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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28690

FusionGeneSummary for PRKAR1A_BCAS3

check button Fusion gene summary
Fusion gene informationFusion gene name: PRKAR1A_BCAS3
Fusion gene ID: 28690
HgeneTgene
Gene symbol

PRKAR1A

BCAS3

Gene ID

5573

54828

Gene nameprotein kinase cAMP-dependent type I regulatory subunit alphaBCAS3, microtubule associated cell migration factor
SynonymsACRDYS1|ADOHR|CAR|CNC|CNC1|PKR1|PPNAD1|PRKAR1|TSE1GAOB1|MAAB
Cytomap

17q24.2

17q23.2

Type of geneprotein-codingprotein-coding
DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunitCarney complex type 1cAMP-dependent protein kinase regulatory subunit RIalphacAMP-dependent protein kinase type I-alpha regulatory chainprotein kinase A type 1a regulatory subunitprotein kibreast carcinoma-amplified sequence 3BCAS4/BCAS3 fusionRudhirabreast carcinoma amplified sequence 4/3 fusion proteinmetastasis associated antigen of breast cancerprotein Maab1
Modification date2018052320180523
UniProtAcc

P10644

Q9H6U6

Ensembl transtripts involved in fusion geneENST00000358598, ENST00000392711, 
ENST00000589228, ENST00000536854, 
ENST00000586397, ENST00000588188, 
ENST00000589222, ENST00000407086, 
ENST00000390652, ENST00000408905, 
ENST00000588462, ENST00000585744, 
ENST00000588874, ENST00000585812, 
Fusion gene scores* DoF score9 X 10 X 4=36026 X 15 X 15=5850
# samples 1241
** MAII scorelog2(12/360*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(41/5850*10)=-3.83474080985268
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRKAR1A [Title/Abstract] AND BCAS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRKAR1A

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984

TgeneBCAS3

GO:0043085

positive regulation of catalytic activity

17505058

TgeneBCAS3

GO:0045944

positive regulation of transcription by RNA polymerase II

17505058

TgeneBCAS3

GO:0071391

cellular response to estrogen stimulus

17505058


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-D8-A140-01APRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000358598ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000358598ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000358598ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000392711ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000392711ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000589228ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000589228ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000536854ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000536854ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000586397ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000586397ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000589222PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000407086PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000390652PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000408905PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000588462PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000585744PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
Frame-shitENST00000588188ENST00000588874PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+
5CDS-3UTRENST00000588188ENST00000585812PRKAR1Achr17

66511717

+BCAS3chr17

59445688

+

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FusionProtFeatures for PRKAR1A_BCAS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRKAR1A

P10644

BCAS3

Q9H6U6

Regulatory subunit of the cAMP-dependent protein kinasesinvolved in cAMP signaling in cells. {ECO:0000269|PubMed:16491121,ECO:0000269|PubMed:20215566, ECO:0000269|PubMed:26405036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRKAR1A_BCAS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRKAR1A_BCAS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRKAR1APRKAR1B, AKAP1, MYO7A, AKAP10, C2orf88, PLEKHF2, PYCARD, NPRL2, UBE2M, NUAK1, MCRS1, PRKACA, PRKAR1A, AKAP4, ARFGEF2, ARFGEF1, EGFR, GRB2, PRKX, AKAP11, GABARAPL1, WNK1, UBC, PJA2, CBS, NELL2, C2orf44, BAHD1, ZBED1, MAPK6, TAB1, ELAVL1, SLC2A4, CUL3, PATZ1, PRPF31, SAFB, HSP90AA4P, MEN1, SLC38A5, SMURF1, PRPF40A, SMAD2, CDK2, CCNE1, RFC2, PPP1CA, NPM1, SOX2, HIVEP1, CAPN11, SETD7, SET, DYRK1B, DYRK1A, GSK3B, ARPC3, PFDN5, PRKACB, AGO2, AGO3, CEP250, MAPT, RAF1, CUL7, CCDC8, ILK, MTOR, BTRC, STOML2, PRKACG, PALM2-AKAP2, AKAP3, GPR161, ANKRD26, FRMD5, IFI16, XPO1, VAPA, VAPB, PRKAR2B, IQCB1, YWHAZBCAS3CTBP1, CTBP2, CDC23, C16orf70, ZDHHC17, ESR1, PELP1, HIST1H3A, KAT2B, WIPI2, ATM, BAG4, CCND1, FBXW7, KRAS, PALB2, PHB, PTPN1, SMAD4, STK11, TGFB1, TSG101, XRCC3, OFD1, CEP128, FBF1, NPHP1, SCLT1, XPO1, CD14, HDAC1, IRF3, MAGEE1, IL17RA, DOCK5, VWA5A, RAB2B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRKAR1A_BCAS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PRKAR1A_BCAS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRKAR1AC3276228ACRODYSOSTOSIS 1 WITH OR WITHOUT HORMONE RESISTANCE6UNIPROT
HgenePRKAR1AC2607929Carney Complex, Type 13ORPHANET;UNIPROT
HgenePRKAR1AC0001627Congenital adrenal hyperplasia1CTD_human
HgenePRKAR1AC0010481Cushing Syndrome1CTD_human
HgenePRKAR1AC0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
HgenePRKAR1AC3887949Apparent mineralocorticoid excess1CTD_human