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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29009

FusionGeneSummary for PRSS1_PNLIP

check button Fusion gene summary
Fusion gene informationFusion gene name: PRSS1_PNLIP
Fusion gene ID: 29009
HgeneTgene
Gene symbol

PRSS1

PNLIP

Gene ID

5644

5406

Gene nameserine protease 1pancreatic lipase
SynonymsTRP1|TRY1|TRY4|TRYP1PL|PNLIPD|PTL
Cytomap

7q34

10q25.3

Type of geneprotein-codingprotein-coding
Descriptiontrypsin-1TCR V beta 4.1beta-trypsincationic trypsinogendigestive zymogennonfunctional trypsin 1protease, serine 1trypsinogen 1trypsinogen Apancreatic triacylglycerol lipasetriacylglycerol acylhydrolase
Modification date2018052320180522
UniProtAcc

P07477

P16233

Ensembl transtripts involved in fusion geneENST00000486171, ENST00000311737, 
ENST00000369221, ENST00000470562, 
Fusion gene scores* DoF score1 X 1 X 1=12 X 2 X 2=8
# samples 12
** MAII scorelog2(1/1*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: PRSS1 [Title/Abstract] AND PNLIP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTissue-specifically expressed gene involved fusion gene, inframe and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePNLIP

GO:0061365

positive regulation of triglyceride lipase activity

9631512


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-IB-AAUM-01APRSS1chr7

142457375

+PNLIPchr10

118314690

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000486171ENST00000369221PRSS1chr7

142457375

+PNLIPchr10

118314690

+
5CDS-intronENST00000486171ENST00000470562PRSS1chr7

142457375

+PNLIPchr10

118314690

+
In-frameENST00000311737ENST00000369221PRSS1chr7

142457375

+PNLIPchr10

118314690

+
5CDS-intronENST00000311737ENST00000470562PRSS1chr7

142457375

+PNLIPchr10

118314690

+

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FusionProtFeatures for PRSS1_PNLIP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRSS1

P07477

PNLIP

P16233


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePNLIPchr7:142457375chr10:118314690ENST00000369221+513355_465190466DomainPLAT

- In-frame and not-retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePRSS1chr7:142457375chr10:118314690ENST00000311737+1524_24413248DomainPeptidase S1


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FusionGeneSequence for PRSS1_PNLIP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PRSS1_ENST00000486171_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_289aa
MNPLLILTFVAAARLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDG
IWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRY
KVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFN

>In-frame_PRSS1_ENST00000311737_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_289aa
MNPLLILTFVAAARLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDG
IWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRY
KVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFN


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PRSS1_ENST00000486171_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_867nt
ATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCGGTTGGACCCAGCAGAACCTTGCTTTCAGGGCACACCTGAATTAGTCCGA
TTGGACCCCAGCGATGCCAAATTTGTGGATGTAATTCACACGGATGGTGCCCCCATAGTCCCCAATTTGGGGTTTGGAATGAGCCAAGTC
GTGGGCCACCTAGATTTCTTTCCAAATGGAGGAGTGGAAATGCCTGGATGTAAAAAGAACATTCTCTCTCAGATTGTGGACATAGACGGA
ATCTGGGAAGGGACTCGAGACTTTGCGGCCTGTAATCACTTAAGAAGCTACAAATATTACACTGATAGCATCGTCAACCCTGATGGCTTT
GCTGGATTCCCCTGTGCCTCTTACAACGTCTTCACTGCAAACAAGTGTTTCCCTTGTCCAAGTGGAGGCTGCCCACAGATGGGTCACTAT
GCTGATAGATATCCTGGGAAAACAAATGATGTGGGCCAGAAATTTTATCTAGACACTGGTGATGCCAGTAATTTTGCACGTTGGAGGTAT
AAGGTATCTGTCACACTGTCTGGAAAAAAGGTTACAGGACACATACTAGTTTCTTTGTTCGGAAATAAAGGAAACTCTAAGCAGTATGAA
ATTTTCAAGGGCACTCTCAAACCAGATAGTACTCATTCCAATGAATTTGACTCAGATGTGGATGTTGGGGACTTGCAGATGGTTAAATTT
ATTTGGTATAACAATGTGATCAACCCAACTTTACCTAGAGTGGGAGCATCCAAGATTATAGTGGAGACAAATGTTGGAAAACAGTTCAAC

>In-frame_PRSS1_ENST00000311737_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_867nt
ATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCGGTTGGACCCAGCAGAACCTTGCTTTCAGGGCACACCTGAATTAGTCCGA
TTGGACCCCAGCGATGCCAAATTTGTGGATGTAATTCACACGGATGGTGCCCCCATAGTCCCCAATTTGGGGTTTGGAATGAGCCAAGTC
GTGGGCCACCTAGATTTCTTTCCAAATGGAGGAGTGGAAATGCCTGGATGTAAAAAGAACATTCTCTCTCAGATTGTGGACATAGACGGA
ATCTGGGAAGGGACTCGAGACTTTGCGGCCTGTAATCACTTAAGAAGCTACAAATATTACACTGATAGCATCGTCAACCCTGATGGCTTT
GCTGGATTCCCCTGTGCCTCTTACAACGTCTTCACTGCAAACAAGTGTTTCCCTTGTCCAAGTGGAGGCTGCCCACAGATGGGTCACTAT
GCTGATAGATATCCTGGGAAAACAAATGATGTGGGCCAGAAATTTTATCTAGACACTGGTGATGCCAGTAATTTTGCACGTTGGAGGTAT
AAGGTATCTGTCACACTGTCTGGAAAAAAGGTTACAGGACACATACTAGTTTCTTTGTTCGGAAATAAAGGAAACTCTAAGCAGTATGAA
ATTTTCAAGGGCACTCTCAAACCAGATAGTACTCATTCCAATGAATTTGACTCAGATGTGGATGTTGGGGACTTGCAGATGGTTAAATTT
ATTTGGTATAACAATGTGATCAACCCAACTTTACCTAGAGTGGGAGCATCCAAGATTATAGTGGAGACAAATGTTGGAAAACAGTTCAAC


* Fusion transcript sequences (Full-length transcript).
>In-frame_PRSS1_ENST00000486171_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_941nt
AGGCACACTCTACCACCATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCGGTTGGACCCAGCAGAACCTTGCTTTCAGGGCA
CACCTGAATTAGTCCGATTGGACCCCAGCGATGCCAAATTTGTGGATGTAATTCACACGGATGGTGCCCCCATAGTCCCCAATTTGGGGT
TTGGAATGAGCCAAGTCGTGGGCCACCTAGATTTCTTTCCAAATGGAGGAGTGGAAATGCCTGGATGTAAAAAGAACATTCTCTCTCAGA
TTGTGGACATAGACGGAATCTGGGAAGGGACTCGAGACTTTGCGGCCTGTAATCACTTAAGAAGCTACAAATATTACACTGATAGCATCG
TCAACCCTGATGGCTTTGCTGGATTCCCCTGTGCCTCTTACAACGTCTTCACTGCAAACAAGTGTTTCCCTTGTCCAAGTGGAGGCTGCC
CACAGATGGGTCACTATGCTGATAGATATCCTGGGAAAACAAATGATGTGGGCCAGAAATTTTATCTAGACACTGGTGATGCCAGTAATT
TTGCACGTTGGAGGTATAAGGTATCTGTCACACTGTCTGGAAAAAAGGTTACAGGACACATACTAGTTTCTTTGTTCGGAAATAAAGGAA
ACTCTAAGCAGTATGAAATTTTCAAGGGCACTCTCAAACCAGATAGTACTCATTCCAATGAATTTGACTCAGATGTGGATGTTGGGGACT
TGCAGATGGTTAAATTTATTTGGTATAACAATGTGATCAACCCAACTTTACCTAGAGTGGGAGCATCCAAGATTATAGTGGAGACAAATG
TTGGAAAACAGTTCAACTTCTGTAGTCCAGAAACCGTCAGGGAGGAAGTTCTGCTCACCCTCACACCGTGTTAGGAGACTACTGTTATTT

>In-frame_PRSS1_ENST00000311737_chr7_142457375_+_PNLIP_ENST00000369221_chr10_118314690_+_930nt
ACCACCATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCGGTTGGACCCAGCAGAACCTTGCTTTCAGGGCACACCTGAATTA
GTCCGATTGGACCCCAGCGATGCCAAATTTGTGGATGTAATTCACACGGATGGTGCCCCCATAGTCCCCAATTTGGGGTTTGGAATGAGC
CAAGTCGTGGGCCACCTAGATTTCTTTCCAAATGGAGGAGTGGAAATGCCTGGATGTAAAAAGAACATTCTCTCTCAGATTGTGGACATA
GACGGAATCTGGGAAGGGACTCGAGACTTTGCGGCCTGTAATCACTTAAGAAGCTACAAATATTACACTGATAGCATCGTCAACCCTGAT
GGCTTTGCTGGATTCCCCTGTGCCTCTTACAACGTCTTCACTGCAAACAAGTGTTTCCCTTGTCCAAGTGGAGGCTGCCCACAGATGGGT
CACTATGCTGATAGATATCCTGGGAAAACAAATGATGTGGGCCAGAAATTTTATCTAGACACTGGTGATGCCAGTAATTTTGCACGTTGG
AGGTATAAGGTATCTGTCACACTGTCTGGAAAAAAGGTTACAGGACACATACTAGTTTCTTTGTTCGGAAATAAAGGAAACTCTAAGCAG
TATGAAATTTTCAAGGGCACTCTCAAACCAGATAGTACTCATTCCAATGAATTTGACTCAGATGTGGATGTTGGGGACTTGCAGATGGTT
AAATTTATTTGGTATAACAATGTGATCAACCCAACTTTACCTAGAGTGGGAGCATCCAAGATTATAGTGGAGACAAATGTTGGAAAACAG
TTCAACTTCTGTAGTCCAGAAACCGTCAGGGAGGAAGTTCTGCTCACCCTCACACCGTGTTAGGAGACTACTGTTATTTGACCAATGAAT


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FusionGenePPI for PRSS1_PNLIP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRSS1SERPINB8, SERPINF2, DDX5, ALB, LGR4, CEP250, STK38L, KRT1, KRT10, KRT2, SNCA, HUWE1, VPS18, CDC73, FOXA1PNLIPYWHAE, LMF1, PNLIPRP2, ETNK1, ZNF444, SUMF1, ZGPAT, ZNF787, RSAD1, LAMC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRSS1_PNLIP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRSS1P07477DB06692AprotininTrypsin-1biotechapproved|investigational|withdrawn
TgenePNLIPP16233DB01083OrlistatPancreatic triacylglycerol lipasesmall moleculeapproved|investigational

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RelatedDiseases for PRSS1_PNLIP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRSS1C0238339Hereditary pancreatitis9CTD_human;ORPHANET;UNIPROT
HgenePRSS1C0030305Pancreatitis1CTD_human;HPO
HgenePRSS1C0149521Pancreatitis, Chronic1CTD_human