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Fusion gene ID: 29234 |
FusionGeneSummary for PSMG2_SETMAR |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSMG2_SETMAR | Fusion gene ID: 29234 | Hgene | Tgene | Gene symbol | PSMG2 | SETMAR | Gene ID | 56984 | 6419 |
| Gene name | proteasome assembly chaperone 2 | SET domain and mariner transposase fusion gene | |
| Synonyms | CLAST3|HCCA3|HsT1707|MDS003|PAC2|TNFSF5IP1 | METNASE|Mar1 | |
| Cytomap | 18p11.21 | 3p26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome assembly chaperone 2CD40 ligand-activated specific transcript 3HDCMC29PHSPC260PAC-2hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-susceptibility protein 3likely ortholog of mouse CD40 ligand-activated specific tr | histone-lysine N-methyltransferase SETMARSET domain and mariner transposase fusion gene-containing proteinSET domain and mariner transposase fusion protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q969U7 | Q53H47 | |
| Ensembl transtripts involved in fusion gene | ENST00000585331, ENST00000317615, ENST00000590217, ENST00000589405, | ENST00000358065, ENST00000430981, ENST00000425863, ENST00000462115, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: PSMG2 [Title/Abstract] AND SETMAR [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PSMG2 | GO:0043248 | proteasome assembly | 16251969 |
| Tgene | SETMAR | GO:0000729 | DNA double-strand break processing | 21491884 |
| Tgene | SETMAR | GO:0000737 | DNA catabolic process, endonucleolytic | 20521842|21491884 |
| Tgene | SETMAR | GO:0006303 | double-strand break repair via nonhomologous end joining | 16332963 |
| Tgene | SETMAR | GO:0010452 | histone H3-K36 methylation | 16332963 |
| Tgene | SETMAR | GO:0051568 | histone H3-K4 methylation | 16332963 |
| Tgene | SETMAR | GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | 18790802 |
| Tgene | SETMAR | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining | 20620605|21491884 |
| Tgene | SETMAR | GO:2001251 | negative regulation of chromosome organization | 20620605 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-ZG-A9L2-01A | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000585331 | ENST00000358065 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000585331 | ENST00000430981 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000585331 | ENST00000425863 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000585331 | ENST00000462115 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000317615 | ENST00000358065 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000317615 | ENST00000430981 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000317615 | ENST00000425863 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000317615 | ENST00000462115 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000590217 | ENST00000358065 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| In-frame | ENST00000590217 | ENST00000430981 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| Frame-shift | ENST00000590217 | ENST00000425863 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| 5CDS-3UTR | ENST00000590217 | ENST00000462115 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000589405 | ENST00000358065 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000589405 | ENST00000430981 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| intron-3CDS | ENST00000589405 | ENST00000425863 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
| intron-3UTR | ENST00000589405 | ENST00000462115 | PSMG2 | chr18 | 12706720 | + | SETMAR | chr3 | 4354582 | + |
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FusionProtFeatures for PSMG2_SETMAR |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSMG2 | SETMAR |
| Chaperone protein which promotes assembly of the 20Sproteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2heterodimer binds to the PSMA5 and PSMA7 proteasome subunits,promotes assembly of the proteasome alpha subunits into theheteroheptameric alpha ring and prevents alpha ring dimerization.{ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}. | Protein derived from the fusion of a methylase with thetransposase of an Hsmar1 transposon that plays a role in DNAdouble-strand break repair, stalled replication fork restart andDNA integration. DNA-binding protein, it is indirectly recruitedto sites of DNA damage through protein-protein interactions. Hasalso kept a sequence-specific DNA-binding activity recognizing the19-mer core of the 5'-terminal inverted repeats (TIRs) of theHsmar1 element and displays a DNA nicking and end joining activity(PubMed:16332963, PubMed:16672366, PubMed:17877369,PubMed:17403897, PubMed:18263876, PubMed:22231448,PubMed:24573677, PubMed:20521842). In parallel, has a histonemethyltransferase activity and methylates 'Lys-4' and 'Lys-36' ofhistone H3. Specifically mediates dimethylation of H3 'Lys-36' atsites of DNA double-strand break and may recruit proteins requiredfor efficient DSB repair through non-homologous end-joining(PubMed:16332963, PubMed:21187428, PubMed:22231448). Alsoregulates replication fork processing, promoting replication forkrestart and regulating DNA decatenation through stimulation of thetopoisomerase activity of TOP2A (PubMed:18790802,PubMed:20457750). {ECO:0000269|PubMed:16332963,ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897,ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802,ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842,ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448,ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSMG2_SETMAR |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PSMG2_ENST00000585331_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_359aa MDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVHSXSCSWTWSRHXSHSNNLSRMHLCQNSLPPWHLLLSPPWRELX XXLMPXRYRIWRKVCRACFXMQCPVPMQXPLQKQSGPERSTVPLPSVQDAXKRLGTSYLGIYTERKVCLXICWXGFRILXSSEKNSLTNK IRLQLHYSHQGTCLXWAGNGNICXPYLYRKYWKIPXSFLXAKPFDDSCPNXLNGTXVGTFCSQRYCARRRTLLXLFRKISXSNSQXRQRK >In-frame_PSMG2_ENST00000317615_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_390aa MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVHSXSCSWTWSRHX SHSNNLSRMHLCQNSLPPWHLLLSPPWRELXXXLMPXRYRIWRKVCRACFXMQCPVPMQXPLQKQSGPERSTVPLPSVQDAXKRLGTSYL GIYTERKVCLXICWXGFRILXSSEKNSLTNKIRLQLHYSHQGTCLXWAGNGNICXPYLYRKYWKIPXSFLXAKPFDDSCPNXLNGTXVGT FCSQRYCARRRTLLXLFRKISXSNSQXRQRKARSWETKETLLLWCQIMYCFPAFXQFSVLPRRKVEHQLWKXEGTQHVWLSPFCVPLLQA >In-frame_PSMG2_ENST00000590217_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_390aa MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVHSXSCSWTWSRHX SHSNNLSRMHLCQNSLPPWHLLLSPPWRELXXXLMPXRYRIWRKVCRACFXMQCPVPMQXPLQKQSGPERSTVPLPSVQDAXKRLGTSYL GIYTERKVCLXICWXGFRILXSSEKNSLTNKIRLQLHYSHQGTCLXWAGNGNICXPYLYRKYWKIPXSFLXAKPFDDSCPNXLNGTXVGT FCSQRYCARRRTLLXLFRKISXSNSQXRQRKARSWETKETLLLWCQIMYCFPAFXQFSVLPRRKVEHQLWKXEGTQHVWLSPFCVPLLQA |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PSMG2_ENST00000585331_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_1078nt ATGGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATAT GCGACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCC CACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGA TGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCA CTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGA ATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAA ATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAA TATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTT TGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAG GCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCC CGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATT >In-frame_PSMG2_ENST00000317615_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_1171nt ATGTTCGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGCCGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTT GCAATGGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCA TATGCGACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGA TCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTA TGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGA CCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTT GGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAAC AAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGG AAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACT TTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGA AAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTG CCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCG ATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTA >In-frame_PSMG2_ENST00000590217_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_1171nt ATGTTCGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGCCGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTT GCAATGGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCA TATGCGACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGA TCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTA TGATGATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGA CCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTT GGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAAC AAAATCCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGG AAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACT TTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGA AAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTG CCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCG ATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PSMG2_ENST00000585331_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_1713nt TGGTTGAATACCTCCCTCTCCACTCCCATCTTCAGGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCT ACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAAT TCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCC CGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAG AGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGT CCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAG GTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACAT TATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAA TCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGT GCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACT AAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACAT CAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCT GTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGG AATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAG AATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATC CTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCC TGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCT GACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAAT AATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAACCAATTTTAACAGTAATAAAGCTGACTTTTTGATTTCTGTC >In-frame_PSMG2_ENST00000317615_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_2416nt GGCAGGAGGGAAAGGTTATGGGTCGGCCCGGCGGTCTCTCCCAGCACCCGCGACTCTCACCTTGCTCAGCTGCTGGTGGATGAGCTGCTT CAGCTCGGAGGCTTTCTCCGGAGGCAGCGACATGCTGGCAGCCGGCGTCTCCCCGCCGCTTCTCCCCGCCTCAGATGCCCTAACTGCGCG GCCCCGGCCGGGCCAGGGAGCGTTAGGAGCGACTGGAGCACAAAGCGCCGCAGCCGTTCGCCTAGCGCAGCTCCCGGGGGACGCAACGCC GCGTCAGGCCGGGGGCTGACCTGGAAATGAGGCCCCGGCGGCGGCGGCGCCAACTGTTTTCAAACAGTGGCGGACAAACAGGGCTTGGGG CTGGCCCGCACGCTGCCTGATCGTTTCCGCCCGCCGCTCCACCTCCCCGCGGGCCCCGCACCCCGAGACCTCAGCGCACCCCATCGCCTT GCTTGCCAGGGTCTCCGAAAGCGCTGCTGGCCCCTCTTCGCGGCCACCCGGCGGCCTCTTTCCGCCCTCTGAACCGGCAGTTAGCTGGAC GGGCCTCAAGGGCCCGGCGCCCAGGGACTCAAAGGACCCTCCCGCGCCCCGCGAGGCTCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCC CTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTTCGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGC CGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAATGGATCTGATTATTTCTACACTGAATATGTCTAA GATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGCGACCACAGAAGGAAATTCAACAGAACTTAGCAT AAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCACTCAAATAACCTTTCCCGGATGCATTTGTGTCA AAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATGATAACTCATGCCTTAGAGATATAGGATCTGGAG GAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACTGCAGAAACAGAGTGGTCCAGAAAGGTCTACAGT TCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAATTTATACCGAAAGGAAGGTTTGTCTGTGAATATG CTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAATCCGACTCCAATTACATTATAGCCATCAGGGAAC ATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATATTGGAAGATTCCTTAATCATTCTTGTGAGCCAA ACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTGCAGCCAAAGATATTGTGCCAGAAGAAGAACTCT CTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGCTAGATCATGGGAAACTAAGGAAACCTTGTTACT GTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCGTAGAAAAGTCGAACATCAGTTGTGGAAATGAGA AGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGACCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGC TTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTACATAAGTTTAACTCAGGAATGTGGCAGAGACTGC AAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAAGTACATGACTACCCAGAATACTCACTTTCCTAG TTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTCCTTAAATGGAGATATCCTGCCCTTCACCTCCTC TTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTAGACCCCAGGATGACCCTGGGAAAGGAAGCCATT GCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATCCTGTCAGTCGTGATCTGACACCTTTGTACTTTC AGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCACTAACATCGAACCTAATAATGATCCAAGAAACCC >In-frame_PSMG2_ENST00000590217_chr18_12706720_+_SETMAR_ENST00000430981_chr3_4354582_+_1819nt TCCGGGGTCTCGGGCTTCCGCCTTCTTGCTGCCCTCGTTCTTGCCAGGGCCGCGGTTAGTCCCTGCTGGCCACCCCACTGCGACCATGTT CGTTCCCTGCGGGGAGTCGGCCCCCGACCTTGCCGGCTTCACCCTCCTAATGCCAGCAGTATCTGTTGGAAATGTTGGCCAGCTTGCAAT GGATCTGATTATTTCTACACTGAATATGTCTAAGATTGGTTACTTCTATACCGATTGTCTTGTGCCAATGGTTGGAAACAATCCATATGC GACCACAGAAGGAAATTCAACAGAACTTAGCATAAATGCTGAAGTACACTCCTGATCATGTAGTTGGACCTGGAGCAGACATTGATCCCA CTCAAATAACCTTTCCCGGATGCATTTGTGTCAAAACTCCCTGCCTCCCTGGCACTTGCTCCTGTCTCCGCCATGGAGAGAACTATGATG ATAACTCATGCCTTAGAGATATAGGATCTGGAGGAAAGTATGCAGAGCCTGTTTTTGAATGCAATGTCCTGTGCCGATGCAGTGACCACT GCAGAAACAGAGTGGTCCAGAAAGGTCTACAGTTCCACTTCCAAGTGTTCAAGACGCATAAAAAAGGCTGGGGACTTCGTACCTTGGAAT TTATACCGAAAGGAAGGTTTGTCTGTGAATATGCTGGTGAGGTTTTAGGATTCTCTGAAGTTCAGAGAAGAATTCACTTACAAACAAAAT CCGACTCCAATTACATTATAGCCATCAGGGAACATGTTTATAATGGGCAGGTAATGGAAACATTTGTTGACCCTACTTATATAGGAAATA TTGGAAGATTCCTTAATCATTCTTGTGAGCCAAACCTTTTGATGATTCCTGTCCGAATTGACTCAATGGTACCTAAGTTGGCACTTTTTG CAGCCAAAGATATTGTGCCAGAAGAAGAACTCTCTTATGATTATTCAGGAAGATATCTTAATCTAACAGTCAGTGAAGACAAAGAAAGGC TAGATCATGGGAAACTAAGGAAACCTTGTTACTGTGGTGCCAAATCATGTACTGCTTTCCTGCCTTTTGACAGTTCTCTGTACTGCCCCG TAGAAAAGTCGAACATCAGTTGTGGAAATGAGAAGGAACCCAGCATGTGTGGCTCAGCCCCTTCTGTGTTCCCCTCCTGCAAGCGATTGA CCCTTGAGGTGAGTCTGTTCAGTGATAAGCAGCTTGCCCCTCCCTATAGTGGAAGACAGTGGTTGGCTAGCTTTACCTCTGCCTAGTTAC ATAAGTTTAACTCAGGAATGTGGCAGAGACTGCAAGTTGTCCATCAGTATCCTTTCCCCTTTCTGTAATAGAATTCTCCATTTAACAAAA GTACATGACTACCCAGAATACTCACTTTCCTAGTTAGATTTGTCTTAGTGACTGTTCTAGTTAATAGGATATAAGCAAAAATGACAAGTC CTTAAATGGAGATATCCTGCCCTTCACCTCCTCTTTCTTCCTGCTGGCTGGAATGTATACATGATGACTGGAACTGGAGCAGTCATCCTA GACCCCAGGATGACCCTGGGAAAGGAAGCCATTGCATAGAAAAATCAACAAGGTTAAAAGGAGTCTAGGTGTCTGGTACTGTAGAACATC CTGTCAGTCGTGATCTGACACCTTTGTACTTTCAGGTGAGAAATAGTCTCTCCCTTGCTTAAGTCACTGTTATTGTAAGTTTTCTAGCAC TAACATCGAACCTAATAATGATCCAAGAAACCCTTGTGGCTGCATACCTAAACCCTGCTTGCCAACCAATTTTAACAGTAATAAAGCTGA |
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FusionGenePPI for PSMG2_SETMAR |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PSMG2 | SLC35F6, PSMA2, PSMA4, POMP, PSMG1, THOP1, FN1, PSMA6, PSMG3, SHFM1, KRT31, TCF4, NOTCH2NL, PSMA1, PSMB4, FBXO7, PSMB7, PSMA5, PSMG4, PSMF1, PSMB9, WDR83, FOXR2, CA10, C16orf70, FARSA, PAFAH1B2, PSMD13, CCDC22, PSMA3, PSMB3, PSMB5, PSMB6, PSMC3, PSMC5, PSMD7, WARS, PSMB2, PSMB1, NRIP3, SPATA8, XAGE3, SOST, A1CF, LINGO1, PSME1 | SETMAR | SETMAR, TOP2A, XRCC4, PCNA, RAD9A, PRPF19, H3F3C, CHEK1, CCDC94, IKZF3, LEO1, DOC2A, HSPA8, SETX, PCBP1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSMG2_SETMAR |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMG2_SETMAR |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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