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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29154

FusionGeneSummary for PSMC4_WNT7B

check button Fusion gene summary
Fusion gene informationFusion gene name: PSMC4_WNT7B
Fusion gene ID: 29154
HgeneTgene
Gene symbol

PSMC4

WNT7B

Gene ID

5704

7477

Gene nameproteasome 26S subunit, ATPase 4Wnt family member 7B
SynonymsMIP224|RPT3|S6|TBP-7|TBP7-
Cytomap

19q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Description26S proteasome regulatory subunit 6B26S protease regulatory subunit 6B26S proteasome AAA-ATPase subunit RPT3MB67-interacting proteinTat-binding protein 7protease 26S subunit 6proteasome (prosome, macropain) 26S subunit, ATPase, 4protein Wnt-7bwingless-type MMTV integration site family, member 7B
Modification date2018052320180523
UniProtAcc

P43686

P56706

Ensembl transtripts involved in fusion geneENST00000157812, ENST00000455878, 
ENST00000339464, ENST00000409496, 
ENST00000410089, ENST00000410058, 
Fusion gene scores* DoF score3 X 4 X 2=243 X 3 X 3=27
# samples 53
** MAII scorelog2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSMC4 [Title/Abstract] AND WNT7B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneWNT7B

GO:0060070

canonical Wnt signaling pathway

28733458


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI143487PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000157812ENST00000339464PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000157812ENST00000409496PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000157812ENST00000410089PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000157812ENST00000410058PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-3UTRENST00000455878ENST00000339464PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000455878ENST00000409496PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000455878ENST00000410089PSMC4chr19

40487233

-WNT7Bchr22

46316371

-
3UTR-intronENST00000455878ENST00000410058PSMC4chr19

40487233

-WNT7Bchr22

46316371

-

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FusionProtFeatures for PSMC4_WNT7B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSMC4

P43686

WNT7B

P56706

Component of the 26S proteasome, a multiprotein complexinvolved in the ATP-dependent degradation of ubiquitinatedproteins. This complex plays a key role in the maintenance ofprotein homeostasis by removing misfolded or damaged proteins,which could impair cellular functions, and by removing proteinswhose functions are no longer required. Therefore, the proteasomeparticipates in numerous cellular processes, including cell cycleprogression, apoptosis, or DNA damage repair. PSMC4 belongs to theheterohexameric ring of AAA (ATPases associated with diversecellular activities) proteins that unfolds ubiquitinated targetproteins that are concurrently translocated into a proteolyticchamber and degraded into peptides. {ECO:0000269|PubMed:1317798,ECO:0000269|PubMed:8060531}. Ligand for members of the frizzled family of seventransmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells.Required for normal fusion of the chorion and the allantois duringplacenta development. {ECO:0000250|UniProtKB:P28047}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSMC4_WNT7B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSMC4_WNT7B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSMC4_WNT7B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSMC4_WNT7B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource