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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 29279

FusionGeneSummary for PTCH1_TPM1

check button Fusion gene summary
Fusion gene informationFusion gene name: PTCH1_TPM1
Fusion gene ID: 29279
HgeneTgene
Gene symbol

PTCH1

TPM1

Gene ID

5727

7168

Gene namepatched 1tropomyosin 1
SynonymsBCNS|NBCCS|PTC|PTC1|PTCHC15orf13|CMD1Y|CMH3|HEL-S-265|HTM-alpha|LVNC9|TMSA
Cytomap

9q22.32

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionprotein patched homolog 1tropomyosin alpha-1 chainalpha-tropomyosincardiomyopathy, hypertrophic 3epididymis secretory protein Li 265sarcomeric tropomyosin kappatropomyosin 1 (alpha)
Modification date2018052320180523
UniProtAcc

Q13635

P09493

Ensembl transtripts involved in fusion geneENST00000331920, ENST00000418258, 
ENST00000421141, ENST00000437951, 
ENST00000430669, ENST00000429896, 
ENST00000375274, ENST00000548379, 
ENST00000468211, 		ENST00000288398, 
ENST00000358278, ENST00000560445, 
ENST00000403994, ENST00000357980, 
ENST00000559556, ENST00000559397, 
ENST00000267996, ENST00000334895, 
ENST00000404484, ENST00000560959, 
ENST00000559281, ENST00000317516, 
Fusion gene scores* DoF score5 X 5 X 3=756 X 6 X 4=144
# samples 57
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PTCH1 [Title/Abstract] AND TPM1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTCH1

GO:0010875

positive regulation of cholesterol efflux

21931618

HgenePTCH1

GO:0072659

protein localization to plasma membrane

11278759


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6B9-01APTCH1chr9

98224138

-TPM1chr15

63349184

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000331920ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000331920ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000331920ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
In-frameENST00000418258ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
In-frameENST00000418258ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000418258ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000421141ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000421141ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000421141ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000437951ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000437951ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000437951ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
In-frameENST00000430669ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
In-frameENST00000430669ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000430669ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000429896ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000429896ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000429896ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000375274ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
Frame-shiftENST00000375274ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
5CDS-intronENST00000375274ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-3CDSENST00000548379ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-3CDSENST00000548379ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000548379ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-3CDSENST00000468211ENST00000288398PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-3CDSENST00000468211ENST00000358278PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000560445PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000403994PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000357980PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000559556PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000559397PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000267996PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000334895PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000404484PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000560959PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000559281PTCH1chr9

98224138

-TPM1chr15

63349184

+
intron-intronENST00000468211ENST00000317516PTCH1chr9

98224138

-TPM1chr15

63349184

+

Top

FusionProtFeatures for PTCH1_TPM1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PTCH1

Q13635

TPM1

P09493


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PTCH1_TPM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_955aa
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL
QSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLS
FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLY
RREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIV
PRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEK
MEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSD

>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_955aa
MFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKL
QSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLS
RKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLS
FTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVG
VDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLY
RREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVT
VTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIV
PRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPN
NYKNGSDDGVLAYKLLVQTGSRDKPIDISQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEK
MEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSD

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_1040aa
MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQ
LMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA
YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMH
WQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT
LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF
LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR
RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDT
LSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR
EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNG
SDDGVLAYKLLVQTGSRDKPIDISQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQE
IQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEA

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_1040aa
MGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQ
LMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTA
YLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMH
WQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTT
LDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVF
LLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDR
RLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDT
LSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETR
EYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNG
SDDGVLAYKLLVQTGSRDKPIDISQAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQE
IQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGQVRQLEEQLRIMDQTLKALMAAEDKYSQKEDRYEEEIKVLSDKLKEA


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_2865nt
ATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCG
GCACTCCAGGCCAGCCGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACA
GAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTA
CAGTCTGGGACAGCATACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATA
AACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGAT
CCAGACTGCCCCGCCACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCC
AGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAG
ACCATGTTCCAGTTAATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAA
GCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCC
TTCACCACCACGACCCTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCC
TATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTG
GCTGCAGGACTGGGCCTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGT
GTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTG
AAGCGCACAGGAGCCAGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGG
GCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATAT
CGACGCGAGGACAGGAGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACC
GACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACT
GTCCAGCTCCGCACGGAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACC
GTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCAC
TGCCTCGAGCCCCCCTGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTA
GTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTA
CCTCGGGAAACCAGAGAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGAC
TACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCC
AAAATGTGGCTGCACTACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAAC
AATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAG
GCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTG
CAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAA
ATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTC
ATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATG
GATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGAC
AAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTG

>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_2865nt
ATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCG
GCACTCCAGGCCAGCCGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACA
GAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTA
CAGTCTGGGACAGCATACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATA
AACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGAT
CCAGACTGCCCCGCCACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCC
AGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAG
ACCATGTTCCAGTTAATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAA
GCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCC
TTCACCACCACGACCCTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCC
TATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTG
GCTGCAGGACTGGGCCTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGT
GTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTG
AAGCGCACAGGAGCCAGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGG
GCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATAT
CGACGCGAGGACAGGAGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACC
GACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACT
GTCCAGCTCCGCACGGAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACC
GTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCAC
TGCCTCGAGCCCCCCTGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTA
GTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTA
CCTCGGGAAACCAGAGAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGAC
TACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCC
AAAATGTGGCTGCACTACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAAC
AATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAG
GCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTG
CAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAA
ATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTC
ATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATG
GATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGAC
AAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGAGAAAGTG

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_3120nt
ATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAA
AACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAG
GAGCTGTGGGTGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAATTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAA
CTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGC
CGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATG
GATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCA
TACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGAC
AGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCC
ACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCAC
TGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTA
ATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTG
GAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACC
CTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACC
ATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGC
CTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTT
CTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCC
AGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAG
GCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGG
AGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAAT
ACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACG
GAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACC
CTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCC
TGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTT
TTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGA
GAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAG
CACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCAC
TACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGA
TCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTA
GCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAA
GCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAG
ATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGAC
CTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAA
GCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCT
GAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTG

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_3120nt
ATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAA
AACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAG
GAGCTGTGGGTGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAATTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAA
CTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGC
CGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATG
GATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCA
TACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGAC
AGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCC
ACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCAC
TGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTA
ATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTG
GAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACC
CTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACC
ATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGC
CTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTT
CTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCC
AGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAG
GCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGG
AGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAAT
ACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACG
GAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACC
CTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCC
TGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTT
TTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGA
GAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAG
CACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCAC
TACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGA
TCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTA
GCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAA
GCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAG
ATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGAC
CTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAA
GCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCT
GAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_3622nt
AATTCAGCTCACACAGCCTCTCCCCACGCTATGGAAATGCGTCGGGAGTGAACTCCGGCGGCCGCGCTCACCACGTGGATCCCCACTTAC
TACCATTCTCGGCGGGGGTCCAGTTGGGGGAACCCGCAATATGTTGTTCCAAAGAGCGCTCGCCCCTAGCGCCCGTCCCCGAGGGTGATG
GACAGAGCAGGACTGGTTTGCTGGCTCCTGAACCTTGGGCTCCATCGCTGGGATTACGCAGCCCCTCCCTTCTCAGCTCTGGGGGGAAGG
CTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCA
AGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGG
TGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAATTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAACTCATGATAC
AGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGCCGTGTCCATG
TATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATGGATCAGATAA
TAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCATACCTCCTAG
GTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGACAGCTGGGAGG
AAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCCACAGCCCCCA
ACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCACTGGCAGGAGG
AGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTAATGACTCCCA
AGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTGGAGGCCTGGC
AGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACCCTGGACGACA
TCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACCATGCTGCGCT
GGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGCCTGTGCTCAT
TGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTTCTTCTGGCCC
ACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCCAGCGTGGCCC
TCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAGGCAGCGGTAG
TAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGGAGACTGGATA
TTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAATACCCGCTACA
GCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACGGAGTACGACC
CCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACCCTCAGCTGCC
AGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCCTGTACGAAGT
GGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTTTTTCTGGGCT
TGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGAGAATATGACT
TTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAGCACTTACTTT
ACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCACTACTTCAGAG
ACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGATCAGACGATG
GAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTAGCTTCTCTGA
ACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGG
CAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGA
AAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTG
CAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGG
CTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGG
CTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGAAGTACAAAG
CCATCAGCGAGGAGCTGGACCACGCTCTCAACGATATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTGCCCTCATGC
TAATATAAGTTTCTTTGCTTCACTTCTCCCAAGACTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGTCTATTCTCC
AGCTGACCCTGGTTCTCTCTCTTAGCATCCTGCCTTAGAGCCAGGCACACACTGTGCTTTCTATTGTACAGAAGCTCTTCGTTTCAGTGT

>In-frame_PTCH1_ENST00000418258_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_4097nt
AATTCAGCTCACACAGCCTCTCCCCACGCTATGGAAATGCGTCGGGAGTGAACTCCGGCGGCCGCGCTCACCACGTGGATCCCCACTTAC
TACCATTCTCGGCGGGGGTCCAGTTGGGGGAACCCGCAATATGTTGTTCCAAAGAGCGCTCGCCCCTAGCGCCCGTCCCCGAGGGTGATG
GACAGAGCAGGACTGGTTTGCTGGCTCCTGAACCTTGGGCTCCATCGCTGGGATTACGCAGCCCCTCCCTTCTCAGCTCTGGGGGGAAGG
CTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGCGAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCA
AGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGCCTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGG
TGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAATTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAACTCATGATAC
AGACCCCTAAAGAAGAAGGTGCTAATGTCCTGACCACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGCCGTGTCCATG
TATACATGTACAACAGGCAGTGGAAATTGGAACATTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATGGATCAGATAA
TAGAATATCTTTACCCTTGTTTGATTATTACACCTTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCATACCTCCTAG
GTAAACCTCCTTTGCGGTGGACAAACTTCGACCCTTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGACAGCTGGGAGG
AAATGCTGAATAAGGCTGAGGTTGGTCATGGTTACATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCCACAGCCCCCA
ACAAAAATTCAACCAAACCTCTTGATATGGCCCTTGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCACTGGCAGGAGG
AGTTGATTGTGGGTGGCACAGTCAAGAACAGCACTGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTAATGACTCCCA
AGCAAATGTACGAGCACTTCAAGGGGTACGAGTATGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTGGAGGCCTGGC
AGAGGACATATGTGGAGGTGGTTCATCAGAGTGTCGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACCCTGGACGACA
TCCTGAAATCCTTCTCTGACGTCAGTGTCATCCGCGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACCATGCTGCGCT
GGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCTGGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGCCTGTGCTCAT
TGATCGGAATTTCCTTTAACGCTGCAACAACTCAGGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTTCTTCTGGCCC
ACGCCTTCAGTGAAACAGGACAGAATAAAAGAATCCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCCAGCGTGGCCC
TCACGTCCATCAGCAATGTCACAGCCTTCTTCATGGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAGGCAGCGGTAG
TAGTGGTGTTCAATTTTGCCATGGTTCTGCTCATTTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGGAGACTGGATA
TTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAGAGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAATACCCGCTACA
GCCCCCCACCTCCCTACAGCAGCCACAGCTTTGCCCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACGGAGTACGACC
CCCACACGCACGTGTACTACACCACCGCTGAGCCGCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACCCTCAGCTGCC
AGAGCCCAGAGAGCACCAGCTCCACAAGGGACCTGCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCCTGTACGAAGT
GGACACTCTCATCTTTTGCTGAGAAGCACTATGCTCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTTTTTCTGGGCT
TGCTGGGGGTCAGCCTTTATGGCACCACCCGAGTGAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGAGAATATGACT
TTATTGCTGCACAATTCAAATACTTTTCTTTCTACAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAGCACTTACTTT
ACGACCTACACAGGAGTTTCAGTAACGTGAAGTATGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCACTACTTCAGAG
ACTGGCTTCAGGGACTTCAGGATGCATTTGACAGTGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGATCAGACGATG
GAGTCCTTGCCTACAAACTCCTGGTGCAAACCGGCAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTAGCTTCTCTGA
ACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGATCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGG
CAGCAGATGAGAGTGAGAGAGGCATGAAAGTCATTGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGA
AAGAGGCCAAGCACATTGCTGAAGATGCCGACCGCAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTG
CAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGTCCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGG
CTGCAGAGGATAAGTACTCGCAGAAGGAAGACAGATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGG
CTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTA
GTATGCATCAGATGCTGGATCAGACTTTACTGGAGTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCGTTTTGTTTT
GTTTTGTTTTTAAACACCTGCTTACCCCTTAAATGCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATACCAGCTAGGT
CAGGGGGTGGGGAAAACACATACAAAAAGGCAAGCCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCAC
ACTTTGTAGAGAGTTTAGCAACACAGTGTGCTTAGTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGTGCCAATGAT
AGAGTCAACAGGAAGGTTAATGTTGGAAACACAATCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTCTTTTGTTCA
ACATTGTACAATGTAGAACTCTGTCCAACACTAATTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAA
TTCACTAAAGCCAAGGGTCTGTAAGCCACGCTGCTCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCATGACAATCTG
TAGGATAACAATCAGTGTGGATTTCCACTCTTTTCAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGGACGTTTTCT

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000288398_chr15_63349184_+_3948nt
CGGCCGCGGGGGGCGGGGAGAGGGTGGCTAGGCTCGCGGGAGCTCGCCGGGCAGGGCGCCTCCCAGGAAGGCGGGGAGGGGAGCGCCTGT
TTACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCG
TCACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATT
GTGAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGA
GGAGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGCAAGGGGGAGACGA
GGGAAGACTGGGAGAAGACGGAGGAGCGGAGGACGAGGAAAGGGGGGCCAGGGAAAAAAAAGGAATTGATGTGAAATCCAAGCCCAGCGT
CCGCGCCATCGGCACCCGCGCTCCGAGCAGGGGTTGACGGCCGGCTATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGC
GAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGC
CTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAA
TTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGAC
CACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGCCGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACA
TTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACC
TTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCATACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCC
TTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTA
CATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCCACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCT
TGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCAC
TGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTAATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTA
TGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGT
CGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACCCTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCG
CGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCT
GGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGCCTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCA
GGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAAT
CCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCCAGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCAT
GGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCAT
TTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGGAGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAG
AGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGC
CCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACGGAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCC
GCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCT
GCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCCTGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGC
TCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGT
GAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGAGAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTA
CAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTA
TGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCACTACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAG
TGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGG
CAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGA
TCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCAT
TGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCG
CAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGT
CCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAG
ATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGA
GAAAAGCATTGATGACTTAGAAGACGAGCTGTACGCTCAGAAACTGAAGTACAAAGCCATCAGCGAGGAGCTGGACCACGCTCTCAACGA
TATGACTTCCATGTAAACGTTCATCCACTCTGCCTGCTTACACCCTGCCCTCATGCTAATATAAGTTTCTTTGCTTCACTTCTCCCAAGA
CTCCCTCGTCGAGCTGGATGTCCCACCTCTCTGAGCTCTGCATTTGTCTATTCTCCAGCTGACCCTGGTTCTCTCTCTTAGCATCCTGCC

>In-frame_PTCH1_ENST00000430669_chr9_98224138_-_TPM1_ENST00000358278_chr15_63349184_+_4423nt
CGGCCGCGGGGGGCGGGGAGAGGGTGGCTAGGCTCGCGGGAGCTCGCCGGGCAGGGCGCCTCCCAGGAAGGCGGGGAGGGGAGCGCCTGT
TTACCCAGGAGGGCTGTGCTGATAGCACGTTCCTCGAGTTTACTTTGCTTTCCTTGAGTTTATTGTAAAGGGGTAAAGTTTTCGGATCCG
TCACGTGACCCTGACAGGTCCTGCCTATGGCGCGGCAGACCACCCACGCCGAGGGCCATGGAACTGCTTAATAGAAACAGGCTTGTAATT
GTGAGTCCGCGCTGCACTCCGCCGAAAGCCTCCGGCGGCCCAGCGCGCCGGGGTTTTTACACTTTCCGTTCCTTTTGTAAAGACGGAGGA
GGAGGAGAAGAAGAAGAAGAAAACGGAGGAGAAGAAAAAGACGACAGGGGAGACAAAGAGACCCGCAGCGACAAGGCAAGGGGGAGACGA
GGGAAGACTGGGAGAAGACGGAGGAGCGGAGGACGAGGAAAGGGGGGCCAGGGAAAAAAAAGGAATTGATGTGAAATCCAAGCCCAGCGT
CCGCGCCATCGGCACCCGCGCTCCGAGCAGGGGTTGACGGCCGGCTATGGGGAAGGCTACTGGCCGGAAAGCGCCGCTGTGGCTGAGAGC
GAAGTTTCAGAGACTCTTATTTAAACTGGGTTGTTACATTCAAAAAAACTGCGGCAAGTTCTTGGTTGTGGGCCTCCTCATATTTGGGGC
CTTCGCGGTGGGATTAAAAGCAGCGAACCTCGAGACCAACGTGGAGGAGCTGTGGGTGGAAGTTGGAGGACGAGTAAGTCGTGAATTAAA
TTATACTCGCCAGAAGATTGGAGAAGAGGCTATGTTTAATCCTCAACTCATGATACAGACCCCTAAAGAAGAAGGTGCTAATGTCCTGAC
CACAGAAGCGCTCCTACAACACCTGGACTCGGCACTCCAGGCCAGCCGTGTCCATGTATACATGTACAACAGGCAGTGGAAATTGGAACA
TTTGTGTTACAAATCAGGAGAGCTTATCACAGAAACAGGTTACATGGATCAGATAATAGAATATCTTTACCCTTGTTTGATTATTACACC
TTTGGACTGCTTCTGGGAAGGGGCGAAATTACAGTCTGGGACAGCATACCTCCTAGGTAAACCTCCTTTGCGGTGGACAAACTTCGACCC
TTTGGAATTCCTGGAAGAGTTAAAGAAAATAAACTATCAAGTGGACAGCTGGGAGGAAATGCTGAATAAGGCTGAGGTTGGTCATGGTTA
CATGGACCGCCCCTGCCTCAATCCGGCCGATCCAGACTGCCCCGCCACAGCCCCCAACAAAAATTCAACCAAACCTCTTGATATGGCCCT
TGTTTTGAATGGTGGATGTCATGGCTTATCCAGAAAGTATATGCACTGGCAGGAGGAGTTGATTGTGGGTGGCACAGTCAAGAACAGCAC
TGGAAAACTCGTCAGCGCCCATGCCCTGCAGACCATGTTCCAGTTAATGACTCCCAAGCAAATGTACGAGCACTTCAAGGGGTACGAGTA
TGTCTCACACATCAACTGGAACGAGGACAAAGCGGCAGCCATCCTGGAGGCCTGGCAGAGGACATATGTGGAGGTGGTTCATCAGAGTGT
CGCACAGAACTCCACTCAAAAGGTGCTTTCCTTCACCACCACGACCCTGGACGACATCCTGAAATCCTTCTCTGACGTCAGTGTCATCCG
CGTGGCCAGCGGCTACTTACTCATGCTCGCCTATGCCTGTCTAACCATGCTGCGCTGGGACTGCTCCAAGTCCCAGGGTGCCGTGGGGCT
GGCTGGCGTCCTGCTGGTTGCACTGTCAGTGGCTGCAGGACTGGGCCTGTGCTCATTGATCGGAATTTCCTTTAACGCTGCAACAACTCA
GGTTTTGCCATTTCTCGCTCTTGGTGTTGGTGTGGATGATGTTTTTCTTCTGGCCCACGCCTTCAGTGAAACAGGACAGAATAAAAGAAT
CCCTTTTGAGGACAGGACCGGGGAGTGCCTGAAGCGCACAGGAGCCAGCGTGGCCCTCACGTCCATCAGCAATGTCACAGCCTTCTTCAT
GGCCGCGTTAATCCCAATTCCCGCTCTGCGGGCGTTCTCCCTCCAGGCAGCGGTAGTAGTGGTGTTCAATTTTGCCATGGTTCTGCTCAT
TTTTCCTGCAATTCTCAGCATGGATTTATATCGACGCGAGGACAGGAGACTGGATATTTTCTGCTGTTTTACAAGCCCCTGCGTCAGCAG
AGTGATTCAGGTTGAACCTCAGGCCTACACCGACACACACGACAATACCCGCTACAGCCCCCCACCTCCCTACAGCAGCCACAGCTTTGC
CCATGAAACGCAGATTACCATGCAGTCCACTGTCCAGCTCCGCACGGAGTACGACCCCCACACGCACGTGTACTACACCACCGCTGAGCC
GCGCTCCGAGATCTCTGTGCAGCCCGTCACCGTGACACAGGACACCCTCAGCTGCCAGAGCCCAGAGAGCACCAGCTCCACAAGGGACCT
GCTCTCCCAGTTCTCCGACTCCAGCCTCCACTGCCTCGAGCCCCCCTGTACGAAGTGGACACTCTCATCTTTTGCTGAGAAGCACTATGC
TCCTTTCCTCTTGAAACCAAAAGCCAAGGTAGTGGTGATCTTCCTTTTTCTGGGCTTGCTGGGGGTCAGCCTTTATGGCACCACCCGAGT
GAGAGACGGGCTGGACCTTACGGACATTGTACCTCGGGAAACCAGAGAATATGACTTTATTGCTGCACAATTCAAATACTTTTCTTTCTA
CAACATGTATATAGTCACCCAGAAAGCAGACTACCCGAATATCCAGCACTTACTTTACGACCTACACAGGAGTTTCAGTAACGTGAAGTA
TGTCATGTTGGAAGAAAACAAACAGCTTCCCAAAATGTGGCTGCACTACTTCAGAGACTGGCTTCAGGGACTTCAGGATGCATTTGACAG
TGACTGGGAAACCGGGAAAATCATGCCAAACAATTACAAGAATGGATCAGACGATGGAGTCCTTGCCTACAAACTCCTGGTGCAAACCGG
CAGCCGCGATAAGCCCATCGACATCAGCCAGGCTGAAGCCGACGTAGCTTCTCTGAACAGACGCATCCAGCTGGTTGAGGAAGAGTTGGA
TCGTGCCCAGGAGCGTCTGGCAACAGCTTTGCAGAAGCTGGAGGAAGCTGAGAAGGCAGCAGATGAGAGTGAGAGAGGCATGAAAGTCAT
TGAGAGTCGAGCCCAAAAAGATGAAGAAAAAATGGAAATTCAGGAGATCCAACTGAAAGAGGCCAAGCACATTGCTGAAGATGCCGACCG
CAAATATGAAGAGGTGGCCCGTAAGCTGGTCATCATTGAGAGCGACCTGGAACGTGCAGAGGAGCGGGCTGAGCTCTCAGAAGGCCAAGT
CCGACAGCTGGAAGAACAATTAAGAATAATGGATCAGACCTTGAAAGCATTAATGGCTGCAGAGGATAAGTACTCGCAGAAGGAAGACAG
ATATGAGGAAGAGATCAAGGTCCTTTCCGACAAGCTGAAGGAGGCTGAGACTCGGGCTGAGTTTGCGGAGAGGTCAGTAACTAAATTGGA
GAAAAGCATTGATGACTTAGAAGAGAAAGTGGCTCATGCCAAAGAAGAAAACCTTAGTATGCATCAGATGCTGGATCAGACTTTACTGGA
GTTAAACAACATGTGAAAACCTCCTTAGCTGCGACCACATTCTTTCGTTTTGTTTTGTTTTGTTTTTAAACACCTGCTTACCCCTTAAAT
GCAATTTATTTACTTTTACCACTGTCACAGAAACATCCACAAGATACCAGCTAGGTCAGGGGGTGGGGAAAACACATACAAAAAGGCAAG
CCCATGTCAGGGCGATCCTGGTTCAAATGTGCCATTTCCCGGGTTGATGCTGCCACACTTTGTAGAGAGTTTAGCAACACAGTGTGCTTA
GTCAGCGTAGGAATCCTCACTAAAGCAGAAGAAGTTCCATTCAAAGTGCCAATGATAGAGTCAACAGGAAGGTTAATGTTGGAAACACAA
TCAGGTGTGGATTGGTGCTACTTTGAACAAAAGGTCCCCCTGTGGTCTTTTGTTCAACATTGTACAATGTAGAACTCTGTCCAACACTAA
TTTATTTTGTCTTGAGTTTTACTACAAGATGAGACTATGGATCCCGCATGCCTGAATTCACTAAAGCCAAGGGTCTGTAAGCCACGCTGC
TCTTCCGAGACTTCCATTCCTTTCTGATTGGCACACGTGCAGCTCATGACAATCTGTAGGATAACAATCAGTGTGGATTTCCACTCTTTT
CAGTCCTTCATGTTAAAGATTTAGACACCACATACAACTGGTAAAGGACGTTTTCTTGAGAGTTTTAACTATATGTAAACATTGTATAAT


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FusionGenePPI for PTCH1_TPM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PTCH1SMO, CAV1, ITCH, WWP2, NEDD4, NEDD4L, SMURF1, SMURF2, WWP1, CASP9, FHL2, CNTNAP3, B4GALT7, CACNA2D2, IMPAD1, SEMA6A, PLXNA1, TMEM132A, PAM, HLA-C, HLA-A, HSPA5, TMEM160, PLXNB2, NDST2, TPST2, CNNM4, CNNM1, POMGNT2, CHST14, SPPL2B, EXT1, ADAM17, ENPP1, DDX19B, TTC17, MUCL1, COCH, ASPH, TMEM131, EGFR, MOXD1, UGT8, ITGA7, HS6ST2, SLIT2, POMT2, B4GALT1, SULF2, ATF6B, CHST12, MAN2A1, ARSK, ITGA6, NETO2, CCPG1, ST3GAL6, CHSY1, CACNA2D1, UGT3A2, MGAT5, B4GALT3, PXYLP1, GCNT1, COL18A1, DHFRL1, TXNDC15, SEMA4F, B3GALTL, FUT11, TOR1AIP1, ABCA2, ST8SIA4, RNF130, ITGA8, ST3GAL4, ST6GALNAC3, ITGA4, CHPF, ENDOG, TMEM2, LRFN3, GALNT7, TGFBR3, MGAT1, PDF, KIAA1161, YAP1, GALNT18, CHST3, BTN2A1, NPTX1, ITGAV, ABHD14A, CCNB1TPM1KXD1, TNNT1, CNN1, TPM1, TNNT2, TPM2, EGFR, YWHAQ, ELAVL1, SP1, ERG, MYOC, LRRK2, ACTC1, ACTA2, TPM4, SRXN1, RBM15, ZYX, TPM3, DBN1, NUDCD2, SF3B2, SULT1A1, SF3B1, THOC1, THOC2, SORD, PPP4R2, AHCYL1, SEC23A, CNN2, RPS3, BRCA1, MDC1, ATF2, SPTBN1, TGFBR1, PAN2, LRCH3, PARK2, ABI2, APPL2, CDC37, ETFA, FOXK1, HSP90B1, KIAA1598, MGEA5, PPP6R3, STUB1, DNAJC7, TP53, GOLGA2, MAD1L1, TFPT, SYCE1, C1orf216, CAGE1, TSSC4, GOLGA3, CROCC, EXOC4, IKBKG, KLHL21, CCDC102A, CNTLN, RUFY2, HOMER1, JUND, DLG5, ENDOG, SCLT1, NEB, ACTN1, CKB, COX5A, MYH4, MYH6, ACTN2, ACTN4, ATP5F1, COX4I1, MYH1, MYH2, MYH7B, MYH8, NDUFB10, TNNI1, CAPZA2, CDK2, FLNA, MYH9, PPP1CB, IQGAP1, PDLIM7, SYNPO, ANLN, MYO19, MYO18A, CFAP97, C10orf2, RBPJ, ZNF746, SPAG9, COX15, DLD, DLST, DNM1L, PARK7, SOAT1, VDAC1, G3BP1, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PTCH1_TPM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneTPM1P09493DB11638ArtenimolTropomyosin alpha-1 chainsmall moleculeapproved|investigational

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RelatedDiseases for PTCH1_TPM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePTCH1C0004779Basal Cell Nevus Syndrome13CTD_human;ORPHANET;UNIPROT
HgenePTCH1C0007117Basal cell carcinoma3CTD_human;HPO
HgenePTCH1C0025149Medulloblastoma3CTD_human;HPO
HgenePTCH1C1835820HOLOPROSENCEPHALY 73CTD_human;UNIPROT
HgenePTCH1C0376634Craniofacial Abnormalities2CTD_human
HgenePTCH1C0006118Brain Neoplasms1CTD_human
HgenePTCH1C0008924Cleft Lip1CTD_human;HPO
HgenePTCH1C0008925Cleft Palate1CTD_human;HPO
HgenePTCH1C0019693HIV Infections1CTD_human
HgenePTCH1C0030297Pancreatic Neoplasm1CTD_human
HgenePTCH1C0035412Rhabdomyosarcoma1CTD_human
HgenePTCH1C0037286Skin Neoplasms1CTD_human
HgenePTCH1C0206663Neuroectodermal Tumor, Primitive1CTD_human
TgeneTPM1C1861863CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 3 (disorder)5CTD_human;UNIPROT
TgeneTPM1C2678476Cardiomyopathy, Dilated, 1y2CTD_human;UNIPROT
TgeneTPM1C0014859Esophageal Neoplasms1CTD_human
TgeneTPM1C0020538Hypertensive disease1CTD_human
TgeneTPM1C0022548Keloid1CTD_human
TgeneTPM1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneTPM1C0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneTPM1C0949658Cardiomyopathy, Hypertrophic, Familial1CTD_human