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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28522

FusionGeneSummary for PPP6R1_ZGLP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP6R1_ZGLP1
Fusion gene ID: 28522
HgeneTgene
Gene symbol

PPP6R1

ZGLP1

Gene ID

22870

100125288

Gene nameprotein phosphatase 6 regulatory subunit 1zinc finger, GATA-like protein 1
SynonymsKIAA1115|PP6R1|SAP190|SAPS1GATAD3|GLP-1|GLP1
Cytomap

19q13.42

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory subunit 1SAPS domain family, member 1GATA-type zinc finger protein 1GATA zinc finger domain containing 3GATA-like protein 1
Modification date2018051920180408
UniProtAcc

Q9UPN7

P0C6A0

Ensembl transtripts involved in fusion geneENST00000412770, ENST00000587283, 
ENST00000403903, ENST00000403352, 
Fusion gene scores* DoF score5 X 4 X 2=403 X 4 X 3=36
# samples 1311
** MAII scorelog2(13/40*10)=1.70043971814109
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(11/36*10)=1.61143471208235
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP6R1 [Title/Abstract] AND ZGLP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePPP6R1

GO:0043666

regulation of phosphoprotein phosphatase activity

16716191


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BM771193PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM766818PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM771447PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM756490PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM770178PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM742279PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM771939PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM770116PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
ChiTaRS3.1BM765851PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000412770ENST00000403903PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
5UTR-5UTRENST00000412770ENST00000403352PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
intron-3CDSENST00000587283ENST00000403903PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-
intron-5UTRENST00000587283ENST00000403352PPP6R1chr19

55769801

-ZGLP1chr19

10419229

-

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FusionProtFeatures for PPP6R1_ZGLP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP6R1

Q9UPN7

ZGLP1

P0C6A0

Regulatory subunit of protein phosphatase 6 (PP6). Mayfunction as a scaffolding PP6 subunit. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation inresponse to TNF-alpha. {ECO:0000269|PubMed:16769727}. Transcriptional repressor that plays a central role insomatic cells of the gonad and is required for germ celldevelopment. Able to repress GATA transcription factor function(By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP6R1_ZGLP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP6R1_ZGLP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP6R1_ZGLP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP6R1_ZGLP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource