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Fusion gene ID: 29330 |
FusionGeneSummary for PTGIS_IFT52 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PTGIS_IFT52 | Fusion gene ID: 29330 | Hgene | Tgene | Gene symbol | PTGIS | IFT52 | Gene ID | 5740 | 51098 |
| Gene name | prostaglandin I2 synthase | intraflagellar transport 52 | |
| Synonyms | CYP8|CYP8A1|PGIS|PTGI | C20orf9|CGI-53|NGD2|NGD5 | |
| Cytomap | 20q13.13 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prostacyclin synthasecytochrome P450, family 8, subfamily A, polypeptide 1prostaglandin I2 (prostacyclin) synthase | intraflagellar transport protein 52 homologprotein NGD5 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q16647 | Q9Y366 | |
| Ensembl transtripts involved in fusion gene | ENST00000244043, ENST00000478971, | ENST00000373030, ENST00000373039, ENST00000471199, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 7 X 7 X 6=294 |
| # samples | 1 | 7 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PTGIS [Title/Abstract] AND IFT52 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PTGIS | GO:0001516 | prostaglandin biosynthetic process | 20122998|21296955 |
| Hgene | PTGIS | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20159982 |
| Hgene | PTGIS | GO:0035360 | positive regulation of peroxisome proliferator activated receptor signaling pathway | 11551955 |
| Hgene | PTGIS | GO:0045019 | negative regulation of nitric oxide biosynthetic process | 20159982 |
| Hgene | PTGIS | GO:0050728 | negative regulation of inflammatory response | 20159982 |
| Hgene | PTGIS | GO:0071456 | cellular response to hypoxia | 21296955 |
| Hgene | PTGIS | GO:0097190 | apoptotic signaling pathway | 11551955 |
| Hgene | PTGIS | GO:1900119 | positive regulation of execution phase of apoptosis | 11551955 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-EE-A3AD-06A | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000244043 | ENST00000373030 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| In-frame | ENST00000244043 | ENST00000373039 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| 5CDS-intron | ENST00000244043 | ENST00000471199 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| 5UTR-3CDS | ENST00000478971 | ENST00000373030 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| 5UTR-3CDS | ENST00000478971 | ENST00000373039 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
| 5UTR-intron | ENST00000478971 | ENST00000471199 | PTGIS | chr20 | 48156107 | - | IFT52 | chr20 | 42232823 | + |
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FusionProtFeatures for PTGIS_IFT52 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PTGIS | IFT52 |
| Catalyzes the isomerization of prostaglandin H2 toprostacyclin (= prostaglandin I2). {ECO:0000269|PubMed:18032380,ECO:0000269|PubMed:25623425}. | Involved in ciliogenesis as part of a complex involvedin intraflagellar transport (IFT), the bi-directional movement ofparticles required for the assembly, maintenance and functioningof primary cilia (PubMed:27466190). Required for the anterogradetransport of IFT88 (PubMed:27466190).{ECO:0000269|PubMed:27466190}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PTGIS | chr20:48156107 | chr20:42232823 | ENST00000244043 | - | 5 | 10 | 1_20 | 224 | 501 | Transmembrane | Helical |
| Tgene | >IFT52 | chr20:48156107 | chr20:42232823 | ENST00000373030 | + | 3 | 14 | 348_351 | 112 | 438 | Compositional bias | Note=Poly-Pro |
| Tgene | >IFT52 | chr20:48156107 | chr20:42232823 | ENST00000373039 | + | 3 | 14 | 348_351 | 112 | 438 | Compositional bias | Note=Poly-Pro |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PTGIS | chr20:48156107 | chr20:42232823 | ENST00000244043 | - | 5 | 10 | 358_359 | 224 | 501 | Region | Substrate binding |
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FusionGeneSequence for PTGIS_IFT52 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373030_chr20_42232823_+_550aa MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEP RTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVDAVVRNVYHKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSG NNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLN QIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAV FPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKLNQEHDIDT >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373039_chr20_42232823_+_550aa MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEP RTRLDFHAYAIFLMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVDAVVRNVYHKYFHPKEALVSSGVLNREISRAAGKAVPGIIDEESSG NNAQALTFVYPFGATLSVMKPAVAVLSTGSVCFPLNRPILAFYHSKNQGGKLAVLGSCHMFSDQYLDKEENSKIMDVVFQWLTTGDIHLN QIDAEDPEISDYMMLPYTATLSKRNRECLQESDEIPRDFTTLFDLSIFQLDTTSFHSVIEAHEQLNVKHEPLQLIQPQFETPLPTLQPAV FPPSFRELPPPPLELFDLDETFSSEKARLAQITNKCTEEDLEFYVRKCGDILGVTSKLPKDQQDAKHILEHVFFQVVEFKKLNQEHDIDT |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373030_chr20_42232823_+_1650nt ATGGCTTGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGCCGCCGCCGCACGCGGCGACCTGGTGAGCCT CCCCTGGACCTGGGCAGCATCCCCTGGTTGGGGTATGCCTTGGACTTTGGAAAAGATGCTGCCAGCTTCCTCACGAGGATGAAGGAGAAG CACGGTGACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCACACTCCTACGACGCGGTGGTGTGGGAGCCT CGCACCAGGCTCGACTTCCATGCCTATGCCATCTTCCTCATGGAGAGGATTTTTGATGTGCAGCTTCCACATTACAGCCCCAGTGATGAA AAGGCCAGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATGTATACCAACCTCCATGCAGTGCTGTTGGGC GATGCTACAGAAGCAGGCAGTGGCTGGCACGAGATGGGTCTCCTCGACTTCTCCTACAGCTTCCTGCTCAGAGCCGGCTACCTGACTCTT TACGGAATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCAGCTGATGTCTTCCACACCTTTCGCCAGCTC GACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTGTCAGTGGATGCTGTGGTTAGAAATGTATATCACAAATATTTCCATCCTAAAGAA GCTCTAGTTTCCAGTGGAGTCTTGAACAGGGAAATTAGCCGAGCTGCAGGAAAGGCTGTGCCTGGGATCATTGATGAGGAAAGCAGTGGA AACAATGCCCAGGCTCTCACCTTTGTGTATCCTTTTGGTGCCACATTGAGTGTCATGAAACCAGCAGTGGCGGTTCTGTCTACAGGTTCT GTCTGCTTCCCACTTAACAGACCCATTTTGGCTTTCTATCACTCAAAGAACCAAGGTGGGAAGCTGGCAGTGCTTGGTTCATGTCACATG TTCAGTGATCAATATTTGGACAAAGAAGAAAACAGCAAAATCATGGATGTTGTTTTCCAGTGGCTCACGACAGGAGACATCCACCTAAAC CAGATTGATGCTGAGGACCCAGAGATTTCTGACTACATGATGCTGCCCTACACAGCCACCCTATCAAAGCGGAATCGAGAGTGTCTCCAG GAGAGTGATGAGATCCCAAGGGACTTTACCACCCTCTTCGACCTGTCCATCTTCCAGCTGGATACCACCTCCTTCCACAGCGTCATCGAG GCTCACGAGCAGCTAAATGTGAAACATGAACCACTCCAGCTCATCCAGCCTCAGTTTGAGACGCCGCTGCCAACCCTTCAGCCTGCGGTT TTTCCTCCCAGTTTCCGGGAGTTACCACCTCCTCCTCTGGAGCTATTTGATTTAGATGAAACGTTCTCCTCTGAGAAGGCACGGCTGGCT CAGATTACCAATAAGTGTACTGAAGAAGACCTGGAATTTTATGTCAGGAAGTGTGGTGATATTCTTGGAGTAACCAGTAAACTACCAAAG GACCAACAGGATGCCAAACATATCCTTGAGCACGTCTTCTTCCAAGTGGTGGAGTTCAAGAAATTGAACCAGGAACATGACATCGATACA >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373039_chr20_42232823_+_1650nt ATGGCTTGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGCCGCCGCCGCACGCGGCGACCTGGTGAGCCT CCCCTGGACCTGGGCAGCATCCCCTGGTTGGGGTATGCCTTGGACTTTGGAAAAGATGCTGCCAGCTTCCTCACGAGGATGAAGGAGAAG CACGGTGACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCACACTCCTACGACGCGGTGGTGTGGGAGCCT CGCACCAGGCTCGACTTCCATGCCTATGCCATCTTCCTCATGGAGAGGATTTTTGATGTGCAGCTTCCACATTACAGCCCCAGTGATGAA AAGGCCAGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATGTATACCAACCTCCATGCAGTGCTGTTGGGC GATGCTACAGAAGCAGGCAGTGGCTGGCACGAGATGGGTCTCCTCGACTTCTCCTACAGCTTCCTGCTCAGAGCCGGCTACCTGACTCTT TACGGAATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCAGCTGATGTCTTCCACACCTTTCGCCAGCTC GACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTGTCAGTGGATGCTGTGGTTAGAAATGTATATCACAAATATTTCCATCCTAAAGAA GCTCTAGTTTCCAGTGGAGTCTTGAACAGGGAAATTAGCCGAGCTGCAGGAAAGGCTGTGCCTGGGATCATTGATGAGGAAAGCAGTGGA AACAATGCCCAGGCTCTCACCTTTGTGTATCCTTTTGGTGCCACATTGAGTGTCATGAAACCAGCAGTGGCGGTTCTGTCTACAGGTTCT GTCTGCTTCCCACTTAACAGACCCATTTTGGCTTTCTATCACTCAAAGAACCAAGGTGGGAAGCTGGCAGTGCTTGGTTCATGTCACATG TTCAGTGATCAATATTTGGACAAAGAAGAAAACAGCAAAATCATGGATGTTGTTTTCCAGTGGCTCACGACAGGAGACATCCACCTAAAC CAGATTGATGCTGAGGACCCAGAGATTTCTGACTACATGATGCTGCCCTACACAGCCACCCTATCAAAGCGGAATCGAGAGTGTCTCCAG GAGAGTGATGAGATCCCAAGGGACTTTACCACCCTCTTCGACCTGTCCATCTTCCAGCTGGATACCACCTCCTTCCACAGCGTCATCGAG GCTCACGAGCAGCTAAATGTGAAACATGAACCACTCCAGCTCATCCAGCCTCAGTTTGAGACGCCGCTGCCAACCCTTCAGCCTGCGGTT TTTCCTCCCAGTTTCCGGGAGTTACCACCTCCTCCTCTGGAGCTATTTGATTTAGATGAAACGTTCTCCTCTGAGAAGGCACGGCTGGCT CAGATTACCAATAAGTGTACTGAAGAAGACCTGGAATTTTATGTCAGGAAGTGTGGTGATATTCTTGGAGTAACCAGTAAACTACCAAAG GACCAACAGGATGCCAAACATATCCTTGAGCACGTCTTCTTCCAAGTGGTGGAGTTCAAGAAATTGAACCAGGAACATGACATCGATACA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373030_chr20_42232823_+_1993nt GCCAGCCCCGCCAGCCCCGCCAGCCCCGCGATGGCTTGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGC CGCCGCCGCACGCGGCGACCTGGTGAGCCTCCCCTGGACCTGGGCAGCATCCCCTGGTTGGGGTATGCCTTGGACTTTGGAAAAGATGCT GCCAGCTTCCTCACGAGGATGAAGGAGAAGCACGGTGACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCA CACTCCTACGACGCGGTGGTGTGGGAGCCTCGCACCAGGCTCGACTTCCATGCCTATGCCATCTTCCTCATGGAGAGGATTTTTGATGTG CAGCTTCCACATTACAGCCCCAGTGATGAAAAGGCCAGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATG TATACCAACCTCCATGCAGTGCTGTTGGGCGATGCTACAGAAGCAGGCAGTGGCTGGCACGAGATGGGTCTCCTCGACTTCTCCTACAGC TTCCTGCTCAGAGCCGGCTACCTGACTCTTTACGGAATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCA GCTGATGTCTTCCACACCTTTCGCCAGCTCGACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTGTCAGTGGATGCTGTGGTTAGAAAT GTATATCACAAATATTTCCATCCTAAAGAAGCTCTAGTTTCCAGTGGAGTCTTGAACAGGGAAATTAGCCGAGCTGCAGGAAAGGCTGTG CCTGGGATCATTGATGAGGAAAGCAGTGGAAACAATGCCCAGGCTCTCACCTTTGTGTATCCTTTTGGTGCCACATTGAGTGTCATGAAA CCAGCAGTGGCGGTTCTGTCTACAGGTTCTGTCTGCTTCCCACTTAACAGACCCATTTTGGCTTTCTATCACTCAAAGAACCAAGGTGGG AAGCTGGCAGTGCTTGGTTCATGTCACATGTTCAGTGATCAATATTTGGACAAAGAAGAAAACAGCAAAATCATGGATGTTGTTTTCCAG TGGCTCACGACAGGAGACATCCACCTAAACCAGATTGATGCTGAGGACCCAGAGATTTCTGACTACATGATGCTGCCCTACACAGCCACC CTATCAAAGCGGAATCGAGAGTGTCTCCAGGAGAGTGATGAGATCCCAAGGGACTTTACCACCCTCTTCGACCTGTCCATCTTCCAGCTG GATACCACCTCCTTCCACAGCGTCATCGAGGCTCACGAGCAGCTAAATGTGAAACATGAACCACTCCAGCTCATCCAGCCTCAGTTTGAG ACGCCGCTGCCAACCCTTCAGCCTGCGGTTTTTCCTCCCAGTTTCCGGGAGTTACCACCTCCTCCTCTGGAGCTATTTGATTTAGATGAA ACGTTCTCCTCTGAGAAGGCACGGCTGGCTCAGATTACCAATAAGTGTACTGAAGAAGACCTGGAATTTTATGTCAGGAAGTGTGGTGAT ATTCTTGGAGTAACCAGTAAACTACCAAAGGACCAACAGGATGCCAAACATATCCTTGAGCACGTCTTCTTCCAAGTGGTGGAGTTCAAG AAATTGAACCAGGAACATGACATCGATACAAGTGAAACAGCATTCCAGAACAATTTCTGAAGACCATGCCTCTTGAAGCTTTTTCTGCCT CCTGATTCTCTCTTTGTAAACTATTTTCAAATTGTTTTTCAACTCCTTATCAAAATTGTTTATACACTCTTTCCTCCATGAGCTCTGGAA GGTATATGCATCTTCTGTAATACTCAGATAGGTATAAGATTTTTCACAAAATCCTTATGTAAGATACATTCCATTTTTAAAAATTAAATG TATGGTTGCATCTGTCTTTTTATACCCTATGAAACAGTCTTGATTTTTTTTTCTCAACCCCAGTTCTGGATTTGAGTCTTTTATCAAAGA >In-frame_PTGIS_ENST00000244043_chr20_48156107_-_IFT52_ENST00000373039_chr20_42232823_+_1919nt GCCAGCCCCGCCAGCCCCGCCAGCCCCGCGATGGCTTGGGCCGCGCTCCTCGGCCTCCTGGCCGCACTGTTGCTGCTGCTGCTACTGAGC CGCCGCCGCACGCGGCGACCTGGTGAGCCTCCCCTGGACCTGGGCAGCATCCCCTGGTTGGGGTATGCCTTGGACTTTGGAAAAGATGCT GCCAGCTTCCTCACGAGGATGAAGGAGAAGCACGGTGACATCTTTACTATACTGGTTGGGGGCAGGTATGTCACCGTTCTCCTGGACCCA CACTCCTACGACGCGGTGGTGTGGGAGCCTCGCACCAGGCTCGACTTCCATGCCTATGCCATCTTCCTCATGGAGAGGATTTTTGATGTG CAGCTTCCACATTACAGCCCCAGTGATGAAAAGGCCAGGATGAAACTGACTCTTCTCCACAGAGAGCTCCAGGCACTCACAGAAGCCATG TATACCAACCTCCATGCAGTGCTGTTGGGCGATGCTACAGAAGCAGGCAGTGGCTGGCACGAGATGGGTCTCCTCGACTTCTCCTACAGC TTCCTGCTCAGAGCCGGCTACCTGACTCTTTACGGAATTGAGGCGCTGCCACGCACCCATGAAAGCCAGGCCCAGGACCGCGTCCACTCA GCTGATGTCTTCCACACCTTTCGCCAGCTCGACCGGCTGCTCCCCAAACTGGCCCGTGGCTCCCTGTCAGTGGATGCTGTGGTTAGAAAT GTATATCACAAATATTTCCATCCTAAAGAAGCTCTAGTTTCCAGTGGAGTCTTGAACAGGGAAATTAGCCGAGCTGCAGGAAAGGCTGTG CCTGGGATCATTGATGAGGAAAGCAGTGGAAACAATGCCCAGGCTCTCACCTTTGTGTATCCTTTTGGTGCCACATTGAGTGTCATGAAA CCAGCAGTGGCGGTTCTGTCTACAGGTTCTGTCTGCTTCCCACTTAACAGACCCATTTTGGCTTTCTATCACTCAAAGAACCAAGGTGGG AAGCTGGCAGTGCTTGGTTCATGTCACATGTTCAGTGATCAATATTTGGACAAAGAAGAAAACAGCAAAATCATGGATGTTGTTTTCCAG TGGCTCACGACAGGAGACATCCACCTAAACCAGATTGATGCTGAGGACCCAGAGATTTCTGACTACATGATGCTGCCCTACACAGCCACC CTATCAAAGCGGAATCGAGAGTGTCTCCAGGAGAGTGATGAGATCCCAAGGGACTTTACCACCCTCTTCGACCTGTCCATCTTCCAGCTG GATACCACCTCCTTCCACAGCGTCATCGAGGCTCACGAGCAGCTAAATGTGAAACATGAACCACTCCAGCTCATCCAGCCTCAGTTTGAG ACGCCGCTGCCAACCCTTCAGCCTGCGGTTTTTCCTCCCAGTTTCCGGGAGTTACCACCTCCTCCTCTGGAGCTATTTGATTTAGATGAA ACGTTCTCCTCTGAGAAGGCACGGCTGGCTCAGATTACCAATAAGTGTACTGAAGAAGACCTGGAATTTTATGTCAGGAAGTGTGGTGAT ATTCTTGGAGTAACCAGTAAACTACCAAAGGACCAACAGGATGCCAAACATATCCTTGAGCACGTCTTCTTCCAAGTGGTGGAGTTCAAG AAATTGAACCAGGAACATGACATCGATACAAGTGAAACAGCATTCCAGAACAATTTCTGAAGACCATGCCTCTTGAAGCTTTTTCTGCCT CCTGATTCTCTCTTTGTAAACTATTTTCAAATTGTTTTTCAACTCCTTATCAAAATTGTTTATACACTCTTTCCTCCATGAGCTCTGGAA GGTATATGCATCTTCTGTAATACTCAGATAGGTATAAGATTTTTCACAAAATCCTTATGTAAGATACATTCCATTTTTAAAAATTAAATG |
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FusionGenePPI for PTGIS_IFT52 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PTGIS | APP, PTGS2, PTGS1, CAV1 | IFT52 | ANKRD55, IFT57, ARL13B, IFT80, UBXN10, SBF1, TTC30A, TTC30B, FGF8, IFT74, LRRC27, PTPN21, IFT46, HSPB11, TTC26, IFT22, IFT88, IFT81, SLC35E1, FAM210A, IFT172, IFT27, IFT20, MAPRE1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PTGIS_IFT52 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | PTGIS | Q16647 | DB01240 | Epoprostenol | Prostacyclin synthase | small molecule | approved |
| Hgene | PTGIS | Q16647 | DB00812 | Phenylbutazone | Prostacyclin synthase | small molecule | approved|vet_approved |
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RelatedDiseases for PTGIS_IFT52 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PTGIS | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Hgene | PTGIS | C0013274 | Patent ductus arteriosus | 1 | CTD_human |
| Hgene | PTGIS | C0024121 | Lung Neoplasms | 1 | CTD_human |
| Hgene | PTGIS | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
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