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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29074

FusionGeneSummary for PSD3_MYO1D

check button Fusion gene summary
Fusion gene informationFusion gene name: PSD3_MYO1D
Fusion gene ID: 29074
HgeneTgene
Gene symbol

PSD3

MYO1D

Gene ID

23362

4642

Gene namepleckstrin and Sec7 domain containing 3myosin ID
SynonymsEFA6D|EFA6R|HCA67PPP1R108|myr4
Cytomap

8p22

17q11.2

Type of geneprotein-codingprotein-coding
DescriptionPH and SEC7 domain-containing protein 3ADP-ribosylation factor guanine nucleotide factor 6epididymis tissue protein Li 20mPexchange factor for ADP-ribosylation factor guanine nucleotide factor 6exchange factor for ADP-ribosylation factor guanine nucleunconventional myosin-Idmyosin-I gammaprotein phosphatase 1, regulatory subunit 108
Modification date2018052320180519
UniProtAcc

Q9NYI0

O94832

Ensembl transtripts involved in fusion geneENST00000327040, ENST00000440756, 
ENST00000286485, ENST00000428502, 
ENST00000523619, ENST00000520789, 
ENST00000318217, ENST00000394649, 
ENST00000579584, ENST00000584232, 
ENST00000583621, 
Fusion gene scores* DoF score8 X 7 X 6=33615 X 9 X 8=1080
# samples 815
** MAII scorelog2(8/336*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1080*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PSD3 [Title/Abstract] AND MYO1D [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMYO1D

GO:0010923

negative regulation of phosphatase activity

19389623


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK057818PSD3chr8

18743734

+MYO1Dchr17

30832662

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000327040ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000327040ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000327040ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000327040ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000327040ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000440756ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000440756ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000440756ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000440756ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000440756ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000286485ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000286485ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000286485ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000286485ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000286485ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000428502ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000428502ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000428502ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000428502ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000428502ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000523619ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000523619ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000523619ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000523619ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000523619ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000520789ENST00000318217PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000520789ENST00000394649PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000520789ENST00000579584PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000520789ENST00000584232PSD3chr8

18743734

+MYO1Dchr17

30832662

-
intron-intronENST00000520789ENST00000583621PSD3chr8

18743734

+MYO1Dchr17

30832662

-

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FusionProtFeatures for PSD3_MYO1D


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PSD3

Q9NYI0

MYO1D

O94832

Guanine nucleotide exchange factor for ARF6.{ECO:0000250}. Myosins are actin-based motor molecules with ATPaseactivity. Unconventional myosins serve in intracellular movements.Their highly divergent tails are presumed to bind to membranouscompartments, which would be moved relative to actin filaments (Bysimilarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PSD3_MYO1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PSD3_MYO1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PSD3_MYO1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PSD3_MYO1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePSD3C0017638Glioma1CTD_human
HgenePSD3C0036341Schizophrenia1PSYGENET
HgenePSD3C0236733Amphetamine-Related Disorders1CTD_human
TgeneMYO1DC0004352Autistic Disorder1CTD_human