FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 29167

FusionGeneSummary for PSMD11_CTNND1

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMD11_CTNND1
Fusion gene ID: 29167
HgeneTgene
Gene symbol

PSMD11

CTNND1

Gene ID

5717

1500

Gene nameproteasome 26S subunit, non-ATPase 11catenin delta 1
SynonymsRpn6|S9|p44.5BCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN)
Cytomap

17q11.2

11q12.1

Type of geneprotein-codingprotein-coding
Description26S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit 926S proteasome regulatory subunit RPN626S proteasome regulatory subunit S926S proteasome regulatory subunit p44.5proteasome (prosome, macropain) 26S subunit, non-ATPasecatenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenin
Modification date2018052320180523
UniProtAcc

O00231

O60716

Ensembl transtripts involved in fusion geneENST00000261712, ENST00000457654, 
ENST00000524630, ENST00000529919, 
ENST00000399039, ENST00000360682, 
ENST00000361796, ENST00000361391, 
ENST00000530094, ENST00000428599, 
ENST00000361332, ENST00000527467, 
ENST00000415361, ENST00000532245, 
ENST00000532463, ENST00000528232, 
ENST00000529986, ENST00000531014, 
ENST00000358694, ENST00000526772, 
ENST00000532787, ENST00000533667, 
ENST00000529873, ENST00000525902, 
ENST00000529526, ENST00000532649, 
ENST00000426142, ENST00000532844, 
ENST00000528621, ENST00000399050, 
ENST00000526357, ENST00000530748, 
ENST00000534579, ENST00000526938, 
Fusion gene scores* DoF score10 X 5 X 6=3008 X 7 X 5=280
# samples 119
** MAII scorelog2(11/300*10)=-1.44745897697122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSMD11 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW835516PSMD11chr17

30777413

-CTNND1chr11

57536507

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000261712ENST00000524630PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000529919PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000399039PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000360682PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000361796PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000361391PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000530094PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000428599PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000361332PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000527467PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000415361PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000532245PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000532463PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000528232PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000529986PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000531014PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000358694PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000526772PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000532787PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000533667PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000529873PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000525902PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000529526PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000532649PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000426142PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000532844PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000528621PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000399050PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000526357PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000530748PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000534579PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000261712ENST00000526938PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000524630PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000529919PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000399039PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000360682PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000361796PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000361391PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000530094PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000428599PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000361332PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000527467PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000415361PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000532245PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000532463PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000528232PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000529986PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000531014PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000358694PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000526772PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000532787PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000533667PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000529873PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000525902PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000529526PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000532649PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000426142PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000532844PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000528621PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000399050PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000526357PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000530748PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000534579PSMD11chr17

30777413

-CTNND1chr11

57536507

+
intron-intronENST00000457654ENST00000526938PSMD11chr17

30777413

-CTNND1chr11

57536507

+

Top

FusionProtFeatures for PSMD11_CTNND1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMD11

O00231

CTNND1

O60716

Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. In the complex,PSMD11 is required for proteasome assembly. Plays a key role inincreased proteasome activity in embryonic stem cells (ESCs): itshigh expression in ESCs promotes enhanced assembly of the 26Sproteasome, followed by higher proteasome activity.{ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PSMD11_CTNND1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PSMD11_CTNND1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PSMD11_CTNND1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PSMD11_CTNND1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource