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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28647

FusionGeneSummary for PRG2_MACROD2

check button Fusion gene summary
Fusion gene informationFusion gene name: PRG2_MACROD2
Fusion gene ID: 28647
HgeneTgene
Gene symbol

PRG2

MACROD2

Gene ID

79948

140733

Gene namephospholipid phosphatase related 3MACRO domain containing 2
SynonymsLPPR3|LPR3|PRG-2|PRG2C20orf133|C2orf133
Cytomap

19p13.3

20p12.1

Type of geneprotein-codingprotein-coding
Descriptionphospholipid phosphatase-related protein type 3PAP-2-like protein 2lipid phosphate phosphatase-related protein type 3plasticity-related gene 2 proteinO-acetyl-ADP-ribose deacetylase MACROD2MACRO domain-containing protein 2[Protein ADP-ribosylglutamate] hydrolase
Modification date2018052320180519
UniProtAcc

P13727

A1Z1Q3

Ensembl transtripts involved in fusion geneENST00000311862, ENST00000533605, 
ENST00000525955, 		ENST00000217246, 
ENST00000310348, ENST00000464883, 
ENST00000402914, ENST00000378058, 
ENST00000407045, 
Fusion gene scores* DoF score5 X 5 X 1=2519 X 14 X 11=2926
# samples 519
** MAII scorelog2(5/25*10)=1
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/2926*10)=-3.94485844580754
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRG2 [Title/Abstract] AND MACROD2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMACROD2

GO:0042278

purine nucleoside metabolic process

21257746

TgeneMACROD2

GO:0051725

protein de-ADP-ribosylation

23474712


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF812990PRG2chr11

57181206

+MACROD2chr20

15520878

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000311862ENST00000217246PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000311862ENST00000310348PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000311862ENST00000464883PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000311862ENST00000402914PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000311862ENST00000378058PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000311862ENST00000407045PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000217246PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000310348PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000464883PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000402914PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000378058PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000533605ENST00000407045PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000217246PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000310348PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000464883PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000402914PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000378058PRG2chr11

57181206

+MACROD2chr20

15520878

-
intron-intronENST00000525955ENST00000407045PRG2chr11

57181206

+MACROD2chr20

15520878

-

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FusionProtFeatures for PRG2_MACROD2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRG2

P13727

MACROD2

A1Z1Q3

Cytotoxin and helminthotoxin. Also induces non-cytolytichistamine release from human basophils. Involved in antiparasiticdefense mechanisms and immune hypersensitivity reactions. Theproform acts as a proteinase inhibitor, reducing the activity ofPAPPA. {ECO:0000269|PubMed:10913121}. Removes ADP-ribose from glutamate residues in proteinsbearing a single ADP-ribose moiety. Inactive towards proteinsbearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, asignaling molecule generated by the deacetylation of acetylatedlysine residues in histones and other proteins.{ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRG2_MACROD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRG2_MACROD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRG2_MACROD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRG2P13727DB00020SargramostimBone marrow proteoglycanbiotechapproved|investigational

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RelatedDiseases for PRG2_MACROD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMACROD2C0004352Autistic Disorder1CTD_human
TgeneMACROD2C0023903Liver neoplasms1CTD_human
TgeneMACROD2C0236969Substance-Related Disorders1CTD_human