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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29317

FusionGeneSummary for PTGES2_CIZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTGES2_CIZ1
Fusion gene ID: 29317
HgeneTgene
Gene symbol

PTGES2

CIZ1

Gene ID

80142

25792

Gene nameprostaglandin E synthase 2CDKN1A interacting zinc finger protein 1
SynonymsC9orf15|GBF-1|GBF1|PGES2|mPGES-2LSFR1|NP94|ZNF356
Cytomap

9q34.11

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionprostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomerasecip1-interacting zinc finger proteinnuclear protein NP94zinc finger protein 356
Modification date2018051920180519
UniProtAcc

Q9H7Z7

Q9ULV3

Ensembl transtripts involved in fusion geneENST00000338961, ENST00000277462, 
ENST00000483625, 
ENST00000372954, 
ENST00000393608, ENST00000541172, 
ENST00000357558, ENST00000325721, 
ENST00000538431, ENST00000277465, 
ENST00000372948, ENST00000372938, 
ENST00000476727, 
Fusion gene scores* DoF score4 X 4 X 4=644 X 4 X 3=48
# samples 44
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTGES2 [Title/Abstract] AND CIZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSTADTCGA-VQ-AA6D-01APTGES2chr9

130890527

-CIZ1chr9

130940042

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000338961ENST00000372954PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000393608PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000541172PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000357558PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000325721PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000538431PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000277465PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000372948PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000338961ENST00000372938PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-intronENST00000338961ENST00000476727PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000372954PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000393608PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000541172PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000357558PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000325721PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000538431PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000277465PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000372948PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-3CDSENST00000277462ENST00000372938PTGES2chr9

130890527

-CIZ1chr9

130940042

-
5UTR-intronENST00000277462ENST00000476727PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000372954PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000393608PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000541172PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000357558PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000325721PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000538431PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000277465PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000372948PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-3CDSENST00000483625ENST00000372938PTGES2chr9

130890527

-CIZ1chr9

130940042

-
intron-intronENST00000483625ENST00000476727PTGES2chr9

130890527

-CIZ1chr9

130940042

-

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FusionProtFeatures for PTGES2_CIZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTGES2

Q9H7Z7

CIZ1

Q9ULV3

Isomerase that catalyzes the conversion of PGH2 into themore stable prostaglandin E2 (PGE2). {ECO:0000269|PubMed:12804604,ECO:0000269|PubMed:18198127}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTGES2_CIZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PTGES2_CIZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTGES2H2AFX, MYC, UQCR11, HTT, PTGES2, EXOSC10, C1orf189, SHISA2, EID3, DLK1, COQ9, NDUFA4, C15orf48, ABCF2, ATP6V0D1, SCGB2A2, RANBP6, FUZ, C5orf28, LRP1, UQCRQCIZ1CDKN1A, SH3BP4, SH3KBP1, ERH, UPF2, CUL7, OBSL1, BMI1, ACP5, MAPK14, NR2E1, EDA, HIST1H2BG, DYNLT1, DYNLL1, L3MBTL2, BCL7C, CCDC97, SAFB2, KLHL22, DYNLL2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTGES2_CIZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTGES2_CIZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTGES2C0040136Thyroid Neoplasm1CTD_human
TgeneCIZ1C0013421Dystonia1CTD_human
TgeneCIZ1C0033578Prostatic Neoplasms1CTD_human
TgeneCIZ1C0553580Ewings sarcoma1CTD_human
TgeneCIZ1C1865819CERVICAL DYSTONIA, PRIMARY1CTD_human