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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28698

FusionGeneSummary for PRKAR1A_ZBTB20

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAR1A_ZBTB20
Fusion gene ID: 28698
HgeneTgene
Gene symbol

PRKAR1A

ZBTB20

Gene ID

5573

26137

Gene nameprotein kinase cAMP-dependent type I regulatory subunit alphazinc finger and BTB domain containing 20
SynonymsACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1DPZF|HOF|ODA-8S|PRIMS|ZNF288
Cytomap

17q24.2

3q13.31

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunitCarney complex type 1cAMP-dependent protein kinase regulatory subunit RIalphacAMP-dependent protein kinase type I-alpha regulatory chainprotein kinase A type 1a regulatory subunitprotein kizinc finger and BTB domain-containing protein 20BTB/POZ zinc finger protein DPZFdendritic cell-derived BTB/POZ zinc fingerzinc finger protein 288
Modification date2018052320180526
UniProtAcc

P10644

Q9HC78

Ensembl transtripts involved in fusion geneENST00000358598, ENST00000392711, 
ENST00000589228, ENST00000536854, 
ENST00000586397, ENST00000588188, 
ENST00000462705, ENST00000393785, 
ENST00000481632, ENST00000471418, 
ENST00000357258, ENST00000464560, 
ENST00000488663, ENST00000474710, 
Fusion gene scores* DoF score9 X 10 X 4=3605 X 5 X 4=100
# samples 125
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAR1A [Title/Abstract] AND ZBTB20 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR1A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A0WA-01APRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358598ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000358598ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000392711ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000589228ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000536854ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000586397ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000462705PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000393785PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000481632PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000471418PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000357258PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000464560PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000488663PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-
5CDS-intronENST00000588188ENST00000474710PRKAR1Achr17

66521099

+ZBTB20chr3

114746421

-

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FusionProtFeatures for PRKAR1A_ZBTB20


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAR1A

P10644

ZBTB20

Q9HC78

Regulatory subunit of the cAMP-dependent protein kinasesinvolved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121,ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}. May be a transcription factor that may be involved inhematopoiesis, oncogenesis, and immune responses(PubMed:11352661). Plays a role in postnatal myogenesis, may beinvolved in the regulation of satellite cells self-renewal (Bysimilarity). {ECO:0000250|UniProtKB:Q8K0L9,ECO:0000269|PubMed:11352661}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRKAR1A_ZBTB20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRKAR1A_ZBTB20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKAR1APRKAR1B, AKAP1, MYO7A, AKAP10, C2orf88, PLEKHF2, PYCARD, NPRL2, UBE2M, NUAK1, MCRS1, PRKACA, PRKAR1A, AKAP4, ARFGEF2, ARFGEF1, EGFR, GRB2, PRKX, AKAP11, GABARAPL1, WNK1, UBC, PJA2, CBS, NELL2, C2orf44, BAHD1, ZBED1, MAPK6, TAB1, ELAVL1, SLC2A4, CUL3, PATZ1, PRPF31, SAFB, HSP90AA4P, MEN1, SLC38A5, SMURF1, PRPF40A, SMAD2, CDK2, CCNE1, RFC2, PPP1CA, NPM1, SOX2, HIVEP1, CAPN11, SETD7, SET, DYRK1B, DYRK1A, GSK3B, ARPC3, PFDN5, PRKACB, AGO2, AGO3, CEP250, MAPT, RAF1, CUL7, CCDC8, ILK, MTOR, BTRC, STOML2, PRKACG, PALM2-AKAP2, AKAP3, GPR161, ANKRD26, FRMD5, IFI16, XPO1, VAPA, VAPB, PRKAR2B, IQCB1, YWHAZZBTB20NR3C1, PPARG, CHD7, ELAVL1, HSP90AA1, FLNA, MYH9, IQGAP1, SYNPO, LIMA1, ANLN, MYO19


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKAR1A_ZBTB20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRKAR1A_ZBTB20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAR1AC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE6UNIPROT
HgenePRKAR1AC2607929Carney Complex, Type 13ORPHANET;UNIPROT
HgenePRKAR1AC0001627Congenital adrenal hyperplasia1CTD_human
HgenePRKAR1AC0010481Cushing Syndrome1CTD_human
HgenePRKAR1AC0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
HgenePRKAR1AC3887949Apparent mineralocorticoid excess1CTD_human
TgeneZBTB20C0038356Stomach Neoplasms1CTD_human
TgeneZBTB20C0796121Primrose syndrome1CTD_human;ORPHANET;UNIPROT