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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 2912

FusionGeneSummary for ASAP2_TAF1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ASAP2_TAF1B
Fusion gene ID: 2912
HgeneTgene
Gene symbol

ASAP2

TAF1B

Gene ID

8853

9014

Gene nameArfGAP with SH3 domain, ankyrin repeat and PH domain 2TATA-box binding protein associated factor, RNA polymerase I subunit B
SynonymsAMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1MGC:9349|RAF1B|RAFI63|SL1|TAFI63
Cytomap

2p25.1|2p24

2p25.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated pTATA box-binding protein-associated factor RNA polymerase I subunit BRNA polymerase I-specific TBP-associated factor 63 kDaSL1, 63kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDTATA box binding protein (TBP)-assoc
Modification date2018052220180523
UniProtAcc

O43150

Q53T94

Ensembl transtripts involved in fusion geneENST00000281419, ENST00000315273, 
ENST00000491413, 
ENST00000263663, 
ENST00000402170, ENST00000396242, 
Fusion gene scores* DoF score4 X 5 X 3=601 X 1 X 1=1
# samples 61
** MAII scorelog2(6/60*10)=0log2(1/1*10)=3.32192809488736
Context

PubMed: ASAP2 [Title/Abstract] AND TAF1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTAF1B

GO:0001188

RNA polymerase I transcriptional preinitiation complex assembly

21921199


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-46-3767-01AASAP2chr2

9347359

+TAF1Bchr2

10022835

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000281419ENST00000263663ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
5CDS-intronENST00000281419ENST00000402170ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
5CDS-5UTRENST00000281419ENST00000396242ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
Frame-shiftENST00000315273ENST00000263663ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
5CDS-intronENST00000315273ENST00000402170ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
5CDS-5UTRENST00000315273ENST00000396242ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
intron-3CDSENST00000491413ENST00000263663ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
intron-intronENST00000491413ENST00000402170ASAP2chr2

9347359

+TAF1Bchr2

10022835

+
intron-5UTRENST00000491413ENST00000396242ASAP2chr2

9347359

+TAF1Bchr2

10022835

+

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FusionProtFeatures for ASAP2_TAF1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASAP2

O43150

TAF1B

Q53T94

Activates the small GTPases ARF1, ARF5 and ARF6.Regulates the formation of post-Golgi vesicles and modulatesconstitutive secretion. Modulates phagocytosis mediated by Fcgamma receptor and ARF6. Modulates PXN recruitment to focalcontacts and cell migration. {ECO:0000269|PubMed:10022920,ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}. Component of RNA polymerase I core factor complex thatacts as a GTF2B/TFIIB-like factor and plays a key role in multiplesteps during transcription initiation such as pre-initiationcomplex (PIC) assembly and postpolymerase recruitment events inpolymerase I (Pol I) transcription. Binds rDNA promoters and playsa role in Pol I recruitment as a component of the SL1/TIF-IBcomplex and, possibly, directly through its interaction with RRN3.{ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:21921198,ECO:0000269|PubMed:21921199, ECO:0000269|PubMed:7491500,ECO:0000269|PubMed:7801123, ECO:0000269|PubMed:7801130}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ASAP2_TAF1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ASAP2_TAF1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ASAP2TBRG4, PXN, PTK2B, SRC, GRB2, THSD7A, ITSN1, ELAVL1, MAP1LC3A, SH3KBP1, NCK2, NTRK1, RAB11FIP3, ASAP3, CLUAP1TAF1BTBP, TAF1A, TAF1C, RRN3, TP53, UBTF, EP300, TAF1D, HIST2H2BE, HIST2H2AC, HIST2H3C, HIST2H4A, THAP7, ESR1, TRB, RXRA, PGR, HIST1H3A, HIST1H4A, HDAC1, NEDD4, NEDD4L, APP, HIST3H3, NAPB, SRPK1, KAT2B, EAF1, NIFK, MPP1, OAZ1, POLR1A, FERMT3, NAF1, BRCA1, TRIM44, ZNF2, RRP8, MECP2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ASAP2_TAF1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ASAP2_TAF1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource