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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 29283

FusionGeneSummary for PTCHD4_CD2AP

check button Fusion gene summary
Fusion gene informationFusion gene name: PTCHD4_CD2AP
Fusion gene ID: 29283
HgeneTgene
Gene symbol

PTCHD4

CD2AP

Gene ID

442213

23607

Gene namepatched domain containing 4CD2 associated protein
SynonymsC6orf138|PTCH53|dJ402H5.2CMS
Cytomap

6p12.3

6p12.3

Type of geneprotein-codingprotein-coding
Descriptionpatched domain-containing protein 4p53-regulated patched proteinpatched domain-containing protein C6orf138CD2-associated proteinCas ligand with multiple Src homology 3 (SH3) domainsadapter protein CMScas ligand with multiple SH3 domains
Modification date2018032920180522
UniProtAcc

Q6ZW05

Q9Y5K6

Ensembl transtripts involved in fusion geneENST00000339488, ENST00000543600, 
ENST00000359314, ENST00000486693, 
Fusion gene scores* DoF score1 X 1 X 1=17 X 7 X 5=245
# samples 17
** MAII scorelog2(1/1*10)=3.32192809488736log2(7/245*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTCHD4 [Title/Abstract] AND CD2AP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDKIRCTCGA-A3-3313-01APTCHD4chr6

47976370

-CD2APchr6

47471016

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000339488ENST00000359314PTCHD4chr6

47976370

-CD2APchr6

47471016

+
5CDS-intronENST00000339488ENST00000486693PTCHD4chr6

47976370

-CD2APchr6

47471016

+
In-frameENST00000543600ENST00000359314PTCHD4chr6

47976370

-CD2APchr6

47471016

+
5CDS-intronENST00000543600ENST00000486693PTCHD4chr6

47976370

-CD2APchr6

47471016

+

Top

FusionProtFeatures for PTCHD4_CD2AP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTCHD4

Q6ZW05

CD2AP

Q9Y5K6

Could act as a repressor of canonical hedgehog signalingby antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, andPTCH2 in PTCHD4-expressing cells. {ECO:0000269|PubMed:25296753}. Seems to act as an adapter protein between membraneproteins and the actin cytoskeleton (PubMed:10339567). Incollaboration with CBLC, modulates the rate of RET turnover andmay act as regulatory checkpoint that limits the potency of GDNFon neuronal survival. Controls CBLC function, converting it froman inhibitor to a promoter of RET degradation (By similarity). Mayplay a role in receptor clustering and cytoskeletal polarity inthe junction between T-cell and antigen-presenting cell (Bysimilarity). May anchor the podocyte slit diaphragm to the actincytoskeleton in renal glomerolus. Also required for cytokinesis(PubMed:15800069). Plays a role in epithelial cell junctionsformation (PubMed:22891260). {ECO:0000250|UniProtKB:F1LRS8,ECO:0000250|UniProtKB:Q9JLQ0, ECO:0000269|PubMed:10339567,ECO:0000269|PubMed:15800069, ECO:0000269|PubMed:22891260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23230_250302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23265_285302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-2341_61302847TransmembraneHelical
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018577_6381640Coiled coilOntology_term=ECO:0000255
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018336_4221640Compositional biasNote=Pro-rich
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018108_1671640DomainSH3 2
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+0181_591640DomainSH3 1%3B truncated
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018269_3301640DomainSH3 3
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018336_3521640MotifSH3-binding
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018378_3971640MotifSH3-binding
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+018410_4221640MotifSH3-binding

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23233_392302847DomainSSD
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23293_313302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23336_356302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23373_393302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23465_485302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23660_680302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23686_706302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23718_738302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23765_785302847TransmembraneHelical
HgenePTCHD4chr6:47976370chr6:47471016ENST00000339488-23787_807302847TransmembraneHelical


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FusionGeneSequence for PTCHD4_CD2AP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTCHD4_ENST00000339488_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_941aa
MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASS
LFPLDQSKSQLTSDLHTPGRTGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQ
TTGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVL
TVCISIITAAGIFFITDGKYNSTLLGIPFFAMVDTIVETDTDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKR
ETEFKDDSLPIKRERHGNVASLVQRISTTGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGT
LNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEK
KPEKPLILQSLGPKTQSVEITKTDTEGKIKAKETCRTLFATEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQIN
ELDKDFPKPKKPPPPAKAPAPKPELIAAEKKTFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPP
PPPIAKINGEVSSISSKFETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGH
SPTHSPEKILKLPKEEDSANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEA

>In-frame_PTCHD4_ENST00000543600_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_924aa
MLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLTSDLHT
PGRTGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTTGSATQDLIGEKWENE
FCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITD
GKYNSTLLGIPFFAMVDTIVETDTDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNFVKEIKRETEFKDDSLPIKRERHG
NVASLVQRISTTGLPAGGIQPHPQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELE
VTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKPEKPLILQSLGPKTQS
VEITKTDTEGKIKAKETCRTLFATEGTNEDELTFKEGEIIHLISKETGEAGWWRGELNGKEGVFPDNFAVQINELDKDFPKPKKPPPPAK
APAPKPELIAAEKKTFSLKPEEKDEKSTLEQKPSKPAAPQVPPKKPTPPTKASNLLRSSGTVYPKRPEKPVPPPPPIAKINGEVSSISSK
FETEPVSKLKLDSEQLPLRPKSVDFDSLTVRTSKETDVVNFDDIASSENLLHLTANRPKMPGRRLPGRFNGGHSPTHSPEKILKLPKEED
SANLKPSELKKDTCYSPKPSVYLSTPSSASKANTTAFLTPLEIKAKVETDDVKKNSLDELRAQIIELLCIVEALKKDHGKELEKLRKDLE


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTCHD4_ENST00000339488_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_2823nt
ATGTGCTTTTTAAGACGGCCGGGAGCGCCTGCGAGCTGGATCTGGTGGAGGATGCTGCGGCAGGTGCTTCGCAGAGGGCTCCAGTCGTTC
TGCCACAGGCTGGGTTTGTGCGTGAGCCGGCACCCGGTCTTTTTCCTCACCGTGCCCGCAGTCCTGACAATCACCTTCGGCCTCAGCGCG
CTCAACCGCTTCCAGCCCGAGGGCGACCTGGAGCGCCTGGTCGCTCCCAGCCACAGCCTGGCCAAGATCGAGCGCAGCCTGGCCAGCAGC
CTTTTCCCCCTGGACCAGTCCAAAAGCCAGCTCTATTCGGACTTACACACCCCTGGGAGGTATGGCAGGGTGATCCTCCTCTCCCCAACC
GGGGACAATATTTTGCTCCAGGCTGAGGGGATCCTGCAGACCCACCGAGCCGTGCTGGAAATGAAGGATGGGAGGAACAGTTTTATTGGA
CACCAACTGGGCGGGGTAGTGGAAGTGCCAAACAGCAAAGATCAGCGGGTCAAGTCAGCCAGAGCCATTCAAATCACCTACTACCTCCAG
ACCTATGGCTCTGCCACCCAAGACCTCATAGGGGAGAAGTGGGAGAATGAGTTCTGTAAGCTTATAAGGAAGCTCCAGGAGGAGCATCAA
GAACTCCAGCTCTACTCTTTAGCATCCTTTAGCCTCTGGAGGGACTTTCATAAGACCAGCATCCTGGCCAGAAGCAAGGTCCTGGTGAGC
CTCGTGCTGATCCTGACCACAGCCACCCTCTCCAGCTCCATGAAGGACTGCTTGCGCAGTAAGCCCTTCCTGGGCCTCCTGGGGGTGCTC
ACAGTATGCATCTCCATCATCACAGCAGCAGGGATCTTCTTCATCACCGATGGAAAGTACAACTCCACCCTGCTGGGAATCCCGTTCTTC
GCCATGGTTGACTATATTGTGGAGTATGACTATGATGCTGTACATGATGATGAATTAACTATTCGAGTTGGAGAAATCATCAGGAATGTG
AAAAAGCTACAGGAGGAAGGGTGGCTGGAAGGAGAACTAAATGGGAGAAGAGGAATGTTCCCTGACAATTTCGTTAAGGAAATTAAAAGA
GAGACGGAATTCAAGGATGACAGTTTGCCCATCAAACGGGAAAGGCATGGGAATGTAGCAAGTCTTGTACAACGAATAAGCACCTATGGA
CTTCCAGCTGGAGGAATTCAGCCACATCCACAAACCAAAAACATTAAGAAGAAGACCAAGAAGCGTCAGTGTAAAGTTCTTTTTGAGTAC
ATTCCACAAAATGAGGATGAACTGGAGCTGAAAGTGGGAGATATTATTGATATTAATGAAGAGGTAGAAGAAGGCTGGTGGAGTGGAACC
CTGAATAACAAGTTGGGACTGTTTCCCTCAAATTTTGTGAAAGAATTAGAGGTAACAGATGATGGTGAAACTCATGAAGCCCAGGACGAT
TCAGAAACTGTTTTGGCTGGGCCTACTTCACCTATACCTTCTCTGGGAAATGTGAGTGAAACTGCATCTGGATCAGTTACACAGCCAAAG
AAAATTCGAGGAATTGGATTTGGAGACATTTTTAAAGAAGGCTCTGTGAAACTTCGGACAAGAACATCCAGTAGTGAAACAGAAGAGAAA
AAACCAGAAAAGCCCTTAATCCTACAGTCACTGGGACCCAAAACTCAGAGTGTGGAGATAACAAAAACAGATACCGAAGGTAAAATTAAA
GCTAAAGAATATTGTAGAACATTATTTGCCTATGAAGGTACTAATGAAGATGAACTTACTTTTAAAGAGGGGGAGATAATCCATTTGATA
AGTAAGGAGACTGGAGAAGCTGGCTGGTGGAGGGGCGAACTTAATGGTAAAGAAGGAGTATTTCCAGACAATTTTGCTGTCCAGATAAAT
GAACTTGATAAAGACTTTCCAAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAACTGATAGCTGCAGAGAAG
AAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCAGCTCCACAAGTCCCACCC
AAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCTGAAAAACCAGTTCCTCCA
CCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCAAAACTAAAGCTAGATTCT
GAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGATGTTGTAAATTTTGATGAC
ATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGCCGTTTCAATGGTGGACAT
TCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCTGAATTAAAAAAAGATACA
TGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTCCTGACTCCATTAGAAATC
AAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTGTTGTGCATTGTAGAAGCA
CTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGTAATCTAGAGATGGAAATA

>In-frame_PTCHD4_ENST00000543600_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_2772nt
ATGCTGCGGCAGGTGCTTCGCAGAGGGCTCCAGTCGTTCTGCCACAGGCTGGGTTTGTGCGTGAGCCGGCACCCGGTCTTTTTCCTCACC
GTGCCCGCAGTCCTGACAATCACCTTCGGCCTCAGCGCGCTCAACCGCTTCCAGCCCGAGGGCGACCTGGAGCGCCTGGTCGCTCCCAGC
CACAGCCTGGCCAAGATCGAGCGCAGCCTGGCCAGCAGCCTTTTCCCCCTGGACCAGTCCAAAAGCCAGCTCTATTCGGACTTACACACC
CCTGGGAGGTATGGCAGGGTGATCCTCCTCTCCCCAACCGGGGACAATATTTTGCTCCAGGCTGAGGGGATCCTGCAGACCCACCGAGCC
GTGCTGGAAATGAAGGATGGGAGGAACAGTTTTATTGGACACCAACTGGGCGGGGTAGTGGAAGTGCCAAACAGCAAAGATCAGCGGGTC
AAGTCAGCCAGAGCCATTCAAATCACCTACTACCTCCAGACCTATGGCTCTGCCACCCAAGACCTCATAGGGGAGAAGTGGGAGAATGAG
TTCTGTAAGCTTATAAGGAAGCTCCAGGAGGAGCATCAAGAACTCCAGCTCTACTCTTTAGCATCCTTTAGCCTCTGGAGGGACTTTCAT
AAGACCAGCATCCTGGCCAGAAGCAAGGTCCTGGTGAGCCTCGTGCTGATCCTGACCACAGCCACCCTCTCCAGCTCCATGAAGGACTGC
TTGCGCAGTAAGCCCTTCCTGGGCCTCCTGGGGGTGCTCACAGTATGCATCTCCATCATCACAGCAGCAGGGATCTTCTTCATCACCGAT
GGAAAGTACAACTCCACCCTGCTGGGAATCCCGTTCTTCGCCATGGTTGACTATATTGTGGAGTATGACTATGATGCTGTACATGATGAT
GAATTAACTATTCGAGTTGGAGAAATCATCAGGAATGTGAAAAAGCTACAGGAGGAAGGGTGGCTGGAAGGAGAACTAAATGGGAGAAGA
GGAATGTTCCCTGACAATTTCGTTAAGGAAATTAAAAGAGAGACGGAATTCAAGGATGACAGTTTGCCCATCAAACGGGAAAGGCATGGG
AATGTAGCAAGTCTTGTACAACGAATAAGCACCTATGGACTTCCAGCTGGAGGAATTCAGCCACATCCACAAACCAAAAACATTAAGAAG
AAGACCAAGAAGCGTCAGTGTAAAGTTCTTTTTGAGTACATTCCACAAAATGAGGATGAACTGGAGCTGAAAGTGGGAGATATTATTGAT
ATTAATGAAGAGGTAGAAGAAGGCTGGTGGAGTGGAACCCTGAATAACAAGTTGGGACTGTTTCCCTCAAATTTTGTGAAAGAATTAGAG
GTAACAGATGATGGTGAAACTCATGAAGCCCAGGACGATTCAGAAACTGTTTTGGCTGGGCCTACTTCACCTATACCTTCTCTGGGAAAT
GTGAGTGAAACTGCATCTGGATCAGTTACACAGCCAAAGAAAATTCGAGGAATTGGATTTGGAGACATTTTTAAAGAAGGCTCTGTGAAA
CTTCGGACAAGAACATCCAGTAGTGAAACAGAAGAGAAAAAACCAGAAAAGCCCTTAATCCTACAGTCACTGGGACCCAAAACTCAGAGT
GTGGAGATAACAAAAACAGATACCGAAGGTAAAATTAAAGCTAAAGAATATTGTAGAACATTATTTGCCTATGAAGGTACTAATGAAGAT
GAACTTACTTTTAAAGAGGGGGAGATAATCCATTTGATAAGTAAGGAGACTGGAGAAGCTGGCTGGTGGAGGGGCGAACTTAATGGTAAA
GAAGGAGTATTTCCAGACAATTTTGCTGTCCAGATAAATGAACTTGATAAAGACTTTCCAAAACCAAAGAAACCACCACCTCCTGCTAAG
GCTCCAGCTCCAAAGCCTGAACTGATAGCTGCAGAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAA
CAGAAACCTTCTAAACCAGCAGCTCCACAAGTCCCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGA
ACAGTGTACCCAAAGCGACCTGAAAAACCAGTTCCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAA
TTTGAAACTGAGCCAGTATCAAAACTAAAGCTAGATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTA
AGGACCTCCAAAGAAACAGATGTTGTAAATTTTGATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATG
CCTGGAAGAAGGTTGCCGGGCCGTTTCAATGGTGGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGAC
AGTGCCAACCTGAAGCCATCTGAATTAAAAAAAGATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCT
AAAGCAAATACAACTGCTTTCCTGACTCCATTAGAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTT
AGAGCCCAGATTATTGAATTGTTGTGCATTGTAGAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTCHD4_ENST00000339488_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_5893nt
GAGAACGGGGTAGCCCGGCGCTTACACATGTCACATGTGCTTTTTAAGACGGCCGGGAGCGCCTGCGAGCTGGATCTGGTGGAGGATGCT
GCGGCAGGTGCTTCGCAGAGGGCTCCAGTCGTTCTGCCACAGGCTGGGTTTGTGCGTGAGCCGGCACCCGGTCTTTTTCCTCACCGTGCC
CGCAGTCCTGACAATCACCTTCGGCCTCAGCGCGCTCAACCGCTTCCAGCCCGAGGGCGACCTGGAGCGCCTGGTCGCTCCCAGCCACAG
CCTGGCCAAGATCGAGCGCAGCCTGGCCAGCAGCCTTTTCCCCCTGGACCAGTCCAAAAGCCAGCTCTATTCGGACTTACACACCCCTGG
GAGGTATGGCAGGGTGATCCTCCTCTCCCCAACCGGGGACAATATTTTGCTCCAGGCTGAGGGGATCCTGCAGACCCACCGAGCCGTGCT
GGAAATGAAGGATGGGAGGAACAGTTTTATTGGACACCAACTGGGCGGGGTAGTGGAAGTGCCAAACAGCAAAGATCAGCGGGTCAAGTC
AGCCAGAGCCATTCAAATCACCTACTACCTCCAGACCTATGGCTCTGCCACCCAAGACCTCATAGGGGAGAAGTGGGAGAATGAGTTCTG
TAAGCTTATAAGGAAGCTCCAGGAGGAGCATCAAGAACTCCAGCTCTACTCTTTAGCATCCTTTAGCCTCTGGAGGGACTTTCATAAGAC
CAGCATCCTGGCCAGAAGCAAGGTCCTGGTGAGCCTCGTGCTGATCCTGACCACAGCCACCCTCTCCAGCTCCATGAAGGACTGCTTGCG
CAGTAAGCCCTTCCTGGGCCTCCTGGGGGTGCTCACAGTATGCATCTCCATCATCACAGCAGCAGGGATCTTCTTCATCACCGATGGAAA
GTACAACTCCACCCTGCTGGGAATCCCGTTCTTCGCCATGGTTGACTATATTGTGGAGTATGACTATGATGCTGTACATGATGATGAATT
AACTATTCGAGTTGGAGAAATCATCAGGAATGTGAAAAAGCTACAGGAGGAAGGGTGGCTGGAAGGAGAACTAAATGGGAGAAGAGGAAT
GTTCCCTGACAATTTCGTTAAGGAAATTAAAAGAGAGACGGAATTCAAGGATGACAGTTTGCCCATCAAACGGGAAAGGCATGGGAATGT
AGCAAGTCTTGTACAACGAATAAGCACCTATGGACTTCCAGCTGGAGGAATTCAGCCACATCCACAAACCAAAAACATTAAGAAGAAGAC
CAAGAAGCGTCAGTGTAAAGTTCTTTTTGAGTACATTCCACAAAATGAGGATGAACTGGAGCTGAAAGTGGGAGATATTATTGATATTAA
TGAAGAGGTAGAAGAAGGCTGGTGGAGTGGAACCCTGAATAACAAGTTGGGACTGTTTCCCTCAAATTTTGTGAAAGAATTAGAGGTAAC
AGATGATGGTGAAACTCATGAAGCCCAGGACGATTCAGAAACTGTTTTGGCTGGGCCTACTTCACCTATACCTTCTCTGGGAAATGTGAG
TGAAACTGCATCTGGATCAGTTACACAGCCAAAGAAAATTCGAGGAATTGGATTTGGAGACATTTTTAAAGAAGGCTCTGTGAAACTTCG
GACAAGAACATCCAGTAGTGAAACAGAAGAGAAAAAACCAGAAAAGCCCTTAATCCTACAGTCACTGGGACCCAAAACTCAGAGTGTGGA
GATAACAAAAACAGATACCGAAGGTAAAATTAAAGCTAAAGAATATTGTAGAACATTATTTGCCTATGAAGGTACTAATGAAGATGAACT
TACTTTTAAAGAGGGGGAGATAATCCATTTGATAAGTAAGGAGACTGGAGAAGCTGGCTGGTGGAGGGGCGAACTTAATGGTAAAGAAGG
AGTATTTCCAGACAATTTTGCTGTCCAGATAAATGAACTTGATAAAGACTTTCCAAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCC
AGCTCCAAAGCCTGAACTGATAGCTGCAGAGAAGAAATATTTTTCTTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAA
ACCTTCTAAACCAGCAGCTCCACAAGTCCCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGT
GTACCCAAAGCGACCTGAAAAACCAGTTCCTCCACCACCTCCTATAGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGA
AACTGAGCCAGTATCAAAACTAAAGCTAGATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGAC
CTCCAAAGAAACAGATGTTGTAAATTTTGATGACATAGCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGG
AAGAAGGTTGCCGGGCCGTTTCAATGGTGGACATTCTCCAACTCACAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGC
CAACCTGAAGCCATCTGAATTAAAAAAAGATACATGCTACTCTCCAAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGC
AAATACAACTGCTTTCCTGACTCCATTAGAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGC
CCAGATTATTGAATTGTTGTGCATTGTAGAAGCACTGAAAAAGGATCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGA
GAAGACAATGAGAAGTAATCTAGAGATGGAAATAGAGAAGCTGAAAAAAGCTGTCCTGTCTTCTTGAGTGGTGTGGACCTGGTGTTCATA
ATGTTCCAGGGATTCAGAAGCAACGCTATGAACTTCAGCTGACTTGTTACTTAAAAATTGTGAATTCTGTTGTTGTGATAAATATGAGCA
AATGAAGTGTAATATCTATAGAAAAGTAGAGTGAGGGTGAATTTATATATATATTTTGTTTTGCCAATATGAAGAAAAAGAGGCCTTATT
TCTTAACTGTGCTGGGATTGCAAACACTTTTTAAAAAATTGTTTGCTTGAAAATACTACTGAATATAAATAAGAATGTGCACAGTAGTTT
TTTTATTGAAACTTGTATTATTTTTAAAGAGATCTATACTATAAATATGGTGATATATTTACAAGTAATCTGTTAAGATATACTATTTGA
GAGGGACAGATTAGCCTTTTAGTAACTATAGTCACTACTTTTTCCATAATGCATAAGGGATATAAACTCTGTGTGTGTGTGTGTGTGTGT
GTGTGTGTGTGTGTGTGTGTGTATATATATATATATATTTTTACTTTTATCCTCTTACCGAAGGTTACACTGTTGTGCCTGTTTGTCTGC
AATGCTGTTTATATTTTGGGTGATGAAATAGGAGTTTCCTAGCTATATAAACCAGATTACTCACCCATGCATATAGTAAGAACTAATGAA
TAATCAAAATAATTTCATCAACTTTTAGAATATTTTATGTTGCTTGCACTATAGGAGTCATAAAAGGAACTTAGTTAAAATATGTTGGAT
TGTTAAACATTTGGGGAAATATGAACTGTATTTTAAATTTGTTAGGTCTGAAGAATCTAAAACTGTTAATTTAACCCTTAACTTGTGCCT
AGAAACTACAGCACATATAAAATATGTAAACACCAGCCTGTTGCTGTACTTTTCTGCTTATTTTACAGCCTCAAATATTTCTCATTATCT
TGTCACTTAGTTCTTCATGTTTCTCCTTCTGACTTTTAATAATGGTAATAGGAAAACAAAACCCAAAGCTTTTCAGAACTTCAGTGTGAG
GTTTCCTATTTTGACAAGTTAACTTGTAAATACTCAGGTTTTACGATGTATAATTTACCTAATAGACCAAACTAACTCATGGAGATATTT
TGAACTATTATTTAGGTACAAACTTTATAAAGAATGTTAGTATGTCATAAAATATAACATTACAGCTTATTTAAAACCAAATATAGTTGA
ACATATTTAAAATACATTTTCACAGAATGGATGAATTAGTTGTTTCTTCAGAGTTACTTATGAACAGTTGAATGCTTTAAAATGTTCTGT
CTGTAGGTAACATCTAAAACACAAGTGGGTTTATTTAAATTTTTAAAATTTGAAATTTTTTATTTGCAAAAAATTGTTTTATGCTTTATT
ATATCGCAAATGAGTGTCAGATTTTTGAGTACCAATGATCATGCTTCCATTTTTTTTAGTTTTAAACCACCAAACCAATATTTTTCCTTT
AAATTTTAATCTTATAATATAGAAATCTTATGTAAATGAAATTTTGTCATGTTTCAAATAAAGAGAACTGAAGTAGAAAATAGAAATGCC
AGTAAACAACATAATGTTTAATTTACAACTTACATTAGGGGTTTGGGGGAATGCTAATTATATATTGAGAATATACATTAGAACTCTTCA
AAATGGGCTCTTCTAATGAGGTCACTACTGAACAAAATTGTTCCCTCTTCTGTTAAATAGAATAGGTTTAAATGACTAGTCAAATGAATT
ATTTTCTTCTTGTTAAATAAATTAAATCTTACTTTCTTTTAATGACCAACCTTAGGTAAAACAAAAATATTGTAATCCTAGAAATTATCC
TCCAGCTTTCTCACCTGAAAATCTATTGAAGTGATCCCTGGTCATCCTAATAATGGGATGAGGGAAGTTTCCAGCAGATTTCAGGCTGTT
CTTAAAGTTTTTGTTGGTCATTTTCTCAATAGTACATGAAATCAAGATGCTTATGAGCATGGAAATGTATTTAAAGTTTTTGCTTGTGTC
CTCCTCAGTCAGAATAGAAAAGTAACTGAAATACTTTTACCTTTCTGTCCTTGATAAAATAGTAAAGAAAACCAAACAAACCCAGGCCTG
ATGGGAAAAATGATTCCTTTATTCTAGCAACTTACTTTCTGTTGGTATGGGAAATGTTATTAATTTCTATTACTAAAGTTCATATCACAA
AATGATATTTAATAATAACCTTGGGGTAAATCATGAATTTTTTTTCTACGTGTGAGTATAAAAGACAAAAGTTGAACAGCATGGAATCTC
ATTGCCAAATTATTAGTGAATGTATAGTTCAGGTATTCTTTGAGACACACAGTATCATTAATTTCTGAATTGTATTTCAGTGTTATTTTT
TGTTTGTGACCACTAAGCTTCTGTCTTAATACAAAGCTGTTACCTTCTACAGAATTTAAGTCTGAAGATGTAAAGAGAGAACAGGCCTTG
TGTAACAGAAGATACTCTTTTTTATGCTCCTTACTGTGATCACAGAAAAATTAAAAATCCAAGTGCTCTCTAGATTTGTTGATAAACATT
TTATGCTTGCATTTAAACTTGAAATGTATGAGCAGAATGAGACAATCAGTTAAATCAGAAATGAGAAGTATTATAATGTAAAGGCCTTGT
TTTGCTGTAGCAATAAAATGACCAAGTGCAATGACTTGATTTAATAAAATCATATTTTAAAAGTTGCTGCTATGAATATTTTTGGCTATA
AAATTTTACCCTGACTTGCTTTCAATAACTGTTACGTAATGCAGTTGATGTTGTAACCTAACATTCCAAAAAAAAAATTGAGAGGGGGAA
TCTCAAAATAGTATATACTTCACTAACTTGTTTACAGGTGCTGTATTTAAAAGCATGCTTCTCTCTCAAAAAGAAAAATTAAAGGATTTT
ATTGCCAGTCGTGTCAGTCTTTATTGGTTATTTTTTGTTAACTTTAGCATTTGTGTATTTCAGAGTATGATGAAAATTATATTACTTCAA

>In-frame_PTCHD4_ENST00000543600_chr6_47976370_-_CD2AP_ENST00000359314_chr6_47471016_+_5848nt
AAGACGGCCGGGAGCGCCTGCGAGCTGGATCTGGTGGAGGATGCTGCGGCAGGTGCTTCGCAGAGGGCTCCAGTCGTTCTGCCACAGGCT
GGGTTTGTGCGTGAGCCGGCACCCGGTCTTTTTCCTCACCGTGCCCGCAGTCCTGACAATCACCTTCGGCCTCAGCGCGCTCAACCGCTT
CCAGCCCGAGGGCGACCTGGAGCGCCTGGTCGCTCCCAGCCACAGCCTGGCCAAGATCGAGCGCAGCCTGGCCAGCAGCCTTTTCCCCCT
GGACCAGTCCAAAAGCCAGCTCTATTCGGACTTACACACCCCTGGGAGGTATGGCAGGGTGATCCTCCTCTCCCCAACCGGGGACAATAT
TTTGCTCCAGGCTGAGGGGATCCTGCAGACCCACCGAGCCGTGCTGGAAATGAAGGATGGGAGGAACAGTTTTATTGGACACCAACTGGG
CGGGGTAGTGGAAGTGCCAAACAGCAAAGATCAGCGGGTCAAGTCAGCCAGAGCCATTCAAATCACCTACTACCTCCAGACCTATGGCTC
TGCCACCCAAGACCTCATAGGGGAGAAGTGGGAGAATGAGTTCTGTAAGCTTATAAGGAAGCTCCAGGAGGAGCATCAAGAACTCCAGCT
CTACTCTTTAGCATCCTTTAGCCTCTGGAGGGACTTTCATAAGACCAGCATCCTGGCCAGAAGCAAGGTCCTGGTGAGCCTCGTGCTGAT
CCTGACCACAGCCACCCTCTCCAGCTCCATGAAGGACTGCTTGCGCAGTAAGCCCTTCCTGGGCCTCCTGGGGGTGCTCACAGTATGCAT
CTCCATCATCACAGCAGCAGGGATCTTCTTCATCACCGATGGAAAGTACAACTCCACCCTGCTGGGAATCCCGTTCTTCGCCATGGTTGA
CTATATTGTGGAGTATGACTATGATGCTGTACATGATGATGAATTAACTATTCGAGTTGGAGAAATCATCAGGAATGTGAAAAAGCTACA
GGAGGAAGGGTGGCTGGAAGGAGAACTAAATGGGAGAAGAGGAATGTTCCCTGACAATTTCGTTAAGGAAATTAAAAGAGAGACGGAATT
CAAGGATGACAGTTTGCCCATCAAACGGGAAAGGCATGGGAATGTAGCAAGTCTTGTACAACGAATAAGCACCTATGGACTTCCAGCTGG
AGGAATTCAGCCACATCCACAAACCAAAAACATTAAGAAGAAGACCAAGAAGCGTCAGTGTAAAGTTCTTTTTGAGTACATTCCACAAAA
TGAGGATGAACTGGAGCTGAAAGTGGGAGATATTATTGATATTAATGAAGAGGTAGAAGAAGGCTGGTGGAGTGGAACCCTGAATAACAA
GTTGGGACTGTTTCCCTCAAATTTTGTGAAAGAATTAGAGGTAACAGATGATGGTGAAACTCATGAAGCCCAGGACGATTCAGAAACTGT
TTTGGCTGGGCCTACTTCACCTATACCTTCTCTGGGAAATGTGAGTGAAACTGCATCTGGATCAGTTACACAGCCAAAGAAAATTCGAGG
AATTGGATTTGGAGACATTTTTAAAGAAGGCTCTGTGAAACTTCGGACAAGAACATCCAGTAGTGAAACAGAAGAGAAAAAACCAGAAAA
GCCCTTAATCCTACAGTCACTGGGACCCAAAACTCAGAGTGTGGAGATAACAAAAACAGATACCGAAGGTAAAATTAAAGCTAAAGAATA
TTGTAGAACATTATTTGCCTATGAAGGTACTAATGAAGATGAACTTACTTTTAAAGAGGGGGAGATAATCCATTTGATAAGTAAGGAGAC
TGGAGAAGCTGGCTGGTGGAGGGGCGAACTTAATGGTAAAGAAGGAGTATTTCCAGACAATTTTGCTGTCCAGATAAATGAACTTGATAA
AGACTTTCCAAAACCAAAGAAACCACCACCTCCTGCTAAGGCTCCAGCTCCAAAGCCTGAACTGATAGCTGCAGAGAAGAAATATTTTTC
TTTAAAGCCTGAAGAAAAGGATGAAAAATCAACACTGGAACAGAAACCTTCTAAACCAGCAGCTCCACAAGTCCCACCCAAGAAACCTAC
TCCACCTACCAAAGCCAGTAATTTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCTGAAAAACCAGTTCCTCCACCACCTCCTAT
AGCCAAGATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAGCCAGTATCAAAACTAAAGCTAGATTCTGAACAGCTGCC
CCTTAGACCAAAATCAGTAGACTTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAGATGTTGTAAATTTTGATGACATAGCTTCCTC
AGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGGTTGCCGGGCCGTTTCAATGGTGGACATTCTCCAACTCA
CAGCCCCGAAAAAATCTTGAAGTTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCTGAATTAAAAAAAGATACATGCTACTCTCC
AAAGCCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACAACTGCTTTCCTGACTCCATTAGAAATCAAAGCTAAAGT
GGAAACAGATGATGTGAAAAAAAATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTGTTGTGCATTGTAGAAGCACTGAAAAAGGA
TCACGGGAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACAATGAGAAGTAATCTAGAGATGGAAATAGAGAAGCTGAA
AAAAGCTGTCCTGTCTTCTTGAGTGGTGTGGACCTGGTGTTCATAATGTTCCAGGGATTCAGAAGCAACGCTATGAACTTCAGCTGACTT
GTTACTTAAAAATTGTGAATTCTGTTGTTGTGATAAATATGAGCAAATGAAGTGTAATATCTATAGAAAAGTAGAGTGAGGGTGAATTTA
TATATATATTTTGTTTTGCCAATATGAAGAAAAAGAGGCCTTATTTCTTAACTGTGCTGGGATTGCAAACACTTTTTAAAAAATTGTTTG
CTTGAAAATACTACTGAATATAAATAAGAATGTGCACAGTAGTTTTTTTATTGAAACTTGTATTATTTTTAAAGAGATCTATACTATAAA
TATGGTGATATATTTACAAGTAATCTGTTAAGATATACTATTTGAGAGGGACAGATTAGCCTTTTAGTAACTATAGTCACTACTTTTTCC
ATAATGCATAAGGGATATAAACTCTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATATATATATATATATTTTTACT
TTTATCCTCTTACCGAAGGTTACACTGTTGTGCCTGTTTGTCTGCAATGCTGTTTATATTTTGGGTGATGAAATAGGAGTTTCCTAGCTA
TATAAACCAGATTACTCACCCATGCATATAGTAAGAACTAATGAATAATCAAAATAATTTCATCAACTTTTAGAATATTTTATGTTGCTT
GCACTATAGGAGTCATAAAAGGAACTTAGTTAAAATATGTTGGATTGTTAAACATTTGGGGAAATATGAACTGTATTTTAAATTTGTTAG
GTCTGAAGAATCTAAAACTGTTAATTTAACCCTTAACTTGTGCCTAGAAACTACAGCACATATAAAATATGTAAACACCAGCCTGTTGCT
GTACTTTTCTGCTTATTTTACAGCCTCAAATATTTCTCATTATCTTGTCACTTAGTTCTTCATGTTTCTCCTTCTGACTTTTAATAATGG
TAATAGGAAAACAAAACCCAAAGCTTTTCAGAACTTCAGTGTGAGGTTTCCTATTTTGACAAGTTAACTTGTAAATACTCAGGTTTTACG
ATGTATAATTTACCTAATAGACCAAACTAACTCATGGAGATATTTTGAACTATTATTTAGGTACAAACTTTATAAAGAATGTTAGTATGT
CATAAAATATAACATTACAGCTTATTTAAAACCAAATATAGTTGAACATATTTAAAATACATTTTCACAGAATGGATGAATTAGTTGTTT
CTTCAGAGTTACTTATGAACAGTTGAATGCTTTAAAATGTTCTGTCTGTAGGTAACATCTAAAACACAAGTGGGTTTATTTAAATTTTTA
AAATTTGAAATTTTTTATTTGCAAAAAATTGTTTTATGCTTTATTATATCGCAAATGAGTGTCAGATTTTTGAGTACCAATGATCATGCT
TCCATTTTTTTTAGTTTTAAACCACCAAACCAATATTTTTCCTTTAAATTTTAATCTTATAATATAGAAATCTTATGTAAATGAAATTTT
GTCATGTTTCAAATAAAGAGAACTGAAGTAGAAAATAGAAATGCCAGTAAACAACATAATGTTTAATTTACAACTTACATTAGGGGTTTG
GGGGAATGCTAATTATATATTGAGAATATACATTAGAACTCTTCAAAATGGGCTCTTCTAATGAGGTCACTACTGAACAAAATTGTTCCC
TCTTCTGTTAAATAGAATAGGTTTAAATGACTAGTCAAATGAATTATTTTCTTCTTGTTAAATAAATTAAATCTTACTTTCTTTTAATGA
CCAACCTTAGGTAAAACAAAAATATTGTAATCCTAGAAATTATCCTCCAGCTTTCTCACCTGAAAATCTATTGAAGTGATCCCTGGTCAT
CCTAATAATGGGATGAGGGAAGTTTCCAGCAGATTTCAGGCTGTTCTTAAAGTTTTTGTTGGTCATTTTCTCAATAGTACATGAAATCAA
GATGCTTATGAGCATGGAAATGTATTTAAAGTTTTTGCTTGTGTCCTCCTCAGTCAGAATAGAAAAGTAACTGAAATACTTTTACCTTTC
TGTCCTTGATAAAATAGTAAAGAAAACCAAACAAACCCAGGCCTGATGGGAAAAATGATTCCTTTATTCTAGCAACTTACTTTCTGTTGG
TATGGGAAATGTTATTAATTTCTATTACTAAAGTTCATATCACAAAATGATATTTAATAATAACCTTGGGGTAAATCATGAATTTTTTTT
CTACGTGTGAGTATAAAAGACAAAAGTTGAACAGCATGGAATCTCATTGCCAAATTATTAGTGAATGTATAGTTCAGGTATTCTTTGAGA
CACACAGTATCATTAATTTCTGAATTGTATTTCAGTGTTATTTTTTGTTTGTGACCACTAAGCTTCTGTCTTAATACAAAGCTGTTACCT
TCTACAGAATTTAAGTCTGAAGATGTAAAGAGAGAACAGGCCTTGTGTAACAGAAGATACTCTTTTTTATGCTCCTTACTGTGATCACAG
AAAAATTAAAAATCCAAGTGCTCTCTAGATTTGTTGATAAACATTTTATGCTTGCATTTAAACTTGAAATGTATGAGCAGAATGAGACAA
TCAGTTAAATCAGAAATGAGAAGTATTATAATGTAAAGGCCTTGTTTTGCTGTAGCAATAAAATGACCAAGTGCAATGACTTGATTTAAT
AAAATCATATTTTAAAAGTTGCTGCTATGAATATTTTTGGCTATAAAATTTTACCCTGACTTGCTTTCAATAACTGTTACGTAATGCAGT
TGATGTTGTAACCTAACATTCCAAAAAAAAAATTGAGAGGGGGAATCTCAAAATAGTATATACTTCACTAACTTGTTTACAGGTGCTGTA
TTTAAAAGCATGCTTCTCTCTCAAAAAGAAAAATTAAAGGATTTTATTGCCAGTCGTGTCAGTCTTTATTGGTTATTTTTTGTTAACTTT


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FusionGenePPI for PTCHD4_CD2AP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTCHD4CD2APRAB4A, CBL, CD2, CAPZA1, CD2AP, NPHS2, BCAR1, MVB12A, SH3KBP1, NPHS1, NR4A1, NR2C2, HBP1, HOXC11, KHDRBS1, BLNK, TRA, PDCD6IP, ACTC1, CBLB, CTTN, EGFR, SH3GL2, DNM2, TSG101, INPP5D, CAPZB, CBLC, ARHGAP17, CAPZA2, MORF4L1P2, SH3BP1, GRB2, NRAS, VCAM1, ITGA4, LMNA, PTGES3, UBC, GZMB, LOX, ARHGEF10, BRCC3, CCDC6, ELP2, SPAG9, HNRNPR, HUWE1, MTA2, NR3C1, IKBKAP, KIAA0196, KIAA1033, LARP7, NOLC1, NRBP1, RABEP2, TSC22D1, USP34, WDHD1, FRS3, UBE2I, SLC25A41, STAP1, TAS2R7, ASNS, CSTF2, DPH5, GALE, IMPDH2, MSN, NPLOC4, PFDN2, PPA2, PRDX6, SCPEP1, SEC24C, SEC24D, TTC27, UFD1L, ZYX, NIT1, MED4, RPGRIP1L, KIF23, ATP6AP2, RACGAP1, KIF15, NF2, CDH1, TCP10L, ARHGAP44, MRPL12, DACH2, SETX, UBE2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCD2APchr6:47976370chr6:47471016ENST00000359314+0181_1751640ANLN and localization to the midbody


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTCHD4_CD2AP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PTCHD4_CD2AP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCD2APC0002395Alzheimer's Disease2CTD_human