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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29097

FusionGeneSummary for PSIP1_MYL6

check button Fusion gene summary
Fusion gene informationFusion gene name: PSIP1_MYL6
Fusion gene ID: 29097
HgeneTgene
Gene symbol

PSIP1

MYL6

Gene ID

11168

4637

Gene namePC4 and SFRS1 interacting protein 1myosin light chain 6
SynonymsDFS70|LEDGF|PAIP|PSIP2|p52|p75ESMLC|LC17|LC17-GI|LC17-NM|LC17A|LC17B|MLC-3|MLC1SM|MLC3NM|MLC3SM
Cytomap

9p22.3

12q13.2

Type of geneprotein-codingprotein-coding
DescriptionPC4 and SFRS1-interacting proteinCLL-associated antigen KW-7dense fine speckles 70 kDa proteinlens epithelium-derived growth factortranscriptional coactivator p52/p75myosin light polypeptide 617 kDa myosin light chainmyosin light chain A3myosin light chain alkali 3myosin, light chain 6, alkali, smooth muscle and non-musclemyosin, light polypeptide 6, alkali, smooth muscle and non-muscle
Modification date2018051920180522
UniProtAcc

O75475

P60660

Ensembl transtripts involved in fusion geneENST00000380738, ENST00000380733, 
ENST00000380715, ENST00000380716, 
ENST00000397519, ENST00000484265, 
ENST00000550697, ENST00000548580, 
ENST00000293422, ENST00000348108, 
ENST00000549017, ENST00000549566, 
ENST00000536128, ENST00000547649, 
ENST00000547408, ENST00000551589, 
ENST00000548400, ENST00000548293, 
ENST00000551954, 
Fusion gene scores* DoF score3 X 3 X 2=183 X 3 X 1=9
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PSIP1 [Title/Abstract] AND MYL6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePSIP1

GO:0000395

mRNA 5'-splice site recognition

9885563


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN267529PSIP1chr9

15474134

+MYL6chr12

56555275

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000380738ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380738ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380738ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380733ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380733ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380715ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380715ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000380716ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000380716ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000397519ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000397519ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000550697PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000548580PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000293422PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000348108PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000549017PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000549566PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000536128PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000547649PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000547408PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000551589PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-3UTRENST00000484265ENST00000548400PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000548293PSIP1chr9

15474134

+MYL6chr12

56555275

+
intron-intronENST00000484265ENST00000551954PSIP1chr9

15474134

+MYL6chr12

56555275

+

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FusionProtFeatures for PSIP1_MYL6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSIP1

O75475

MYL6

P60660

Transcriptional coactivator involved in neuroepithelialstem cell differentiation and neurogenesis. Involved in particularin lens epithelial cell gene regulation and stress responses. Mayplay an important role in lens epithelial to fiber cell terminaldifferentiation. May play a protective role during stress-inducedapoptosis. Isoform 2 is a more general and strongertranscriptional coactivator. Isoform 2 may also act as an adapterto coordinate pre-mRNA splicing. Cellular cofactor for lentiviralintegration. {ECO:0000269|PubMed:15642333}. Regulatory light chain of myosin. Does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSIP1_MYL6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSIP1_MYL6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PSIP1_MYL6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PSIP1_MYL6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSIP1C0023467Leukemia, Myelocytic, Acute1CTD_human