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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29095

FusionGeneSummary for PSG9_NUDCD3

check button Fusion gene summary
Fusion gene informationFusion gene name: PSG9_NUDCD3
Fusion gene ID: 29095
HgeneTgene
Gene symbol

PSG9

NUDCD3

Gene ID

5678

23386

Gene namepregnancy specific beta-1-glycoprotein 9NudC domain containing 3
SynonymsPS34|PSBG-11|PSBG-9|PSG11|PSGIINudCL
Cytomap

19q13.31

7p13

Type of geneprotein-codingprotein-coding
Descriptionpregnancy-specific beta-1-glycoprotein 9PS-beta-BPS-beta-G-11PS-beta-G-9pregnancy specific beta-1-glycoprotein 11pregnancy-specific beta-1 glycoprotein Bpregnancy-specific beta-1-glycoprotein 11 C-R domainnudC domain-containing protein 3NudC-like protein
Modification date2018051920180523
UniProtAcc

Q00887

Q8IVD9

Ensembl transtripts involved in fusion geneENST00000418820, ENST00000593948, 
ENST00000270077, ENST00000291752, 
ENST00000443718, ENST00000244293, 
ENST00000596730, 
ENST00000355451, 
ENST00000460110, 
Fusion gene scores* DoF score2 X 2 X 1=48 X 8 X 3=192
# samples 29
** MAII scorelog2(2/4*10)=2.32192809488736log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSG9 [Title/Abstract] AND NUDCD3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AF370435PSG9chr19

43772073

+NUDCD3chr7

44507465

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000418820ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000418820ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000593948ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000593948ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000270077ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000270077ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000291752ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000291752ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000443718ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000443718ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000244293ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000244293ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000596730ENST00000355451PSG9chr19

43772073

+NUDCD3chr7

44507465

+
intron-intronENST00000596730ENST00000460110PSG9chr19

43772073

+NUDCD3chr7

44507465

+

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FusionProtFeatures for PSG9_NUDCD3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSG9

Q00887

NUDCD3

Q8IVD9


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSG9_NUDCD3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSG9_NUDCD3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSG9_NUDCD3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSG9_NUDCD3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUDCD3C0023903Liver neoplasms1CTD_human