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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29297

FusionGeneSummary for PTEN_KIF20B

check button Fusion gene summary
Fusion gene informationFusion gene name: PTEN_KIF20B
Fusion gene ID: 29297
HgeneTgene
Gene symbol

PTEN

KIF20B

Gene ID

5728

9585

Gene namephosphatase and tensin homologkinesin family member 20B
Synonyms10q23del|BZS|CWS1|DEC|GLM2|MHAM|MMAC1|PTEN1|PTENbeta|TEP1CT90|KRMP1|MPHOSPH1|MPP-1|MPP1
Cytomap

10q23.31

10q23.31

Type of geneprotein-codingprotein-coding
Descriptionphosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENMMAC1 phosphatase and tensin homolog deleted on chromosome 10mitochondrial PTENalphamitochondrial phosphatase and tensin protein alphamutated in multipkinesin-like protein KIF20BM-phase phosphoprotein 1cancer/testis antigen 90kinesin-related motor interacting with PIN1mitotic kinesin-like proteinmitotic kinesin-related protein
Modification date2018052720180523
UniProtAcc

P60484

Q96Q89

Ensembl transtripts involved in fusion geneENST00000371953, ENST00000472832, 
ENST00000394289, ENST00000260753, 
ENST00000416354, ENST00000371728, 
ENST00000478929, 
Fusion gene scores* DoF score16 X 8 X 9=11523 X 3 X 3=27
# samples 153
** MAII scorelog2(15/1152*10)=-2.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PTEN [Title/Abstract] AND KIF20B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTEN

GO:0001933

negative regulation of protein phosphorylation

20123964

HgenePTEN

GO:0006470

protein dephosphorylation

9256433

HgenePTEN

GO:0008285

negative regulation of cell proliferation

19057511

HgenePTEN

GO:0031658

negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle

21241890

HgenePTEN

GO:0046855

inositol phosphate dephosphorylation

9593664

HgenePTEN

GO:0046856

phosphatidylinositol dephosphorylation

9593664|9811831

HgenePTEN

GO:0050821

protein stabilization

20123964

HgenePTEN

GO:0060070

canonical Wnt signaling pathway

20123964

HgenePTEN

GO:1904668

positive regulation of ubiquitin protein ligase activity

21241890

HgenePTEN

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

21241890

HgenePTEN

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

21241890


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-34-A5IX-01APTENchr10

89653866

+KIF20Bchr10

91497144

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000371953ENST00000394289PTENchr10

89653866

+KIF20Bchr10

91497144

+
Frame-shitENST00000371953ENST00000260753PTENchr10

89653866

+KIF20Bchr10

91497144

+
In-frameENST00000371953ENST00000416354PTENchr10

89653866

+KIF20Bchr10

91497144

+
Frame-shitENST00000371953ENST00000371728PTENchr10

89653866

+KIF20Bchr10

91497144

+
5CDS-3UTRENST00000371953ENST00000478929PTENchr10

89653866

+KIF20Bchr10

91497144

+
intron-3CDSENST00000472832ENST00000394289PTENchr10

89653866

+KIF20Bchr10

91497144

+
intron-3CDSENST00000472832ENST00000260753PTENchr10

89653866

+KIF20Bchr10

91497144

+
intron-3CDSENST00000472832ENST00000416354PTENchr10

89653866

+KIF20Bchr10

91497144

+
intron-3CDSENST00000472832ENST00000371728PTENchr10

89653866

+KIF20Bchr10

91497144

+
intron-3UTRENST00000472832ENST00000478929PTENchr10

89653866

+KIF20Bchr10

91497144

+

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FusionProtFeatures for PTEN_KIF20B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTEN

P60484

KIF20B

Q96Q89

Tumor suppressor. Acts as a dual-specificity proteinphosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase,removing the phosphate in the D3 position of the inositol ringfrom phosphatidylinositol 3,4,5-trisphosphate,phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order ofsubstrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 >PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphataseactivity is critical for its tumor suppressor function.Antagonizes the PI3K-AKT/PKB signaling pathway bydephosphorylating phosphoinositides and thereby modulating cellcycle progression and cell survival. The unphosphorylated formcooperates with AIP1 to suppress AKT1 activation. Dephosphorylatestyrosine-phosphorylated focal adhesion kinase and inhibits cellmigration and integrin-mediated cell spreading and focal adhesionformation. Plays a role as a key modulator of the AKT-mTORsignaling pathway controlling the tempo of the process of newbornneurons integration during adult neurogenesis, including correctneuron positioning, dendritic development and synapse formation.May be a negative regulator of insulin signaling and glucosemetabolism in adipose tissue. The nuclear monoubiquitinated formpossesses greater apoptotic potential, whereas the cytoplasmicnonubiquitinated form induces less tumor suppressive ability. Inmotile cells, suppresses the formation of lateral pseudopods andthereby promotes cell polarization and directed movement.{ECO:0000269|PubMed:26504226}. Isoform alpha: Functional kinase, like isoform 1 itantagonizes the PI3K-AKT/PKB signaling pathway. Plays a role inmitochondrial energetic metabolism by promoting COX activity andATP production, via collaboration with isoform 1 in increasingprotein levels of PINK1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PTEN_KIF20B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTEN_ENST00000371953_chr10_89653866_+_KIF20B_ENST00000416354_chr10_91497144_+_1027aa
MTAIIKEIVSRNKRRTQEDGFDLDLTTITPNIIAMGFPAERLEGVYRNNIDDVVRSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENN
EGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNTDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRS
ITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDTLVSKQVKETRIQEPNRENSFHSSIEAIWEEC
KEIVKASSKKSHQIEELEQQIEKLQAEVKGTKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQ
GVTCTKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQ
LKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDTADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQEL
DMKQRTIQQLKEQLNNQKVEEAIQQTERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNN
QRSNKEHENNTDVLGKLTNLQDELQESEQKTNADRKKWLEEKMMLITQAKEAENIRNKEMKKTAEDRERFFKQQNEMEILTAQLTEKDSD
LQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLD
SCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKK
EQKVAIRPSSKKTTSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTEN_ENST00000371953_chr10_89653866_+_KIF20B_ENST00000416354_chr10_91497144_+_3081nt
ATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGATTCGACTTAGACTTGACCTATATTTATCCA
AACATTATTGCTATGGGATTTCCTGCAGAAAGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTCTATCCATGTTAGT
TCAGCTATCACTGAAGACCAAAAGAAAAGTGAAGAAGTGCGACCGAACATTGCAGAAATTGAAGACATCAGAGTTTTACAAGAAAATAAT
GAAGGACTGAGAGCATTTTTACTCACTATTGAGAATGAACTTAAAAATGAAAAGGAAGAAAAAGCAGAATTAAATAAACAGATTGTTCAT
TTTCAGCAGGAACTTTCTCTTTCTGAAAAAAAGAATTTAACTTTAAGTAAAGAGGTCCAACAAATTCAGTCAAATTATGATATTGCAATT
GCTGAATTACATGTGCAGAAAAGTAAAAATCAAGAACAGGAGGAAAAGATCATGAAATTGTCAAATGAGATAGAAACTGCTACAAGAAGC
ATTACAAATAATGTTTCACAAATAAAATTAATGCACACGAAAATAGACGAACTACGTACTCTTGATTCAGTTTCTCAGATTTCAAACATA
GATTTGCTCAATCTCAGGGATCTGTCAAATGGTTCTGAGGAGGATAATTTGCCAAATACACAGTTAGACCTTTTAGGTAATGATTATTTG
GTAAGTAAGCAAGTTAAAGAATATCGAATTCAAGAACCCAATAGGGAAAATTCTTTCCACTCTAGTATTGAAGCTATTTGGGAAGAATGT
AAAGAGATTGTGAAGGCCTCTTCCAAAAAAAGTCATCAGATTGAGGAACTGGAACAACAAATTGAAAAATTGCAGGCAGAAGTAAAAGGC
TATAAGGATGAAAACAATAGACTAAAGGAGAAGGAGCATAAAAACCAAGATGACCTACTAAAAGAAAAAGAAACTCTTATACAGCAGCTG
AAAGAAGAATTGCAAGAAAAAAATGTTACTCTTGATGTTCAAATACAGCATGTAGTTGAAGGAAAGAGAGCGCTTTCAGAACTTACACAA
GGTGTTACTTGCTATAAGGCAAAAATAAAGGAACTTGAAACAATTTTAGAGACTCAGAAAGTTGAATGTAGTCATTCAGCCAAGTTAGAA
CAAGACATTTTGGAAAAGGAATCTATCATCTTAAAGCTAGAAAGAAATTTGAAGGAATTTCAAGAACATCTTCAGGATTCTGTCAAAAAC
ACCAAAGATTTAAATGTAAAGGAACTCAAGCTGAAAGAAGAAATCACACAGTTAACAAATAATTTGCAAGATATGAAACATTTACTTCAA
TTAAAAGAAGAAGAAGAAGAAACCAACAGGCAAGAAACAGAAAAATTGAAAGAGGAACTCTCTGCAAGCTCTGCTCGTACCCAGAATCTG
AAAGCAGATCTTCAGAGGAAGGAAGAAGATTATGCTGACCTGAAAGAGAAACTGACTGATGCCAAAAAGCAGATTAAGCAAGTACAGAAA
GAGGTATCTGTAATGCGTGATGAGGATAAATTACTGAGGATTAAAATTAATGAACTGGAGAAAAAGAAAAACCAGTGTTCTCAGGAATTA
GATATGAAACAGCGAACCATTCAGCAACTCAAGGAGCAGTTAAATAATCAGAAAGTGGAAGAAGCTATACAACAGTATGAGAGAGCATGC
AAAGATCTAAATGTTAAAGAGAAAATAATTGAAGACATGCGAATGACACTAGAAGAACAGGAACAAACTCAGGTAGAACAGGATCAAGTG
CTTGAGGCTAAATTAGAGGAAGTTGAAAGGCTGGCCACAGAATTGGAAAAATGGAAGGAAAAATGCAATGATTTGGAAACCAAAAACAAT
CAAAGGTCAAATAAAGAACATGAGAACAACACAGATGTGCTTGGAAAGCTCACTAATCTTCAAGATGAGTTACAGGAGTCTGAACAGAAA
TATAATGCTGATAGAAAGAAATGGTTAGAAGAAAAAATGATGCTTATCACTCAAGCGAAAGAAGCAGAGAATATACGAAATAAAGAGATG
AAAAAATATGCTGAGGACAGGGAGCGTTTTTTTAAGCAACAGAATGAAATGGAAATACTGACAGCCCAGCTGACAGAGAAAGATAGTGAC
CTTCAAAAGTGGCGAGAAGAACGAGATCAACTGGTTGCAGCTTTAGAAATACAGCTAAAAGCACTGATATCCAGTAATGTACAGAAAGAT
AATGAAATTGAACAACTAAAAAGGATCATATCAGAGACTTCTAAAATAGAAACACAAATCATGGATATCAAGCCCAAACGTATTAGTTCA
GCAGATCCTGACAAACTTCAAACTGAACCTCTATCGACAAGTTTTGAAATTTCCAGAAATAAAATAGAGGATGGATCTGTAGTCCTTGAC
TCTTGTGAAGTGTCAACAGAAAATGATCAAAGCACTCGATTTCCAAAACCTGAGTTAGAGATTCAATTTACACCTTTACAGCCAAACAAA
ATGGCAGTGAAACACCCTGGTTGTACCACACCAGTGACAGTTAAGATTCCCAAGGCTCGGAAGAGGAAGAGTAATGAAATGGAGGAGGAC
TTGGTGAAATGTGAAAATAAGAAGAATGCTACACCCAGAACTAATTTGAAATTTCCTATTTCAGATGATAGAAATTCTTCTGTCAAAAAG
GAACAAAAGGTTGCCATACGTCCATCATCTAAGAAAACATATTCTTTACGGAGTCAGGCATCCATAATTGGTGTAAACCTGGCCACTAAG
AAAAAAGAAGGAACACTACAGAAATTTGGAGACTTCTTACAACATTCTCCCTCAATTCTTCAATCAAAAGCAAAGAAGATAATTGAAACA
ATGAGCTCTTCAAAGCTCTCAAATGTAGAAGCAAGTAAAGAAAATGTGTCTCAACCAAAACGAGCCAAACGGAAATTATACACAAGTGAA
ATTTCATCTCCTATTGATATATCAGGCCAAGTGATTTTAATGGACCAGAAAATGAAGGAGAGTGATCACCAGATTATCAAACGACGACTT


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTEN_ENST00000371953_chr10_89653866_+_KIF20B_ENST00000416354_chr10_91497144_+_5333nt
GGTAACCTCAGACTCGAGTCAGTGACACTGCTCAACGCACCCATCTCAGCTTTCATCATCAGTCCTCCACCCCCGCCCCACAACAGCCTA
CCCTGCCTCCGGCTGGGTTTCTGGGCAGAGGCCGAGGCTTAGCTCGTTATCCTCGCCTCGCGTTGCTGCAAAAGCCGCAGCAAGTGCAGC
TGCAGGCTGGCGGCTGGGAACCGGCCCGAGCAAGCCCCAGGCAGCTACACTGGGCATGCTCAGTAGAGCCTGCGGCTTGGGGACTCTGCG
CTCGCACCCAGAGCTACCGCTCTGCCCCCTCCTACCGCCCCCTGCCCTGCCCTGCCCTCCCCTCGCCCGGCGCGGTCCCGTCCGCCTCTC
GCTCGCCTCCCGCCTCCCCTCGGTCTTCCGAGGCGCCCGGGCTCCCGGCGCGGCGGCGGAGGGGGCGGGCAGGCCGGCGGGCGGTGATGT
GGCGGGACTCTTTATGCGCTGCGGCAGGATACGCGCTCGGCGCTGGGACGCGACTGCGCTCAGTTCTCTCCTCTCGGAAGCTGCAGCCAT
GATGGAAGTTTGAGAGTTGAGCCGCTGTGAGGCGAGGCCGGGCTCAGGCGAGGGAGATGAGAGACGGCGGCGGCCGCGGCCCGGAGCCCC
TCTCAGCGCCTGTGAGCAGCCGCGGGGGCAGCGCCCTCGGGGAGCCGGCCGGCCTGCGGCGGCGGCAGCGGCGGCGTTTCTCGCCTCCTC
TTCGTCTTTTCTAACCGTGCAGCCTCTTCCTCGGCTTCTCCTGAAAGGGAAGGTGGAAGCCGTGGGCTCGGGCGGGAGCCGGCTGAGGCG
CGGCGGCGGCGGCGGCACCTCCCGCTCCTGGAGCGGGGGGGAGAAGCGGCGGCGGCGGCGGCCGCGGCGGCTGCAGCTCCAGGGAGGGGG
TCTGAGTCGCCTGTCACCATTTCCAGGGCTGGGAACGCCGGAGAGTTGGTCTCTCCCCTTCTACTGCCTCCAACACGGCGGCGGCGGCGG
CTGGCACATCCAGGGACCCGGGCCGGTTTTAAACCTCCCGTGCGCCGCCGCCGCACCCCCCGTGGCCCGGGCTCCGGAGGCCGCCGGCGG
AGGCAGCCGTTCGGAGGATTATTCGTCTTCTCCCCATTCCGCTGCCGCCGCTGCCAGGCCTCTGGCTGCTGAGGAGAAGCAGGCCCAGTC
GCTGCAACCATCCAGCAGCCGCCGCAGCAGCCATTACCCGGCTGCGGTCCAGAGCCAAGCGGCGGCAGAGCGAGGGGCATCAGCTACCGC
CAAGTCCAGAGCCATTTCCATCCTGCAGAAGAAGCCCCGCCACCAGCAGCTTCTGCCATCTCTCTCCTCCTTTTTCTTCAGCCACAGGCT
CCCAGACATGACAGCCATCATCAAAGAGATCGTTAGCAGAAACAAAAGGAGATATCAAGAGGATGGATTCGACTTAGACTTGACCTATAT
TTATCCAAACATTATTGCTATGGGATTTCCTGCAGAAAGACTTGAAGGCGTATACAGGAACAATATTGATGATGTAGTAAGGTCTATCCA
TGTTAGTTCAGCTATCACTGAAGACCAAAAGAAAAGTGAAGAAGTGCGACCGAACATTGCAGAAATTGAAGACATCAGAGTTTTACAAGA
AAATAATGAAGGACTGAGAGCATTTTTACTCACTATTGAGAATGAACTTAAAAATGAAAAGGAAGAAAAAGCAGAATTAAATAAACAGAT
