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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28843

FusionGeneSummary for PROSC_TTLL10

check button Fusion gene summary
Fusion gene informationFusion gene name: PROSC_TTLL10
Fusion gene ID: 28843
HgeneTgene
Gene symbol

PROSC

TTLL10

Gene ID

254173

Gene nametubulin tyrosine ligase like 10
SynonymsTTLL5
Cytomap

1p36.33

Type of geneprotein-coding
Descriptioninactive polyglycylase TTLL10tubulin tyrosine ligase-like family, member 10tubulin tyrosine ligase-like family, member 5tubulin--tyrosine ligase-like protein 10
Modification date20180519
UniProtAcc

Q6ZVT0

Ensembl transtripts involved in fusion geneENST00000328195, ENST00000506177, 
ENST00000379290, ENST00000379289, 
ENST00000379288, 
Fusion gene scores* DoF score7 X 5 X 5=1751 X 1 X 1=1
# samples 91
** MAII scorelog2(9/175*10)=-0.959358015502654
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: PROSC [Title/Abstract] AND TTLL10 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTTLL10

GO:0018094

protein polyglycylation

19524510


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-L5-A891-01APROSCchr8

37633534

+TTLL10chr1

1114569

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000328195ENST00000506177PROSCchr8

37633534

+TTLL10chr1

1114569

+
5CDS-5UTRENST00000328195ENST00000379290PROSCchr8

37633534

+TTLL10chr1

1114569

+
5CDS-5UTRENST00000328195ENST00000379289PROSCchr8

37633534

+TTLL10chr1

1114569

+
5CDS-intronENST00000328195ENST00000379288PROSCchr8

37633534

+TTLL10chr1

1114569

+

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FusionProtFeatures for PROSC_TTLL10


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PROSC

TTLL10

Q6ZVT0

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Inactive polyglycylase. {ECO:0000269|PubMed:19524510}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PROSC_TTLL10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PROSC_TTLL10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PROSCAHSA1, GSR, HK1, NAE1, PAFAH1B2, PPP1R2, ASB6, ASNS, ATIC, CAPN2, CAPNS1, EIF4E, GTF3C4, HEXB, ISOC1, MCTS1, STK26, MYO1E, NAGK, OGFOD1, PDIA4, PRCP, PTMA, TATDN1, TBCB, TUFM, TWF2, UBXN1, YWHAE, SMS, FCGR2A, OXNAD1, SLC25A32, SOX2, CDK5R1, ADI1, ADRBK1, ARFIP1, ENSA, HNRNPA1, HNRNPA3, MYEF2, PAPOLA, PHPT1, CARS, DDX17, PHGDH, SBDS, SUMO3, YARS, PCK2, RPA1, ANAPC15, CHORDC1, PARD6B, MCM2, NDUFS3, NME4, GPX7TTLL10FHL3, MDFI, TRIM27, TRIP6, CADPS, PNMA2, RBPMS, THAP1, CEP70, KRT40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PROSC_TTLL10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PROSC_TTLL10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource