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Fusion gene ID: 28635 |
FusionGeneSummary for PREP_QRSL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PREP_QRSL1 | Fusion gene ID: 28635 | Hgene | Tgene | Gene symbol | PREP | QRSL1 | Gene ID | 5550 | 55278 |
| Gene name | prolyl endopeptidase | glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 | |
| Synonyms | PE|PEP | GatA | |
| Cytomap | 6q21 | 6q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | prolyl endopeptidasedJ355L5.1 (prolyl endopeptidase)post-proline cleaving enzymeprolyl oligopeptidase | glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrialglu-AdT subunit Aglutaminyl-tRNA synthase-like protein 1glutamyl-tRNA(Gln) amidotransferase subunit A homologglutamyl-tRNA(Gln) amidotransferase, subunit A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P48147 | Q9H0R6 | |
| Ensembl transtripts involved in fusion gene | ENST00000369110, | ENST00000369046, ENST00000467262, ENST00000369044, | |
| Fusion gene scores | * DoF score | 12 X 7 X 5=420 | 8 X 5 X 5=200 |
| # samples | 12 | 13 | |
| ** MAII score | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/200*10)=-0.62148837674627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PREP [Title/Abstract] AND QRSL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | QRSL1 | GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation | 19805282 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-E2-A9RU-01A | PREP | chr6 | 105845728 | - | QRSL1 | chr6 | 107088224 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369110 | ENST00000369046 | PREP | chr6 | 105845728 | - | QRSL1 | chr6 | 107088224 | + |
| 5CDS-3UTR | ENST00000369110 | ENST00000467262 | PREP | chr6 | 105845728 | - | QRSL1 | chr6 | 107088224 | + |
| 5CDS-3UTR | ENST00000369110 | ENST00000369044 | PREP | chr6 | 105845728 | - | QRSL1 | chr6 | 107088224 | + |
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FusionProtFeatures for PREP_QRSL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PREP | QRSL1 |
| Cleaves peptide bonds on the C-terminal side of prolylresidues within peptides that are up to approximately 30 aminoacids long. | Allows the formation of correctly charged Gln-tRNA(Gln)through the transamidation of misacylated Glu-tRNA(Gln) in themitochondria. The reaction takes place in the presence ofglutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {ECO:0000255|HAMAP-Rule:MF_03150,ECO:0000269|PubMed:19805282}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PREP_QRSL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_PREP_ENST00000369110_chr6_105845728_-_QRSL1_ENST00000369046_chr6_107088224_+_561aa MLSLQYPDVYRDETAVQDYHGHKICDPYAWLEDPDSEQTKVSAALKQGQITPTELCQKCLSLIKKTKFLNAYITVSEEVALKQAEESEKR YKNGQSLGDLDGIPIAVKDNFSTSGIETTCASNMLKGYIPPYNATVVQKLLDQGALLMGKTNLDEFAMGSGSTDGVFGPVKNPWSYSKQY REKRKQNPHSENEDSDWLITGGSSGGSAAAVSAFTCYAALGSDTGGSTRNPAAHCGLVGFKPSYGLVSRHGLIPLVNSMDVPGILTRCVD DAAIVLGALAGPDPRDSTTVHEPINKPFMLPSLADVSKLCIGIPKEYLVPELSSEVQSLWSKAADLFESEGAKVIEVSLPHTSYSIVCYH VLCTSEVASNMARFDGLQYGHRCDIDVSTEAMYAATRREGFNDVVRGRILSGNFFLLKENYENYFVKAQKVRRLIANDFVNAFNSGVDVL LTPTTLSEAVPYLEFIKEDNRTRSAQDDIFTQAVNMAGLPAVSIPVALSNQGLPIGLQFIGRAFCDQQLLTVAKWFEKQVQFPVIQLQEL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_PREP_ENST00000369110_chr6_105845728_-_QRSL1_ENST00000369046_chr6_107088224_+_1683nt ATGCTGTCCCTTCAGTACCCCGACGTGTACCGCGACGAGACCGCCGTACAGGATTATCATGGTCATAAAATTTGTGACCCTTACGCCTGG CTTGAAGACCCCGACAGTGAACAGACTAAGGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCAACAGAGCTCTGTCAAAAATGTCTC TCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTACATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGAATCAGAAAAGAGA TATAAGAATGGACAGTCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGCACTTCTGGCATTGAGACAACATGT GCATCAAATATGCTGAAAGGTTATATACCACCTTATAATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCTACTAATGGGAAAA ACAAATTTAGATGAGTTTGCTATGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAACCCCTGGAGTTATTCAAAACAATAT AGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAATGAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGGGAGTGCAGCTGCT GTATCGGCGTTCACATGCTACGCGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCTGCCCACTGTGGGCTTGTTGGTTTC AAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTCATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAACCAGATGTGTGGAT GATGCAGCAATTGTGTTGGGTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAACCTATTAATAAACCATTCATGCTT CCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGAATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGTACAGTCTCTTTGG TCCAAAGCTGCTGACCTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACCAGTTATTCAATTGTCTGCTACCAT GTATTGTGCACATCAGAAGTGGCATCGAATATGGCAAGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGATGTGTCCACTGAA GCCATGTATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGAAACTTTTTCTTATTAAAAGAAAAC TATGAAAATTATTTTGTCAAAGCACAGAAAGTGAGACGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGGAGTAGATGTCTTG CTAACTCCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACCCGAAGTGCCCAGGATGATATTTTT ACACAAGCTGTAAATATGGCAGGATTGCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGGACTGCAGTTTATT GGACGTGCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCAACTTCAAGAACTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_PREP_ENST00000369110_chr6_105845728_-_QRSL1_ENST00000369046_chr6_107088224_+_4291nt CTGCTTTCTGCACGTCCTCGCCGCCGCGCCGCCAGTCCGTTTGTGCTAGCTCTGGCCGTGAGCCGGCCGCCCGCTGCCGCCGGCCGCCCC GCAGCTGCCTGCGCCCCAGCCGCGCCTCGCGGCCAGCCCGGCTAGCTCAGGTCCGCTCCCGGAGCCCGCGCCCCTCCACGCTGCCCCCTG CCTGTCCCCGGCCATGCTGTCCCTTCAGTACCCCGACGTGTACCGCGACGAGACCGCCGTACAGGATTATCATGGTCATAAAATTTGTGA CCCTTACGCCTGGCTTGAAGACCCCGACAGTGAACAGACTAAGGTTTCTGCGGCACTGAAACAAGGCCAAATTACACCAACAGAGCTCTG TCAAAAATGTCTCTCTCTTATCAAGAAGACCAAGTTTCTAAATGCCTACATTACTGTGTCAGAAGAGGTGGCCTTAAAACAAGCTGAAGA ATCAGAAAAGAGATATAAGAATGGACAGTCACTTGGGGATTTAGATGGAATTCCTATTGCAGTAAAAGACAATTTCAGCACTTCTGGCAT TGAGACAACATGTGCATCAAATATGCTGAAAGGTTATATACCACCTTATAATGCTACAGTAGTTCAGAAGTTGTTGGATCAGGGAGCTCT ACTAATGGGAAAAACAAATTTAGATGAGTTTGCTATGGGATCTGGGAGCACAGATGGTGTATTTGGACCAGTTAAAAACCCCTGGAGTTA TTCAAAACAATATAGAGAAAAGAGGAAGCAGAATCCCCACAGCGAGAATGAAGATTCAGACTGGCTGATAACTGGAGGAAGCTCAGGTGG GAGTGCAGCTGCTGTATCGGCGTTCACATGCTACGCGGCTTTAGGATCAGATACAGGAGGATCGACCAGAAATCCTGCTGCCCACTGTGG GCTTGTTGGTTTCAAACCAAGCTATGGCTTAGTTTCCCGTCATGGTCTCATTCCCCTGGTGAATTCGATGGATGTGCCAGGAATCTTAAC CAGATGTGTGGATGATGCAGCAATTGTGTTGGGTGCACTGGCCGGACCTGACCCCAGGGACTCTACCACAGTACATGAACCTATTAATAA ACCATTCATGCTTCCCAGTTTGGCAGATGTGAGCAAACTATGTATAGGAATTCCAAAGGAATATCTTGTACCGGAATTATCAAGTGAAGT ACAGTCTCTTTGGTCCAAAGCTGCTGACCTCTTTGAGTCTGAGGGGGCCAAAGTAATTGAAGTATCCCTTCCTCACACCAGTTATTCAAT TGTCTGCTACCATGTATTGTGCACATCAGAAGTGGCATCGAATATGGCAAGATTTGATGGGCTACAATATGGTCACAGATGTGACATTGA TGTGTCCACTGAAGCCATGTATGCTGCAACCAGACGAGAAGGGTTTAATGATGTGGTGAGAGGAAGAATTCTCTCAGGAAACTTTTTCTT ATTAAAAGAAAACTATGAAAATTATTTTGTCAAAGCACAGAAAGTGAGACGCCTCATTGCTAATGACTTTGTAAATGCTTTTAACTCTGG AGTAGATGTCTTGCTAACTCCCACCACCTTGAGTGAGGCAGTACCATACTTGGAGTTCATCAAAGAGGACAACAGAACCCGAAGTGCCCA GGATGATATTTTTACACAAGCTGTAAATATGGCAGGATTGCCAGCAGTGAGTATCCCTGTTGCACTCTCAAACCAAGGGTTGCCAATAGG ACTGCAGTTTATTGGACGTGCGTTTTGTGACCAGCAGCTTCTTACAGTAGCCAAATGGTTTGAAAAACAAGTACAGTTTCCTGTTATTCA ACTTCAAGAACTCATGGATGATTGTTCAGCAGTCCTTGAAAATGAAAAGTTAGCCTCTGTCTCTCTAAAACAGTAAACATATCTTACAAA TTAAAATGACTTTTAGGCTGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGCGAGCGGATCATGAGGTCAGAAG ATCTAGAACAGCCTGGTCAACATGGTGAAACCCCGTCTCTACTAAAAATACAAAAATTAGCCAGGCTTAGTGGCGGGCATCTGTAGTCCC AGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCCTGGAGGTGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTGCACTCC AGCCTGGGTGACAAAGCAAGACTGTGTCTCAAAATAAATAAATAAAATAAAATAAAATGACGTACAGAGATTCTATATTCTAGAGAGTCA AATGGTCTTGCTCAATTCTTGTAATTAGGTTCTTGTTAATACAGTCATTCCATGGAATTACTTTTTAAAATTCCTGTGACAATTAATAAT AAATAACGTGTCAGCATTTAGTAAGCATCCACTAAGTGTACAATACTTCTACAATAACACAAGATACCTGTTCCTCAAAGACAATGCATT CTGCCATAATGTTCATTAAAGAGTTTACAGTAAAAATAAGATTAGGGATAAACTTCTCAAAAATTGTACATCTGTGTAACTAAAGCACTA ACAAAAACATGAATAGTCCTTCTAGAGGTAACTTGGATAGCCTAGGCAGGCAACTTATCATGTGGTGAAGGCCGCCTCAGGGGTTGTTAA AAATGCACAGAAACAATTGAGTGCGATTATTGGCTTCTGAGCGCTGAGCAGAGCAGGTGGAAGAGGAACTTTGAGCACAGGAGGAAATGC AACCAGTCAGGGCCCAGAATCATGCAAATCTCAGGGGTATGCCTCTCTGGGGAGGAGCTCCACTTGCAGGGACTCCTTTTATTTCCCTAA GAAAGAGCTGAAATGACTGAGAACTTTCCTTTCCTCCTTAGAGTTACAATTTTACTTCTGCTATTCCGGAGCCCATGCCTAGAAGCCAGA ACAACTCCATGTTACACTGAGTTCATGCTCCTATTTACTGATCACAAATGAGCTCATTAATGTCATCGAAACATTTATTGTAACCTAACA GACCATCACAGATTGGAAACTTGGTAGATAGCAGAGCATGGTATTAGTGAAAAAGGTTCAAAATACACAAGTAACATACACTCTGAAAAA CATGCAGATAATTTGCTGATGAAGCAGAAGAGGGGATGCGCATGGCAAGAACTTGCCTTACCCCAGATTCTCTATATCTCATGGTTTCCT TTTCCTCTTGACTGTCTTTACGAGTGTTTTTTATTTGGGACCCTCGAGCCCAGAGATATTAATGGATATCTGTATTCAATATTTGACAAA ATCTAATGGAAACCATCCATTTACTCATGATAAGGCTTCATCACTGGATTTCTGTGTCTTCACTAGAACACCATTGTCATCTCATATTGA TCAGGTATTTTAATCTAGCACTTACATATTGTTGATAAATGAAAGCTGAATTGTTACTTAATAAATTCACTTTGTTTAGTAAAAAAAAAT TGTTTTCTAAATATGACGTTCATGAAGAGAAAATAATGAGTCAGAATCATCTGCAGAACCACTGGAATGTTTCATCGTCACCTGTTAGTT TTCATAAACAGTTTTCTGTCCTCTCTGAGATCCTCCCGCTCCCAAATACTCAACCTGATTAACTTCACATAAAAGTCTTATGTGCCAGGC TTAGTAATATTCCTATAGATTTTGACTCTGAATCCCTGAAAGAGGAAGAAATCCATGAGAGAAAATTGCATTACTTTATAGCAAGAGGAA ACCGTTTTAAGTTTTTTAATTGCTCAGACACCACAACATCCTAGATGGAGGAAACCATTTTAGTTGAAGGAGCAAATATGATGTCAAAAG CAAGTAAATAAACAAACCGTTGCCCCAATCTGTTTTTATGTAATGAATTTAAAAAAAAAGAGAGAGAGAGAGAGATGGGCTCTCCCTGTG TTGCCCAGGCTAGTCTCAAACTCCTGGGCTCAAGTGATCTGCCTCCCTCAGCCTCCCAAAGTGCTGAGATTAAAGACGTGAGCCACCACA CCTGGCCGAAATAATAATATTCAATATTATATATTCAATGATATTATTCAGTATTCAATATTATTTCAAATAATATTAAATCTCTTGTTC CTGTATCTCTACATGAGCTGCACTAATAATTTGAATCTGGAAATTAAAAAGTGAAACATTTACCGTTCTCATATACTGATACCCAACTAC CATGAAATGATACCTAATTTGTTTTTCTTTTCTCTTCATTTTTACTCTTAATCTAGTAGGTCTCATTTTGCCAAGTCACTGTCTGGGAAT |
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FusionGenePPI for PREP_QRSL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PREP | SIRT7, TARS, BRCA1, SGOL2, AIP, GLO1, HSPA4, HSPD1, HSPH1, KCNAB2, PABPC4, ALDOA, ALDOC, CTH, GDI2, ISYNA1, ME1, OAT, PABPC1, QDPR, NTRK1, SUCO, MTG2, NSMAF, RHPN1, KIF3A, SNCA | QRSL1 | KRT8, XRCC6, GATC, GPBP1L1, GATB, USP47, ARSG |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PREP_QRSL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PREP_QRSL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PREP | C0002622 | Amnesia | 1 | CTD_human |
| Hgene | PREP | C0002624 | Retrograde amnesia | 1 | CTD_human |
| Hgene | PREP | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Hgene | PREP | C0038356 | Stomach Neoplasms | 1 | CTD_human |
| Hgene | PREP | C0338831 | Manic | 1 | PSYGENET |
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