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Fusion gene ID: 2912 |
FusionGeneSummary for ASAP2_TAF1B |
Fusion gene summary |
Fusion gene information | Fusion gene name: ASAP2_TAF1B | Fusion gene ID: 2912 | Hgene | Tgene | Gene symbol | ASAP2 | TAF1B | Gene ID | 8853 | 9014 |
Gene name | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | TATA-box binding protein associated factor, RNA polymerase I subunit B | |
Synonyms | AMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1 | MGC:9349|RAF1B|RAFI63|SL1|TAFI63 | |
Cytomap | 2p25.1|2p24 | 2p25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p | TATA box-binding protein-associated factor RNA polymerase I subunit BRNA polymerase I-specific TBP-associated factor 63 kDaSL1, 63kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDTATA box binding protein (TBP)-assoc | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | O43150 | Q53T94 | |
Ensembl transtripts involved in fusion gene | ENST00000281419, ENST00000315273, ENST00000491413, | ENST00000263663, ENST00000402170, ENST00000396242, | |
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/60*10)=0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ASAP2 [Title/Abstract] AND TAF1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TAF1B | GO:0001188 | RNA polymerase I transcriptional preinitiation complex assembly | 21921199 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-46-3767-01A | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000281419 | ENST00000263663 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
5CDS-intron | ENST00000281419 | ENST00000402170 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
5CDS-5UTR | ENST00000281419 | ENST00000396242 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
Frame-shift | ENST00000315273 | ENST00000263663 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
5CDS-intron | ENST00000315273 | ENST00000402170 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
5CDS-5UTR | ENST00000315273 | ENST00000396242 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
intron-3CDS | ENST00000491413 | ENST00000263663 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
intron-intron | ENST00000491413 | ENST00000402170 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
intron-5UTR | ENST00000491413 | ENST00000396242 | ASAP2 | chr2 | 9347359 | + | TAF1B | chr2 | 10022835 | + |
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FusionProtFeatures for ASAP2_TAF1B |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
ASAP2 | TAF1B |
Activates the small GTPases ARF1, ARF5 and ARF6.Regulates the formation of post-Golgi vesicles and modulatesconstitutive secretion. Modulates phagocytosis mediated by Fcgamma receptor and ARF6. Modulates PXN recruitment to focalcontacts and cell migration. {ECO:0000269|PubMed:10022920,ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. | Component of RNA polymerase I core factor complex thatacts as a GTF2B/TFIIB-like factor and plays a key role in multiplesteps during transcription initiation such as pre-initiationcomplex (PIC) assembly and postpolymerase recruitment events inpolymerase I (Pol I) transcription. Binds rDNA promoters and playsa role in Pol I recruitment as a component of the SL1/TIF-IBcomplex and, possibly, directly through its interaction with RRN3.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198,ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500,ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ASAP2_TAF1B |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ASAP2_TAF1B |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ASAP2 | TBRG4, PXN, PTK2B, SRC, GRB2, THSD7A, ITSN1, ELAVL1, MAP1LC3A, SH3KBP1, NCK2, NTRK1, RAB11FIP3, ASAP3, CLUAP1 | TAF1B | TBP, TAF1A, TAF1C, RRN3, TP53, UBTF, EP300, TAF1D, HIST2H2BE, HIST2H2AC, HIST2H3C, HIST2H4A, THAP7, ESR1, TRB, RXRA, PGR, HIST1H3A, HIST1H4A, HDAC1, NEDD4, NEDD4L, APP, HIST3H3, NAPB, SRPK1, KAT2B, EAF1, NIFK, MPP1, OAZ1, POLR1A, FERMT3, NAF1, BRCA1, TRIM44, ZNF2, RRP8, MECP2 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ASAP2_TAF1B |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ASAP2_TAF1B |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |