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Fusion gene ID: 29154 |
FusionGeneSummary for PSMC4_WNT7B |
Fusion gene summary |
Fusion gene information | Fusion gene name: PSMC4_WNT7B | Fusion gene ID: 29154 | Hgene | Tgene | Gene symbol | PSMC4 | WNT7B | Gene ID | 5704 | 7477 |
Gene name | proteasome 26S subunit, ATPase 4 | Wnt family member 7B | |
Synonyms | MIP224|RPT3|S6|TBP-7|TBP7 | - | |
Cytomap | 19q13.2 | 22q13.31 | |
Type of gene | protein-coding | protein-coding | |
Description | 26S proteasome regulatory subunit 6B26S protease regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3MB67-interacting proteinTat-binding protein 7protease 26S subunit 6proteasome (prosome, macropain) 26S subunit, ATPase, 4 | protein Wnt-7bwingless-type MMTV integration site family, member 7B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P43686 | P56706 | |
Ensembl transtripts involved in fusion gene | ENST00000157812, ENST00000455878, | ENST00000339464, ENST00000409496, ENST00000410089, ENST00000410058, | |
Fusion gene scores | * DoF score | 3 X 4 X 2=24 | 3 X 3 X 3=27 |
# samples | 5 | 3 | |
** MAII score | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PSMC4 [Title/Abstract] AND WNT7B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | WNT7B | GO:0060070 | canonical Wnt signaling pathway | 28733458 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI143487 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000157812 | ENST00000339464 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000157812 | ENST00000409496 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000157812 | ENST00000410089 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000157812 | ENST00000410058 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-3UTR | ENST00000455878 | ENST00000339464 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000455878 | ENST00000409496 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000455878 | ENST00000410089 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
3UTR-intron | ENST00000455878 | ENST00000410058 | PSMC4 | chr19 | 40487233 | - | WNT7B | chr22 | 46316371 | - |
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FusionProtFeatures for PSMC4_WNT7B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PSMC4 | WNT7B |
Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC4 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798,ECO:0000269|PubMed:8060531}. | Ligand for members of the frizzled family of seventransmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells.Required for normal fusion of the chorion and the allantois duringplacenta development. {ECO:0000250|UniProtKB:P28047}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PSMC4_WNT7B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PSMC4_WNT7B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PSMC4_WNT7B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PSMC4_WNT7B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |