FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28788

FusionGeneSummary for PRKDC_FAU

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKDC_FAU
Fusion gene ID: 28788
HgeneTgene
Gene symbol

PRKDC

FAU

Gene ID

5591

2197

Gene nameprotein kinase, DNA-activated, catalytic polypeptideFAU, ubiquitin like and ribosomal protein S30 fusion
SynonymsDNA-PKcs|DNAPK|DNPK1|HYRC|HYRC1|IMD26|XRCC7|p350FAU1|Fub1|Fubi|MNSFbeta|RPS30|S30|asr1
Cytomap

8q11.21

11q13.1

Type of geneprotein-codingprotein-coding
DescriptionDNA-dependent protein kinase catalytic subunitDNA-PK catalytic subunithyper-radiosensitivity of murine scid mutation, complementing 1p460ubiquitin-like protein fubi and ribosomal protein S3040S ribosomal protein S30FAU-encoded ubiquitin-like proteinFBR-MuSV-associated ubiquitously expressedFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)monoclo
Modification date2018052320180522
UniProtAcc

P78527

P62861

Ensembl transtripts involved in fusion geneENST00000338368, ENST00000314191, 
ENST00000523565, 
ENST00000529639, 
ENST00000531743, ENST00000525297, 
ENST00000527548, ENST00000279259, 
ENST00000529259, ENST00000434372, 
Fusion gene scores* DoF score17 X 20 X 10=34007 X 6 X 2=84
# samples 227
** MAII scorelog2(22/3400*10)=-3.9499593175004
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKDC [Title/Abstract] AND FAU [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKDC

GO:0002218

activation of innate immune response

28712728

HgenePRKDC

GO:0018105

peptidyl-serine phosphorylation

15194694|19303849


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA469444PRKDCchr8

48792421

+FAUchr11

64888102

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338368ENST00000529639PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000531743PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000525297PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000527548PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000279259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000529259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000338368ENST00000434372PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000529639PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000531743PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000525297PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000527548PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000279259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000529259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000314191ENST00000434372PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000529639PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000531743PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000525297PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000527548PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000279259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000529259PRKDCchr8

48792421

+FAUchr11

64888102

+
intron-intronENST00000523565ENST00000434372PRKDCchr8

48792421

+FAUchr11

64888102

+

Top

FusionProtFeatures for PRKDC_FAU


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKDC

P78527

FAU

P62861


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PRKDC_FAU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PRKDC_FAU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PRKDC_FAU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRKDCP78527DB00201CaffeineDNA-dependent protein kinase catalytic subunitsmall moleculeapproved

Top

RelatedDiseases for PRKDC_FAU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKDCC0033578Prostatic Neoplasms2CTD_human
HgenePRKDCC4014833IMMUNODEFICIENCY 26 WITH OR WITHOUT NEUROLOGIC ABNORMALITIES2ORPHANET;UNIPROT
HgenePRKDCC0001364Massive Hepatic Necrosis1CTD_human
HgenePRKDCC0007137Squamous cell carcinoma1CTD_human
HgenePRKDCC0010606Adenoid Cystic Carcinoma1CTD_human
HgenePRKDCC0019151Hepatic Encephalopathy1CTD_human
HgenePRKDCC0024115Lung diseases1CTD_human
HgenePRKDCC4277682Chemical and Drug Induced Liver Injury1CTD_human