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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28923

FusionGeneSummary for PRR13_VIM

check button Fusion gene summary
Fusion gene informationFusion gene name: PRR13_VIM
Fusion gene ID: 28923
HgeneTgene
Gene symbol

PRR13

VIM

Gene ID

54458

7431

Gene nameproline rich 13vimentin
SynonymsTXR1-
Cytomap

12q13.13

10p13

Type of geneprotein-codingprotein-coding
Descriptionproline-rich protein 13taxane-resistance proteinvimentin
Modification date2018051920180527
UniProtAcc

Q9NZ81

P08670

Ensembl transtripts involved in fusion geneENST00000429243, ENST00000549924, 
ENST00000551003, ENST00000549068, 
ENST00000549740, ENST00000546581, 
ENST00000549581, ENST00000547368, 
ENST00000379786, ENST00000549135, 
ENST00000544301, ENST00000224237, 
ENST00000485947, 
Fusion gene scores* DoF score4 X 4 X 1=169 X 6 X 4=216
# samples 48
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRR13 [Title/Abstract] AND VIM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ573942PRR13chr12

53837289

-VIMchr10

17277363

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000429243ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000429243ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000429243ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549924ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549924ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000549924ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000551003ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000551003ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000551003ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000549068ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000549068ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
intron-intronENST00000549068ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549740ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549740ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000549740ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000546581ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000546581ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
intron-intronENST00000546581ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000549581ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000549581ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
intron-intronENST00000549581ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000547368ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000547368ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000547368ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000379786ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
intron-3CDSENST00000379786ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
intron-intronENST00000379786ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549135ENST00000544301PRR13chr12

53837289

-VIMchr10

17277363

-
In-frameENST00000549135ENST00000224237PRR13chr12

53837289

-VIMchr10

17277363

-
5CDS-intronENST00000549135ENST00000485947PRR13chr12

53837289

-VIMchr10

17277363

-

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FusionProtFeatures for PRR13_VIM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRR13

Q9NZ81

VIM

P08670

Negatively regulates TSP1 expression at the level oftranscription. This down-regulation was shown to reduce taxane-induced apoptosis. {ECO:0000269|PubMed:16847352}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRR13_VIM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0aa

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000429243_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549924_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000551003_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549740_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000547368_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000544301_chr10_17277363_-_0nt

>In-frame_PRR13_ENST00000549135_chr12_53837289_-_VIM_ENST00000224237_chr10_17277363_-_0nt


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FusionGenePPI for PRR13_VIM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRR13_VIM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneVIMP08670DB11638ArtenimolVimentinsmall moleculeapproved|investigational

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RelatedDiseases for PRR13_VIM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRR13C0007131Non-Small Cell Lung Carcinoma1CTD_human
HgenePRR13C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC1458155Mammary Neoplasms3CTD_human
TgeneVIMC0023890Liver Cirrhosis2CTD_human
TgeneVIMC0029408Degenerative polyarthritis2CTD_human
TgeneVIMC0033578Prostatic Neoplasms2CTD_human
TgeneVIMC0007140Carcinosarcoma1CTD_human
TgeneVIMC0007621Neoplastic Cell Transformation1CTD_human
TgeneVIMC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneVIMC0027627Neoplasm Metastasis1CTD_human
TgeneVIMC0027720Nephrosis1CTD_human
TgeneVIMC0031149Peritoneal Neoplasms1CTD_human
TgeneVIMC0035126Reperfusion Injury1CTD_human
TgeneVIMC0035309Retinal Diseases1CTD_human
TgeneVIMC0039101synovial sarcoma1CTD_human
TgeneVIMC0043094Weight Gain1CTD_human
TgeneVIMC0085084Motor Neuron Disease1CTD_human
TgeneVIMC0086543Cataract1CTD_human
TgeneVIMC0345967Malignant mesothelioma1CTD_human
TgeneVIMC0524851Neurodegenerative Disorders1CTD_human
TgeneVIMC0948089Acute Coronary Syndrome1CTD_human
TgeneVIMC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human
TgeneVIMC3805411CATARACT 301UNIPROT
TgeneVIMC4277682Chemical and Drug Induced Liver Injury1CTD_human