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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28618

FusionGeneSummary for PRDX6_PPP1R8

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDX6_PPP1R8
Fusion gene ID: 28618
HgeneTgene
Gene symbol

PRDX6

PPP1R8

Gene ID

25824

5511

Gene nameperoxiredoxin 5protein phosphatase 1 regulatory subunit 8
SynonymsACR1|AOEB166|B166|HEL-S-55|PLP|PMP20|PRDX6|PRXV|SBBI10|prx-VARD-1|ARD1|NIPP-1|NIPP1|PRO2047
Cytomap

11q13.1

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionperoxiredoxin-5, mitochondrialAlu co-repressor 1TPx type VIantioxidant enzyme B166epididymis secretory protein Li 55liver tissue 2D-page spot 71Bperoxiredoxin Vperoxisomal antioxidant enzymethioredoxin peroxidase PMP20thioredoxin reductasenuclear inhibitor of protein phosphatase 1RNase Eactivator of RNA decaynuclear inhibitor of protein phosphatase-1 alphanuclear inhibitor of protein phosphatase-1 betanuclear subunit of PP-1protein phosphatase 1, regulatory (inhibitor) subunit 8
Modification date2018052320180523
UniProtAcc

P30041

Q12972

Ensembl transtripts involved in fusion geneENST00000340385, ENST00000470017, 
ENST00000311772, ENST00000236412, 
ENST00000373931, ENST00000486634, 
Fusion gene scores* DoF score6 X 5 X 4=1202 X 2 X 1=4
# samples 62
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: PRDX6 [Title/Abstract] AND PPP1R8 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePRDX6

GO:0006979

response to oxidative stress

10521424

HgenePRDX6

GO:0016480

negative regulation of transcription by RNA polymerase III

10095767


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM477858PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000340385ENST00000311772PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
3UTR-intronENST00000340385ENST00000236412PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
3UTR-intronENST00000340385ENST00000373931PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
3UTR-intronENST00000340385ENST00000486634PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
5CDS-intronENST00000470017ENST00000311772PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
5CDS-intronENST00000470017ENST00000236412PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
5CDS-intronENST00000470017ENST00000373931PRDX6chr1

173457150

+PPP1R8chr1

28167331

-
5CDS-intronENST00000470017ENST00000486634PRDX6chr1

173457150

+PPP1R8chr1

28167331

-

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FusionProtFeatures for PRDX6_PPP1R8


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRDX6

P30041

PPP1R8

Q12972

Thiol-specific peroxidase that catalyzes the reductionof hydrogen peroxide and organic hydroperoxides to water andalcohols, respectively. Can reduce H(2)O(2) and short chainorganic, fatty acid, and phospholipid hydroperoxides. Also hasphospholipase activity, and can therefore either reduce theoxidized sn-2 fatty acyl grup of phospholipids (peroxidaseactivity) or hydrolyze the sn-2 ester bond of phospholipids(phospholipase activity). These activities are dependent onbinding to phospholipids at acidic pH and to oxidized phospholipdsat cytosolic pH. Plays a role in cell protection against oxidativestress by detoxifying peroxides and in phospholipid homeostasis.{ECO:0000269|PubMed:10893423, ECO:0000269|PubMed:9497358}. Inhibitor subunit of the major nuclear proteinphosphatase-1 (PP-1). It has RNA-binding activity but does notcleave RNA and may target PP-1 to RNA-associated substrates. Mayalso be involved in pre-mRNA splicing. Binds DNA and might act asa transcriptional repressor. Seems to be required for cellproliferation. Isoform Gamma is a site-specific single-strandendoribonuclease that cleaves single strand RNA 3' to purines andpyrimidines in A+U-rich regions. It generates 5'-phosphate terminiat the site of cleavage. This isoform does not inhibit PP-1. Maybe implicated in mRNA splicing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRDX6_PPP1R8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRDX6_PPP1R8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRDX6_PPP1R8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgenePRDX6P30041DB02325Isopropyl AlcoholPeroxiredoxin-6small moleculeapproved|investigational

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RelatedDiseases for PRDX6_PPP1R8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePRDX6C0011616Contact Dermatitis1CTD_human
HgenePRDX6C0013080Down Syndrome1CTD_human
HgenePRDX6C0024121Lung Neoplasms1CTD_human
HgenePRDX6C0035222Respiratory Distress Syndrome, Adult1CTD_human
HgenePRDX6C0036341Schizophrenia1PSYGENET
HgenePRDX6C0151744Myocardial Ischemia1CTD_human
HgenePRDX6C2239176Liver carcinoma1CTD_human