TGTTCATTTTCAGCAGGAACTTTCTCTTTCTGAAAAAAAGAATTTAACTTTAAGTAAAGAGGTCCAACAAATTCAGTCAAATTATGATAT
TGCAATTGCTGAATTACATGTGCAGAAAAGTAAAAATCAAGAACAGGAGGAAAAGATCATGAAATTGTCAAATGAGATAGAAACTGCTAC
AAGAAGCATTACAAATAATGTTTCACAAATAAAATTAATGCACACGAAAATAGACGAACTACGTACTCTTGATTCAGTTTCTCAGATTTC
AAACATAGATTTGCTCAATCTCAGGGATCTGTCAAATGGTTCTGAGGAGGATAATTTGCCAAATACACAGTTAGACCTTTTAGGTAATGA
TTATTTGGTAAGTAAGCAAGTTAAAGAATATCGAATTCAAGAACCCAATAGGGAAAATTCTTTCCACTCTAGTATTGAAGCTATTTGGGA
AGAATGTAAAGAGATTGTGAAGGCCTCTTCCAAAAAAAGTCATCAGATTGAGGAACTGGAACAACAAATTGAAAAATTGCAGGCAGAAGT
AAAAGGCTATAAGGATGAAAACAATAGACTAAAGGAGAAGGAGCATAAAAACCAAGATGACCTACTAAAAGAAAAAGAAACTCTTATACA
GCAGCTGAAAGAAGAATTGCAAGAAAAAAATGTTACTCTTGATGTTCAAATACAGCATGTAGTTGAAGGAAAGAGAGCGCTTTCAGAACT
TACACAAGGTGTTACTTGCTATAAGGCAAAAATAAAGGAACTTGAAACAATTTTAGAGACTCAGAAAGTTGAATGTAGTCATTCAGCCAA
GTTAGAACAAGACATTTTGGAAAAGGAATCTATCATCTTAAAGCTAGAAAGAAATTTGAAGGAATTTCAAGAACATCTTCAGGATTCTGT
CAAAAACACCAAAGATTTAAATGTAAAGGAACTCAAGCTGAAAGAAGAAATCACACAGTTAACAAATAATTTGCAAGATATGAAACATTT
ACTTCAATTAAAAGAAGAAGAAGAAGAAACCAACAGGCAAGAAACAGAAAAATTGAAAGAGGAACTCTCTGCAAGCTCTGCTCGTACCCA
GAATCTGAAAGCAGATCTTCAGAGGAAGGAAGAAGATTATGCTGACCTGAAAGAGAAACTGACTGATGCCAAAAAGCAGATTAAGCAAGT
ACAGAAAGAGGTATCTGTAATGCGTGATGAGGATAAATTACTGAGGATTAAAATTAATGAACTGGAGAAAAAGAAAAACCAGTGTTCTCA
GGAATTAGATATGAAACAGCGAACCATTCAGCAACTCAAGGAGCAGTTAAATAATCAGAAAGTGGAAGAAGCTATACAACAGTATGAGAG
AGCATGCAAAGATCTAAATGTTAAAGAGAAAATAATTGAAGACATGCGAATGACACTAGAAGAACAGGAACAAACTCAGGTAGAACAGGA
TCAAGTGCTTGAGGCTAAATTAGAGGAAGTTGAAAGGCTGGCCACAGAATTGGAAAAATGGAAGGAAAAATGCAATGATTTGGAAACCAA
AAACAATCAAAGGTCAAATAAAGAACATGAGAACAACACAGATGTGCTTGGAAAGCTCACTAATCTTCAAGATGAGTTACAGGAGTCTGA
ACAGAAATATAATGCTGATAGAAAGAAATGGTTAGAAGAAAAAATGATGCTTATCACTCAAGCGAAAGAAGCAGAGAATATACGAAATAA
AGAGATGAAAAAATATGCTGAGGACAGGGAGCGTTTTTTTAAGCAACAGAATGAAATGGAAATACTGACAGCCCAGCTGACAGAGAAAGA
TAGTGACCTTCAAAAGTGGCGAGAAGAACGAGATCAACTGGTTGCAGCTTTAGAAATACAGCTAAAAGCACTGATATCCAGTAATGTACA
GAAAGATAATGAAATTGAACAACTAAAAAGGATCATATCAGAGACTTCTAAAATAGAAACACAAATCATGGATATCAAGCCCAAACGTAT
TAGTTCAGCAGATCCTGACAAACTTCAAACTGAACCTCTATCGACAAGTTTTGAAATTTCCAGAAATAAAATAGAGGATGGATCTGTAGT
CCTTGACTCTTGTGAAGTGTCAACAGAAAATGATCAAAGCACTCGATTTCCAAAACCTGAGTTAGAGATTCAATTTACACCTTTACAGCC
AAACAAAATGGCAGTGAAACACCCTGGTTGTACCACACCAGTGACAGTTAAGATTCCCAAGGCTCGGAAGAGGAAGAGTAATGAAATGGA
GGAGGACTTGGTGAAATGTGAAAATAAGAAGAATGCTACACCCAGAACTAATTTGAAATTTCCTATTTCAGATGATAGAAATTCTTCTGT
CAAAAAGGAACAAAAGGTTGCCATACGTCCATCATCTAAGAAAACATATTCTTTACGGAGTCAGGCATCCATAATTGGTGTAAACCTGGC
CACTAAGAAAAAAGAAGGAACACTACAGAAATTTGGAGACTTCTTACAACATTCTCCCTCAATTCTTCAATCAAAAGCAAAGAAGATAAT
TGAAACAATGAGCTCTTCAAAGCTCTCAAATGTAGAAGCAAGTAAAGAAAATGTGTCTCAACCAAAACGAGCCAAACGGAAATTATACAC
AAGTGAAATTTCATCTCCTATTGATATATCAGGCCAAGTGATTTTAATGGACCAGAAAATGAAGGAGAGTGATCACCAGATTATCAAACG
ACGACTTCGAACAAAAACAGCCAAATAAATCACTTATGGAAATGTTTAATATAAATTTTATAGTCATAGTCATTGGAACTTGCATCCTGT
ATTGTAAATATAAATGTATATATTATGCATTAAATCACTCTGCATATAGATTGCTGTTTTATACATAGTATAATTTTAATTCAATAAATG
AGTCAAAATTTGTATATTTTTATAAGGCTTTTTTATAATAGCTTCTTTCAAACTGTATTTCCCTATTATCTCAGACATTGGATCAGTGAA
GATCCTAGGAAAGAGGCTGTTATTCTCATTTATTTTGCTATACAGGATGTAATAGGTCAGGTATTTGGTTTACTTATATTTAACAATGTC
TTATGAATTTTTTTTACTTTATCTGTTATACAACTGATTTTACATATCTGTTTGGATTATAGCTAGGATTTGGAGAATAAGTGTGTACAG
ATCACAAAACATGTATATACATTATTTAGAAAAGATCTCAAGTCTTTAATTAGAATGTCTCACTTATTTTGTAAACATTTTGTGGGTACA
TAGTACATGTATATATTTACGGGGTATGTGAGATGTTTTGACACAGGCATGCAATGTGAAATACGTGTATCATGGAGAATGAGGTATCCA
TCCCCTCAAGCATTTTTCCTTTGAATTACAGATAATCCAATTACATTCTTTAGATCATTTAAAAATATACAAGTAAGTTATTATTGATTA
TAGTCACTCTATTGTGCTATCAGATAGTAGATCATTCTTTTTATCTTATTTGTTTTTGTACCCATTAACCATCCCCACCTCCCCCTGCAA
CCGTCAGTACCCTTACCAGCCACTGGTAACCATTCTTCTACTCTGTATGCCCATGAGGTCAATTGATTTTATTTTTAGATCCCATAAATA


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FusionGenePPI for PTEN_KIF20B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTENAR, ESR1, UBE2L3, UBE2I, TP53, CSNK2A1, CSNK2A2, UTP14A, ANG, CHGB, COPS6, HBA1, PTK2, MVP, MAGI3, CAV1, PXN, NEDD4, NDFIP1, NDFIP2, XIAP, CASP8, CCNE2, IRS4, PPP2R4, WNT4, QRFPR, ARHGAP26, G3BP2, CENPC, DBF4B, GPR113, INHBE, GFRA2, SMTN, KRT14, AMHR2, PTK2B, CRKL, MAP2K6, PKN2, PDGFRA, PINK1, P3H4, PTPN14, TCEB3C, BAP1, WWP2, MED12, ZNF787, FBN2, TTBK2, RPL14, EEF1A2, FRK, AKT1, PPP3CA, EGR1, SLC9A3R1, STUB1, ELAVL1, PPP1CA, SHARPIN, BMI1, KAT2B, PARK7, CDC27, ANAPC4, ANAPC5, ANAPC7, FZR1, NCOA3, FBXW7, LATS1, CBL, EPHB1, USP7, USP8, USP10, USP13, USP39, USP4, UBC, CDH1, CTNNB1, WWP1, TNKS, TNKS2, RNF146, TXNDC11, CFB, YME1L1, SUV39H1, HES5, GPER1, MXD1, TTC31, EME2, OPRL1, OSBP2, RFTN1, PBX3, FBXL6, PIGN, POLM, TUBA1A, UBAP2L, TRIM8, CDC42EP5, ST8SIA6, ENO2, BLOC1S1, HES6, IFIH1, CYB5R3, PSMB2, SLC36A1, THBD, CARS2, NOTCH1, PPAP2B, UBE2D1, HEATR6, LLGL2, SLC25A6, KIAA0196, PKMYT1, HAGHL, RASSF2, SOCS1, TRIM24, ACACA, PC, PCCA, PCCB, MCCC2, MCCC1, HSPA8, DBT, HSP90AA1, HSPA1A, TUBA3C, HSPA1L, TUBB2A, AMOT, ETS1, HSPA6, STIP1, TUBB4B, ACACB, HSP90AB1, HSPA2, BCKDHA, TUBA1C, HNRNPU, PPP1R10, TUBB3, BEX1, CXCL1, IL24, OSGIN1, POLDIP2, PELO, RPS2, RPL10A, RPLP0, SSR4, ANXA2, FASN, AKAP12, DBN1, PRDX1, DSP, NME1, HSD17B1, UTRN, SPTAN1, RPS9, RPL38, GNAI1, GNAI2, MPRIP, RPS15A, GSTM2, SKP1, EEF2, GNB4, RPL27, SSFA2, DNAJA1, SPTBN1, LIMA1, RPL22L1, RPLP2, RPL27A, FLNB, MYO1D, TUBB, PLEC, MTHFD2, LDHB, RPS17, SDC1, RPS25, CFL1, RCC2, MYOF, RPS6, GPC1, RPL7, TUBA1B, ATP5C1, JUP, ARF4, PPL, RPL13A, RPL23, NCF1, RPS20, GPC4, RPS27, TUFM, HIST1H2AB, S100A8, MYH10, HSPD1, ATP5A1, KBTBD4, PKM, RPS4X, SLC25A5, DCAF11, S100A9, RPL12, LGALS1, MYO1B, RPS3, SDC4, RPS13, MYL12A, CALM1, SLC25A3, RPL31, SNTB2, MYO1C, SETX, RPL13, RPS26, RPS27A, C16orf13, YES1, DDB1, SDCBP, TXN, PDGFRB, OTUD3, PBK, NGB, BCAR1, SPOP, PLK1, CHEK1, BRD4, VHL, MTOR, NF1, ADA, MET, KDM6A, CDK4, CDKN2A, BRAF, PTEN, PIK3R2, PLEKHA1, PTPN13, DLG1, INS, AATK, ERBB3, PTK7, DLC1, RHOA, EIF2AK2, EGFR, ITPR3, MCRS1KIF20BPIN1, ELAVL1, CBX8, CRY1, EEF1G, ACSL3, HSP90B1, CDC42BPA, STAG1, KDM2A, ASTE1, SLC38A2, IMPACT, CCDC94, VCPIP1, CMBL, C1orf52, NANOG, HYPK, CCDC89, NDEL1, TCP10L, MXD3, MLF1, DNAJC7, ID2, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTEN_KIF20B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTEN_KIF20B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTENC0018553Hamartoma Syndrome, Multiple29CTD_human;ORPHANET;UNIPROT
HgenePTENC0033578Prostatic Neoplasms11CTD_human
HgenePTENC0265326Bannayan-Riley-Ruvalcaba Syndrome6ORPHANET;UNIPROT
HgenePTENC0376634Craniofacial Abnormalities6CTD_human
HgenePTENC3714756Intellectual Disability5CTD_human;HPO
HgenePTENC0004352Autistic Disorder4CTD_human;HPO
HgenePTENC0014170Endometrial Neoplasms4CTD_human
HgenePTENC1458155Mammary Neoplasms4CTD_human;HPO
HgenePTENC0008073Developmental Disabilities3CTD_human
HgenePTENC0025202melanoma3CTD_human;HPO
HgenePTENC0085261Proteus Syndrome3CTD_human;ORPHANET
HgenePTENC0376358Malignant neoplasm of prostate3UNIPROT
HgenePTENC0282612Prostatic Intraepithelial Neoplasias2CTD_human
HgenePTENC1168401Squamous cell carcinoma of the head and neck2CTD_human;ORPHANET;UNIPROT
HgenePTENC1854416MACROCEPHALY/AUTISM SYNDROME2CTD_human;ORPHANET;UNIPROT
HgenePTENC0001418Adenocarcinoma1CTD_human
HgenePTENC0003081Anisometropia1CTD_human
HgenePTENC0004096Asthma1CTD_human
HgenePTENC0007134Renal Cell Carcinoma1CTD_human
HgenePTENC0010606Adenoid Cystic Carcinoma1CTD_human
HgenePTENC0014173Endometrial Hyperplasia1CTD_human
HgenePTENC0015695Fatty Liver1CTD_human
HgenePTENC0017638Glioma1CTD_human
HgenePTENC0018916Hemangioma1CTD_human;HPO
HgenePTENC0020538Hypertensive disease1CTD_human
HgenePTENC0020564Hypertrophy1CTD_human
HgenePTENC0021655Insulin Resistance1CTD_human
HgenePTENC0023014Language Development Disorders1CTD_human
HgenePTENC0023418leukemia1CTD_human
HgenePTENC0023798Lipoma1CTD_human;HPO
HgenePTENC0023801Lipomatosis1CTD_human
HgenePTENC0023976Long QT Syndrome1CTD_human
HgenePTENC0024121Lung Neoplasms1CTD_human
HgenePTENC0024299Lymphoma1CTD_human
HgenePTENC0025286Meningioma1CTD_human;HPO
HgenePTENC0026613Motor Skills Disorders1CTD_human
HgenePTENC0027055Myocardial Reperfusion Injury1CTD_human
HgenePTENC0027626Neoplasm Invasiveness1CTD_human
HgenePTENC0027627Neoplasm Metastasis1CTD_human
HgenePTENC0030297Pancreatic Neoplasm1CTD_human
HgenePTENC0035126Reperfusion Injury1CTD_human
HgenePTENC0036920Sezary Syndrome1CTD_human
HgenePTENC0037274Dermatologic disorders1CTD_human
HgenePTENC0149925Small cell carcinoma of lung1CTD_human
HgenePTENC0152427Polydactyly1CTD_human
HgenePTENC0175704LEOPARD Syndrome1CTD_human
HgenePTENC0206669Hepatocellular Adenoma1CTD_human
HgenePTENC0206698Cholangiocarcinoma1CTD_human
HgenePTENC0476089Endometrial Carcinoma1HPO;UNIPROT
HgenePTENC0919267ovarian neoplasm1CTD_human;HPO
HgenePTENC1848599VACTERL Association With Hydrocephalus1CTD_human
HgenePTENC2239176Liver carcinoma1CTD_human
HgenePTENC2751642GLIOMA SUSCEPTIBILITY 21UNIPROT
HgenePTENC2931822Nasopharyngeal carcinoma1CTD_human