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Fusion gene ID: 28580 |
FusionGeneSummary for PRC1_VPS33B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: PRC1_VPS33B | Fusion gene ID: 28580 | Hgene | Tgene | Gene symbol | PRC1 | VPS33B | Gene ID | 9055 | 26276 |
| Gene name | protein regulator of cytokinesis 1 | VPS33B, late endosome and lysosome associated | |
| Synonyms | ASE1 | - | |
| Cytomap | 15q26.1 | 15q26.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein regulator of cytokinesis 1anaphase spindle elongation 1 homologprotein regulating cytokinesis 1 | vacuolar protein sorting-associated protein 33Bvacuolar protein sorting 33 homolog Bvacuolar protein sorting 33-like protein B | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | O43663 | Q9H267 | |
| Ensembl transtripts involved in fusion gene | ENST00000394249, ENST00000361919, ENST00000361188, ENST00000442656, ENST00000556129, | ENST00000333371, ENST00000535843, ENST00000535906, ENST00000557358, | |
| Fusion gene scores | * DoF score | 2 X 3 X 2=12 | 4 X 4 X 4=64 |
| # samples | 3 | 5 | |
| ** MAII score | log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: PRC1 [Title/Abstract] AND VPS33B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | PRC1 | GO:0032465 | regulation of cytokinesis | 17351640 |
| Tgene | VPS33B | GO:0016192 | vesicle-mediated transport | 15790593 |
| Tgene | VPS33B | GO:0032400 | melanosome localization | 15790593 |
| Tgene | VPS33B | GO:0032418 | lysosome localization | 15790593 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-25-2397-01A | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| TCGA | LD | OV | TCGA-24-1556-01A | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000394249 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000394249 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000394249 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000394249 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000361919 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000361919 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361919 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361919 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000361188 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000361188 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361188 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000361188 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| In-frame | ENST00000442656 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-5UTR | ENST00000442656 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000442656 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5CDS-intron | ENST00000442656 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-3CDS | ENST00000556129 | ENST00000333371 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-5UTR | ENST00000556129 | ENST00000535843 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-intron | ENST00000556129 | ENST00000535906 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| 5UTR-intron | ENST00000556129 | ENST00000557358 | PRC1 | chr15 | 91527923 | - | VPS33B | chr15 | 91561115 | - |
| Frame-shift | ENST00000394249 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000394249 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000394249 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000394249 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361919 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000361919 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000361188 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000361188 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| Frame-shift | ENST00000442656 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| 5CDS-intron | ENST00000442656 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000333371 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000535843 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-3CDS | ENST00000556129 | ENST00000535906 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
| intron-intron | ENST00000556129 | ENST00000557358 | PRC1 | chr15 | 91523472 | - | VPS33B | chr15 | 91542284 | - |
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FusionProtFeatures for PRC1_VPS33B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| PRC1 | VPS33B |
| Key regulator of cytokinesis that cross-linksantiparrallel microtubules at an average distance of 35 nM.Essential for controlling the spatiotemporal formation of themidzone and successful cytokinesis. Required for KIF14localization to the central spindle and midbody. Required torecruit PLK1 to the spindle. Stimulates PLK1 phosphorylation ofRACGAP1 to allow recruitment of ECT2 to the central spindle. Actsas an oncogene for promoting bladder cancer cells proliferation,apoptosis inhibition and carcinogenic progression(PubMed:17409436). {ECO:0000269|PubMed:12082078,ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105,ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:17409436,ECO:0000269|PubMed:19468300, ECO:0000269|PubMed:20691902,ECO:0000269|PubMed:9885575}. | May play a role in vesicle-mediated protein traffickingto lysosomal compartments and in membrane docking/fusion reactionsof late endosomes/lysosomes. Mediates phagolysosomal fusion inmacrophages (PubMed:18474358). Proposed to be involved inendosomal maturation implicating VIPAS39. In epithelial cells, theVPS33B:VIPAS39 complex may play a role in the apical recyclingpathway and in the maintenance of the apical-basolateral polarity(PubMed:20190753). Seems to be involved in the sorting of specificcargos from the trans-Golgi network to alpha-granule-destinedmultivesicular bodies (MVBs) promoting MVBs maturation inmegakaryocytes (By similarity). {ECO:0000250|UniProtKB:P59016,ECO:0000269|PubMed:18474358, ECO:0000305|PubMed:20190753,ECO:0000305|PubMed:23918659}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 211_304 | 48 | 621 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 383_463 | 48 | 621 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 96_133 | 48 | 621 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 211_304 | 48 | 526 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 383_463 | 48 | 526 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 96_133 | 48 | 526 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 1_341 | 48 | 621 | Region | Note=Dimerization |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 342_466 | 48 | 621 | Region | Note=Spectrin-fold |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000394249 | - | 2 | 15 | 467_620 | 48 | 621 | Region | Note=Unstructured%2C Arg/Lys rich |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 1_341 | 48 | 526 | Region | Note=Dimerization |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 342_466 | 48 | 526 | Region | Note=Spectrin-fold |
| Hgene | >PRC1 | chr15:91527923 | chr15:91561115 | ENST00000442656 | - | 2 | 13 | 467_620 | 48 | 526 | Region | Note=Unstructured%2C Arg/Lys rich |
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FusionGeneSequence for PRC1_VPS33B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PRC1_VPS33B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| PRC1 | USHBP1, KRT20, TRIM37, CCDC85B, KIF4A, KIF23, CENPE, MYC, SH3KBP1, TACC2, CDK2, CCNE1, CCNA2, CCNB1, CDK1, LTBR, IFI30, GTPBP1, HIST1H2BG, HIST1H3A, DCTN1, EXOSC2, WDR5, FOXM1, NANOG, ACSM1, TRIM25 | VPS33B | VIPAS39, MAPK8IP2, ZAK, UVRAG, VPS41, APP, VPS35, UBE2N, ATP6V1B1, SF3B3, UFD1L, DDX39B, VPS29, UCHL3, SNX5, YWHAB, HECW2, TNIP1, SSFA2, NTRK1, SPICE1, SNW1, CDC5L, AP3D1, CLTB, HGS, MTMR7, CCDC22, MATN4, COLGALT2, KIF1B, LYG2, COMMD6, COMMD1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PRC1_VPS33B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PRC1_VPS33B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | PRC1 | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |
| Hgene | PRC1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
| Tgene | VPS33B | C1859722 | Arthrogryposis renal dysfunction cholestasis syndrome | 2 | CTD_human;ORPHANET;UNIPROT |
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