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Fusion gene ID: 29221 |
FusionGeneSummary for PSME3_GPR37L1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PSME3_GPR37L1 | Fusion gene ID: 29221 | Hgene | Tgene | Gene symbol | PSME3 | GPR37L1 | Gene ID | 10197 | 9283 |
| Gene name | proteasome activator subunit 3 | G protein-coupled receptor 37 like 1 | |
| Synonyms | HEL-S-283|Ki|PA28-gamma|PA28G|PA28gamma|REG-GAMMA | ET(B)R-LP-2|ETBR-LP-2|ETBRLP2 | |
| Cytomap | 17q21.31 | 1q32.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proteasome activator complex subunit 311S regulator complex gamma subunit11S regulator complex subunit gammaKi antigenKi nuclear autoantigenPA28 gamma variant 5REG gamma-3activator of multicatalytic protease subunit 3epididymis secretory protein L | prosaposin receptor GPR37L1endothelin B receptor-like protein 2endothelin type b receptor-like protein 2 | |
| Modification date | 20180523 | 20180520 | |
| UniProtAcc | P61289 | O60883 | |
| Ensembl transtripts involved in fusion gene | ENST00000545225, ENST00000590720, ENST00000541124, ENST00000592578, ENST00000441946, ENST00000293362, ENST00000592169, | ENST00000367282, | |
| Fusion gene scores | * DoF score | 5 X 4 X 3=60 | 8 X 2 X 6=96 |
| # samples | 6 | 9 | |
| ** MAII score | log2(6/60*10)=0 | log2(9/96*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PSME3 [Title/Abstract] AND GPR37L1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PSME3 | GO:0061136 | regulation of proteasomal protein catabolic process | 18309296 |
| Hgene | PSME3 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 18309296 |
| Tgene | GPR37L1 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway | 23690594 |
| Tgene | GPR37L1 | GO:0043410 | positive regulation of MAPK cascade | 23690594 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A1B1-01A | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000545225 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| Frame-shift | ENST00000590720 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| 3UTR-3CDS | ENST00000541124 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| intron-3CDS | ENST00000592578 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| Frame-shift | ENST00000441946 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| Frame-shift | ENST00000293362 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
| Frame-shift | ENST00000592169 | ENST00000367282 | PSME3 | chr17 | 40991397 | + | GPR37L1 | chr1 | 202096869 | + |
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FusionProtFeatures for PSME3_GPR37L1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PSME3 | GPR37L1 |
| Subunit of the 11S REG-gamma (also called PA28-gamma)proteasome regulator, a doughnut-shaped homoheptamer whichassociates with the proteasome. 11S REG-gamma activates thetrypsin-like catalytic subunit of the proteasome but inhibits thechymotrypsin-like and postglutamyl-preferring (PGPH) subunits.Facilitates the MDM2-p53/TP53 interaction which promotesubiquitination- and MDM2-dependent proteasomal degradation ofp53/TP53, limiting its accumulation and resulting in inhibitedapoptosis after DNA damage. May also be involved in cell cycleregulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition(PubMed:25361978). {ECO:0000269|PubMed:10835274,ECO:0000269|PubMed:11185562, ECO:0000269|PubMed:11432824,ECO:0000269|PubMed:15111123, ECO:0000269|PubMed:18309296,ECO:0000269|PubMed:25361978, ECO:0000269|PubMed:9325261}. | Receptor for the neuroprotective and glioprotectivefactor prosaposin. Ligand binding induces endocytosis, followed byan ERK phosphorylation cascade. {ECO:0000269|PubMed:23690594}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSME3_GPR37L1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSME3_GPR37L1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PSME3 | FXR2, WDR25, ZCCHC10, KANSL1, NUDT18, BBS2, SERF2, PSME3, ITPKB, MCC, RNPS1, ATP5B, ADAP1, HSPA5, MDM2, TP53, CDKN1A, CDKN2A, BAP1, TAF1D, USP43, WDR48, SLX1B, UBC, SMURF1, NCOA3, DTNBP1, TBXA2R, PML, CHEK2, PARD3, AICDA, PSMD4, ATN1, COIL, PSMA1, PSMA7, PSMB1, PSMB4, PSMA5, PSMB3, PSMA4, PSMA6, PSMB2, PSMD11, PSMC5, PSMD1, PSMD2, PSMD8, PSMC2, PSMD12, PSMA8, MYH9, VCAM1, ITGA4, CBX2, CBX4, PARK2, NPM1, BAG3, CLK3, CLK2, YWHAQ, C1QBP, ADARB2, GTPBP4, SHFM1, PSMD14, CREBBP, SIRT1, PRKAB2, TUBGCP3, HUWE1, PFDN5, SPG7, DIP2A, FBXO7, TXN2, PRR13, EAF1, TNFAIP8L1, MOV10, NXF1, CAMTA2, FAM192A, TSHZ3, CSRP2BP, YEATS2, PRR14L, SALL2, SNAPC4, ZKSCAN1, ZNF324, THAP11, FLYWCH2, GATAD2A, SNAPC1, MGA, CHD8, ZBTB9, STRBP, ZZZ3, TSR1, TRMT6, GTF2F1, DIEXF, L3MBTL2, MBTD1, TADA2A, FBXL19, RALY, ELF2, ZNF891, TRIM33, MBIP, PCGF6, RAD18, RTEL1, SNAPC3, RAB40A, CMSS1, RSRP1, LIG3, RAB40AL, LUC7L, PSMB9, CCAR2, AHCYL1, HDGF, HIBCH, AHNAK, ARHGEF2, NUP50, PSMA2, PSMA3, SF3A3, SF3B2, SRRT, SRSF2, SF3B3, SF3B5, SFN, MED4, LCA5, EAF2, DEPTOR, ZNF526, KLF2, PIAS1, UBE2I, HYPK, CDC25B, RASL10B, RPL15, MRPS34, CCDC69, TP53TG5, KLHDC8A, HUS1B, TSPYL6, ZMAT5, SSH3, PPM1E, GATAD2B, TSPYL1, DLD, HSD17B10, TRIM25, BRCA1 | GPR37L1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSME3_GPR37L1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSME3_GPR37L1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PSME3 | C0019693 | HIV Infections | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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