FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 28590

FusionGeneSummary for PRDM10_COL12A1

check button Fusion gene summary
Fusion gene informationFusion gene name: PRDM10_COL12A1
Fusion gene ID: 28590
HgeneTgene
Gene symbol

PRDM10

COL12A1

Gene ID

56980

1303

Gene namePR/SET domain 10collagen type XII alpha 1 chain
SynonymsPFM7BA209D8.1|BTHLM2|COL12A1L|DJ234P15.1|EDSMYP|UCMD2
Cytomap

11q24.3

6q13-q14.1

Type of geneprotein-codingprotein-coding
DescriptionPR domain zinc finger protein 10PR domain 10PR domain containing 10PR domain-containing protein 10PR-domain family member 7PRDM zinc finger transcription factortristanincollagen alpha-1(XII) chaincollagen type XII proteoglycancollagen, type XII, alpha 1
Modification date2018052620180523
UniProtAcc

Q9NQV6

Q99715

Ensembl transtripts involved in fusion geneENST00000358825, ENST00000304538, 
ENST00000360871, ENST00000423662, 
ENST00000528746, ENST00000526082, 
ENST00000322507, ENST00000345356, 
ENST00000416123, ENST00000483888, 
ENST00000511023, 
Fusion gene scores* DoF score4 X 4 X 2=327 X 9 X 2=126
# samples 49
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(9/126*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: PRDM10 [Title/Abstract] AND COL12A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF843989PRDM10chr11

129784637

+COL12A1chr6

75828796

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000358825ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000358825ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000358825ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000358825ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000358825ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000304538ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000304538ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000304538ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000304538ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000304538ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000360871ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000360871ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000360871ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000360871ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000360871ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000423662ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000423662ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000423662ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000423662ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000423662ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000528746ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000528746ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000528746ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000528746ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000528746ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000526082ENST00000322507PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000526082ENST00000345356PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000526082ENST00000416123PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-3CDSENST00000526082ENST00000483888PRDM10chr11

129784637

+COL12A1chr6

75828796

-
intron-intronENST00000526082ENST00000511023PRDM10chr11

129784637

+COL12A1chr6

75828796

-

Top

FusionProtFeatures for PRDM10_COL12A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PRDM10

Q9NQV6

COL12A1

Q99715

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with thesurface of the fibrils, and the COL2 and NC3 domains may belocalized in the perifibrillar matrix. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for PRDM10_COL12A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for PRDM10_COL12A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for PRDM10_COL12A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for PRDM10_COL12A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCOL12A1C4225313BETHLEM MYOPATHY 22UNIPROT
TgeneCOL12A1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneCOL12A1C0345967Malignant mesothelioma1CTD_human