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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29210

FusionGeneSummary for PSMD8_MAP2K5

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD8_MAP2K5
Fusion gene ID: 29210
HgeneTgene
Gene symbol

PSMD8

MAP2K5

Gene ID

5714

5607

Gene nameproteasome 26S subunit, non-ATPase 8mitogen-activated protein kinase kinase 5
SynonymsHEL-S-91n|HIP6|HYPF|Nin1p|Rpn12|S14|p31HsT17454|MAPKK5|MEK5|PRKMK5
Cytomap

19q13.2

15q23

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 826S proteasome regulatory subunit RPN1226S proteasome regulatory subunit S1426S proteasome regulatory subunit p31epididymis secretory sperm binding protein Li 91nproteasome (prosome, macropain) 26S subunidual specificity mitogen-activated protein kinase kinase 5MAP kinase kinase 5MAP kinase kinase MEK5bMAPK/ERK kinase 5MAPKK 5MEK 5
Modification date2018052320180523
UniProtAcc

P48556

Q13163

Ensembl transtripts involved in fusion geneENST00000215071, ENST00000602911, 
ENST00000592035, 
ENST00000178640, 
ENST00000560591, ENST00000395476, 
ENST00000354498, ENST00000340972, 
Fusion gene scores* DoF score6 X 5 X 5=1508 X 7 X 9=504
# samples 613
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD8 [Title/Abstract] AND MAP2K5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBLCATCGA-DK-A1A3-01APSMD8chr19

38872868

+MAP2K5chr15

68098984

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000215071ENST00000178640PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000215071ENST00000560591PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000215071ENST00000395476PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000215071ENST00000354498PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000215071ENST00000340972PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
Frame-shiftENST00000602911ENST00000178640PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000602911ENST00000560591PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000602911ENST00000395476PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000602911ENST00000354498PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000602911ENST00000340972PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
Frame-shiftENST00000592035ENST00000178640PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000592035ENST00000560591PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000592035ENST00000395476PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000592035ENST00000354498PSMD8chr19

38872868

+MAP2K5chr15

68098984

+
5CDS-intronENST00000592035ENST00000340972PSMD8chr19

38872868

+MAP2K5chr15

68098984

+

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FusionProtFeatures for PSMD8_MAP2K5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMD8

P48556

MAP2K5

Q13163

Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair.{ECO:0000269|PubMed:1317798}. Acts as a scaffold for the formation of a ternaryMAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of thispathway appears to play a critical role in protecting cells fromstress-induced apoptosis, neuronal survival and cardiacdevelopment and angiogenesis. {ECO:0000269|PubMed:7759517,ECO:0000269|PubMed:9384584}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMD8_MAP2K5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMD8_MAP2K5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PSMD8PSMD6, PAAF1, PSMD13, UCHL5, RNF185, UBC, PSMD4, SHFM1, PSMC2, RAD23A, PSMD3, PSMC3, PSMC4, PSMC1, PSMC5, PSMC6, PFDN5, PSMA2, CDK2, TUBG1, PSMD11, PSMD12, PSMD7, PSMD1, PSMD2, PSMD14, PSMD10, PSMA6, PSMA7, PSMB1, PSMA3, PSMA5, PSMB7, PSMA4, PSMB2, PSMB3, PSMB4, PSMA1, PSMB5, PSMB6, PSME3, PSMB8, PSMA8, TP53BP1, NOS2, SMAD9, SMAD2, PARK2, RNF11, BAG3, ADRM1, DHX9, DYNC1I2, PPFIA1, ABCF1, DYNC1LI1, KIAA0368, HNRNPA0, KCMF1, MAP2, RPS12, RPS21, TXNL1, RPS8, HUWE1, ABCE1, DVL2, CCDC74B, CCDC92, PSMB9, AMBRA1, HEATR1, NLRP13, ASPM, PSMD5, PSMD9, PUS1, SIL1, NTRK1, FOXN2, MAD2L1, ANAPC4, UBLCP1, PTPN2, INTU, BBS5, MTNR1B, TRIM25, RNF157MAP2K5MAP3K3, MAP3K2, PRKCZ, MAPK7, MAP2K5, YWHAZ, CDC42BPB, ENO1, SQSTM1, ASRGL1, STAMBP, PRKCI, PARD6A, HSP90AA1, GCH1, XRCC6, ESRRA, RPL28, NXF1, LNX2, TRAF7, C10orf88, CDC37


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMD8_MAP2K5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMD8_MAP2K5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSMD8C0019693HIV Infections1CTD_human
TgeneMAP2K5C0005910Body Weight1CTD_human
TgeneMAP2K5C0011581Depressive disorder1PSYGENET
TgeneMAP2K5C0236733Amphetamine-Related Disorders1CTD_human