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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28734

FusionGeneSummary for PRKCB_BCL11A

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKCB_BCL11A
Fusion gene ID: 28734
HgeneTgene
Gene symbol

PRKCB

BCL11A

Gene ID

5579

53335

Gene nameprotein kinase C betaB cell CLL/lymphoma 11A
SynonymsPKC-beta|PKCB|PRKCB1|PRKCB2BCL11A-L|BCL11A-S|BCL11A-XL|BCL11a-M|CTIP1|DILOS|EVI9|HBFQTL5|ZNF856
Cytomap

16p12.2-p12.1

2p16.1

Type of geneprotein-codingprotein-coding
Descriptionprotein kinase C beta typePKC-Bprotein kinase C, beta 1 polypeptideB-cell lymphoma/leukemia 11AB-cell CLL/lymphoma 11A (zinc finger protein) isoform 2BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1C2H2-type zinc finger proteinCOUP-TF-interacting protein 1ecotropic viral integration site 9 homologecot
Modification date2018052320180527
UniProtAcc

P05771

Q9H165

Ensembl transtripts involved in fusion geneENST00000321728, ENST00000303531, 
ENST00000482000, ENST00000498058, 
ENST00000356842, ENST00000359629, 
ENST00000538214, ENST00000537768, 
ENST00000335712, ENST00000477659, 
ENST00000358510, 
Fusion gene scores* DoF score3 X 3 X 1=99 X 8 X 3=216
# samples 38
** MAII scorelog2(3/9*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(8/216*10)=-1.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKCB [Title/Abstract] AND BCL11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKCB

GO:0035408

histone H3-T6 phosphorylation

20228790

TgeneBCL11A

GO:0000122

negative regulation of transcription by RNA polymerase II

19153051


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI030492PRKCBchr16

23895679

-BCL11Achr2

60679529

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000321728ENST00000356842PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000321728ENST00000359629PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000321728ENST00000538214PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000321728ENST00000537768PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000321728ENST00000335712PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000321728ENST00000477659PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000321728ENST00000358510PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000303531ENST00000356842PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000303531ENST00000359629PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000303531ENST00000538214PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000303531ENST00000537768PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000303531ENST00000335712PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000303531ENST00000477659PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000303531ENST00000358510PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000482000ENST00000356842PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000482000ENST00000359629PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000482000ENST00000538214PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000482000ENST00000537768PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000482000ENST00000335712PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000482000ENST00000477659PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000482000ENST00000358510PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000498058ENST00000356842PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-3UTRENST00000498058ENST00000359629PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000498058ENST00000538214PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000498058ENST00000537768PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000498058ENST00000335712PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000498058ENST00000477659PRKCBchr16

23895679

-BCL11Achr2

60679529

+
intron-intronENST00000498058ENST00000358510PRKCBchr16

23895679

-BCL11Achr2

60679529

+

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FusionProtFeatures for PRKCB_BCL11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKCB

P05771

BCL11A

Q9H165


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRKCB_BCL11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRKCB_BCL11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKCB_BCL11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRKCBP05771DB08862CholecystokininProtein kinase C beta typesmall moleculeapproved|investigational

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RelatedDiseases for PRKCB_BCL11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKCBC0004352Autistic Disorder1CTD_human
HgenePRKCBC0009404Colorectal Neoplasms1CTD_human
HgenePRKCBC0011860Diabetes Mellitus, Non-Insulin-Dependent1CTD_human
HgenePRKCBC0018800Cardiomegaly1CTD_human
HgenePRKCBC0020456Hyperglycemia1CTD_human
HgenePRKCBC0023493Adult T-Cell Lymphoma/Leukemia1CTD_human
HgenePRKCBC0023893Liver Cirrhosis, Experimental1CTD_human
HgenePRKCBC0038356Stomach Neoplasms1CTD_human
HgenePRKCBC0041696Unipolar Depression1PSYGENET
HgenePRKCBC1269683Major Depressive Disorder1PSYGENET
TgeneBCL11AC0003635Apraxias1CTD_human
TgeneBCL11AC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneBCL11AC0023014Language Development Disorders1CTD_human
TgeneBCL11AC0032460Polycystic Ovary Syndrome1CTD_human
TgeneBCL11AC0036095Salivary Gland Neoplasms1CTD_human
TgeneBCL11AC0036341Schizophrenia1PSYGENET