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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 29

FusionGeneSummary for AAGAB_AAGAB

check button Fusion gene summary
Fusion gene informationFusion gene name: AAGAB_AAGAB
Fusion gene ID: 29
HgeneTgene
Gene symbol

AAGAB

AAGAB

Gene ID

79719

79719

Gene namealpha and gamma adaptin binding proteinalpha and gamma adaptin binding protein
SynonymsKPPP1|PPKP1|PPKP1A|p34KPPP1|PPKP1|PPKP1A|p34
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
Descriptionalpha- and gamma-adaptin-binding protein p34alpha- and gamma-adaptin-binding protein p34
Modification date2018051920180519
UniProtAcc

Q6PD74

Q6PD74

Ensembl transtripts involved in fusion geneENST00000261880, ENST00000538028, 
ENST00000561452, ENST00000542650, 
ENST00000261880, ENST00000538028, 
ENST00000561452, ENST00000542650, 
Fusion gene scores* DoF score2 X 3 X 2=123 X 6 X 3=54
# samples 47
** MAII scorelog2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(7/54*10)=0.374395514781498
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: AAGAB [Title/Abstract] AND AAGAB [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BP354992AAGABchr15

67494034

-AAGABchr15

67547003

-
ChiTaRS3.1BE676486AAGABchr15

67514912

-AAGABchr15

67516947

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000261880ENST00000261880AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000261880ENST00000538028AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000261880ENST00000561452AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000261880ENST00000542650AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000538028ENST00000261880AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000538028ENST00000538028AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000538028ENST00000561452AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000538028ENST00000542650AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000561452ENST00000261880AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000561452ENST00000538028AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000561452ENST00000561452AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000561452ENST00000542650AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000542650ENST00000261880AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000542650ENST00000538028AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-5UTRENST00000542650ENST00000561452AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000542650ENST00000542650AAGABchr15

67494034

-AAGABchr15

67547003

-
intron-intronENST00000261880ENST00000261880AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000261880ENST00000538028AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000261880ENST00000561452AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000261880ENST00000542650AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000538028ENST00000261880AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000538028ENST00000538028AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000538028ENST00000561452AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000538028ENST00000542650AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000561452ENST00000261880AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000561452ENST00000538028AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000561452ENST00000561452AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000561452ENST00000542650AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000542650ENST00000261880AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000542650ENST00000538028AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000542650ENST00000561452AAGABchr15

67514912

-AAGABchr15

67516947

-
intron-intronENST00000542650ENST00000542650AAGABchr15

67514912

-AAGABchr15

67516947

-

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FusionProtFeatures for AAGAB_AAGAB


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AAGAB

Q6PD74

AAGAB

Q6PD74

May be involved in endocytic recycling of growth factorreceptors such as EGFR. {ECO:0000269|PubMed:23064416}. May be involved in endocytic recycling of growth factorreceptors such as EGFR. {ECO:0000269|PubMed:23064416}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for AAGAB_AAGAB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for AAGAB_AAGAB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for AAGAB_AAGAB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for AAGAB_AAGAB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAAGABC0022596Palmoplantar Keratosis1CTD_human
TgeneAAGABC0022596Palmoplantar Keratosis1CTD_human