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Fusion gene ID: 28912 |
FusionGeneSummary for PRR12_FDX1L |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRR12_FDX1L | Fusion gene ID: 28912 | Hgene | Tgene | Gene symbol | PRR12 | FDX1L | Gene ID | 57479 | 112812 |
| Gene name | proline rich 12 | ferredoxin 2 | |
| Synonyms | KIAA1205 | FDX1L | |
| Cytomap | 19q13.33 | 19p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | proline-rich protein 12 | ferredoxin-2, mitochondrialadrenodoxin-like protein, mitochondrialferredoxin 1 like | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9ULL5 | ||
| Ensembl transtripts involved in fusion gene | ENST00000418929, | ENST00000541276, ENST00000393708, ENST00000492239, ENST00000494368, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 3 X 3 X 3=27 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/378*10)=-1.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: PRR12 [Title/Abstract] AND FDX1L [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Transcription factor involved fusion gene, inframe and retained DNA-binding domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-ER-A3ET-06A | PRR12 | chr19 | 50105175 | + | FDX1L | chr19 | 10421616 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000418929 | ENST00000541276 | PRR12 | chr19 | 50105175 | + | FDX1L | chr19 | 10421616 | - |
| Frame-shift | ENST00000418929 | ENST00000393708 | PRR12 | chr19 | 50105175 | + | FDX1L | chr19 | 10421616 | - |
| 5CDS-5UTR | ENST00000418929 | ENST00000492239 | PRR12 | chr19 | 50105175 | + | FDX1L | chr19 | 10421616 | - |
| 5CDS-5UTR | ENST00000418929 | ENST00000494368 | PRR12 | chr19 | 50105175 | + | FDX1L | chr19 | 10421616 | - |
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FusionProtFeatures for PRR12_FDX1L |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRR12 | FDX1L |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | PRR12 | chr19:50105175 | chr19:10421616 | ENST00000418929 | + | 6 | 14 | 5_724 | 1591 | 2037 | Compositional bias | Note=Pro-rich |
| Hgene | PRR12 | chr19:50105175 | chr19:10421616 | ENST00000418929 | + | 6 | 14 | 845_916 | 1591 | 2037 | Compositional bias | Note=Pro-rich |
| Hgene | PRR12 | chr19:50105175 | chr19:10421616 | ENST00000418929 | + | 6 | 14 | 347_359 | 1591 | 2037 | DNA binding | Note=A.T hook 1 |
| Hgene | PRR12 | chr19:50105175 | chr19:10421616 | ENST00000418929 | + | 6 | 14 | 381_393 | 1591 | 2037 | DNA binding | Note=A.T hook 2 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FDX1L | chr19:50105175 | chr19:10421616 | ENST00000393708 | - | 2 | 5 | 68_170 | 102 | 184 | Domain | 2Fe-2S ferredoxin-type |
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FusionGeneSequence for PRR12_FDX1L |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PRR12_ENST00000418929_chr19_50105175_+_FDX1L_ENST00000541276_chr19_10421616_-_1591aa MDRNYPSAGFGDPLGAGAGWSYERSAKASLVYGSSRTSHPETDILHRQAYAAPHPLQSYATNHHPAGLSGLFDTGLHHAGSAGPDASVMN LISALESRGPQPGPSASSLLSQFRSPSWQTAMHTPGPTELFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPAN GLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGPAGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSG AAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASG RATGPEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQG LLGPQAYGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHSQGLPTASPSLSYSTGHSPA LSGHGGGWGPSSLGGGGEASPSHIIRPLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGG PPAERTEDEEFLIQHLLQAPSPPRTSGADGLVGEDGAADASKGLGGSGGAGGPPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAALEL GLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAP SPSPSASKVGVHLLEPATRDGAPQPPPPPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPAPGDTGVG PPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAYDPY GPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHL LRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRLNPRRLPDLVSSCRSRPALSPLGDIDFCPPNPGPDGPRRRGRKPTKAKRDGPPRP RGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSLDSSLTR EKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAA ESEGLGLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLAPAAAVPGPPPLPGLP SANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEP |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PRR12_ENST00000418929_chr19_50105175_+_FDX1L_ENST00000541276_chr19_10421616_-_4773nt ATGGACAGGAACTACCCCAGCGCCGGCTTCGGGGACCCGCTCGGCGCCGGGGCGGGATGGAGTTACGAGAGGTCAGCGAAAGCTAGCTTG GTTTATGGCAGCTCCAGGACCTCGCACCCCGAGACGGACATCTTACACCGCCAGGCCTATGCGGCCCCCCACCCACTGCAAAGCTATGCC ACCAACCACCACCCGGCAGGCCTCTCTGGACTCTTCGACACTGGCCTCCACCACGCGGGCTCAGCAGGGCCCGACGCCTCCGTCATGAAC CTTATCTCGGCCCTGGAATCCCGGGGCCCCCAGCCTGGCCCCTCCGCCTCCTCTCTCCTCTCCCAGTTCCGCAGTCCTTCCTGGCAAACA GCCATGCACACGCCAGGCCCCACGGAGCTCTTCATCTCGGGTGCCCTGCCGGGTTCCAGCACCTTTCCGTCCTCATCTGCCCTGTCGGCT TACCAACACCCGGCTTCCTTCGGCAGCCGCCCCTTCCCAGTGCCCTCGTCCCTCAGCCTCCAGGACCCCCCATTCAGCCCTCCAGCTAAC GGGCTCCTGTCCCCTCATGACGTGCTGCACCTGAAGCCCTCGCAGGCACCCACGGTGCCCTCTTCACTGGGCTTCGAGCGCCTGGCAGGG GGCGGTGTCTTGGGGCCAGCTGGTCTCGGTCCAGCCCAGACCCCCCCTTACCGCCCTGGCCCCCCAGACCCACCACCACCTCCTCGCCAC CTCCCAACTCAGTTCAACCTGCTGGCTTCCTCTTCCGCTGCCGCCGCCGCTGCCGAGCAGTCCTCCCCACAGCTCTATAACTTCTCGGGT GCTGCCCCGGGCCCACCGCCGCCTGAGCGGGCCCTGCCACGCCAGGACACGGTCATCAAGCACTACCAGCGGCCAGCCAGTGCCCAGCCC CCACCACCCCCGCCACCAGCCCATGCGCTCCAGCACTATCTGAGCTGTGGAGGCAGCTACCCCTCCATGGGCCACCGGGCCAACCTGGCC TGCAGCCCCCTGGGTGGTGGGGAGCCCTCCCCGGGTGCTGGGGAGCCTAGCAAGGCTGGTCCCAGCGGAGCCACGGCTGGGGCATCTGGC CGGGCCACGGGCCCTGAGGCAGCAGGGGGCGGTGGGGCTGGGGGTGGTGGTGGAGGTTACCGCCCCATCATTCAGTCGCCTGGGTACAAG ACGGGCAAAGGTGGTTATGGAGCAGCTGCCGGGGGTGCCACCAGGCCCCCCCCACCCCGTTCGACCGCCACCCCCAAATGTCAGAGCCTG GGTGGGCCAGCAGCCGCCTATGCCACTGGGAAGGCCTCTGGGGCTGGAGGGGCAGGGGGCCAGGCTTATTCCCCCGGTCAGCCTCAAGGG CTTCTGGGACCCCAGGCCTACGGGCAAGGGTTTGGAGGGGGGCAGGCACAGGACTTGAGCAAAGCCCCCAGCTACTCAGGGGGCCCCCCA CAGCCCCCCAGCGGCCCCCCTCCTCCTGGCCTGGCCACATGTCAGAGCTACTCCCCGGACCAGCTGCAGGGGCAGCTGTATGGGGTGCAG GGCGAGCCATACCCAGGGCCAGCCGCCCACTCCCAGGGGCTGCCCACAGCCAGCCCCTCGCTCAGCTACAGTACCGGCCATTCCCCAGCG CTCTCGGGCCATGGGGGTGGCTGGGGACCCAGCTCCCTGGGAGGCGGCGGTGAGGCCAGCCCATCTCACATCATTCGTCCGCTCCAGTCA CCGCCTGCCACCGGCCGTCCACCTGGAGTCGGCTCTCCAGGAGCCCCTGGCAAATACCTGAGCTCAGTCTTGGCCTCAGCGCCTTTCCTG GCACCTCCGGGAGCTGGCAGCTATGCAGCCGGAGCAGGTGGCTACAAGGGCAAGGGGGATGGCTCGGAGCTGCTGGCGGGCCCAGGTGGG CCTCCTGCGGAGCGCACAGAGGATGAGGAGTTCCTTATCCAGCACCTCTTGCAGGCGCCCAGCCCTCCTCGGACCTCAGGGGCGGACGGC TTGGTGGGCGAGGACGGGGCAGCAGATGCCTCTAAGGGACTTGGGGGGAGTGGCGGGGCCGGGGGACCACCGGGTACACCCTACGAGTTG GCCAAGGAAGACCCCCAGAGGTACCACCTGCAGAGTGTCATCCGCACCAGTGCCAGCCTGGATGAGGGTGCCACTGCGGCACTGGAGCTG GGCCTGGGGAGGCTGAAGGAGAAGAAGAAAGGGCCAGAGCGGGGTGGCGAGACCCCCGAGGGGCTGGCCACCTCTGTTGTCCACTACGGG GCAGGCGCCAAGGAGCTGGGGGCCTTCTTGCAAAAGAGCCCTCCGCCCCCACCTCCCACGGCCCAGTCTACCCAGCCCACTCCCCATGGC CTCCTTCTGGAGGCCGGGGGCCCTGACCTCCCACTGGTGCTGCCTCCGCCTCCCCCCCAGCTGCTCCCCTCGGTCCTCAGCCATGCCCCC AGTCCCTCTCCCAGCGCCTCCAAAGTCGGCGTCCACCTCCTTGAGCCAGCCACCCGCGATGGGGCACCCCAGCCACCTCCACCGCCACCC CCGCCTCCACCACCCATGCCCCTGCAGCTCGAGGCCCACCTCCGCAGCCATGGCCTGGAGCCCGCGGCCCCCAGCCCCCGCCTGCGACCC GAGGAGAGCCTGGATCCGCCAGGCGCCATGCAGGAATTGCTCGGGGCTCTGGAGCCGCTGCCCCCGGCGCCTGGGGATACTGGCGTAGGC CCACCAAACTCGGAGGGCAAGGATCCCGCAGGCGCCTACCGCAGCCCCAGCCCGCAAGGCACCAAGGCGCCGCGTTTCGTGCCGCTCACC TCCATCTGCTTCCCTGACTCCTTGCTCCAAGACGAGGAGCGCAGCTTCTTCCCCACCATGGAGGAGATGTTCGGTGGAGGGGCCGCGGAC GACTACGGCAAGGCCGGGCCACCTGAGGACGAGGGGGACCCCAAGGCTGGCGCTGGGCCACCCCCCGGCCCCCCTGCTTATGATCCCTAT GGGCCCTACTGTCCTGGCCGGGCGTCGGGAGCCGGGCCCGAGACACCGGGCCTGGGCCTGGACCCCAACAAACCGCCTGAACTGCCCTCC ACGGTCAACGCCGAGCCGCTGGGCCTGATCCAGAGTGGCCCCCACCAGGCGGCGCCACCACCCCCGCCTCCGCCACCGCCGCCTCCCGCG CCGGCCTCCGAACCCAAGGGTGGCCTCACCTCGCCCATCTTCTGCTCTACCAAGCCAAAGAAGCTGCTCAAGACATCCTCCTTCCACCTG CTGCGGCGCCGCGACCCACCCTTCCAGACCCCCAAGAAGCTGTACGCCCAGGAGTACGAGTTCGAGGCGGACGAGGACAAGGCCGATGTT CCCGCCGACATCCGCCTCAACCCCCGGCGCTTGCCTGACCTGGTCTCCAGCTGCCGCTCCCGTCCGGCCCTCTCGCCACTGGGGGACATC GACTTCTGCCCACCCAACCCAGGACCCGATGGCCCCCGGCGCCGTGGCCGCAAGCCCACGAAGGCGAAACGTGATGGGCCACCCCGGCCA CGGGGGAGGCCCCGGATCCGCCCCCTGGAGGTCCCGACCACTGCGGGGCCCGCCTCGGCCTCCACGCCCACCGATGGCGCCAAGAAACCC CGGGGCCGGGGCCGAGGCCGGGGTCGAAAGGCTGAGGAGGCAGGGGGCACCCGGTTGGAGCCCCTGAAGCCACTTAAGATCAAGCTGTCT GTGCCCAAGGCTGGCGAGGGTCTGGGAACCTCATCGGGTGATGCCATATCAGGCACTGACCACAACAGCCTGGACTCGAGCCTGACTCGG GAGAAGATCGAGGCCAAGATTAAGGAGGTGGAGGAGAAGCAGCCGGAGATGAAGTCGGGTTTCATGGCCTCCTTCTTGGACTTCCTCAAG TCAGGCAAGCGCCACCCACCACTCTACCAGGCGGGCCTGACGCCTCCGCTCAGCCCTCCCAAGAGTGTGCCACCCTCTGTGCCAGCCCGA GGCCTGCAGCCCCAGCCCCCTGCCACCCCTGCTGTGCCACATCCCCCACCTTCCGGAGCCTTTGGGCTTGGGGGCGCCCTGGAGGCTGCA GAGAGTGAGGGTCTGGGGCTTGGCTGCCCTTCACCCTGCAAGCGGCTTGATGAGGAGCTGAAGCGGAACCTCGAGACGCTGCCCTCCTTC TCCTCGGATGAGGAAGACTCTGTCGCCAAGAACCGAGACCTGCAGGAGAGCATCTCCTCCGCCATCTCTGCCCTCGATGACCCACCCCTT GCTGGGCCAAAAGACACTTCCACCCCAGATGGGCCGCCCTTGGCCCCCGCGGCTGCAGTTCCAGGGCCACCCCCTCTTCCGGGGCTCCCC AGTGCCAACAGCAATGGCACTCCCGAGCCCCCGCTGCTGGAGGAGAAACCCCCACCCACTCCACCTCCTGCCCCGACTCCTCAGCCTCAG CCTCCGCCACCCCCTCCGCCGCCACAGCCAGCCCTGCCCTCGCCACCCCCGCTGGTGGCCCCCACGCCCAGCTCACCACCGCCACCGCCG CTGCCGCCGCCACCTCCACCAGCCATGCCCTCGCCTCCACCACCACCCCCACCAGCCGCTGCCCCACTGGCTGCTCCTCCTGAGGAGCCC GCCGCCCCGTCTCCCGAAGACCCCGAGCTGCCGGACACCCGGCCCCTGCATCTGGCCAAAAAGCAGGAGACGGCGGCAGTGTGTGGGGAG ACGGACGAGGAGGCCGGCGAGAGTGGCGGAGAGGGCATCTTCCGGGAACGGGACGAGTTCGTCATCCGTGCTGAGGACATCCCTTCCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PRR12_ENST00000418929_chr19_50105175_+_FDX1L_ENST00000541276_chr19_10421616_-_6421nt CGCGGCCAATTCATGGACAGGAACTACCCCAGCGCCGGCTTCGGGGACCCGCTCGGCGCCGGGGCGGGATGGAGTTACGAGAGGTCAGCG AAAGCTAGCTTGGTTTATGGCAGCTCCAGGACCTCGCACCCCGAGACGGACATCTTACACCGCCAGGCCTATGCGGCCCCCCACCCACTG CAAAGCTATGCCACCAACCACCACCCGGCAGGCCTCTCTGGACTCTTCGACACTGGCCTCCACCACGCGGGCTCAGCAGGGCCCGACGCC TCCGTCATGAACCTTATCTCGGCCCTGGAATCCCGGGGCCCCCAGCCTGGCCCCTCCGCCTCCTCTCTCCTCTCCCAGTTCCGCAGTCCT TCCTGGCAAACAGCCATGCACACGCCAGGCCCCACGGAGCTCTTCATCTCGGGTGCCCTGCCGGGTTCCAGCACCTTTCCGTCCTCATCT GCCCTGTCGGCTTACCAACACCCGGCTTCCTTCGGCAGCCGCCCCTTCCCAGTGCCCTCGTCCCTCAGCCTCCAGGACCCCCCATTCAGC CCTCCAGCTAACGGGCTCCTGTCCCCTCATGACGTGCTGCACCTGAAGCCCTCGCAGGCACCCACGGTGCCCTCTTCACTGGGCTTCGAG CGCCTGGCAGGGGGCGGTGTCTTGGGGCCAGCTGGTCTCGGTCCAGCCCAGACCCCCCCTTACCGCCCTGGCCCCCCAGACCCACCACCA CCTCCTCGCCACCTCCCAACTCAGTTCAACCTGCTGGCTTCCTCTTCCGCTGCCGCCGCCGCTGCCGAGCAGTCCTCCCCACAGCTCTAT AACTTCTCGGGTGCTGCCCCGGGCCCACCGCCGCCTGAGCGGGCCCTGCCACGCCAGGACACGGTCATCAAGCACTACCAGCGGCCAGCC AGTGCCCAGCCCCCACCACCCCCGCCACCAGCCCATGCGCTCCAGCACTATCTGAGCTGTGGAGGCAGCTACCCCTCCATGGGCCACCGG GCCAACCTGGCCTGCAGCCCCCTGGGTGGTGGGGAGCCCTCCCCGGGTGCTGGGGAGCCTAGCAAGGCTGGTCCCAGCGGAGCCACGGCT GGGGCATCTGGCCGGGCCACGGGCCCTGAGGCAGCAGGGGGCGGTGGGGCTGGGGGTGGTGGTGGAGGTTACCGCCCCATCATTCAGTCG CCTGGGTACAAGACGGGCAAAGGTGGTTATGGAGCAGCTGCCGGGGGTGCCACCAGGCCCCCCCCACCCCGTTCGACCGCCACCCCCAAA TGTCAGAGCCTGGGTGGGCCAGCAGCCGCCTATGCCACTGGGAAGGCCTCTGGGGCTGGAGGGGCAGGGGGCCAGGCTTATTCCCCCGGT CAGCCTCAAGGGCTTCTGGGACCCCAGGCCTACGGGCAAGGGTTTGGAGGGGGGCAGGCACAGGACTTGAGCAAAGCCCCCAGCTACTCA GGGGGCCCCCCACAGCCCCCCAGCGGCCCCCCTCCTCCTGGCCTGGCCACATGTCAGAGCTACTCCCCGGACCAGCTGCAGGGGCAGCTG TATGGGGTGCAGGGCGAGCCATACCCAGGGCCAGCCGCCCACTCCCAGGGGCTGCCCACAGCCAGCCCCTCGCTCAGCTACAGTACCGGC CATTCCCCAGCGCTCTCGGGCCATGGGGGTGGCTGGGGACCCAGCTCCCTGGGAGGCGGCGGTGAGGCCAGCCCATCTCACATCATTCGT CCGCTCCAGTCACCGCCTGCCACCGGCCGTCCACCTGGAGTCGGCTCTCCAGGAGCCCCTGGCAAATACCTGAGCTCAGTCTTGGCCTCA GCGCCTTTCCTGGCACCTCCGGGAGCTGGCAGCTATGCAGCCGGAGCAGGTGGCTACAAGGGCAAGGGGGATGGCTCGGAGCTGCTGGCG GGCCCAGGTGGGCCTCCTGCGGAGCGCACAGAGGATGAGGAGTTCCTTATCCAGCACCTCTTGCAGGCGCCCAGCCCTCCTCGGACCTCA GGGGCGGACGGCTTGGTGGGCGAGGACGGGGCAGCAGATGCCTCTAAGGGACTTGGGGGGAGTGGCGGGGCCGGGGGACCACCGGGTACA CCCTACGAGTTGGCCAAGGAAGACCCCCAGAGGTACCACCTGCAGAGTGTCATCCGCACCAGTGCCAGCCTGGATGAGGGTGCCACTGCG GCACTGGAGCTGGGCCTGGGGAGGCTGAAGGAGAAGAAGAAAGGGCCAGAGCGGGGTGGCGAGACCCCCGAGGGGCTGGCCACCTCTGTT GTCCACTACGGGGCAGGCGCCAAGGAGCTGGGGGCCTTCTTGCAAAAGAGCCCTCCGCCCCCACCTCCCACGGCCCAGTCTACCCAGCCC ACTCCCCATGGCCTCCTTCTGGAGGCCGGGGGCCCTGACCTCCCACTGGTGCTGCCTCCGCCTCCCCCCCAGCTGCTCCCCTCGGTCCTC AGCCATGCCCCCAGTCCCTCTCCCAGCGCCTCCAAAGTCGGCGTCCACCTCCTTGAGCCAGCCACCCGCGATGGGGCACCCCAGCCACCT CCACCGCCACCCCCGCCTCCACCACCCATGCCCCTGCAGCTCGAGGCCCACCTCCGCAGCCATGGCCTGGAGCCCGCGGCCCCCAGCCCC CGCCTGCGACCCGAGGAGAGCCTGGATCCGCCAGGCGCCATGCAGGAATTGCTCGGGGCTCTGGAGCCGCTGCCCCCGGCGCCTGGGGAT ACTGGCGTAGGCCCACCAAACTCGGAGGGCAAGGATCCCGCAGGCGCCTACCGCAGCCCCAGCCCGCAAGGCACCAAGGCGCCGCGTTTC GTGCCGCTCACCTCCATCTGCTTCCCTGACTCCTTGCTCCAAGACGAGGAGCGCAGCTTCTTCCCCACCATGGAGGAGATGTTCGGTGGA GGGGCCGCGGACGACTACGGCAAGGCCGGGCCACCTGAGGACGAGGGGGACCCCAAGGCTGGCGCTGGGCCACCCCCCGGCCCCCCTGCT TATGATCCCTATGGGCCCTACTGTCCTGGCCGGGCGTCGGGAGCCGGGCCCGAGACACCGGGCCTGGGCCTGGACCCCAACAAACCGCCT GAACTGCCCTCCACGGTCAACGCCGAGCCGCTGGGCCTGATCCAGAGTGGCCCCCACCAGGCGGCGCCACCACCCCCGCCTCCGCCACCG CCGCCTCCCGCGCCGGCCTCCGAACCCAAGGGTGGCCTCACCTCGCCCATCTTCTGCTCTACCAAGCCAAAGAAGCTGCTCAAGACATCC TCCTTCCACCTGCTGCGGCGCCGCGACCCACCCTTCCAGACCCCCAAGAAGCTGTACGCCCAGGAGTACGAGTTCGAGGCGGACGAGGAC AAGGCCGATGTTCCCGCCGACATCCGCCTCAACCCCCGGCGCTTGCCTGACCTGGTCTCCAGCTGCCGCTCCCGTCCGGCCCTCTCGCCA CTGGGGGACATCGACTTCTGCCCACCCAACCCAGGACCCGATGGCCCCCGGCGCCGTGGCCGCAAGCCCACGAAGGCGAAACGTGATGGG CCACCCCGGCCACGGGGGAGGCCCCGGATCCGCCCCCTGGAGGTCCCGACCACTGCGGGGCCCGCCTCGGCCTCCACGCCCACCGATGGC GCCAAGAAACCCCGGGGCCGGGGCCGAGGCCGGGGTCGAAAGGCTGAGGAGGCAGGGGGCACCCGGTTGGAGCCCCTGAAGCCACTTAAG ATCAAGCTGTCTGTGCCCAAGGCTGGCGAGGGTCTGGGAACCTCATCGGGTGATGCCATATCAGGCACTGACCACAACAGCCTGGACTCG AGCCTGACTCGGGAGAAGATCGAGGCCAAGATTAAGGAGGTGGAGGAGAAGCAGCCGGAGATGAAGTCGGGTTTCATGGCCTCCTTCTTG GACTTCCTCAAGTCAGGCAAGCGCCACCCACCACTCTACCAGGCGGGCCTGACGCCTCCGCTCAGCCCTCCCAAGAGTGTGCCACCCTCT GTGCCAGCCCGAGGCCTGCAGCCCCAGCCCCCTGCCACCCCTGCTGTGCCACATCCCCCACCTTCCGGAGCCTTTGGGCTTGGGGGCGCC CTGGAGGCTGCAGAGAGTGAGGGTCTGGGGCTTGGCTGCCCTTCACCCTGCAAGCGGCTTGATGAGGAGCTGAAGCGGAACCTCGAGACG CTGCCCTCCTTCTCCTCGGATGAGGAAGACTCTGTCGCCAAGAACCGAGACCTGCAGGAGAGCATCTCCTCCGCCATCTCTGCCCTCGAT GACCCACCCCTTGCTGGGCCAAAAGACACTTCCACCCCAGATGGGCCGCCCTTGGCCCCCGCGGCTGCAGTTCCAGGGCCACCCCCTCTT CCGGGGCTCCCCAGTGCCAACAGCAATGGCACTCCCGAGCCCCCGCTGCTGGAGGAGAAACCCCCACCCACTCCACCTCCTGCCCCGACT CCTCAGCCTCAGCCTCCGCCACCCCCTCCGCCGCCACAGCCAGCCCTGCCCTCGCCACCCCCGCTGGTGGCCCCCACGCCCAGCTCACCA CCGCCACCGCCGCTGCCGCCGCCACCTCCACCAGCCATGCCCTCGCCTCCACCACCACCCCCACCAGCCGCTGCCCCACTGGCTGCTCCT CCTGAGGAGCCCGCCGCCCCGTCTCCCGAAGACCCCGAGCTGCCGGACACCCGGCCCCTGCATCTGGCCAAAAAGCAGGAGACGGCGGCA GTGTGTGGGGAGACGGACGAGGAGGCCGGCGAGAGTGGCGGAGAGGGCATCTTCCGGGAACGGGACGAGTTCGTCATCCGTGCTGAGGAC ATCCCTTCCCTCAAGGGGCCTGTGAAGCCTCCCTGGCCTGCTCCACCTGCCATGTGTATGTGAGTGAAGACCACCTGGATCTCCTGCCTC CTCCCGAGGAGAGGAGAACTCGCGGCTGGGCTGCCAGATTGTGCTGACACCGGAGCTGGAAGGAGCGGAATTCACCCTGCCCAAGATCAC CAGGAACTTCTACGTGGATGGCCATGTCCCCAAGCCCCACTGACATGAACACCTGGACCATTCCACATTGCCATGGCCCCAGGGCCCAGA TTGAGGGAATAGCCAGGTGCCAGCCCTGCCCAGAGTGCGGACAGGCCCGGGAGAGACGTGGAAGCCCCTGTGAAGGACAACACCCCTGCT TGGGAGAGAGTCCCATGTCCAGGCCCCTGAGAATCAGGGTTTGAGTAGGAGTGGACTCATATTGGAGCTGCAATAAATCGATAACACAGG CCCCAGCATGTTGAGTGTCCTTGGGGGACAGATCTGGGGTCTACAGGTGGCTCACACCTGTAATCCTAGCACTTTGGGAAGCCAAGATGG GAGGATCACTTGAGGCCAGGAGCTTAAGACCATCCTGGGCAACATGGCGAGACCTCGTCTCTATAAAAACAGTAAAAATTAGCGTGGAGT GGTGGTAAGTGCCTGTAGTCCCAGCTACTCGGGAGACTGAGGTGGGAGGATCACTTGAGCCCAGGGGATTTAGGCTGCAGTGGAGCGGTG ATCAGGCCATTCCACTCCAGCCTGGGTGACAGAGTGAGGCCCTGTCTCAAAAAAAAAAAAAACAAAAACAAAAACAAACCACACCTGCAT CTGCTGTGCTGGGCCCCCGGTTCTCTTTTCCCTCTGGGATCTAAGATGCCGCTGGGGATCCAAGGCAGAGGCCTGGGAGCCCCCATTTCC GAGGGGGAGGGCTAGCGTGGAAGGCCCCGCCCCGGCAGCTGCGGAGGGATTTGGTGGGGTCCAGGCCGCCCTTGCCACGCAGGGGTGCGC GGATGACCTGAAAAAAGCCAGAAAGAGGAAAGGTGCCGCCGAGGCTGGTCGCTCTCAGCTGGGGCTCATCGCATCCTCTACCAAGAGCGC TCCCACCACACAGGTCCCGCCCCTCCCAGCAAAGCTTCTGGCGCCGCCCTGTCTGAACCTGGAGCGGCTGGGAGGATCCCCCTCCCAGGA GAAGCCGAGGACCCCAGGATGCTGCAGAATCAGTGAGAGGTCCCTCTGGCCTGCATGCCAGGAGTCGGTCACCGCCCTGTGCTTCCTCCA AGAGACAGTGGAGAGGCTGGGGATTCCAAGGACACACAGACCAGGATCAGCCAAAAGGGCCGCCGTCTGCAGCCCCCGGGGACTCCCTCG GCCCCACCCCAGAGAAGGCCCCGGAAACAGCTGAACCCCTGCCGGGGCACCGAGAGAGTGGACCCTGGGTTCGAGGGGGTGACTCTGAAG TTTCAGATAAAGCCGGACTCCAGCCTGCAGATCATCCCCACGTACAGCCTGCCCTGCAGTAGCCGTTCTCAGGAATCCCCTGCAGATGCT GTTGGGGGCCCTGCAGCCCACCCAGGAGGCACCGAGGCCCACTCAGCAGGCAGCGAGGCCCTGGAGCCCCGGCGCTGTGCTTCCTGTCGG |
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FusionGenePPI for PRR12_FDX1L |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRR12 | USP7, RNH1, PUM1, FASN, EWSR1, SOD1, ESR1 | FDX1L | APP, FDX1, LHX4, GFPT2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRR12_FDX1L |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRR12_FDX1L |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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