective1CTD_human