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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28592

FusionGeneSummary for PRDM10_NT5E

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDM10_NT5E
Fusion gene ID: 28592
HgeneTgene
Gene symbol

PRDM10

NT5E

Gene ID

56980

4907

Gene namePR/SET domain 105'-nucleotidase ecto
SynonymsPFM7CALJA|CD73|E5NT|NT|NT5|NTE|eN|eNT
Cytomap

11q24.3

6q14.3

Type of geneprotein-codingprotein-coding
DescriptionPR domain zinc finger protein 10PR domain 10PR domain containing 10PR domain-containing protein 10PR-domain family member 7PRDM zinc finger transcription factortristanin5'-nucleotidase5'-NTPurine 5-Prime-Nucleotidaseecto-5'-nucleotidase
Modification date2018052620180520
UniProtAcc

Q9NQV6

P21589

Ensembl transtripts involved in fusion geneENST00000358825, ENST00000304538, 
ENST00000360871, ENST00000423662, 
ENST00000528746, ENST00000526082, 
ENST00000369646, ENST00000257770, 
ENST00000369651, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 2 X 2=8
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: PRDM10 [Title/Abstract] AND NT5E [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNT5E

GO:0007159

leukocyte cell-cell adhesion

7595232


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-UB-A7ME-01APRDM10chr11

129788434

-NT5Echr6

86194953

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000358825ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000358825ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000358825ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000304538ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000304538ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000304538ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000360871ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000360871ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000360871ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000423662ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000423662ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000423662ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000528746ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000528746ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000528746ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000526082ENST00000369646PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000526082ENST00000257770PRDM10chr11

129788434

-NT5Echr6

86194953

+
5CDS-intronENST00000526082ENST00000369651PRDM10chr11

129788434

-NT5Echr6

86194953

+

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FusionProtFeatures for PRDM10_NT5E


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRDM10

Q9NQV6

NT5E

P21589

Hydrolyzes extracellular nucleotides into membranepermeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidaseactivities. {ECO:0000269|PubMed:21933152}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PRDM10_NT5E


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PRDM10_NT5E


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PRDM10BAP1, CUL1, REL, TMEFF1, CASQ2, FOXK2, SDC2, PRICKLE3, CD44, SDC1, RAP1GDS1, BHLHA15, PPAN, PRDM5, HIST1H1TNT5EAFF1, SLC30A5, NDUFA2, SYNJ2BP, PCDH7, TMEM177, XPO7, CHD1L, FLVCR1, ATR, RPTOR, GLMN, RDH13, SCAMP1, USP22, HSDL1, RFC2, RAB9A, DNAAF5, MTOR, GHITM, PDS5A, RHOG, TNPO2, PLAA, SLC7A2, ARL2, STEAP3, SLC41A1, ADIPOR1, SLC47A1, ARF5, DEGS1, SAR1B, USP36, GJA1, SLC44A1, GNL3L, SLC16A2, SLC26A6, ARL8A, SLC6A8, VANGL2, NR2F2, CYP2S1, USP3, CXCR4, TMEM192


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PRDM10_NT5E


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneNT5EP21589DB00806Pentoxifylline5'-nucleotidasesmall moleculeapproved|investigational

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RelatedDiseases for PRDM10_NT5E


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNT5EC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneNT5EC0038356Stomach Neoplasms1CTD_human
TgeneNT5EC1859372Calcification of Joints and Arteries1CTD_human;ORPHANET;UNIPROT