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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 286

FusionGeneSummary for ABR_CLUH

check button Fusion gene summary
Fusion gene informationFusion gene name: ABR_CLUH
Fusion gene ID: 286
HgeneTgene
Gene symbol

ABR

CLUH

Gene ID

29

23277

Gene nameABR, RhoGEF and GTPase activating proteinclustered mitochondria homolog
SynonymsMDBCLU1|KIAA0664
Cytomap

17p13.3

17p13.3

Type of geneprotein-codingprotein-coding
Descriptionactive breakpoint cluster region-related proteinactive BCR-relatedclustered mitochondria protein homologclustered mitochondria (cluA/CLU1) homolog
Modification date2018052320180519
UniProtAcc

Q12979

O75153

Ensembl transtripts involved in fusion geneENST00000302538, ENST00000544583, 
ENST00000572441, ENST00000574437, 
ENST00000291107, ENST00000543210, 
ENST00000536794, ENST00000573895, 
ENST00000538975, ENST00000435359, 
ENST00000570628, 
Fusion gene scores* DoF score13 X 10 X 13=16901 X 1 X 1=1
# samples 291
** MAII scorelog2(29/1690*10)=-2.54289844115461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ABR [Title/Abstract] AND CLUH [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0FJ-01AABRchr17

953290

-CLUHchr17

2607858

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000302538ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000302538ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000302538ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-intronENST00000544583ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000544583ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000544583ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
intron-intronENST00000572441ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000572441ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000572441ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-intronENST00000574437ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000574437ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000574437ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-intronENST00000291107ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000291107ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000291107ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
intron-intronENST00000543210ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000543210ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000543210ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-intronENST00000536794ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000536794ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
5CDS-5UTRENST00000536794ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-
intron-intronENST00000573895ENST00000538975ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000573895ENST00000435359ABRchr17

953290

-CLUHchr17

2607858

-
intron-5UTRENST00000573895ENST00000570628ABRchr17

953290

-CLUHchr17

2607858

-

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FusionProtFeatures for ABR_CLUH


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABR

Q12979

CLUH

O75153

mRNA-binding protein involved in proper cytoplasmicdistribution of mitochondria. Specifically binds mRNAs of nuclear-encoded mitochondrial proteins in the cytoplasm and regulatestransport or translation of these transcripts close tomitochondria, playing a role in mitochondrial biogenesis.{ECO:0000255|HAMAP-Rule:MF_03013, ECO:0000269|PubMed:25349259}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ABR_CLUH


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ABR_CLUH


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ABRLNX1, APP, ECT2, ERBB2IP, AURKB, CDKN1A, CEP250, CEP57, CEP76, TP53, MOV10, NXF1, HERC2, TRIM25CLUHSIRT7, APPL1, CYFIP1, HSP90AB2P, MCM4, MCM7, TRIM16, NCKAP1, FAHD1, WDR37, WDR90, ARPC3, PPA2, MPPED1, NDUFA10, MOS, DCAF4L2, APOPT1, ABCF2, HDLBP, UBA6, DYNC1LI1, DYNC1LI2, ERCC2, UBL7, YARS, NTRK1, RPGRIP1L, CLPB, TEKT3, FECH, PMPCA, THOC3, PFKFB3, HDAC11, MTUS1, DCAF4, ACSM5, RNGTT, TEFM, RPP25L, GKAP1, NPHP4


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ABR_CLUH


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ABR_CLUH


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABRC0033578Prostatic Neoplasms1CTD_human