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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28819

FusionGeneSummary for PRMT2_DPF1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRMT2_DPF1
Fusion gene ID: 28819
HgeneTgene
Gene symbol

PRMT2

DPF1

Gene ID

3275

8193

Gene nameprotein arginine methyltransferase 2double PHD fingers 1
SynonymsHRMT1L1BAF45b|NEUD4|neuro-d4
Cytomap

21q22.3

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein arginine N-methyltransferase 2HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1HMT1 hnRNP methyltransferase-like 1PRMT2 alphaPRMT2 betaPRMT2 gammahistone-arginine N-methyltransferase PRMT2zinc finger protein neuro-d4BRG1-associated factor 45BD4, zinc and double PHD fingers family 1neuro-d4 homolog
Modification date2018052320180524
UniProtAcc

P55345

Q92782

Ensembl transtripts involved in fusion geneENST00000355680, ENST00000397638, 
ENST00000291705, ENST00000458387, 
ENST00000451211, ENST00000397637, 
ENST00000334494, ENST00000397628, 
ENST00000440086, ENST00000491389, 
ENST00000420980, ENST00000412732, 
ENST00000416611, ENST00000414789, 
ENST00000355526, ENST00000456296, 
Fusion gene scores* DoF score6 X 6 X 4=1446 X 2 X 6=72
# samples 66
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRMT2 [Title/Abstract] AND DPF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRMT2

GO:0016571

histone methylation

19405910

HgenePRMT2

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16648481

HgenePRMT2

GO:0045892

negative regulation of transcription, DNA-templated

16648481

HgenePRMT2

GO:0045893

positive regulation of transcription, DNA-templated

12039952

HgenePRMT2

GO:0060765

regulation of androgen receptor signaling pathway

17587566


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-C8-A12P-01APRMT2chr21

48056902

+DPF1chr19

38713348

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355680ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000355680ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000355680ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000355680ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000355680ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000355680ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000397638ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397638ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397638ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397638ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397638ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397638ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000291705ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000291705ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000291705ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000291705ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000291705ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000291705ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000458387ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000458387ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000458387ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000458387ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000458387ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000458387ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000451211ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000451211ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000451211ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000451211ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000451211ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000451211ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000397637ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397637ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397637ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397637ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397637ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397637ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000334494ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000334494ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000334494ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000334494ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000334494ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000334494ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000397628ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397628ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397628ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397628ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397628ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000397628ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
Frame-shiftENST00000440086ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000440086ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000440086ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000440086ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000440086ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
5CDS-5UTRENST00000440086ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-3CDSENST00000491389ENST00000420980PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-5UTRENST00000491389ENST00000412732PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-5UTRENST00000491389ENST00000416611PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-5UTRENST00000491389ENST00000414789PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-5UTRENST00000491389ENST00000355526PRMT2chr21

48056902

+DPF1chr19

38713348

-
intron-5UTRENST00000491389ENST00000456296PRMT2chr21

48056902

+DPF1chr19

38713348

-

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FusionProtFeatures for PRMT2_DPF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRMT2

P55345

DPF1

Q92782

May have an important role in developing neurons byparticipating in regulation of cell survival, possibly as aneurospecific transcription factor. Belongs to the neuron-specificchromatin remodeling complex (nBAF complex). During neuraldevelopment a switch from a stem/progenitor to a post-mitoticchromatin remodeling mechanism occurs as neurons exit the cellcycle and become committed to their adult state. The transitionfrom proliferating neural stem/progenitor cells to post-mitoticneurons requires a switch in subunit composition of the npBAF andnBAF complexes. As neural progenitors exit mitosis anddifferentiate into neurons, npBAF complexes which containACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologousalternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunitsin neuron-specific complexes (nBAF). The npBAF complex isessential for the self-renewal/proliferative capacity of themultipotent neural stem cells. The nBAF complex along with CRESTplays a role regulating the activity of genes essential fordendrite growth (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRMT2_DPF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRMT2_DPF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRMT2PRRC2A, DMRTB1, CPSF7, HNRNPUL1, ESR1, HNRNPA1, RB1, E2F1, PSMB3, BAG6, FIP1L1, RIPK2, SPAG8, PSRC1, UBB, SALL2, GET4, SHANK3, HTT, TAB1, KANK2, LRFN1, PLEKHH3, POM121, SF1, L3MBTL3, TIGD5, KSR1, KRBA1, RBPMS, PPM1E, ANTXR1, TRAPPC2, SETD1B, SETD1A, PIK3R1, FHOD1, CXXC1, ERF, TTC28, SETD5, SAMD1, VCPIP1, C15orf39, MAP3K7, FASLG, CHEK2, UBR5, PIK3R2DPF1SMARCA2, SMARCA4, SMARCC1, RELA, NFKB1, SMARCE1, SMARCB1, SS18, SMARCD1, SMARCC2, BCL7C, BCL7A, AR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRMT2_DPF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRMT2_DPF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource