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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 28512

FusionGeneSummary for PPP5C_GADD45GIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: PPP5C_GADD45GIP1
Fusion gene ID: 28512
HgeneTgene
Gene symbol

PPP5C

GADD45GIP1

Gene ID

5536

90480

Gene nameprotein phosphatase 5 catalytic subunitGADD45G interacting protein 1
SynonymsPP5|PPP5|PPTCKBBP2|CKbetaBP2|CRIF1|MRP-L59|PLINP|PLINP-1|PRG6|Plinp1
Cytomap

19q13.32

19p13.13

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 5PP-Tprotein phosphatase Tgrowth arrest and DNA damage-inducible proteins-interacting protein 139S ribosomal protein L59, mitochondrialCKII beta binding protein 2CKII beta-associating proteinCR6 interacting factor 1growth arrest and DNA-damage-inducible, gamma interacting pro
Modification date2018052320180522
UniProtAcc

P53041

Q8TAE8

Ensembl transtripts involved in fusion geneENST00000012443, ENST00000391919, 
ENST00000316939, 
Fusion gene scores* DoF score5 X 3 X 4=606 X 1 X 4=24
# samples 55
** MAII scorelog2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/24*10)=1.05889368905357
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: PPP5C [Title/Abstract] AND GADD45GIP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGADD45GIP1

GO:0071850

mitotic cell cycle arrest

24520316


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCESCTCGA-VS-A8Q9-01APPP5Cchr19

46879831

+GADD45GIP1chr19

13065340

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000012443ENST00000316939PPP5Cchr19

46879831

+GADD45GIP1chr19

13065340

-
Frame-shiftENST00000391919ENST00000316939PPP5Cchr19

46879831

+GADD45GIP1chr19

13065340

-

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FusionProtFeatures for PPP5C_GADD45GIP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PPP5C

P53041

GADD45GIP1

Q8TAE8

Serine/threonine-protein phosphatase thatdephosphorylates a myriad of proteins involved in differentsignaling pathways including the kinases CSNK1E, ASK1/MAP3K5,PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2,SMAD proteins and TAU/MAPT. Implicated in wide ranging cellularprocesses, including apoptosis, differentiation, DNA damageresponse, cell survival, regulation of ion channels or circadianrhythms, in response to steroid and thyroid hormones, calcium,fatty acids, TGF-beta as well as oxidative and genotoxic stresses.Participates in the control of DNA damage response mechanisms suchas checkpoint activation and DNA damage repair through, forinstance, the regulation ATM/ATR-signaling and dephosphorylationof PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosisinduced by oxidative stress. Plays a positive role inadipogenesis, mainly through the dephosphorylation and activationof PPARG transactivation function. Also dephosphorylates andinhibits the anti-adipogenic effect of NR3C1. Regulates thecircadian rhythms, through the dephosphorylation and activation ofCSNK1E. May modulate TGF-beta signaling pathway by the regulationof SMAD3 phosphorylation and protein expression levels.Dephosphorylates and may play a role in the regulation ofTAU/MAPT. Through their dephosphorylation, may play a role in theregulation of ions channels such as KCNH2.{ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:14764652,ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15383005,ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16260606,ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:16892053,ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:19948726,ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22399290,ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23102700,ECO:0000269|PubMed:9000529}. Acts as a negative regulator of G1 to S cell cycle phaseprogression by inhibiting cyclin-dependent kinases. Inhibitoryeffects are additive with GADD45 proteins but occurs also in theabsence of GADD45 proteins. Acts as a repressor of the orphannuclear receptor NR4A1 by inhibiting AB domain-mediatedtranscriptional activity. May be involved in the hormone-mediatedregulation of NR4A1 transcriptional activity. May play a role inmitochondrial protein synthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for PPP5C_GADD45GIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for PPP5C_GADD45GIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
PPP5CCSE1L, CDC27, GNA12, GNA13, MAP3K5, CRY2, USP49, PHLPP1, EGFR, HSPA4, HSP90AA1, DISC1, MAP3K7, CDK20, NR3C1, NR3C2, PGR, AR, PTGES3, APP, DIS3, AHSG, HNRNPA1, MAPT, ESR2, ESR1, GRB2, STIP1, HSPA8, HSPA1B, HSP90AB1, CCT4, CDC37, CDK18, ABHD14A, BZW2, EIF6, GINS3, GSS, NAPRT, PAFAH1B2, PAPSS1, PLD3, CTPS1, DCPS, DFFA, FUBP1, GAPDH, PPIB, TUFM, VCL, RAP1GDS1, XPO1, AHSA1, CDC37L1, IRS4, CHORDC1, ENO1, SHMT2, MOV10, NXF1, BPHL, DUT, MINPP1, NOL10, PSPC1, TATDN1, NTRK1, PSEN2, RBBP6, RPS6KB1, ABCF2, USP45, FLCN, HSPA6, DUSP8, POLD2, RAB41, TPTE, TRIM25GADD45GIP1GADD45G, GADD45A, GADD45B, NR4A1, CSNK2B, IKBKG, AR, ICT1, NFE2L2, HNRNPA1, COPS5, APP, MRPL12, TSR1, EIF3C, TMEM177, MRPL11, MRPL14, TAP1, PTRH2, EXOSC4, UPF2, LIN28A, FBXW11, CCDC8, ABCE1, RPL13, MRPL28, NIFK, RPS8, MRPL4, MRPL37, MRPS30, MRPL47, ELF3, HIST1H3E, KIF2A, RAB5C, MRPL50, MRPL9, MRPL1, KRBOX4, FOXB1, FOXL1, FOXL2, FOXS1, ACP1, CDC14B, MTMR10, FAN1, MTMR2, PTP4A1, MRPL42, MRPL41, MRPL10, ZC3HAV1, PTP4A2, PTPN2, PTPN6, RNGTT, TENC1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for PPP5C_GADD45GIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for PPP5C_GADD45GIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource