FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29203

FusionGeneSummary for PSMD5-AS1_EHD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD5-AS1_EHD2
Fusion gene ID: 29203
HgeneTgene
Gene symbol

PSMD5-AS1

EHD2

Gene ID

30846

Gene nameEH domain containing 2
SynonymsPAST2
Cytomap

19q13.33

Type of geneprotein-coding
DescriptionEH domain-containing protein 2PAST homolog 2
Modification date20180519
UniProtAcc

Q9NZN4

Ensembl transtripts involved in fusion geneENST00000589026, ENST00000609388, 
ENST00000586907, ENST00000442982, 
ENST00000588973, ENST00000608862, 
ENST00000447891, ENST00000432640, 
ENST00000450803, ENST00000586423, 
ENST00000263277, ENST00000538399, 
ENST00000540884, 
Fusion gene scores* DoF score2 X 2 X 1=46 X 7 X 1=42
# samples 27
** MAII scorelog2(2/4*10)=2.32192809488736log2(7/42*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMD5-AS1 [Title/Abstract] AND EHD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BC062554PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000589026ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000589026ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000589026ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000609388ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000609388ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000609388ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000586907ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000586907ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000586907ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000442982ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000442982ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000442982ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000588973ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000588973ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000588973ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000608862ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000608862ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000608862ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000447891ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000447891ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000447891ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000432640ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000432640ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000432640ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000450803ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000450803ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000450803ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-3CDSENST00000586423ENST00000263277PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000586423ENST00000538399PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+
intron-intronENST00000586423ENST00000540884PSMD5-AS1chr9

123605983

+EHD2chr19

48219880

+

Top

FusionProtFeatures for PSMD5-AS1_EHD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMD5-AS1

EHD2

Q9NZN4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. ATP- and membrane-binding protein that controls membranereorganization/tubulation upon ATP hydrolysis (By similarity).Plays a role in membrane trafficking between the plasma membraneand endosomes (PubMed:17233914). Important for the internalizationof GLUT4. Required for fusion of myoblasts to skeletal musclemyotubes. Required for normal translocation of FER1L5 to theplasma membrane (By similarity). Regulates the equilibrium betweencell surface-associated and cell surface-dissociated caveolae byconstraining caveolae at the cell membrane (PubMed:25588833).{ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914,ECO:0000269|PubMed:25588833}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PSMD5-AS1_EHD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PSMD5-AS1_EHD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PSMD5-AS1_EHD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PSMD5-AS1_EHD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource