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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28860

FusionGeneSummary for PRPF31_ZNF547

check button Fusion gene summary
Fusion gene informationFusion gene name: PRPF31_ZNF547
Fusion gene ID: 28860
HgeneTgene
Gene symbol

PRPF31

ZNF547

Gene ID

26121

284306

Gene namepre-mRNA processing factor 31zinc finger protein 547
SynonymsNY-BR-99|PRP31|RP11|SNRNP61-
Cytomap

19q13.42

19q13.43

Type of geneprotein-codingprotein-coding
DescriptionU4/U6 small nuclear ribonucleoprotein Prp31PRP31 pre-mRNA processing factor 31 homologU4/U6 snRNP 61 kDa proteinhPrp31protein 61Kserologically defined breast cancer antigen NY-BR-99zinc finger protein 547
Modification date2018052320180522
UniProtAcc

Q8WWY3

Q8IVP9

Ensembl transtripts involved in fusion geneENST00000321030, ENST00000419967, 
ENST00000391755, ENST00000498612, 
ENST00000282282, 
Fusion gene scores* DoF score3 X 2 X 3=181 X 1 X 1=1
# samples 31
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: PRPF31 [Title/Abstract] AND ZNF547 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRPF31

GO:0000244

spliceosomal tri-snRNP complex assembly

11867543

HgenePRPF31

GO:0000398

mRNA splicing, via spliceosome

11867543|28781166


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-L5-A891-01APRPF31chr19

54629992

+ZNF547chr19

57879912

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000321030ENST00000282282PRPF31chr19

54629992

+ZNF547chr19

57879912

+
5CDS-5UTRENST00000419967ENST00000282282PRPF31chr19

54629992

+ZNF547chr19

57879912

+
5CDS-5UTRENST00000391755ENST00000282282PRPF31chr19

54629992

+ZNF547chr19

57879912

+
3UTR-5UTRENST00000498612ENST00000282282PRPF31chr19

54629992

+ZNF547chr19

57879912

+

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FusionProtFeatures for PRPF31_ZNF547


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRPF31

Q8WWY3

ZNF547

Q8IVP9

Involved in pre-mRNA splicing as component of thespliceosome (PubMed:11867543, PubMed:28781166). Required for theassembly of the U4/U5/U6 tri-snRNP complex, one of the buildingblocks of the spliceosome (PubMed:11867543).{ECO:0000269|PubMed:11867543, ECO:0000269|PubMed:28781166}. May be involved in transcriptional regulation.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRPF31_ZNF547


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRPF31_ZNF547


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRPF31FANCA, USP15, USP39, USP4, PRPF4, SART3, MEPCE, TAF10, RPAP2, CTNNBL1, KPNA2, KPNA1, CHAF1A, AGO3, CUL3, COPS5, RNU4ATAC, RNU6ATAC, NHP2L1, PPIH, PRPF3, PRPF31, PRPF6, SART1, SF3B1, SF3B3, XAB2, SF3A1, SF3A3, SNRPA1, SNRPB2, SF3A2, PHF5A, PRKAR1A, TFDP1, UPF2, STRN3, SMURF1, RBM25, RBM4, HNRNPH2, GNB2L1, UBL4A, PRPF4B, WWOX, VCP, AES, PHC2, GOLGA2, HNRNPK, KRT15, RBMY1A1, TRIM27, SIAH1, TADA2A, TP53BP2, MKRN3, STX11, PSTPIP1, PNMA1, PDE4DIP, JAKMIP2, TMCC2, CALCOCO2, KHDRBS3, PNMA2, MID2, MTUS2, LDOC1, TFIP11, CDCA7L, ZNF250, CCDC136, CEP70, TSGA10, ZNF587, C1QTNF1, SSX2IP, KRT40, PRICKLE1, MIPOL1, RBMY1F, KCTD6, KHDRBS2, CCDC57, KRTAP10-9, KRTAP10-1, KRTAP10-8, KRTAP10-3, NOTCH2NL, LURAP1, OBSL1, SNRNP40, BZW1, HNRNPA1, NTRK1, CD2BP2, DDX23, EFTUD2, FBL, SNRPD1, SNRPD2, PRPF8, SNRNP200, KRAS, XPO1, HIST1H3E, AHSA1, RNPS1, RPL10, CTR9, WIZ, FOXB1, GAN, RC3H1, ZNF746, DIEXF, ZNF622, TUT1, FBRS, MTHFR, SNRPF, SNRPG, SNRPN, LSM6, LSM5, SUFU, WBP4, SNRPE, ARIH1, SNRPB, RPS19, OLA1, OSBPL1A, SNRPD3, SSB, TTC21B, COPS8, IFT46, UBE2N, RANBP9, FANCC, CYLD, TRIM25, RNU4-1, ZNHIT3, NUFIP1, RUVBL1, SMN1ZNF547


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRPF31_ZNF547


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRPF31_ZNF547


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRPF31C1838601Retinitis Pigmentosa 111CTD_human;UNIPROT