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Fusion gene ID: 28512 |
FusionGeneSummary for PPP5C_GADD45GIP1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: PPP5C_GADD45GIP1 | Fusion gene ID: 28512 | Hgene | Tgene | Gene symbol | PPP5C | GADD45GIP1 | Gene ID | 5536 | 90480 |
Gene name | protein phosphatase 5 catalytic subunit | GADD45G interacting protein 1 | |
Synonyms | PP5|PPP5|PPT | CKBBP2|CKbetaBP2|CRIF1|MRP-L59|PLINP|PLINP-1|PRG6|Plinp1 | |
Cytomap | 19q13.32 | 19p13.13 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein phosphatase 5PP-Tprotein phosphatase T | growth arrest and DNA damage-inducible proteins-interacting protein 139S ribosomal protein L59, mitochondrialCKII beta binding protein 2CKII beta-associating proteinCR6 interacting factor 1growth arrest and DNA-damage-inducible, gamma interacting pro | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P53041 | Q8TAE8 | |
Ensembl transtripts involved in fusion gene | ENST00000012443, ENST00000391919, | ENST00000316939, | |
Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 6 X 1 X 4=24 |
# samples | 5 | 5 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/24*10)=1.05889368905357 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: PPP5C [Title/Abstract] AND GADD45GIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | GADD45GIP1 | GO:0071850 | mitotic cell cycle arrest | 24520316 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | CESC | TCGA-VS-A8Q9-01A | PPP5C | chr19 | 46879831 | + | GADD45GIP1 | chr19 | 13065340 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000012443 | ENST00000316939 | PPP5C | chr19 | 46879831 | + | GADD45GIP1 | chr19 | 13065340 | - |
Frame-shift | ENST00000391919 | ENST00000316939 | PPP5C | chr19 | 46879831 | + | GADD45GIP1 | chr19 | 13065340 | - |
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FusionProtFeatures for PPP5C_GADD45GIP1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
PPP5C | GADD45GIP1 |
Serine/threonine-protein phosphatase thatdephosphorylates a myriad of proteins involved in differentsignaling pathways including the kinases CSNK1E, ASK1/MAP3K5,PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2,SMAD proteins and TAU/MAPT. Implicated in wide ranging cellularprocesses, including apoptosis, differentiation, DNA damageresponse, cell survival, regulation of ion channels or circadianrhythms, in response to steroid and thyroid hormones, calcium,fatty acids, TGF-beta as well as oxidative and genotoxic stresses.Participates in the control of DNA damage response mechanisms suchas checkpoint activation and DNA damage repair through, forinstance, the regulation ATM/ATR-signaling and dephosphorylationof PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosisinduced by oxidative stress. Plays a positive role inadipogenesis, mainly through the dephosphorylation and activationof PPARG transactivation function. Also dephosphorylates andinhibits the anti-adipogenic effect of NR3C1. Regulates thecircadian rhythms, through the dephosphorylation and activation ofCSNK1E. May modulate TGF-beta signaling pathway by the regulationof SMAD3 phosphorylation and protein expression levels.Dephosphorylates and may play a role in the regulation ofTAU/MAPT. Through their dephosphorylation, may play a role in theregulation of ions channels such as KCNH2.{ECO:0000269|PubMed:14734805, ECO:0000269|PubMed:14764652,ECO:0000269|PubMed:14871926, ECO:0000269|PubMed:15383005,ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16260606,ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:16892053,ECO:0000269|PubMed:19176521, ECO:0000269|PubMed:19948726,ECO:0000269|PubMed:21144835, ECO:0000269|PubMed:22399290,ECO:0000269|PubMed:22781750, ECO:0000269|PubMed:23102700,ECO:0000269|PubMed:9000529}. | Acts as a negative regulator of G1 to S cell cycle phaseprogression by inhibiting cyclin-dependent kinases. Inhibitoryeffects are additive with GADD45 proteins but occurs also in theabsence of GADD45 proteins. Acts as a repressor of the orphannuclear receptor NR4A1 by inhibiting AB domain-mediatedtranscriptional activity. May be involved in the hormone-mediatedregulation of NR4A1 transcriptional activity. May play a role inmitochondrial protein synthesis. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for PPP5C_GADD45GIP1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for PPP5C_GADD45GIP1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
PPP5C | CSE1L, CDC27, GNA12, GNA13, MAP3K5, CRY2, USP49, PHLPP1, EGFR, HSPA4, HSP90AA1, DISC1, MAP3K7, CDK20, NR3C1, NR3C2, PGR, AR, PTGES3, APP, DIS3, AHSG, HNRNPA1, MAPT, ESR2, ESR1, GRB2, STIP1, HSPA8, HSPA1B, HSP90AB1, CCT4, CDC37, CDK18, ABHD14A, BZW2, EIF6, GINS3, GSS, NAPRT, PAFAH1B2, PAPSS1, PLD3, CTPS1, DCPS, DFFA, FUBP1, GAPDH, PPIB, TUFM, VCL, RAP1GDS1, XPO1, AHSA1, CDC37L1, IRS4, CHORDC1, ENO1, SHMT2, MOV10, NXF1, BPHL, DUT, MINPP1, NOL10, PSPC1, TATDN1, NTRK1, PSEN2, RBBP6, RPS6KB1, ABCF2, USP45, FLCN, HSPA6, DUSP8, POLD2, RAB41, TPTE, TRIM25 | GADD45GIP1 | GADD45G, GADD45A, GADD45B, NR4A1, CSNK2B, IKBKG, AR, ICT1, NFE2L2, HNRNPA1, COPS5, APP, MRPL12, TSR1, EIF3C, TMEM177, MRPL11, MRPL14, TAP1, PTRH2, EXOSC4, UPF2, LIN28A, FBXW11, CCDC8, ABCE1, RPL13, MRPL28, NIFK, RPS8, MRPL4, MRPL37, MRPS30, MRPL47, ELF3, HIST1H3E, KIF2A, RAB5C, MRPL50, MRPL9, MRPL1, KRBOX4, FOXB1, FOXL1, FOXL2, FOXS1, ACP1, CDC14B, MTMR10, FAN1, MTMR2, PTP4A1, MRPL42, MRPL41, MRPL10, ZC3HAV1, PTP4A2, PTPN2, PTPN6, RNGTT, TENC1, TRIM25 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for PPP5C_GADD45GIP1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for PPP5C_GADD45GIP1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |