FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29223

FusionGeneSummary for PSME3_PSME3

check button Fusion gene summary
Fusion gene informationFusion gene name: PSME3_PSME3
Fusion gene ID: 29223
HgeneTgene
Gene symbol

PSME3

PSME3

Gene ID

10197

10197

Gene nameproteasome activator subunit 3proteasome activator subunit 3
SynonymsHEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMAHEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionproteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein Lproteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein L
Modification date2018052320180523
UniProtAcc

P61289

P61289

Ensembl transtripts involved in fusion geneENST00000545225, ENST00000590720, 
ENST00000541124, ENST00000592578, 
ENST00000441946, ENST00000293362, 
ENST00000592169, 		ENST00000545225, 
ENST00000590720, ENST00000541124, 
ENST00000592578, ENST00000441946, 
ENST00000293362, ENST00000592169, 
Fusion gene scores* DoF score5 X 4 X 3=603 X 3 X 2=18
# samples 64
** MAII scorelog2(6/60*10)=0log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSME3 [Title/Abstract] AND PSME3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePSME3

GO:0061136

regulation of proteasomal protein catabolic process

18309296

HgenePSME3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

18309296

TgenePSME3

GO:0061136

regulation of proteasomal protein catabolic process

18309296

TgenePSME3

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

18309296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM971211PSME3chr17

40995206

-PSME3chr17

40995091

+
ChiTaRS3.1BU678578PSME3chr17

40995206

-PSME3chr17

40995091

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000545225ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000545225ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000545225ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000545225ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000545225ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000545225ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000545225ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000590720ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000590720ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000590720ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000590720ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000590720ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000590720ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000590720ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000541124ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000541124ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000541124ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000541124ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000541124ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000541124ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000541124ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592578ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592578ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592578ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592578ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592578ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592578ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592578ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000441946ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000441946ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000441946ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000441946ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000441946ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000441946ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000441946ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000293362ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000293362ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000293362ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000293362ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000293362ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-3UTRENST00000293362ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
3UTR-intronENST00000293362ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592169ENST00000545225PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592169ENST00000590720PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592169ENST00000541124PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592169ENST00000592578PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592169ENST00000441946PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-3UTRENST00000592169ENST00000293362PSME3chr17

40995206

-PSME3chr17

40995091

+
intron-intronENST00000592169ENST00000592169PSME3chr17

40995206

-PSME3chr17

40995091

+

Top

FusionProtFeatures for PSME3_PSME3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSME3

P61289

PSME3

P61289

Subunit of the 11S REG-gamma (also called PA28-gamma)proteasome regulator, a doughnut-shaped homoheptamer whichassociates with the proteasome. 11S REG-gamma activates thetrypsin-like catalytic subunit of the proteasome but inhibits thechymotrypsin-like and postglutamyl-preferring (PGPH) subunits.Facilitates the MDM2-p53/TP53 interaction which promotesubiquitination- and MDM2-dependent proteasomal degradation ofp53/TP53, limiting its accumulation and resulting in inhibitedapoptosis after DNA damage. May also be involved in cell cycleregulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). {ECO:0000269|PubMed:10835274,ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824,ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296,ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. Subunit of the 11S REG-gamma (also called PA28-gamma)proteasome regulator, a doughnut-shaped homoheptamer whichassociates with the proteasome. 11S REG-gamma activates thetrypsin-like catalytic subunit of the proteasome but inhibits thechymotrypsin-like and postglutamyl-preferring (PGPH) subunits.Facilitates the MDM2-p53/TP53 interaction which promotesubiquitination- and MDM2-dependent proteasomal degradation ofp53/TP53, limiting its accumulation and resulting in inhibitedapoptosis after DNA damage. May also be involved in cell cycleregulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). {ECO:0000269|PubMed:10835274,ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824,ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296,ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PSME3_PSME3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PSME3_PSME3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PSME3_PSME3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PSME3_PSME3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSME3C0019693HIV Infections1CTD_human
TgenePSME3C0019693HIV Infections1CTD_human